Lars Maegdefessel

Om mig
Publikationer
Populärvetenskap och samverkan

Forskningsbeskrivning

Min forskning är inriktad på icke-kodande RNA inom vaskulär biologi och
medicin.
Läs mer på min forskargruppsida [1](på engelska)
[1] http://ki.se/en/meds/lars-maegdefessel-group

Artiklar

Article: NATURE COMMUNICATIONS. 2025;16(1):2297
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis
El Bounkari O; Zan C; Yang B; Ebert S; Wagner J; Bugar E; Kramer N; Bourilhon P; Kontos C; Zarwel M; Sinitski D; Milic J; Jansen Y; Kempf WE; Sachs N; Maegdefessel L; Ji H; Gokce O; Riols F; Haid M; Gerra S; Hoffmann A; Brandhofer M; Avdic M; Bucala R; Megens RTA; Willemsen N; Messerer D; Schulz C; Bartelt A; Harm T; Rath D; Doering Y; Gawaz M; Weber C; Kapurniotu A; Bernhagen J
Article: CIRCULATION. 2025;151(19):1391-1408
Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis
Bonfiglio CA; Lacy M; Triantafyllidou V; Farina FM; Janjic A; Nitz K; Wu Y; Bazioti V; Avcilar-Kuecuekgoeze I; Marques YFS; Joppich M; Kumkum M; Roess K; Venkatasubramani AV; Imhof A; Enard W; Maegdefessel L; de Winther M; Weber C; Santovito D; Lutgens E; Atzler D
Article: CARDIOVASCULAR RESEARCH. 2025;:405-423
CircRNAs increase during vascular cell differentiation and are biomarkers for vascular disease.
Northoff BH; Herbst A; Wenk C; Weindl L; Gäbel G; Brezski A; Zarnack K; Küpper A; Dimmeler S; Moretti A; Laugwitz K-L; Engelhardt S; Maegdefessel L; Boon R; Doppler S; Dreßen M; Lahm H; Lange R; Krane M; Krohn K; Kohlmaier A; Holdt LM; Teupser D
Article: JOURNAL OF CLINICAL INVESTIGATION. 2024;135(1):e182939
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice
Liu W; Hardaway BD; Kim E; Pauli J; Wettich JL; Yalcinkaya M; Hsu C-C; Xiao T; Reilly MP; Tabas I; Maegdefessel L; Schlepckow K; Haass C; Wang N; Tall AR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(5):H1296-H1302
Red blood cells as potential materials for microRNA biomarker study: overcoming heparin-related challenges
Kontidou E; Humoud R; Chernogubova E; Alvarsson M; Maegdefessel L; Collado A; Pernow J; Zhou Z
Article: CARDIOVASCULAR RESEARCH. 2024;120(12):1411-1426
Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.
Wang Y; Li G; Chen B; Shakir G; Volz M; van der Vorst EPC; Maas SL; Geiger M; Jethwa C; Bartelt A; Li Z; Wettich J; Sachs N; Maegdefessel L; Nazari Jahantigh M; Hristov M; Lacy M; Lutz B; Weber C; Herzig S; Guillamat Prats R; Steffens S
Article: NATURE COMMUNICATIONS. 2024;15(1):8034
Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis
Bamezai S; Zhang Y; Kumari M; Lotfi M; Alsaigh T; Luo L; Kumar GS; Wang F; Ye J; Puri M; Manchanda R; Paluri S; Adkar SS; Kojima Y; Ingelsson A; Bell CF; Lopez NG; Fu C; Choi RB; Miller Z; Barrios L; Walsh S; Ahmad F; Maegdefessel L; Smith BR; Leeper NJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2024;81(1):331
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
Pourteymour S; Fan J; Majhi RK; Guo S; Sun X; Huang Z; Liu Y; Winter H; Baecklund A; Skenteris N-T; Chernogubova E; Werngren O; Li Z; Skogsberg J; Li Y; Matic L; Hedin U; Maegdefessel L; Ehrenborg E; Tian Y; Jin H
Article: CIRCULATION. 2024;149(24):1885-1898
Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease
Pan H; Ho SE; Xue C; Cui J; Johanson QS; Sachs N; Ross LS; Li F; Solomon RA; Connolly ES; Patel VI; Maegdefessel L; Zhang H; Reilly MP
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(4):930-945
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
Bashore AC; Yan H; Xue C; Zhu LY; Kim E; Mawson T; Coronel J; Chung A; Sachs N; Ho S; Ross LS; Kissner M; Passegue E; Bauer RC; Maegdefessel L; Li M; Reilly MP
Article: MOLECULAR METABOLISM. 2024;82:101912
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(6):e2302907
Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases
Paloschi V; Pauli J; Winski G; Wu Z; Li Z; Botti L; Meucci S; Conti P; Rogowitz F; Glukha N; Hummel N; Busch A; Chernogubova E; Jin H; Sachs N; Eckstein H-H; Dueck A; Boon RA; Bausch AR; Maegdefessel L
Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(1):60-75
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis
Fidler TP; Dunbar A; Kim E; Hardaway B; Pauli J; Xue C; Abramowicz S; Xiao T; O'Connor K; Sachs N; Wang N; Maegdefessel L; Levine R; Reilly M; Tall AR
Article: CIRCULATION RESEARCH. 2023;133(8):674-686
ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1
Sharifi MA; Wierer M; Dang TA; Milic J; Moggio A; Sachs N; von Scheidt M; Hinterdobler J; Mueller P; Werner J; Stiller B; Aherrahrou Z; Erdmann J; Zaliani A; Graettinger M; Reinshagen J; Gul S; Gribbon P; Maegdefessel L; Bernhagen J; Sager HB; Mann M; Schunkert H; Kessler T
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2023;33:848-865
The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms
Fasolo F; Winski G; Li Z; Wu Z; Winter H; Ritzer J; Glukha N; Roy J; Hultgren R; Pauli J; Busch A; Sachs N; Knappich C; Eckstein H-H; Boon RA; Paloschi V; Maegdefessel L
Article: JCI INSIGHT. 2023;8(17):e170845
Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
Martinez MA; Ritsvall O; Bastrup JA; Celik S; Jakobsson G; Daoud F; Winqvist C; Aspberg A; Rippe C; Maegdefessel L; Schiopu A; Jepps TA; Holmberg J; Sward K; Albinsson S
