Pete Williams

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53
Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism.
Canovai A; Williams PA
Article: MOLECULAR BRAIN. 2024;17(1):84
Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma
Rombaut A; Brautaset R; Williams PA; Tribble JR
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2024;65(12):4
Ganglion Cell Complex Thickness and Visual Function in Chronic Leber Hereditary Optic Neuropathy
Hedstrom J; Nilsson M; Engvall M; Williams PA; Venkataraman AP
Journal article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137
Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma.
Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
Article: NATURE MEDICINE. 2024;30(8):2362-2370
Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss
Petriti B; Rabiolo A; Chau K-Y; Williams PA; Montesano G; Lascaratos G; Garway-Heath DF
Article: NATURE COMMUNICATIONS. 2024;15(1):6256
NMNAT2 is a druggable target to drive neuronal NAD production
Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):79
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Rombaut A; Jovancevic D; Wong RC-B; Nicol A; Brautaset R; Finkelstein DI; Nguyen CTO; Tribble JR; Williams PA
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):65
Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
Kim M; Kim JY; Rhim W-K; Cimaglia G; Want A; Morgan JE; Williams PA; Park CG; Han DK; Rho S
Article: BMC NEUROLOGY. 2024;24(1):111
Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol
Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):37
Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume
Otmani A; Johannesson G; Brautaset R; Tribble JR; Williams PA
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137
Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma
Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)
Neuroprotective effects of GLP‐1 receptor agonists and their potential in retinal diseases
Mouhammad ZA; von Spreckelsen A; Bermudez MYG; Vohra R; Williams P; Kolko M
Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)
Preventing retinal homocysteine dysregulation protects against retinal ganglion cell death
Tribble JR; Rutigliani C; Canovai A; Williams PA
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(14):34
Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma
Gustavsson ST; Enz TJ; Tribble JR; Nilsson M; Lindqvist A; Linden C; Hagstrom A; Rutigliani C; Lardner E; Stalhammar G; Williams PA; Johannesson G
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):146
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Canovai A; Tribble JR; Joe M; Westerlund DY; Amato R; Trounce IA; Dal Monte M; Williams PA
Article: GENE THERAPY. 2023;30(6):503-519
Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters
Nieuwenhuis B; Laperrousaz E; Tribble JR; Verhaagen J; Fawcett JW; Martin KR; Williams PA; Osborne A
Article: BMC CANCER. 2023;23(1):277
A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival
Herrspiegel C; Plastino F; Lardner E; Seregard S; Williams PA; Andre H; Stalhammar G
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18
NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve
Tribble JR; Hagstrom A; Jusseaume K; Lardner E; Wong RC-B; Stalhammar G; Williams PA
Article: JOURNAL OF BIOPHOTONICS. 2022;15(12):e202200169
Volume-rendered optical coherence tomography angiography during ocular interventions: Advocating for noninvasive intraoperative retinal perfusion monitoring
Enz TJ; Maloca PM; Tschopp M; Menke MN; Tribble JR; Williams PA; Inglin N; Steitz U; Scholl HPN; Papazoglou A
Article: DISCOVER ONCOLOGY. 2022;13(1):116
The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989
Stalhammar G; Williams PA; Landelius T
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):118
Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients
Rutigliani C; Tribble JR; Hagstrom A; Lardner E; Johannesson G; Stalhammar G; Williams PA
Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2022;11(2):1
Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging
Enz TJ; Bittner M; Tribble JR; Williams PA; Thiel MA; Schmid MK; Bachmann LM; Bochmann F
Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma A Phase 2 Randomized Clinical Trial
De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:903436
Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model
Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(17):3938
Comparison of Glaucoma-Relevant Transcriptomic Datasets Identifies Novel Drug Targets for Retinal Ganglion Cell Neuroprotection
Enz TJ; Tribble JR; Williams PA
