Nick Tobin

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
Article: BREAST CANCER RESEARCH. 2024;26(1):38
Clinically relevant gene signatures provide independent prognostic information in older breast cancer patients
Castresana-Aguirre M; Johansson A; Matikas A; Foukakis T; Lindstroem LS; Tobin NP
Article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(35):4071-4082
Twenty-Year Benefit From Adjuvant Goserelin and Tamoxifen in Premenopausal Patients With Breast Cancer in a Controlled Randomized Clinical Trial
Johansson A; Dar H; Veer LJVT; Tobin NP; Perez-Tenorio G; Nordenskjold A; Johansson U; Hartman J; Skoog L; Yau C; Benz CC; Esserman LJ; Stal O; Nordenskjold B; Fornander T; Lindstrom LS
Article: NPJ PRECISION ONCOLOGY. 2022;6(1):59
Reclassifying tumour cell cycle activity in terms of its tissue of origin
Lundberg A; Yi JJJ; Lindstrom LS; Tobin NP
Article: INTERNATIONAL JOURNAL OF CANCER. 2022;150(12):2072-2082
Clinical and molecular characteristics of estrogen receptor-positive ultralow risk breast cancer tumors identified by the 70-gene signature
Johansson A; Yu NY; Iftimi A; Tobin NP; 't Veer L; Nordenskjold B; Benz CC; Fornander T; Perez-Tenorio G; Stal O; Esserman LJ; Yau C; Lindstrom LS
Article: PLOS COMPUTATIONAL BIOLOGY. 2022;18(3):e1010020
Survival analysis of pathway activity as a prognostic determinant in breast cancer
Jeuken GS; Tobin NP; Kall L
Article: EUROPEAN JOURNAL OF CANCER. 2022;162:194-205
Interval breast cancer is associated with interferon immune response
Ugalde-Morales E; Grassmann F; Humphreys K; Li J; Eriksson M; Tobin NP; Lindstrom LS; Vallon-Christersson J; Borg A; Hall P; Czene K
Article: GENETICS IN MEDICINE. 2022;24(1):157-169
Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma
Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
Article: CELL REPORTS. 2021;36(8):109616
The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
Zhang Y; Zhang Y; Kameishi S; Barutello G; Zheng Y; Tobin NP; Nicosia J; Hennig K; Chiu DK-C; Balland M; Barker TH; Cavallo F; Holmgren L
Article: CANCERS. 2021;13(5):1175
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma
Su Y; Tsagkozis P; Papakonstantinou A; Tobin NP; Gultekin O; Malmerfelt A; Ingelshed K; Neo SY; Lundquist J; Chaabane W; Nisancioglu MH; Leiss LW; Ostman A; Bergh J; Sedimbi S; Lehti K; Lundqvist A; Stragliotto CL; Haglund F; Ehnman M
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;148(4):884-894
Association between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns
Ugalde-Morales E; Grassmann F; Humphreys K; Li J; Eriksson M; Tobin NP; Borg A; Vallon-Christersson J; Hall P; Czene K
Article: ONCOGENE. 2020;39(32):5430-5440
A pan-cancer analysis of the frequency of DNA alterations across cell cycle activity levels
Lundberg A; Lindstrom LS; Parker JS; Loverli E; Perou CM; Bergh J; Tobin NP
Article: MOLECULAR ONCOLOGY. 2020;14(5):951-963
Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease
Zerdes I; Sifakis EG; Matikas A; Chretien S; Tobin NP; Hartman J; Rassidakis GZ; Bergh J; Foukakis T
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
Article: GLIA. 2020;68(2):316-327
Astrocytes enhance glioblastoma growth
Mega A; Nilsen MH; Leiss LW; Tobin NP; Miletic H; Sleire L; Strell C; Nelander S; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
Article: EBIOMEDICINE. 2019;48:212-223
Generation of in situ sequencing based OncoMaps to spatially resolve gene expression profiles of diagnostic and prognostic markers in breast cancer
Svedlund J; Strell C; Qian X; Zilkens KJC; Tobin NP; Bergh J; Sieuwerts AM; Nilsson M
Article: CANCERS. 2019;11(10):E1479-1479
STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer
Zerdes I; Wallerius M; Sifakis EG; Wallmann T; Betts S; Bartish M; Tsesmetzis N; Tobin NP; Coucoravas C; Bergh J; Rassidakis GZ; Rolny C; Foukakis T
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ
Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
Article: JAMA ONCOLOGY. 2019;5(9):1304-1309
Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer
Yu NY; Iftimi A; Yau C; Tobin NP; van 't Veer L; Hoadley KA; Benz CC; Nordenskjold B; Fornander T; Stal O; Czene K; Esserman LJ; Lindstrom LS
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2019;68(6):927-936
An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma
Tsagozis P; Augsten M; Zhang Y; Li T; Hesla A; Bergh J; Haglund F; Tobin NP; Ehnman M
Article: BREAST CANCER RESEARCH. 2019;21(1):36
Separation of breast cancer and organ microenvironment transcriptomes in metastases
Alzubi MA; Turner TH; Olex AL; Sohal SS; Tobin NP; Recio SG; Bergh J; Hatschek T; Parker JS; Sartorius CA; Perou CM; Dozmorov MG; Harrell JC
Article: BREAST CANCER RESEARCH. 2019;21(1):34
The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours
Lundberg A; Lindstroem LS; Li J; Harrell JC; Darai-Ramqvist E; Sifakis EG; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
Article: JOURNAL OF CLINICAL PATHOLOGY. 2018;71(9):787-794
Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer
Robertson S; Stalhammar G; Darai-Ramqvist E; Rantalainen M; Tobin NP; Bergh J; Hartman J
Article: BRITISH JOURNAL OF CANCER. 2018;118(4):480-488
Immune gene expression and response to chemotherapy in advanced breast cancer
Foukakis T; Lovrot J; Matikas A; Zerdes I; Lorent J; Tobin N; Suzuki C; Brage SE; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Ferno M; Skoog L; Bergh J; Hatschek T
Article: BMC CANCER. 2018;18(1):174
Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)
Kjallquist U; Erlandsson R; Tobin NP; Alkodsi A; Ullah I; Stalhammar G; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
Article: CLINICAL CANCER RESEARCH. 2017;23(24):7512-7520
Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts
Lundberg A; Lindstrom LS; Harrell JC; Falato C; Carlson JW; Wright PK; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
Article: CLINICAL CANCER RESEARCH. 2017;23(23):7225-7231
PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients
Tobin NP; Lundberg A; Lindstrom LS; Harrell JC; Foukakis T; Carlsson L; Einbeigi Z; Linderholm BK; Loman N; Malmberg M; Ferno M; Czene K; Perou CM; Bergh J; Hatschek T
Article: JAMA ONCOLOGY. 2017;3(11):1503-1510
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades
Esserman LJ; Yau C; Thompson CK; van't Veer LJ; Borowsky AD; Hoadley KA; Tobin NP; Nordenskjold B; Fornander T; Stal O; Benz CC; Lindstrom LS
Article: EUROPEAN JOURNAL OF CANCER. 2017;84:278-289
Breast cancer in young women and prognosis: How important are proliferation markers?
Fredholm H; Magnusson K; Lindstrom LS; Tobin NP; Lindman H; Bergh J; Holmberg L; Ponten F; Frisell J; Fredriksson I
Article: CLINICAL CANCER RESEARCH. 2017;23(10):2584-2592
Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes
Li J; Ivansson E; Klevebring D; Tobin NP; Lindstrom LS; Holm J; Prochazka G; Cristando C; Palmgren J; Tornberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Gronberg H; Czene K
Article: SCIENTIFIC REPORTS. 2017;7(1):1089
Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer
Kruger K; Wik E; Knutsvik G; Nalwoga H; Klingen TA; Arnes JB; Chen Y; Mannelqvist M; Dimitrakopoulou K; Stefansson IM; Birkeland E; Aas T; Tobin NP; Jonassen I; Bergh J; Foulkes WD; Akslen LA
Article: JOURNAL OF PATHOLOGY CLINICAL RESEARCH. 2017;3(1):38-43
High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer
Paulsson J; Ryden L; Strell C; Frings O; Tobin NP; Fornander T; Bergh J; Landberg G; Stal O; Ostman A
Article: CANCER RESEARCH. 2016;76(11):3166-3178
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Wallerius M; Wallmann T; Bartish M; Ostling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Ponten F; Hartman J; Bergh J; DeMilito A; De Palma M; Ostman A; Andersson J; Rolny C
Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426
An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors
Tobin NP; Wennmalm K; Lindstrom LS; Foukakis T; He L; Genove G; Ostman A; Landberg G; Betsholtz C; Bergh J