Article: MEDRXIV. 2023;:2023.07.13.23292633
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
Bashore AC; Yan H; Xue C; Zhu LY; Kim E; Mawson T; Coronel J; Chung A; Ho S; Ross LS; Kissner M; Passegué E; Bauer RC; Maegdefessel L; Li M; Reilly MP
Article: CIRCULATION. 2023;148(1):47-67
INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10
Zhang W; Zhao J; Deng L; Ishimwe N; Pauli J; Wu W; Shan S; Kempf W; Ballantyne MD; Kim D; Lyu Q; Bennett M; Rodor J; Turner AW; Lu YW; Gao P; Choi M; Warthi G; Kim HW; Barroso MM; Bryant WB; Miller CL; Weintraub NL; Maegdefessel L; Miano JM; Baker AH; Long X
Article: BIOMOLECULES. 2023;13(7):1074
Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease
Pauli J; Reisenauer T; Winski G; Sachs N; Chernogubova E; Freytag H; Otto C; Reeps C; Eckstein H-H; Scholz C-J; Maegdefessel L; Busch A
Article: MOLECULAR THERAPY. 2023;31(6):1775-1790
Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression
Winter H; Winski G; Busch A; Chernogubova E; Fasolo F; Wu Z; Baecklund A; Khomtchouk BB; Booven DJV; Sachs N; Eckstein H-H; Wittig I; Boon RA; Jin H; Maegdefessel L
Article: VASCULAR PHARMACOLOGY. 2023;150:107167
Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification
Skenteris NT; Hemme E; Delfos L; Karadimou G; Karlof E; Lengquist M; Kronqvist M; Zhang X; Maegdefessel L; Schurgers LJ; Arnardottir H; Biessen EAL; Bot I; Matic L
Article: CARDIOVASCULAR RESEARCH. 2023;119(3):867-878
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1
Mulorz J; Spin JM; Mulorz P; Wagenhaeuser M; Deng A; Mattern K; Rhee YH; Toyama K; Adam M; Schelzig H; Maegdefessel L; Tsao PS
Article: THROMBOSIS AND HAEMOSTASIS. 2023;123(05):545-554
Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging
Ferraro B; Giustetto P; Schengel O; Weckbach LT; Maegdefessel L; Soehnlein O
Article: ATHEROSCLEROSIS. 2023;371:1-13
A comparative gene expression matrix in Apoe-deficient mice identifies unique and atherosclerotic disease stage-specific gene regulation patterns in monocytes and macrophages
Haerdtner C; Kumar A; Ehlert CA; Vico TA; Starz C; von Ehr A; Krebs K; Dufner B; Hoppe N; Stachon P; Heidt T; Wolf D; von zur Muehlen C; Gruening B; Robbins CS; Maegdefessel L; Westermann D; Dederichs T-S; Hilgendorf I
Article: VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. 2023;52(2):124-132
CXCR4 - a possible serum marker for risk stratification of abdominal aortic aneurysms.
Reutersberg B; Metschl S; Salvermoser M; Eckstein H-H; Knappich C; Maegdefessel L; Jaroslav P; Busch A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(2):286-299
Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1)
Cynn E; Li DY; O'Reilly ME; Wang Y; Bashore AC; Jha A; Foulkes AS; Zhang H; Winter H; Maegdefessel L; Yan H; Li M; Ross L; Xue C; Reilly MP
Article: JVS - VASCULAR SCIENCE. 2023;4:100093
Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth.
Zschäpitz D; Bohmann B; Lutz B; Eckstein H-H; Reeps C; Maegdefessel L; Gasser CT; Busch A
Article: SCIENTIFIC REPORTS. 2022;12(1):20990
Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms
Lim C; Pratama MY; Rivera C; Silvestro M; Tsao PSS; Maegdefessel L; Gallagher KAA; Maldonado T; Ramkhelawon B
Article: CELL REPORTS. 2022;41(7):111670
Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2.
Oo JA; Pálfi K; Warwick T; Wittig I; Prieto-Garcia C; Matkovic V; Tomašković I; Boos F; Izquierdo Ponce J; Teichmann T; Petriukov K; Haydar S; Maegdefessel L; Wu Z; Pham MD; Krishnan J; Baker AH; Günther S; Ulrich HD; Dikic I; Leisegang MS; Brandes RP
Article: NATURE CARDIOVASCULAR RESEARCH. 2022;1(11):1056-1071
GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation
Guillamat-Prats R; Hering D; Derle A; Rami M; Haerdtner C; Santovito D; Rinne P; Bindila L; Hristov M; Pagano S; Vuilleumier N; Schmid S; Janjic A; Enard W; Weber C; Maegdefessel L; Faussner A; Hilgendorf I; Steffens S
Article: CARDIOVASCULAR RESEARCH. 2022;118(13):2792-2804
Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells
Wang Y; Gao H; Wang F; Ye Z; Mokry M; Turner AW; Ye J; Koplev S; Luo L; Alsaigh T; Adkar SS; Elishaev M; Gao X; Maegdefessel L; Bjorkegren JLM; Pasterkamp G; Miller CL; Ross EG; Leeper NJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(10):512
Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation.
Brandhofer M; Hoffmann A; Blanchet X; Siminkovitch E; Rohlfing A-K; El Bounkari O; Nestele JA; Bild A; Kontos C; Hille K; Rohde V; Fröhlich A; Golemi J; Gokce O; Krammer C; Scheiermann P; Tsilimparis N; Sachs N; Kempf WE; Maegdefessel L; Otabil MK; Megens RTA; Ippel H; Koenen RR; Luo J; Engelmann B; Mayo KH; Gawaz M; Kapurniotu A; Weber C; von Hundelshausen P; Bernhagen J
Article: METABOLITES. 2022;12(9):840
Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR
Bauer S; Eigenmann J; Zhao Y; Fleig J; Hawe JS; Pan C; Bongiovanni D; Wengert S; Ma A; Lusis AJ; Kovacic JC; Bjoerkegren JLM; Maegdefessel L; Schunkert H; von Scheidt M
Article: THROMBOSIS AND HAEMOSTASIS. 2022;122(9):1513-1523
Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture.