Article: REDOX BIOLOGY. 2021;43:101988
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Joe M; Lardner E; Venkataraman AP; Dominguez-Vicent A; Kokkali E; Rho S; Johnnesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):21
Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma
Tribble JR; Otmani A; Kokkali E; Lardner E; Morgan JE; Williams PA
Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):22
When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma
Tribble JR; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; Andre H; Morgan JE; Williams PA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin
Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):216
Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease
Bevan RJ; Hughes TR; Williams PA; Good MA; Morgan BP; Morgan JE
Article: JOURNAL OF NEUROINFLAMMATION. 2020;17(1):336
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice
Harder JM; Williams PA; Braine CE; Yang HS; Thomas JM; Foxworth NE; John SWM; Howell GR
Article: NATURE COMMUNICATIONS. 2020;11(1):5614
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS
Petrova V; Pearson CS; Ching J; Tribble JR; Solano AG; Yang Y; Love FM; Watt RJ; Osborne A; Reid E; Williams PA; Martin KR; Geller HM; Eva R; Fawcett JW
Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914
Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial
Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa101
OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory
Bevan RJ; Williams PA; Waters CT; Thirgood R; Mui A; Seto S; Good M; Morgan JE; Votruba M; Erchova I
Article: MOLECULAR BRAIN. 2020;13(1):81
Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice
Tribble J; Harder JM; Williams P; John SWM
Article: MOLECULAR NEURODEGENERATION. 2019;14(1):6
Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
Williams PA; Braine CE; Kizhatil K; Foxworth NE; Tolman NG; Harder JM; Scott RA; Sousa GL; Panitch A; Howell GR; John SWM
Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035
Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma
Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
Article: MOLECULAR BRAIN. 2018;11(1):69
Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma
Tribble JR; Williams PA; Caterson B; Sengpiel F; Morgan JE
Article: CELL DEATH & DISEASE. 2018;9(6):705
Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice
Harder JM; Williams PA; Soto I; Foxworth NE; Fernandes KA; Freeburg NF; Libby RT; John SWM
Article: NATURE COMMUNICATIONS. 2018;9(1):2278
A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci
Choquet H; Paylakhi S; Kneeland SC; Thai KK; Hoffmann TJ; Yin J; Kvale MN; Banda Y; Tolman NG; Williams PA; Schaefer C; Melles RB; Risch N; John SWM; Nair KS; Jorgenson E
Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2018;11(1):e1356956
Nicotinamide treatment robustly protects from inherited mouse glaucoma.
Williams PA; Harder JM; Cardozo BH; Foxworth NE; John SWM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3839-E3848
Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective
Harder JM; Braine CE; Williams PA; Zhu X; MacNicoll KH; Sousa GL; Buchanan RA; Smith RS; Libby RT; Howell GR; John SWM
Article: JOURNAL OF NEUROINFLAMMATION. 2017;14(1):93
GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma
Williams PA; Braine CE; Foxworth NE; Cochran KE; John SWM
Article: EXPERIMENTAL EYE RESEARCH. 2017;157:20-27
Neuroinflammation in glaucoma: A new opportunity
Williams PA; Marsh-Armstrong N; Howell GR
Article: SCIENCE. 2017;355(6326):756-760
Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice
Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM
Article: FRONTIERS IN NEUROSCIENCE. 2017;11:232
Nicotinamide and WLD^S Act Together to Prevent Neurodegeneration in Glaucoma
Williams PA; Harder JM; Foxworth NE; Cardozo BH; Cochran KE; John SWM
Article: MOLECULAR NEURODEGENERATION. 2016;11:26
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
Williams PA; Tribble JR; Pepper KW; Cross SD; Morgan BP; Morgan JE; John SWM; Howell GR
Article: EXPERIMENTAL EYE RESEARCH. 2015;141:42-56
Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities
Fernandes KA; Harder JM; Williams PA; Rausch RL; Kiernan AE; Nair KS; Anderson MG; John SWM; Howell GR; Libby RT
Article: IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING. 2015;23(4):655-664
A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator
Lee ST; Williams PA; Braine CE; Lin D-T; John SWM; Irazoqui PP
Article: NEUROBIOLOGY OF AGING. 2013;34(7):1799-1806
Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease
Williams PA; Thirgood RA; Oliphant H; Frizzati A; Littlewood E; Votruba M; Good MA; Williams J; Morgan JE
Article: PLOS ONE. 2013;8(8):e72282
Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma
Williams PA; Howell GR; Barbay JM; Braine CE; Sousa GL; John SWM; Morgan JE
Article: BRAIN. 2012;135(Pt 2):493-505
Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity
Williams PA; Piechota M; von Ruhland C; Taylor E; Morgan JE; Votruba M
Article: EXPERIMENTAL EYE RESEARCH. 2011;93(5):771-777
Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy
Barnard AR; Issa PC; Perganta G; Williams PA; Davies VJ; Sekaran S; Votruba M; MacLaren RE
Article: BRAIN. 2010;133(10):2942-2951
Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy
Williams PA; Morgan JE; Votruba M
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Alla övriga publikationer

Review: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53
Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism
Canovai A; Williams PA
Review: SURVEY OF OPHTHALMOLOGY. 2025;70(1):38-46
Choroidal nevi and melanoma doubling times and implications for delays in treatment: A systematic review and meta-analysis
Stalhammar G; Hagstrom A; Conradi ME; Williams PA
Corrigendum: NATURE COMMUNICATIONS. 2024;15(1):8143
NMNAT2 is a druggable target to drive neuronal NAD production (vol 15, 6256, 2024)
Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
Editorial comment: NEURAL REGENERATION RESEARCH. 2024;19(8):1637-1638
Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma
Williams PA; Casson RJ
Preprint: MEDRXIV. 2024
Evaluating the effect of rapamycin treatment in Alzheimer's Disease and aging usingin vivoimaging: the ERAP phase IIa clinical study protocol
Svensson J; Bolin M; Thor D; Williams P; Brautaset R; Carlsson M; Sörensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Morén AF; Kivipelto M; Plavén-Sigray P
Book chapter: REFERENCE MODULE IN NEUROSCIENCE AND BIOBEHAVIORAL PSYCHOLOGY. 2024;p.
Mitochondria and Primary Open Angle Glaucoma
Williams PA; Hui F
Preprint: RESEARCH SQUARE. 2023
Mitochondrial respiratory function is strongly associated with progressive glaucomatous vision loss
Petriti B; Rabiolo A; Chau K-Y; Williams P; Montesano G; Lascaratos G; Garway-Heath D
Review: MOLECULAR NEURODEGENERATION. 2023;18(1):64
Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium
Soucy JR; Aguzzi EA; Cho J; Gilhooley MJ; Keuthan C; Luo Z; Monavarfeshani A; Saleem MA; Wang X-W; Wohlschlegel J; Baranov P; Di Polo A; Fortune B; Gokoffski KK; Goldberg JL; Guido W; Kolodkin AL; Mason CA; Ou Y; Reh TA; Ross AG; Samuels BC; Welsbie D; Zack DJ; Johnson TV
Review: MOLECULAR ASPECTS OF MEDICINE. 2023;92:101193
Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering
Tribble JR; Hui F; Quintero H; El Hajji S; Bell K; Di Polo A; Williams PA
Review: FRONTIERS IN OPHTHALMOLOGY. 2023;3:1290465
Glial metabolic alterations during glaucoma pathogenesis
Rombaut A; Brautaset R; Williams PA; Tribble JR
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)
Glaucoma: Understanding the biological contributions of Aging and Sex
Williams P
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)
Metabolomic profiling of dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)
Komaromy A; Harman C; Anderson A; Williams P
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)
Effect of short-term nicotinamide supplementation on inner retinal function in dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)
Halsmer EL; DeQuattro C; Wang S; Harman C; Anderson A; Williams P; Komaromy AM
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)
Primary open angle glaucoma patients have lower systemic mitochondrial function, associated with lower systemic nicotinamide adenine dinucleotide (NAD) levels, compared to Controls
Petriti B; Rabiolo A; Williams P; Chau K-Y; Lascaratos G; Garway-Heath DF
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)
NMNAT2 is a druggable target for neuroprotection in glaucoma
Williams P; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)
Development of neuroprotective small molecular drugs targeting NMNAT2
Joe M; Tribble JR; Varricchio C; Brancale A; Johannesson G; Wheelock C; Williams P
Review: BMC CANCER. 2022;22(1):398
The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature
Hagstrom A; Kal Omar R; Williams PA; Stalhammar G
Preprint: RESEARCH SQUARE. 2022
The Rationale For Treating Uveal Melanoma With Adjuvant Melatonin: A Review of The Literature
Hagström A; Omar RK; Williams P; Stålhammar G
Review: FRONTIERS IN NEUROSCIENCE. 2022;16:824054
Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?
