Team Lars Maegdefessel

Vårt team fokuserar på att förstå den terapeutiska potentialen och biomarkörspotentialen hos icke-kodande RNA vid vaskulära sjukdomar.

Molekylär kärlmedicin

Laboratoriet syftar till att bestämma mikroarkitekturen för aterosklerotiska plack med hjälp av multi-omics-metoder, såsom enskilda cell -, bulk- och rumslig RNA-sekvensering och proteomik. Genom att använda multi-omics-data siktar vi på att identifiera nya terapier och biomarkörer för kärlsjukdomar, såsom karotisartärsjukdomar och aortaaneurysm.

Team medlemmar

Lars Maegdefessel

Senior forskare/ Teamledare.

Alumni:

  • Daniel Y. Li, PhD
  • Susanne Eken, MD PhD
  • Albert Busch, MD, PhD
  • Changyan Sun, MSc
  • Alexandra Bäcklund, PhD

Konsortier och nätverk

  •     European Vascular Biology Organisation (EVBO; ledamot i rådsutskottet)
  •     Arteriosclerosis Trombos and Vascular Biology Sektionen av American Heart Association (AHA; ledarskapsråd)

Finansiering

  •     ERC
  •     Vetenkapsrådet
  •     Hjärt Lungfonden
  •     Ragnar Söderbergs stiftelse

Priser och utmärkelser

  •     ERC Starting (2016) och Consolidator Grants (2022)
  •     Ragnar Söderberg Fellow in Medicine (2014)
  •     Prince Daniel Research Award från HLF (2014)

Avhandlingar

Greg Winski. Non-coding RNA-based therapeutics and biomarkers for treatment and detection of vascular disease. 2022.01.21

Susanne M. Eken. Role and therapeutic potential of non-coding RNAs in vascular remodeling and atherosclerotic plaque formation. 2017.06.08

Kontakt

Ekaterina Chernogubova

Laboratorieingenjör/ forskningssamordnare.
08-517 732 21

Utvalda publikationer

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression.
Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L
Mol Ther 2023 Jun;31(6):1775-1790

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.
Paloschi V, Sabater-Lleal M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L
Cardiovasc Res 2021 Dec;117(14):2742-2754

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O
Nature 2019 May;569(7755):236-240

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization.
Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Bäcklund A, Bergmark C, Paloschi V, Maegdefessel L
Circulation 2021 Nov;144(19):1567-1583

miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease.
Eken SM, Christersdottir T, Winski G, Sangsuwan T, Jin H, Chernogubova E, Pirault J, Sun C, Simon N, Winter H, Backlund A, Haghdoost S, Hansson GK, Halle M, Maegdefessel L
JACC Basic Transl Sci 2019 Feb;4(1):72-82

H19 Induces Abdominal Aortic Aneurysm Development and Progression.
Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam D, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L
Circulation 2018 Oct;138(15):1551-1568

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions.
Jin H, Li DY, Chernogubova E, Sun C, Busch A, Eken SM, Saliba-Gustafsson P, Winter H, Winski G, Raaz U, Schellinger IN, Simon N, Hegenloh R, Matic LP, Jagodic M, Ehrenborg E, Pelisek J, Eckstein HH, Hedin U, Backlund A, Maegdefessel L
Mol Ther 2018 Apr;26(4):1040-1055

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions.
Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L
Circ Res 2017 Feb;120(4):633-644

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ
Nature 2016 Aug;536(7614):86-90

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S
Nature 2014 May;509(7502):641-4

LM
Innehållsgranskare:
Lars Maegdefessel
2023-08-25