Metschl S; Bruder L; Paloschi V; Jakob K; Reutersberg B; Reeps C; Maegdefessel L; Gee M; Eckstein H-H; Pelisek J
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2022;64(2-3):255-264
Radiation and Chemotherapy are Associated with Altered Aortic Aneurysm Growth in Patients with Cancer: Impact of Synchronous Cancer and Aortic Aneurysm
von Rose AB; Kobus K; Bohmann B; Lindquist-Lilljequist M; Eilenberg W; Bassermann F; Reeps C; Eckstein H-H; Trenner M; Maegdefessel L; Neumayer C; Brostjan C; Roy J; Hultgren R; Schwaiger BJ; Busch A
Article: CIRCULATION RESEARCH. 2022;131(1):42-58
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages
My-Anh N; Huy-Dung H; Rasheed A; Duchez A-C; Wyatt H; Cottee ML; Graber TE; Susser L; Robichaud S; Berber I; Geoffrion M; Ouimet M; Kazan H; Maegdefessel L; Mulvihill EE; Alain T; Rayner KJ
Article: JOURNAL OF CELL SCIENCE. 2022;135(12):jcs259671
The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and-494 processing
Kremer V; Stanicek L; van Ingen E; Bink DI; Hilderink S; Tijsen AJ; Wittig I; Maegdefessel L; Nossent AY; Boon RA
Article: NATURE COMMUNICATIONS. 2022;13(1):2867
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.
Kaufmann JO; Brangsch J; Kader A; Saatz J; Mangarova DB; Zacharias M; Kempf WE; Schwaar T; Ponader M; Adams LC; Möckel J; Botnar RM; Taupitz M; Mägdefessel L; Traub H; Hamm B; Weller MG; Makowski MR
Article: EUROPEAN HEART JOURNAL. 2022;43(19):1864-1877
Interferon regulatory factor-5-dependent CD11c⁺ macrophages contribute to the formation of rupture-prone atherosclerotic plaques
Edsfeldt A; Swart M; Singh P; Dib L; Sun J; Cole JE; Park I; Al-Sharify D; Persson A; Nitulescu M; Borges PDN; Kassiteridi C; Goddard ME; Lee R; Volkov P; Orho-Melander M; Maegdefessel L; Nilsson J; Udalova I; Goncalves I; Monaco C
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):197
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Roell W; Pfeifer A
Article: NATURE CARDIOVASCULAR RESEARCH. 2022;1(3):253-262
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis
Jarr K-U; Ye J; Kojima Y; Ye Z; Gao H; Schmid S; Luo L; Baylis RA; Lotfi M; Lopez N; Eberhard AV; Smith BR; Weissman IL; Maegdefessel L; Leeper NJ
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(2):e682
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification
Skenteris NT; Seime T; Witasp A; Karlof E; Wasilewski GB; Heuschkel MA; Jaminon AMG; Oduor L; Dzhanaev R; Kronqvist M; Lengquist M; Peeters FECM; Soderberg M; Hultgren R; Roy J; Maegdefessel L; Arnardottir H; Bengtsson E; Goncalves I; Quertermous T; Goettsch C; Stenvinkel P; Schurgers LJ; Matic L
Article: DIABETES. 2022;71(2):285-297
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: PLOS ONE. 2022;17(9):e0265160
Aging-regulated TUG1 is dispensable for endothelial cell function
Gimbel AT; Koziarek S; Theodorou K; Schulz JF; Stanicek L; Kremer V; Ali T; Guenther S; Kumar S; Jo H; Huebner N; Maegdefessel L; Dimmeler S; van Heesch S; Boon RA
Article: CARDIOVASCULAR RESEARCH. 2021;117(14):2767-2780
Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability
Tsantilas P; Lao S; Wu Z; Eberhard A; Winski G; Vaerst M; Nanda V; Wang Y; Kojima Y; Ye J; Flores A; Jarr K-U; Pelisek J; Eckstein H-H; Matic L; Hedin U; Tsao PS; Paloschi V; Maegdefessel L; Leeper NJ
Article: BIOMOLECULES. 2021;11(11):1683
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.
Neiburga KD; Vilne B; Bauer S; Bongiovanni D; Ziegler T; Lachmann M; Wengert S; Hawe JS; Güldener U; Westerlund AM; Li L; Pang S; Yang C; Saar K; Huebner N; Maegdefessel L; DigiMed Bayern Consortium; Lange R; Krane M; Schunkert H; von Scheidt M
Article: CIRCULATION. 2021;144(19):1567-1583
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Baecklund A; Bergmark C; Paloschi V; Maegdefessel L
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2021;62(5):716-726
Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling
Karlof E; Buckler A; Liljeqvist ML; Lengquist M; Kronqvist M; Toonsi MA; Maegdefessel L; Matic LP; Hedin U
Article: EUROPEAN HEART JOURNAL. 2021;42(39):4077-4088
Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
Hinterdobler J; Schott S; Jin H; Meesmann A; Steinsiek A-L; Zimmermann A-S; Wobst J; Mueller P; Mauersberger C; Vilne B; Baecklund A; Chen C-S; Moggio A; Braster Q; Molitor M; Krane M; Kempf WE; Ladwig K-H; Hristov M; Hulsmans M; Hilgendorf I; Weber C; Wenzel P; Scheiermann C; Maegdefessel L; Soehnlein O; Libby P; Nahrendorf M; Schunkert H; Kessler T; Sager HB
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(17):e020231
Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression
Gabel G; Northoff BH; Balboa A; Becirovic-Agic M; Petri M; Busch A; Maegdefessel L; Mahlmann A; Ludwig S; Teupser D; de Waard V; Golledge J; Wanhainen A; Wagsater D; Holdt LM; Lindeman JHN
Article: JCI INSIGHT. 2021;6(15):140364
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility
Busch A; Pauli J; Winski G; Bleichert S; Chernogubova E; Metschl S; Winter H; Trenner M; Wiegering A; Otto C; Fischer J; Reiser J; Werner J; Roy J; Brostjan C; Knappich C; Eckstein H-H; Paloschi V; Maegdefessel L
Article: TRANSLATIONAL RESEARCH. 2021;233:32-46
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms
Eilenberg W; Zagrapan B; Bleichert S; Ibrahim N; Knobl V; Brandau A; Martelanz L; Grasl M-T; Hayden H; Nawrozi P; Rajic R; Hausler C; Potolidis A; Schirwani N; Scheuba A; Klopf J; Teubenbacher P; Weigl MP; Kirchweger P; Beitzke D; Stiglbauer-Tscholakoff A; Panzenbock A; Lang I; Mauracher L-M; Hell L; Pabinger I; Bailey MA; Scott DJA; Maegdefessel L; Busch A; Huk I; Neumayer C; Brostjan C
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2021;24:188-199
MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening
Schellinger IN; Wagenhaeuser M; Chodisetti G; Mattern K; Dannert A; Petzold A; Jakubizka-Smorag J; Emrich F; Haunschild J; Schuster A; Schwob E; Schulz K; Maegdefessel L; Spin JM; Stumvoll M; Hasenfuss G; Tsao PS; Raaz U
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(6):2038-2048
Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability
Georgakis MK; van der Laan SW; Asare Y; Mekke JM; Haitjema S; Schoneveld AH; de Jager SCA; Nurmohamed NS; Kroon J; Stroes ESG; de KDPV; de Borst GJ; Maegdefessel L; Soehnlein O; Pasterkamp G; Dichgans M
Article: CELLS. 2021;10(6):1276
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification
Seime T; Akbulut AC; Liljeqvist ML; Siika A; Jin H; Winski G; van Gorp RH; Karlof E; Lengquist M; Buckler AJ; Kronqvist M; Waring OJ; Lindeman JHN; Biessen EAL; Maegdefessel L; Razuvaev A; Schurgers LJ; Hedin U; Matic L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(5):1738-1750
Virtual Transcriptomics Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging
Buckler AJ; Karlof E; Lengquist M; Gasser TC; Maegdefessel L; Perisic Matic L; Hedin U
Article: REDOX BIOLOGY. 2021;41:101903
MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
Gao P; Gao P; Zhao J; Shan S; Luo W; Slivano OJ; Zhang W; Tabuchi A; LeMaire SA; Maegdefessel L; Shen YH; Miano JM; Singer HA; Long X
Article: CIRCULATION. 2021;143(3):254-266
Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion
Schumski A; Ortega-Gomez A; Wichapong K; Winter C; Lemnitzer P; Viola JR; Pinilla-Vera M; Folco E; Solis-Mezarino V; Volker-Albert M; Maas SL; Pan C; Olivares LP; Winter J; Hackeng T; Karlsson MCI; Zeller T; Imhof A; Baron RM; Nicolaes GAF; Libby P; Maegdefessel L; Kamp F; Benoit M; Doring Y; Soehnlein O
Journal article: CIRCULATION. 2021;144(19):1567-1583
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DYY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Backlund A; Bergmark C; Paloschi V; Maegdefessel L
Article: ATHEROSCLEROSIS. 2020;314:1-9
A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?
Rakipovski G; Rolin B; Barascuk N; Lund HE; Bonde MFB; Djordjevic D; Wulff-Larsen PG; Petersen M; Kirk RK; Hultman K; Manfe V; Blume N; Zahn S; Lengquist M; Maegdefessel L; Hovingh GK; Conde-Knape K; Hedin U; Matic L; Nyberg M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(12):2821-2828
18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.
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Article: NATURE COMMUNICATIONS. 2020;11(1):5981
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
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Functional investigation of the coronary artery disease gene SVEP1
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Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15818-15826
Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade
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Article: NEUROLOGY. 2020;94(22):e2346-e2360
Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(6):1464-1478
Macrophage-Enriched lncRNA RAPIA: A Novel Therapeutic Target for Atherosclerosis.
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Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2020;75(15):1788-1800
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MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice
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The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment
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Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization.
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Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA
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Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis
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Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability
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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
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Therapeutic Targeting of Neutrophil Extracellular Traps in Atherogenic Inflammation
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Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129
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Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation
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Article: JOURNAL OF CLINICAL MEDICINE. 2019;8(2):E251-251
Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank.
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Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm Possible Therapeutic Targets?
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Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(1):72-82
miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease
Eken SM; Christersdottir T; Winski G; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Backlund A; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
Article: JOURNAL OF VASCULAR RESEARCH. 2019;56(5):217-229
Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.
Sangha GS; Busch A; Acuna A; Berman AG; Phillips EH; Trenner M; Eckstein H-H; Maegdefessel L; Goergen CJ
Article: CARDIOVASCULAR RESEARCH. 2019;115(1):230-242
Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling
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The long noncoding RNA CHROME regulates cholesterol homeostasis in primates
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Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms
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H19 Induces Abdominal Aortic Aneurysm Development and Progression
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Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm
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Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion
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Article: MOLECULAR THERAPY. 2018;26(4):1040-1055
Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions
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Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm
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Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration
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Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A
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Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms
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Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function
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MicroRNA-Based Therapy of GATA 2-Deficient Vascular Disease
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Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
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Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness
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Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
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CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
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Guidelines for the functional annotation of microRNAs using the Gene Ontology
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miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux
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CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels
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Local MicroRNA Modulation Using a Novel Anti-miR21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis
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Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus
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MicroRNA Regulation of Vascular Smooth Muscle Function and Phenotype Early Career Committee Contribution
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Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Article: PLOS GENETICS. 2014;10(3):e1004263
Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
Miller CL; Haas U; Diaz R; Leeper NJ; Kundu RK; Patlolla B; Assimes TL; Kaiser FJ; Perisic L; Hedin U; Maegdefessel L; Schunkert H; Erdmann J; Quertermous T; Sczakiel G
Article: VASCULAR MEDICINE. 2014;19(1):3-8
The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model
Downing KP; Nead KT; Kojima Y; Assimes T; Maegdefessel L; Quertermous T; Cooke JP; Leeper NJ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(1):e1-e10
Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Leeper NJ; Raiesdana A; Kojima Y; Kundu RK; Cheng H; Maegdefessel L; Toh R; Ahn G-O; Ali ZA; Anderson DR; Miller CL; Roberts SC; Spin JM; de Almeida PE; Wu JC; Xu B; Cheng K; Quertermous M; Kundu S; Kortekaas KE; Berzin E; Downing KP; Dalman RL; Tsao PS; Schadt EE; Owens GK; Quertermous T