Mouhammad ZA; Vohra R; Horwitz A; Thein A-S; Rovelt J; Cvenkel B; Williams PA; Azuara-Blanco A; Kolko M
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)
Valproic acid reduces resident neuroinflammation and provides neuroprotection following retinal ganglion cell axotomy
Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)
Targeting NMNAT2 for neuroprotection in glaucoma
Williams PA; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
Review: CELLS. 2021;10(6):1402
Neuroprotection in Glaucoma: NAD⁺/NADH Redox State as a Potential Biomarker and Therapeutic Target
Petriti B; Williams PA; Lascaratos G; Chau K-Y; Garway-Heath DF
Review: PROGRESS IN RETINAL AND EYE RESEARCH. 2021;81:100881
Retinal energy metabolism in health and glaucoma
Casson RJ; Chidlow G; Crowston JG; Williams PA; Wood JPM
Review: CELLS. 2021;10(2):295
Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma
Tribble JR; Hui F; Joe M; Bell K; Chrysostomou V; Crowston JG; Williams PA
Preprint: BIORXIV. 2020
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Jöe M; Lardner E; Venkataraman AP; Domínguez-Vicent A; Kokkali E; Rho S; Jóhannesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
Review: NUTRIENTS. 2020;12(9):E2871-2871
Potential Therapeutic Benefit of NAD⁺Supplementation for Glaucoma and Age-Related Macular Degeneration
Cimaglia G; Votruba M; Morgan JE; Andre H; Williams PA
Preprint: BIORXIV. 2020
Computational approaches towards reducing contamination in single-cell RNA-seq data
Yousefi S; Chen H; Ingels J; McCarty M; Centeno A; Chintalapudi S; Mulligan M; Williams P; John S; Jones B; Jablonski M; Hollingsworth TJ; Geisert E; Lu L; Williams R
Preprint: RESEARCH SQUARE. 2020
Anaphylatoxin Receptor C3AR1 Promotesoptic Nerve Degeneration in DBA/2J Mice
Harder JM; Williams P; Braine C; Yang H; Thomas J; Foxworth N; John S; Howell G
Preprint: BIORXIV. 2020
Oral pyruvate prevents glaucomatous neurodegeneration
Williams P; Harder J; Guymer C; Wood J; Daskalaki E; Chidlow G; Cardozo B; Foxworth N; Cochran K; Ouellette T; Wheelock C; Casson R; John S
Preprint: MEDRXIV. 2020
Improvement in Inner Retinal Function in Glaucoma with Nicotinamide (Vitamin B3) Supplementation: A Crossover Randomised Clinical Trial
Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
Preprint: BIORXIV. 2020
Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system
Petrova V; Pearson C; Tribble J; Solano A; Reid E; Williams P; Geller H; Eva R; Fawcett J
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2020;61(7)
Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial
Hui F; Tang J; Williams P; McGuinness M; Hadoux X; Casson RJ; Coote M; Trounce I; Martin KR; van Wijngaarden P; Crowston JG
Preprint: BIORXIV. 2019
Suppression of homeostatic gene expression and increased expression of metabolism-related genes are early features of glaucoma in optic nerve head microglia
Tribble J; Harder J; Williams P; John S
Preprint: BIORXIV. 2019
When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma
Tribble J; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; André H; Morgan J; Williams P
Review: JOURNAL OF GLAUCOMA. 2017;26(12):1161-1168
Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma
Williams PA; Harder JM; John SWM
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(12)
The yin and yang of the complement cascade in glaucoma - the importance of timing and location
Howell GR; Williams P; Harder J; Tribble J; Pepper K; Cross S; Morgan P; Morgan JE; John SW
Published conference paper: VISION RESEARCH. 2011;51(2):229-234
Mouse models of dominant optic atrophy: What do they tell us about the pathophysiology of visual loss?
Williams PA; Morgan JE; Votruba M
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Forskningsbidrag

Targeting NAD metabolism for neuroprotection in age-related ophthalmic and neurodegenerative disease
Swedish Research Council
1 January 2023 - 31 December 2026
Targeting neuronal metabolism and mitochondria for neuroprotection in glaucoma
Swedish Research Council
1 January 2019 - 31 December 2022

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