Mikael Karlsson

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Mikael Karlsson, professor i immunologi vid institutionen för mikrobiologi, tumör- och cellbiologi, forskar om hur immunsystemet regleras och varför det ibland hamnar i obalans – vilket ger upphov till sjukdom. Särskilt intresserar han sig för B-celler och makrofager. Hans forskning bidrar till ökad kunskap om autoimmun sjukdom och har också koppling till cancer.

Artiklar

Article: BLOOD ADVANCES. 2024;8(8):1981-1990
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not in fl uence biological function
Estupinan HY; Bouderlique T; He C; Berglof A; Cappelleri A; Frengen N; Zain R; Karlsson MCI; Mansson R; Smith CIE
Article: ELIFE. 2023;12:e86454
The role of B cells in immune cell activation in polycystic ovary syndrome
Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teschl S; Menezes J; Sandor K; Ohlsson C; Svensson CI; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
Article: CANCER RESEARCH. 2023;83(10):1628-1645
FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner
He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(2):217-227
Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti-PD-1 and Anti-PD-L1 Treatment in a Checkpoint Refractory Melanoma Model
Veerman RE; Akpinar GG; Offens A; Steiner L; Larssen P; Lundqvist A; Karlsson MCI; Gabrielsson S
Article: ISCIENCE. 2022;25(11):105317
Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer
Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy
Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
Article: SCIENTIFIC REPORTS. 2022;12(1):12931
Deficiency of mature B cells does not alter the atherogenic response to castration in male mice
Wilhelmson AS; Johansson I; Fogelstrand L; Fagman JB; Arnal J-F; Karlsson MCI; Tivesten A
Article: AUTOPHAGY. 2022;18(1):204-222
LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells
Nabar NR; Heijjer CN; Shi C-S; Hwang I-Y; Ganesan S; Karlsson MCI; Kehrl JH
Article: AUTOPHAGY. 2021;17(11):3577-3591
CD36 and LC3B initiated autophagy in B cells regulates the humoral immune response
He C; Wang S; Zhou C; He M; Wang J; Ladds M; Lianoudaki D; Sedimbi SK; Lane DP; Westerberg LS; Li S; Karlsson MCI
Article: NATURE COMMUNICATIONS. 2021;12(1):4127
Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma
van Hooren L; Vaccaro A; Ramachandran M; Vazaios K; Libard S; van de Walle T; Georganaki M; Huang H; Pietilae I; Lau J; Ulvmar MH; Karlsson MCI; Zetterling M; Mangsbo SM; Jakola AS; Bontell TO; Smits A; Essand M; Dimberg A
Article: CANCER RESEARCH. 2021;81(4):956-967
Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function
La Fleur L; Botling J; He F; Pelicano C; Zhou C; He C; Palano G; Mezheyeuski A; Micke P; Ravetch JV; Karlsson MCI; Sarhan D
Article: IMMUNITY. 2021;54(2):259-275.e7
Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: JOURNAL OF AUTOIMMUNITY. 2021;117:102582
The B cell response to both protein and nucleic acid antigens displayed on apoptotic cells are dependent on endosomal pattern recognition receptors
Garimella MG; He C; Chen G; Li Q-Z; Huang X; Karlsson MCI
Article: MOLECULAR IMMUNOLOGY. 2021;130:49-54
Reading the room: iNKT cells influence B cell responses
Leadbetter EA; Karlsson MCI
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243
GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens
Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173
SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development
Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: BLOOD ADVANCES. 2020;4(16):3971-3976
Platelets mediate serological memory to neutralize viruses in vitro and in vivo
Schrottmaier WC; Salzmann M; Badrnya S; Mussbacher M; Kral-Pointner JB; Morava S; Pirabe A; Brunnthaler L; Yaiw KC; Heber UM; Pereyra D; Andersen JT; Bergthaler A; Soederberg-Naucler C; Karlsson MCI; Assinger A; Forsell MNE
Article: BLOOD ADVANCES. 2020;4(11):2439-2450
Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects
Estupinan HY; Bouderlique T; He C; Berglof A; Gupta D; Saher O; Daza Cruz MA; Pena-Perez L; Yu L; Zain R; Karlsson MCI; Mansson R; Smith CIE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(16):9054-9063
Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses
Sedimbi SK; Hagglof T; Garimella MG; Wang S; Duhlin A; Coelho A; Ingelshed K; Mondoc E; Malin SG; Holmdahl R; Lane DP; Leadbetter EA; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2019;203(4):825-834
Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo
Larssen P; Veerman RE; Akpinar GG; Hiltbrunner S; Karlsson MCI; Gabrielsson S
Article: NATURE COMMUNICATIONS. 2019;10(1):2870
Actomyosin-driven force patterning controls endocytosis at the immune synapse
Kumari A; Pineau J; Saez PJ; Maurin M; Lankar D; San Roman M; Hennig K; Boura VF; Voituriez R; Karlsson MCI; Balland M; Dumenil A-ML; Pierobon P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(3):443-453
Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses
Tripathi P; Sedimbi SK; Singh AK; Lofboml L; Issazadeh-Navikas S; Weiss S; Foerster I; Karlsson MCI; Yrlid U; Kadri N; Cardell SL
Article: JOURNAL OF IMMUNOLOGY. 2019;202(5):1510-1520
Gα_i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination
Vural A; Nabar NR; Hwang I-Y; Sohn S; Park C; Karlsson MCI; Blumer JB; Kehrl JH
Article: EMBO JOURNAL. 2019;38(2):e100010-19
Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells
Boenelt P; Woehner M; Minnich M; Tagoh H; Fischer M; Jaritz M; Kavirayani A; Garimella M; Karlsson MCI; Busslinger M
Article: CIRCULATION. 2018;138(22):2513-2526
Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice
Gistera A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
Article: INTERNATIONAL JOURNAL OF CANCER. 2018;143(7):1741-1752
Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer
La Fleur L; Boura VF; Alexeyenko A; Berglund A; Ponten V; Mattsson JSM; Djureinovic D; Persson J; Brunnstrom H; Isaksson J; Branden E; Koyi H; Micke P; Karlsson MCI; Botling J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(7):1519-1527
Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial CellsBrief Report
Wilhelmson AS; Rodriguez ML; Eriksson ES; Johansson I; Fogelstrand P; Stubelius A; Lindgren S; Fagman JB; Hansson GK; Carlsten H; Karlsson MCI; Ekwall O; Tivesten A
Article: NATURE COMMUNICATIONS. 2018;9(1):2067
Testosterone is an endogenous regulator of BAFF and splenic B cell number
Wilhelmson AS; Rodriguez ML; Stubelius A; Fogelstrand P; Johansson I; Buechler MB; Lianoglou S; Kapoor VN; Johansson ME; Fagman JB; Duhlin A; Tripathi P; Camponeschi A; Porse BT; Rolink AG; Nissbrandt H; Turley SJ; Carlsten H; Martensson I-L; Karlsson MCI; Tivesten A
Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia
Chen X; Gustafsson S; Whitington T; Borne Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hagg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engstrom G; Lind L; Karlsson MCI; Pedersen NL; Frostegard J; Magnusson PKE
Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787
Altered Marginal Zone B Cell Selection in the Absence of IκBNS
Adori M; Pedersen GK; Adori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033
Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis
Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
Article: JOURNAL OF INFECTIOUS DISEASES. 2017;216(10):1308-1317
A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense
Svedin E; Utorova R; Huhn MH; Larsson PG; Stone VM; Garimella M; Lind K; Hagglof T; Pincikova T; Laitinen OH; McInerney GM; Scholte B; Hjelte L; Karlsson MCI; Flodstrom-Tullberg M
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2017;15(1):152
The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype
Lundgren S; Karnevi E; Elebro J; Nodin B; Karlsson MCI; Eberhard J; Leandersson K; Jirstrom K
Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791
Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system
Karlsson MC; Gonzalez SF; Welin J; Fuxe J
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:738
Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback
Forsell MNE; Kvastad L; Sedimbi SK; Andersson J; Karlsson MCI
Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414
Neutrophils license iNKT cells to regulate self reactive mouse B cell responses
Hagglof T; Sedimbi SK; Yates JL; Parsa R; Salas BH; Harris RA; Leadbetter EA; Karlsson MCI
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789
Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions
Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hagglof T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626
Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development
Duhlin A; Chen Y; Wermeling F; Sedimbi SK; Lindh E; Shinde R; Halaby MJ; Kaiser Y; Winqvist O; McGaha TL; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068
Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
Prokopec KE; Georgoudaki A-M; Sohn S; Wermeling F; Gronlund H; Lindh E; Carroll MC; Karlsson MCI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2016;213(8):1537-1553
BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis
Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
Article: NATURE COMMUNICATIONS. 2016;7:12175
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Lieden A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylen S; Westerberg LS
Article: ONCOTARGET. 2016;7(25):38707-38717
Exosomal cancer immunotherapy is independent of MHC molecules on exosomes
Hiltbrunner S; Larssen P; Eldh M; Martinez-Bravo M-J; Wagner AK; Karlsson MCI; Gabrielsson S
Article: CELL REPORTS. 2016;15(9):2000-2011
Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(40):12474-12479
Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells
Vomhof-DeKrey EE; Yates J; Hagglof T; Lanthier P; Amiel E; Veerapen N; Besra GS; Karlsson MCI; Leadbetter EA