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2012;(63):e3663
Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis
Hua X; Deuse T; Michelakis ED; Haromy A; Tsao PS; Maegdefessel L; Erben RG; Bergow C; Behnisch BB; Reichenspurner H; Robbins RC; Schrepfer S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(122):122ra22
MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Maegdefessel L; Azuma J; Toh R; Deng A; Merk DR; Raiesdana A; Leeper NJ; Raaz U; Schoelmerich AM; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):497-506
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Maegdefessel L; Azuma J; Toh R; Merk DR; Deng A; Chin JT; Raaz U; Schoelmerich AM; Raiesdana A; Leeper NJ; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: CIRCULATION RESEARCH. 2012;110(2):312-324
miR-29b Participates in Early Aneurysm Development in Marfan Syndrome
Merk DR; Chin JT; Dake BA; Maegdefessel L; Miller MO; Kimura N; Tsao PS; Iosef C; Berry GJ; Mohr FW; Spin JM; Alvira CM; Robbins RC; Fischbein MP
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2011;32(4):417-425
Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study
Kaeberich A; Reindl I; Raaz U; Maegdefessel L; Vogt A; Linde T; Steinseifer U; Perzborn E; Hauroeder B; Buerke M; Werdan K; Schlitt A
Article: PHYSIOLOGICAL GENOMICS. 2011;43(17):993-1003
Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm
Spin JM; Hsu M; Azuma J; Tedesco MM; Deng A; Dyer JS; Maegdefessel L; Dalman RL; Tsao PS
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2011;226(4):1035-1043
MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function
Leeper NJ; Raiesdana A; Kojima Y; Chun HJ; Azuma J; Maegdefessel L; Kundu RK; Quertermous T; Tsao PS; Spin JM
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(2):270-279
Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms
Goergen CJ; Azuma J; Barr KN; Magdefessel L; Kallop DY; Gogineni A; Grewall A; Weimer RM; Connolly AJ; Dalman RL; Taylor CA; Tsao PS; Greve JM
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2011;7:693-699
Comparison of outcome in 1809 patients treated with drug-eluting stents or bare-metal stents in a real-world setting
Vogt A; Schoelmerich A; Pollner F; Schlitt M; Raaz U; Maegdefessel L; Reindl I; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2011;2011:252141
Assessment of Elastase-Induced Murine Abdominal Aortic Aneurysms: Comparison of Ultrasound Imaging with In Situ Video Microscopy
Azuma J; Maegdefessel L; Kitagawa T; Dalman RL; McConnell MV; Tsao PS
Article: THROMBOSIS RESEARCH. 2010;126(3):e196-e200
In vitro comparison of dabigatran, unfractionated heparin, and low-molecular-weight heparin in preventing thrombus formation on mechanical heart valves
Maegdefessel L; Linde T; Krapiec F; Hamilton K; Steinseifer U; van Ryn J; Raaz U; Buerke M; Werdan K; Schlitt A
Article: THROMBOSIS AND HAEMOSTASIS. 2010;103(4):808-814
The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro
Raaz U; Kaeberich A; Maegdefessel L; Buerke M; Busshardt M; Schubert S; Russ M; Plehn A; Ebelt H; Werdan K; Schlitt A
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2010;29(3):265-270
Efficacy of enoxaparin, certoparin and dalteparin in preventing cardiac catheter thrombosis: an in vitro approach
Raaz U; Buerke M; Busshardt M; Maegdefessel L; Plehn A; Hauroeder B; Werdan K; Schlitt A
Article: LIPIDS. 2010;45(2):129-135
Serum Phospholipid Transfer Protein Activity After a High Fat Meal in Patients with Insulin-Treated Type 2 Diabetes
Schlitt A; Schwaab B; Fingscheidt K; Lackner KJ; Heine GH; Vogt A; Buerke M; Maegdefessel L; Raaz U; Werdan K; Jiang X-C
Article: THROMBOSIS AND HAEMOSTASIS. 2009;101(6):1163-1169
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves Results of an in-vitro study
Maegdefessel L; Linde T; Michel T; Hamilton K; Steinseifer U; Friedrich I; Schubert S; Hauroeder B; Raaz U; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF LIPID RESEARCH. 2009;50(4):723-729
PLTP activity is a risk factor for subsequent cardiovascular events in CAD patients under statin therapy: the AtheroGene Study
Schlitt A; Blankenberg S; Bickel C; Lackner KJ; Heine GH; Buerke M; Werdan K; Maegdefessel L; Raaz U; Rupprecht HJ; Munzel T; Jiang X-C
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2009;5:849-857
Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects
Maegdefessel L; Schlitt A; Pippig S; Schwaab B; Fingscheidt K; Raaz U; Buerke M; Loppnow H
Article: THROMBOSIS AND HAEMOSTASIS. 2008;100(4):693-698
Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis Results of an in-vitro study
Maegdefessel L; Buerke M; Schubert S; Reindl I; Michel T; Hauroeder B; Carter JM; Peetz D; Werdan K; Schlitt A
Article: MEDIZINISCHE KLINIK. 2008;103(9):628-632
Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention
Maegdefessel L; Schlitt A; Faerber J; Bond SP; Messow C-M; Buerke M; Raaz U; Werdan K; Munzel T; Weiss C
Article: INTERNIST. 2008;49(7):868-872
27-year old pregnant woman with syncope and dyspnea after aortic alloplastic heart valve replacement 15 years ago
Maegdefessel L; Issa H; Scheler C; Thaele V; Schlitt A; Hartelt U; Grabitz R; Buerke M
Article: CORONARY ARTERY DISEASE. 2008;19(4):279-284
In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus
Schlitt A; Rupprecht HJ; Reindl I; Schubert S; Hauroeder B; Carter JM; Peetz D; Kropff SS; Maegdefessel L; Russ M; Schmidt H; Ebelt H; Werdan K; Buerke M
Article: JOURNAL OF HEART VALVE DISEASE. 2006;15(6):809-814
Comparison of fondaparinux, low molecular-weight heparin and unfractionated heparin in preventing thrombus formation on mechanical heart valves: Results of an in-vitro study
Schlitt A; Hamilton K; Maegdefessel L; Dahm M; Theis C; Eichler M; Brockmann O; Steinseifer U; Hauroeder B; Hitzler WE; Rupprecht HJ
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Letter: CIRCULATION. 2025;151(8):581-584
CXCL12 Derived From ACKR1⁺ Intraplaque Neovessels Mediates CD8⁺ T Cell Recruitment in Human Atherosclerosis
Parma L; Sachs N; Sobczak N; Li Z; Merchant K; Pauli J; Depuydt MAC; Wezel A; Smeets HJ; Bot I; Sluetter B; Maegdefessel L; Weber C; Duchene J; Megens RTA
Preprint: BIORXIV. 2025
PRDM16 controls smooth muscle cell fate in atherosclerosis
Tan JME; Cheng L; Calhoun RP; Weller AH; Drareni K; Fong S; Barbara E; Lim H-W; Xue C; Winter H; Auguste G; Miller CL; Reilly MP; Maegdefessel L; Lutgens E; Seale P
Review: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2025;45(2):172-185
Long Non-Coding RNA Function in Smooth Muscle Cell Plasticity and Atherosclerosis
Maegdefessel L; Fasolo F
Review: CLINICAL RESEARCH IN CARDIOLOGY. 2024;113(5):672-679
The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary
Steffens S; Schroeder K; Krueger M; Maack C; Streckfuss-Boemeke K; Backs J; Backofen R; Baessler B; Devaux Y; Gilsbach R; Heijman J; Knaus J; Kramann R; Linz D; Lister AL; Maatz H; Maegdefessel L; Mayr M; Meder B; Nussbeck SY; Rog-Zielinska EA; Schulz MH; Sickmann A; Yigit G; Kohl P
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(1):3-6
Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives
Maegdefessel L; Boon RA; Dimmeler S
Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS. 2023;6:100048
Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges.
