Inflammatoriska responser kopplade till autoimmunitet och cancer – Mikael Karlssons grupp

Publikationer

Utvalda publikationer

• Article: JOURNAL OF IMMUNOLOGY. 2019;202(5):1510-1520

  Gαi2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination.

  Vural A; Nabar NR; Hwang I-Y; Sohn S; Park C; Karlsson MCI; Blumer JB; Kehrl JH
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(3):443-453

  Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses.

  Tripathi P; Sedimbi SK; Singh AK; Löfbom L; Issazadeh-Navikas S; Weiss S; Förster I; Karlsson MCI; Yrlid U; Kadri N; Cardell SL
• Article: EMBO JOURNAL. 2019;38(2):e100010-19

  Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

  Bönelt P; Wöhner M; Minnich M; Tagoh H; Fischer M; Jaritz M; Kavirayani A; Garimella M; Karlsson MC; Busslinger M
• Article: CIRCULATION. 2018;138(22):2513-2526

  Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice.

  Gisterå A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
• Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787

  Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

  Ádori M; Pedersen GK; Ádori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Karlsson Hedestam GB
• Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033

  Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis.

  Lloyd KA; Wigerblad G; Sahlström P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stålesen R; Ossipova E; Lundqvist C; Ekwall O; Rönnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmström V; Grönwall C
• Article: JOURNAL OF INFECTIOUS DISEASES. 2017;216(10):1308-1317

  A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.

  Svedin E; Utorova R; Hühn MH; Larsson PG; Stone VM; Garimella M; Lind K; Hägglöf T; Pincikova T; Laitinen OH; McInerney GM; Scholte B; Hjelte L; Karlsson MCI; Flodström-Tullberg M
• Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2017;15(1):152

  The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype.

  Lundgren S; Karnevi E; Elebro J; Nodin B; Karlsson MCI; Eberhard J; Leandersson K; Jirström K
• Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791

  Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system.

  Karlsson MC; Gonzalez SF; Welin J; Fuxe J
• Article: FRONTIERS IN IMMUNOLOGY. 2017;8:738

  Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.

  Forsell MNE; Kvastad L; Sedimbi SK; Andersson J; Karlsson MCI
• Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414

  Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.

  Hägglöf T; Sedimbi SK; Yates JL; Parsa R; Salas BH; Harris RA; Leadbetter EA; Karlsson MCI
• Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789

  Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions.

  Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hägglöf T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
• Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626

  Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development.

  Duhlin A; Chen Y; Wermeling F; Sedimbi SK; Lindh E; Shinde R; Halaby MJ; Kaiser Y; Winqvist O; McGaha TL; Karlsson MCI
• Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068

  Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21.

  Prokopec KE; Georgoudaki A-M; Sohn S; Wermeling F; Grönlund H; Lindh E; Carroll MC; Karlsson MCI
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553

  BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.

  Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Ortlieb Guerreiro-Cacais A; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
• Article: NATURE COMMUNICATIONS. 2016;7:12175

  Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

  Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Liedén A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylén S; Westerberg LS
• Article: ONCOTARGET. 2016;7(25):38707-38717

  Exosomal cancer immunotherapy is independent of MHC molecules on exosomes.

  Hiltbrunner S; Larssen P; Eldh M; Martinez-Bravo M-J; Wagner AK; Karlsson MCI; Gabrielsson S
• Article: CELL REPORTS. 2016;15(9):2000-2011

  Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.

  Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Östling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
• Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):26-43

  Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity.

  McGaha TL; Karlsson MCI
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(40):12474-12479

  Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.

  Vomhof-DeKrey EE; Yates J; Hägglöf T; Lanthier P; Amiel E; Veerapen N; Besra GS; Karlsson MCI; Leadbetter EA
• Article: JOURNAL OF AUTOIMMUNITY. 2015;62:81-92

  Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies.

  Dahlberg CIM; Torres M-L; Petersen SH; Baptista MAP; Keszei M; Volpi S; Grasset EK; Karlsson MCI; Walter JE; Snapper SB; Notarangelo LD; Westerberg LS
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(16):E2030-E2038

  Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response.

  Grasset EK; Duhlin A; Agardh HE; Ovchinnikova O; Hägglöf T; Forsell MN; Paulsson-Berne G; Hansson GK; Ketelhuth DFJ; Karlsson MCI
• Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(24):4795-4808

  IL-18 in inflammatory and autoimmune disease.

  Sedimbi SK; Hägglöf T; Karlsson MCI
• Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51

  Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization.

  Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Karlsson Hedestam GB
• Article: CANCER RESEARCH. 2013;73(13):3865-3876

  Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes.

  Gehrmann U; Hiltbrunner S; Georgoudaki A-M; Karlsson MC; Näslund TI; Gabrielsson S
• Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70

  AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment.

  Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Loré K; Winqvist O; Chambers BJ; Karlsson MCI
• Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026

  BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responses.

  Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Karlsson Hedestam GB
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(10):3909-3914

  Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase.

  Ravishankar B; Liu H; Shinde R; Chandler P; Baban B; Tanaka M; Munn DH; Mellor AL; Karlsson MCI; McGaha TL
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):E1399-E1407

  The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells.

  Enoksson SL; Grasset EK; Hägglöf T; Mattsson N; Kaiser Y; Gabrielsson S; McGaha TL; Scheynius A; Karlsson MCI
• Article: BLOOD. 2011;117(20):5403-5412

  Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen.

  McGaha TL; Chen Y; Ravishankar B; van Rooijen N; Karlsson MCI
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):943-952

  Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.

  Wermeling F; Lind SM; Jordö ED; Cardell SL; Karlsson MCI
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460

  A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.

  Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(8):2293-2301

  IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema.

  Lind SM; Kuylenstierna C; Moll M; D Jordö E; Winqvist O; Lundeberg L; Karlsson MA; T Linder M; Johansson C; Scheynius A; Sandberg JK; Karlsson MCI
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18466-18471

  AIRE regulates T-cell-independent B-cell responses through BAFF.

  Lindh E; Lind SM; Lindmark E; Hässler S; Perheentupa J; Peltonen L; Winqvist O; Karlsson MCI
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(10):2259-2265

  Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus.

  Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JV; Tryggvason K; Karlsson MCI
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Medarbetare och kontakt

Gruppledare

• 

  Mikael Karlsson

  Professor | Docent

  Telefon +46852486175

  E-postadress mikael.karlsson@ki.se

Alla medlemmar i gruppen

• 

  Mikael Karlsson

  Professor | Docent

  Telefon +46852486175

  E-postadress mikael.karlsson@ki.se
• Heng Liang

  Postdoktorala Studier

  E-postadress heng.liang@ki.se
• Marion Moreews

  Postdoktorala Studier

  E-postadress marion.moreews@ki.se
• Lars Nitschke

  Anknuten till Forskning

  E-postadress lars.nitschke@ki.se
• Yueyun Pan

  Doktorand

  E-postadress yueyun.pan@ki.se
• 

  Shengduo Pei

  Doktorand

  E-postadress shengduo.pei@ki.se
• 

  Kajsa Westberg

  Doktorand

  E-postadress kajsa.westberg@ki.se