Article: JOURNAL OF AUTOIMMUNITY. 2015;62:81-92
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies
Dahlberg CIM; Torres M-L; Petersen SH; Baptista MAP; Keszei M; Volpi S; Grasset EK; Karlsson MCI; Walter JE; Snapper SB; Notarangelo LD; Westerberg LS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(16):E2030-E2038
Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response
Grasset EK; Duhlin A; Agardh HE; Ovchinnikova O; Hagglof T; Forsell MN; Paulsson-Berne G; Hansson GK; Ketelhuth DFJ; Karlsson MCI
Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2014;34(1):56-70
Invariant Natural Killer T (iNKT) Cells Prevent Autoimmunity, but Induce Pulmonary Inflammation in Cystic Fibrosis
Siegmann N; Worbs D; Effinger F; Bormann T; Gebhardt M; Ulrich M; Wermeling F; Mueller-Hermelink E; Biedermann T; Tighe M; Edwards MJ; Caldwell C; Leadbetter E; Karlsson MCI; Becker KA; Gulbins E; Doering G
Article: CANCER RESEARCH. 2013;73(13):3865-3876
Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes
Gehrmann U; Hiltbrunner S; Georgoudaki A-M; Karlsson MC; Naslund TI; Gabrielsson S
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51
Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization
Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Hedestam GBK
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70
AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment
Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Lore K; Winqvist O; Chambers BJ; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2013;42:1-6
Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1
Lindh E; Brannstrom J; Jones P; Wermeling F; Hassler S; Betterle C; Garty BZ; Stridsberg M; Herrmann B; Karlsson MCI; Winqvist O
Article: JOURNAL OF IMMUNOLOGY. 2013;190(6):2712-2719
Dendritic Cell-Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity
Naslund TI; Gehrmann U; Qazi KR; Karlsson MCI; Gabrielsson S
Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026
BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses
Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Hedestam GBK
Article: PARTICLE AND FIBRE TOXICOLOGY. 2012;9:16
Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
Swedin L; Arrighi R; Andersson-Willman B; Murray A; Chen Y; Karlsson MCI; Georen SK; Tkach AV; Shvedova AA; Fadeel B; Barragan A; Scheynius A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(10):3909-3914
Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase
Ravishankar B; Liu H; Shinde R; Chandler P; Baban B; Tanaka M; Munn DH; Mellor AL; Karlsson MCI; McGaha TL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):E1399-E1407
The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells
Enoksson SL; Grasset EK; Hagglof T; Mattsson N; Kaiser Y; Gabrielsson S; McGaha TL; Scheynius A; Karlsson MCI
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3641-3652
Complement Activation and Complement Receptors on Follicular Dendritic Cells Are Critical for the Function of a Targeted Adjuvant
Mattsson J; Yrlid U; Stensson A; Schon K; Karlsson MCI; Ravetch JV; Lycke NY
Article: CELLULAR AND MOLECULAR IMMUNOLOGY. 2011;8(4):296-304
Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis
Carnrot C; Prokopec KE; Rasbo K; Karlsson MCI; Kleinau S
Article: BLOOD. 2011;117(20):5403-5412
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
McGaha TL; Chen Y; Ravishankar B; van Rooijen N; Karlsson MCI
Article: PLOS ONE. 2011;6(7):e22202
The Expression of BAFF, APRIL and TWEAK Is Altered in Eczema Skin but Not in the Circulation of Atopic and Seborrheic Eczema Patients
Chen Y; Enoksson SL; Johansson C; Karlsson MA; Lundeberg L; Nilsson G; Scheynius A; Karlsson MCI
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(5):943-952
Invariant NKT cells limit activation of autoreactive CD1d-positive B cells
Wermeling F; Lind SM; Jordo ED; Cardell SL; Karlsson MCI
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses
Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
Article: JOURNAL OF AUTOIMMUNITY. 2010;34(1):66-72
AIRE deficiency leads to impaired iNKT cell development
Lindh E; Rosmaraki E; Berg L; Brauner H; Karlsson MCI; Peltonen L; Hoglund P; Winqvist O
Article: AUTOIMMUNITY REVIEWS. 2009;9(1):49-52
An anatomical view on macrophages in tolerance
Wermeling F; Karlsson MCI; McGaha TL
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(8):2293-2301
IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema
Lind SM; Kuylenstierna C; Moll M; Jordo ED; Winqvist O; Lundeberg L; Karlsson MA; Linder MT; Johansson C; Scheynius A; Sandberg JK; Karlsson MCI
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;64(6):919-926
Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergstrom U; Swedin L; Dahlen S-E; Arner E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Gronlund H
Article: BLOOD. 2009;113(12):2673-2683
Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism
Qazi KR; Gehrmann U; Jordo ED; Karlsson MCI; Gabrielsson S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19571-19578
Identification of a receptor required for the anti-inflammatory activity of IVIG
Anthony RM; Wermeling F; Karlsson MCI; Ravetch JV
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18466-18471
AIRE regulates T-cell-independent B-cell responses through BAFF
Lindh E; Lind SM; Lindmark E; Hassler S; Perheentupa J; Peltonen L; Winqvist O; Karlsson MCI
Article: BLOOD. 2008;112(10):4139-4147
WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function
Westerberg LS; de la Fuente MA; Wermeling F; Ochs HD; Karlsson MCI; Snapper SB; Notarangelo LD
Article: JOURNAL OF IMMUNOLOGY. 2008;180(10):6604-6610
A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen
Hjelm F; Karlsson MCI; Heyman B
Article: JOURNAL OF IMMUNOLOGY. 2008;180(8):5670-5679
FcγRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice
McGaha TL; Karlsson MCI; Ravetch JV
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2007;204(10):2259-2265
Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus
Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JRV; Tryggvason K; Karlsson MCI
Article: BLOOD. 2006;108(6):1941-1948
Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma
Hassler S; Ramsey C; Karlsson MC; Larsson D; Herrmann B; Rozell B; Backheden M; Peltonen L; Kampe O; Winqvist O
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2003;198(2):333-340
Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.
Karlsson MCI; Guinamard R; Bolland S; Sankala M; Steinman RM; Ravetch JV
Article: CANCER RESEARCH. 2002;62(23):6891-6900
Disruption of cell-cell adhesion enhances antibody-dependent cellular cytotoxicity: implications for antibody-based therapeutics of cancer.
Green SK; Karlsson MCI; Ravetch JV; Kerbel RS
Article: JOURNAL OF IMMUNOLOGY. 2001;167(10):5558-5564
FcgammaRIIB in IgG-mediated suppression of antibody responses: different impact in vivo and in vitro.
Karlsson MC; Getahun A; Heyman B
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;53(4):381-385
IgE-mediated suppression of primary antibody responses in vivo.
Karlsson MC; Diaz de Ståhl T; Heyman B
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):618-622
IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice.
Wernersson S; Karlsson MC; Dahlström J; Mattsson R; Verbeek JS; Heyman B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(5):2244-2249
Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.
Karlsson MC; Wernersson S; Diaz de Ståhl T; Gustavsson S; Heyman B
Article: IMMUNOGENETICS. 1998;48(5):344-349
Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule
Vestberg M; Brunsberg U; Bergsteinsdottir K; Karlsson M; Gustafsson K; Wedekind D; Hedrich H; Holmdahl R
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Letter: CELLULAR AND MOLECULAR IMMUNOLOGY. 2024;21(1):91-94
Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress
Pei S; Sjolund J; Pan Y; Pietras K; Karlsson MCI
Review: JOURNAL OF CLINICAL MEDICINE. 2023;12(19):6268
B Cell Tolerance and Targeted Therapies in SLE
Parodis I; Long X; Karlsson MCI; Huang X
Editorial comment: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(3):702-705
IgE autoantibodies: An innate connection to adaptive immunity
Huang X; Karlsson MCI
Review: IMMUNOLOGICAL REVIEWS. 2021;299(1):93-107
Invariant natural killer T cells balance B cell immunity
Leadbetter EA; Karlsson MCI
Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):26-43
Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity
McGaha TL; Karlsson MCI
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(24):4795-4808
IL-18 in inflammatory and autoimmune disease
Sedimbi SK; Hagglof T; Karlsson MCI
Review: SEMINARS IN CANCER BIOLOGY. 2012;22(5-6):455-461
TGF-β-induced epithelial-mesenchymal transition: A link between cancer and inflammation
Fuxe J; Karlsson MCI
Review: MOLECULAR IMMUNOLOGY. 2011;48(11):1307-1318
Scavenger receptors as regulators of natural antibody responses and B cell activation in autoimmunity
Jordo ED; Wermeling F; Chen Y; Karlsson MCI
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S64
The Wiskott-Aldrich syndrome protein is essential for development and correct function of the marginal zone
Westerberg L; De La Fuente M; Wermeling F; Ochs H; Karlsson M; Notarangelo L; Snapper S
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;53(4):331-334
No evidence for a role of FcgammaRIIB in suppression of in vivo antibody responses to erythrocytes by passively administered IgG.
Heyman B; Dahlström J; Diaz De Ståhl T; Getahun A; Wernersson S; Karlsson MC

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Professor, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2016-

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Docent, Experimentell immunologi, Karolinska Institutet, 2009

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