Sopić M; Karaduzovic-Hadziabdic K; Kardassis D; Maegdefessel L; Martelli F; Meerson A; Munjas J; Niculescu LS; Stoll M; Magni P; Devaux Y; CardioRNA COST Action CA17129 and AtheroNET COST A
Preprint: MEDRXIV. 2023;MEDRXIV
Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.
von Scheidt M; Bauer S; Ma A; Hao K; Kessler T; Vilne B; Wang Y; Hodonsky CJ; Ghosh SKB; Mokry M; Gao H; Kawai K; Sakamoto A; Kaiser J; Bongiovanni D; Fleig J; Oldenbuettel L; Chen Z; Moggio A; Sager HB; Hecker JS; Bassermann F; Maegdefessel L; Miller CL; Koenig W; Zeiher AM; Dimmeler S; Graw M; Braun C; Ruusalepp A; Leeper NJ; Kovacic JC; Björkegren JLM; Schunkert H
Editorial comment: EUROPEAN HEART JOURNAL. 2023;44(25):2267-2269
Targeting non-coding RNAs for novel treatment strategies in vascular diseases
Winter H; Maegdefessel L
Review: ATHEROSCLEROSIS. 2023;374:99-106
Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing
Bink DI; Pauli J; Maegdefessel L; Boon RA
Review: ATHEROSCLEROSIS. 2023;374:34-43
Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation
Fasolo F; Paloschi V; Maegdefessel L
Preprint: BIORXIV. 2023;BIORXIV
INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10.
Zhang W; Zhao J; Deng L; Ishimwe N; Pauli J; Wu W; Shan S; Kempf W; Ballantyne MD; Kim D; Lyu Q; Bennett M; Rodor J; Turner AW; Lu YW; Gao P; Choi M; Warthi G; Kim HW; Barroso MM; Bryant WB; Miller CL; Weintraub NL; Maegdefessel L; Miano JM; Baker AH; Long X
Review: CARDIOVASCULAR RESEARCH. 2022;118(15):3016-3051
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
van der Velden J; Asselbergs FW; Bakkers J; Batkai S; Bertrand L; Bezzina CR; Bot I; Brundel BJJM; Carrier L; Chamuleau S; Dawson MCD; Davidson SM; Dendorfer A; Duncker DJ; Eschenhagen T; Fabritz L; Falcao-Pires I; Ferdinandy P; Giacca M; Girao H; Gollmann-Tepekoeylue C; Gyongyosi M; Guzik TJ; Hamdani N; Heymans S; Hilfiker A; Hilfiker-Kleiner D; Hoekstra AG; Hulot J-S; Kuster DWD; van Laake LW; Lecour S; Leiner T; Linke WA; Lumens J; Lutgens E; Madonna R; Maegdefessel L; Mayr M; van der Meer P; Passier R; Perbellini F; Perrino C; Pesce M; Priori S; Remme CA; Rosenhahn B; Schotten U; Schulz R; Sipido KR; Sluijter JPG; van Steenbeek F; Steffens S; Terracciano CM; Tocchetti CG; Vlasman P; Yeung KK; Zacchigna S; Zwaagman D; Thum T; Ciccarelli M
Corrigendum: COMMUNICATIONS BIOLOGY. 2022;5(1):298
Author Correction: PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.
Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Röll W; Pfeifer A
Review: CARDIOVASCULAR RESEARCH. 2021;117(14):2742-2754
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases
Paloschi V; Sabater-Lleal M; Middelkamp H; Vivas A; Johansson S; van der Meer A; Tenje M; Maegdefessel L
Review: JVS - VASCULAR SCIENCE. 2021;2:219-234
Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.