Article: MODERN PATHOLOGY. 2016;29(4):318-329
Digital image analysis outperforms manual biomarker assessment in breast cancer
Stalhammar G; Martinez NF; Lippert M; Tobin NP; Molholm I; Kis L; Rosin G; Rantalainen M; Pedersen L; Bergh J; Grunkin M; Hartman J
Article: MOLECULAR ONCOLOGY. 2016;10(4):517-525
Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse
Falato C; Tobin NP; Lorent J; Lindstrom LS; Bergh J; Foukakis T
Article: ONCOTARGET. 2015;6(32):33306-33318
Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications
Kimbung S; Kovacs A; Danielsson A; Bendahl P-O; Lovgren K; Stolt MF; Tobin NP; Lindstrom L; Bergh J; Einbeigi Z; Ferno M; Hatschek T; Hedenfalk I
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: ANNALS OF ONCOLOGY. 2015;26(1):81-88
Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival
Tobin NP; Harrell JC; Lövrot J; Egyhazi Brage S; Frostvik Stolt M; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Walz T; Fernö M; Perou CM; Bergh J; Hatschek T; Lindström LS
Article: MOLECULAR ONCOLOGY. 2014;8(3):741-752
Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients
Tobin NP; Lindstrom LS; Carlson JW; Bjohle J; Bergh J; Wennmalm K
Article: BMC CANCER. 2014;14:119
Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response
Lehn S; Tobin NP; Sims AH; Stal O; Jirstrom K; Axelson H; Landberg G
Article: BMC CANCER. 2013;13:473
Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies
Milosevic J; Klinge J; Borg A-L; Foukakis T; Bergh J; Tobin NP
Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(6):2037-2047
Prognostic Significance in Breast Cancer of a Gene Signature Capturing Stromal PDGF Signaling
Frings O; Augsten M; Tobin NP; Carlson J; Paulsson J; Pena C; Olsson E; Veerla S; Bergh J; Ostman A; Sonnhammer ELL
Article: HUMAN PATHOLOGY. 2012;43(11):2053-2061
Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information
Tobin NP; Lundgren KL; Conway C; Anagnostaki L; Costello S; Landberg G
Article: CURRENT BREAST CANCER REPORTS. 2012;4(3):171-173
Analysis of Cyclin D1 in Breast Cancer: A Call to Arms.
Tobin NP; Bergh J
Article: BMC CANCER. 2011;11:417
Cyclin D1, Id1 and EMT in breast cancer
Tobin NP; Sims AH; Lundgren KL; Lehn S; Landberg G
Article: JOURNAL OF MOLECULAR DIAGNOSTICS. 2011;13(3):340-351
Stromal Expression of β-Arrestin-1 Predicts Clinical Outcome and Tamoxifen Response in Breast Cancer
Lundgren K; Tobin NP; Lehn S; Stal O; Ryden L; Jirstrom K; Landberg G
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(6):2886-2897
Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features
Lehn S; Tobin NP; Berglund P; Nilsson K; Sims AH; Jirstrom K; Harkonen P; Lamb R; Landberg G
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2009;41(11):2287-2294
Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production
Fitzpatrick PA; Guinan AF; Walsh TG; Murphy RP; Killeen MT; Tobin NP; Pierotti AR; Cummins PM
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2008;295(4):H1403-H1413
Helicobacter pylori-induced inhibition of vascular endothelial cell functions:: a role for VacA-dependent nitric oxide reduction
Tobin NP; Henehan GT; Murphy RP; Atherton JC; Guinan AF; Kerrigan SW; Cox D; Cahill PA; Cummins PM
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Letter: CANCER COMMUNICATIONS. 2023;43(7):855-859
Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1
Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colon E; Plogell A-HS; Liu LL; Lundqvist A
Corrigendum: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3):djv434
Erratum.
Review: JOURNAL OF INTERNAL MEDICINE. 2015;278(6):545-570
The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer
Tobin NP; Foukakis T; De Petris L; Bergh J
Corrigendum: MOLECULAR ONCOLOGY. 2014;8(6):1159
Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients (vol 8, pg 741, 2014)
Tobin NP; Lindstrom LS; Carlson JW; Bjohle J; Bergh J; Wennmalm K

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