Busch A; Bleichert S; Ibrahim N; Wortmann M; Eckstein H-H; Brostjan C; Wagenhäuser MU; Goergen CJ; Maegdefessel L
Editorial comment: EUROPEAN HEART JOURNAL. 2020;41(26):2469-2471
Linking obesity with abdominal aortic aneurysm development
Eckstein H-H; Maegdefessel L
Meeting abstract: FASEB JOURNAL. 2020;34:1
The Interplay of Wnt- and PPARγ-signaling in macrophages & vascular smooth muscle cells during vascular calcification
Reinhold S; Temmerman L; Jin H; Maegdefessel L; Hedin U; Matic L; Biessen E; Schurgers L; Blankesteijn M; Foulquier S
Editorial comment: FRONTIERS IN PHYSIOLOGY. 2020;11:60
Editorial: Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System
Zampetaki A; Maegdefessel L
Review: ATHEROSCLEROSIS. 2020;292:112-118
Long noncoding RNAs in key cellular processes involved in aortic aneurysms
Wu Z-Y; Trenner M; Boon RA; Spin JM; Maegdefessel L
Published conference paper: JOURNAL OF VASCULAR SURGERY. 2019;70(4):1318-1326.e5
The structural atrophy of the aneurysm wall in secondary expanding aortic aneurysms with endoleak type II
Menges A-L; Busch A; Reutersberg B; Trenner M; Kath P; Chernogubova E; Maegdefessel L; Eckstein H-H; Zimmermann A
Review: CARDIOVASCULAR RESEARCH. 2019;115(12):1732-1756
Non-coding RNAs in cardiovascular cell biology and atherosclerosis
Fasolo F; Di Gregoli K; Maegdefessel L; Johnson JL
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e287
THE LONG NON-CODING RNA CHROMR REGULATES CHOLESTEROL HOMEOSTASIS IN PRIMATES
Van Solingen C; Hennessy E; Scacalossi K; Ouimet M; Afonso M; Prins J; Koelwyn G; Ramkhelawon B; Maegdefessel L; Teupser D; Holdt L; Moore K
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e269
TIME-DEPENDENT BIOPATHOLOGICAL ALTERNATIONS IN CAROTID ATHEROSCLEROTIC PLAQUES FROM SYMPTOMATIC PATIENTS
Pauli J; Tsantilas P; Kallmayer M; Maegdefessel L; Eckstein HH; Pelisek J
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e47
EPIGENETIC LINK BETWEEN HISTONE MODIFICATION, LONG NON-CODING RNAS AND EXPRESSION OF MATRIX METALLOPROTEINASES IN ATHEROSCLEROTIC LESIONS OF THE EXTRACRANIAL CAROTID ARTERY
Bauer S; Maegdefessel L; Pelisek J; Eckstein HH
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(5):2164
Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis (vol 124, pg 1083, 2014)
Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Review: VASCULAR PHARMACOLOGY. 2019;114:110-121
Non-coding RNAs in aneurysmal aortopathy
Spin JM; Li DY; Maegdefessel L; Tsao PS
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2018;68(2):656
Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion
Busch A; Chernogubova E; Jin H; Meurer F; Eckstein HH; Kim M; Maegdefessel L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:95
REGULATION OF CCL2 EXPRESSION IN VASCULAR ENDOTHELIAL CELLS BY A LONG NONCODING RNA
Khyzha N; Khor M; Hedin U; Maegdefessel L; Wilson MD; Fish JE
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2018;67(6):e236
Inhibition of Abdominal Aortic Aneurysm Expansion in a Preclinical Atherosclerotic LDLR^-/- Minipig Model by miR-29b-Coated Balloon Angioplasty
Busch A; Eckstein H-H; Maegdefessel L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:9
LONG NON-CODING RNA MIAT REGULATES SMOOTH MUSCLE CELL AND MACROPHAGE ACTIVITY IN ATHEROSCLEROTIC LESIONS. A ROLE FOR LIPOPROTEIN(A)/OXIDIZED PHOSPHOLIPIDS
Bergmark CC; Maegdefessel L; Li Y; Perisic L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:11-12
THERAPEUTICALLY TARGETING THE KINASE ACTIVITY OR GENE EXPRESSION OF RIP1 REDUCES INFLAMMATION-DRIVEN ATHEROSCLEROSIS AND PROMOTES PLAQUE STABILITY
Karunakaran D; Geoffrion M; Wei L; Gan W; Perisic L; Maegdefessel L; Hedin U; Sad S; Guo L; Kolodgie F; Ruddy T; Virmani R; Rayner K
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
Nudt6 Inhibition Limits Smooth Muscle Cell Apoptosis and Abdominal Aortic Aneurysm Progression
Jin H; Winter H; Chernogubova E; Li Y; Winski G; Backlund A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
Genetic Depletion of the Long Non-coding RNA H19 in Mice Protects from Elastase-induced Abdominal Aortic Aneurysms
Chernogubova E; Busch A; Li Y; Jin H; Winski G; Hofmann P; Boon RA; Backlund A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
Regulation of CCL2 Expression in Vascular Endothelial Cells by a Long Noncoding RNA
Khyzha N; Khor M; Hedin U; Maegdefessel L; Wilson MD; Fish JE
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
MicroRNA-29b Mediates the Chronic Inflammatory Response in Radiotherapy-induced Vascular Disease
Wiggle G; Eken SM; Christersdottir T; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Tornvall P; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
CHI3L1 and Its Role in Vascular Smooth Muscle Cell Proliferation and Migration in Advanced Atherosclerosis
Tsantilas P; Lao S; Vaerst M; Li Y; Nanda V; Maegdefessel L; Leeper N
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
Local Mir-29b Inhibition Using Drug-eluting Balloons Blocks Abdominal Aortic Aneurysm Expansion in Atherosclerotic Ldlr-/- Mini-pigs
Busch A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
Aorta-on-a-chip: a Tool to Gain Molecular and Translational Insight Into Vascular Diseases
Paloschi V; Rolli C; Buchmann B; Meucci S; Rogowitz F; Bausch A; Maegdefessel L
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(5):982-983
TIMPing the Aorta: Smooth Muscle Cell-Specific Deletion of BMAL1 Limits Murine Abdominal Aortic Aneurysm Development
Winter C; Soehnlein O; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
Repression of Map1lc3a During Atherosclerosis Progression Plays an Important Role in the Regulation of Vascular Smooth Muscle Cell Phenotype
Magne J; Paloschi V; Goncalves I; Saliba-Gustafsson P; Skogsberg J; Razuvaev A; Jin H; Li Y; Ketelhuth DFJ; Maegdefessel L; Hedin U; Eriksson P; Ehrenborg E
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38
H19 Induces Abdominal Aortic Aneurysm Development and Progression
Li DY; Busch A; Jin H; Chernogubova E; Pelisek J; Eriksson P; Roy J; Hofmann P; Boon R; Spin J; Tsao P; Maegdefessel L
Meeting abstract: CARDIOVASCULAR RESEARCH. 2018;114:s69
Hanging drops: a novel in vitro method to analyze human monocytes of relevance for atherosclerosis
Trattner M; Kehe K; Steinritz D; Pelisek J; Kuehnl A; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2018;114(4):611-621
Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease
Leeper NJ; Maegdefessel L
Letter: CIRCULATION. 2018;137(7):750-753
Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation
Kojima Y; Werner N; Ye J; Nanda V; Tsao N; Wang Y; Flores AM; Miller CL; Weissman I; Deng H; Xu B; Dalman RL; Eken SM; Pelisek J; Li Y; Maegdefessel L; Leeper NJ
Editorial comment: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2017;10(4):e001859
Towards Point-of-Care Measurements Using Noncoding RNAs A Novel Tool to Monitor Aggravation of Advanced Atherosclerotic Lesions
Paloschi V; Maegdefessel L
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2017;65(6):23S-24S
Combination of Preoperative CT and Carotid Plaque Gene Expression Profiling Demonstrates an Association Between Calcification and Plaque-Stabilizing Processes
Karlof E; Dias N; Lengquist M; Witasp A; Stenvinkel P; Maegdefessel L; Matic LP; Hedin U
Meeting abstract: TRANSPLANTATION. 2017;101(5):S28
Local microRNA Modulation is a Suitable Way to Prevent In-Stent Restenosis and Coronary Allograft Arteriosclerosis
Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Heeger C; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Maegdefessel L; Schrepfer S
Meeting abstract: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2017;69(11):2023
NON-CODING RNAS COMPREHENSIVELY COUNTERACT ADVERSE ARTERIAL REMODELING AND STIFFENING IN TYPE 2 DIABETES
Raaz U; Schellinger I; Mattern K; Mattes L; Spin J; Schuster A; Maegdefessel L; Hasenfuss G; Tsao P
Review: FRONTIERS IN PHYSIOLOGY. 2017;8:429
Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression
Li Y; Maegdefessel L
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2016;4(12):236
Prospective and therapeutic screening value of non-coding RNA as biomarkers in cardiovascular disease
Busch A; Eken SM; Maegdefessel L
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2016;4(7):144
My heart will go on-beneficial effects of anti-MiR-30 after myocardial infarction
Li Y; Maegdefessel L
Letter: CIRCULATION. 2016;133(1):e11-e12
Response to Letters Regarding Article, "Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development"
Raaz U; Zoellner AM; Schellinger IN; Toh R; Nakagami F; Brandt M; Emrich FC; Kayama Y; Eken S; Adam M; Maegdefessel L; Hertel T; Deng A; Jagger A; Buerke M; Dalman RL; Spin JM; Kuhl E; Tsao PS
Meeting abstract: ATHEROSCLEROSIS. 2015;241(1):E1-E2
ATG16L1 EXPRESSION IN CAROTID ATHEROSCLEROTIC PLAQUES IS ASSOCIATED WITH PLAQUE VULNERABILITY
Magne J; Gustafsson P; Jin H; Maegdefessel L; Hultenby K; Wernerson A; Eriksson P; Franco-Cereceda A; Kovanen PT; Goncalves I; Ehrenborg E
Meeting abstract: VASCULAR MEDICINE. 2015;20(3):301-302
Cyclin-Dependent Kinase Inhibitor 2B Regulates Transforming Growth Factor Beta 1 Mediated Smooth Muscle Cell Recruitment to Ischemic Blood Vessels
Nanda V; Downing K; Kojima Y; DiRenzo D; Dalman J; Connolly AJ; Maegdefessel L; Perisic L; Dandona S; Guo L; Davis HR; Virmani R; Spin J; Leeper N
Meeting abstract: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2015;34(4):S39
Coronary Allograft Arteriosclerosis: Local MicroRNA Modulation Using a Novel Anti-Mir-21-Eluting Stent Prevents in-Stent Restenosis
Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Heeger C; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Maegdefessel L; Schrepfer S
Corrigendum: NATURE COMMUNICATIONS. 2015;6:6506
miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development (vol 5, 5214, 2014)
Maegdefessel L; Spin JM; Raaz U; Eken SM; Toh R; Azuma J; Adam M; Nakagami F; Heymann HM; Chernogubova E; Jin H; Roy J; Hultgren R; Caidahl K; Schrepfer S; Hamsten A; Eriksson P; McConnell MV; Dalman RL; Tsao PS
Review: JOURNAL OF INTERNAL MEDICINE. 2014;276(6):633-644
The emerging role of microRNAs in cardiovascular disease
Maegdefessel L
Editorial comment: THROMBOSIS AND HAEMOSTASIS. 2014;112(1):15
Micro-effects of smoking in cardiovascular disease aetiology
Maegdefessel L
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2014;34(7):1339-1340
New Ways to Dismantle a Ticking Time Bomb MicroRNA 712/205 and Abdominal Aortic Aneurysm Development
Maegdefessel L; Spin JM; Tsao PS
Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(6):914-928
Hemodynamic Regulation of Reactive Oxygen Species: Implications for Vascular Diseases
Raaz U; Toh R; Maegdefessel L; Adam M; Nakagami F; Emrich FC; Spin JM; Tsao PS
Review: ANNUAL REVIEW OF MEDICINE. 2014;65:49-62
Pathogenesis of Abdominal Aortic Aneurysms: MicroRNAs, Proteases, Genetic Associations
Maegdefessel L; Dalman RL; Tsao PS
Review: TRENDS IN CARDIOVASCULAR MEDICINE. 2014;24(1):1-6
MicroRNA-29b regulation of abdominal aortic aneurysm development
Maegdefessel L; Azuma J; Tsao PS
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013;14(7):14374-14394
Micromanaging Abdominal Aortic Aneurysms
Maegdefessel L; Spin JM; Adam M; Raaz U; Toh R; Nakagami F; Tsao PS
Editorial comment: CURRENT VASCULAR PHARMACOLOGY. 2013
Therapeutic Potential of MicroRNAs in Vascular Disease.
Maegdefessel L
Editorial comment: CURRENT VASCULAR PHARMACOLOGY. 2013;13(3):277-279
Therapeutic Potential of microRNAs in Vascular Disease
Maegdefessel L
Review: JOURNAL OF DIABETES RESEARCH. 2013;2013:834727-10
Making Sense in Antisense: Therapeutic Potential of Noncoding RNAs in Diabetes-Induced Vascular Dysfunction
Eken SM; Jin H; Chernogubova E; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2012;95(2):147-155
Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling
Spin JM; Maegdefessel L; Tsao PS
Meeting abstract: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2012;31(4):S126-S127
Pyruvate Dehydrogenase Kinase 2 Controls Vascular Remodeling
Deuse T; Hun X; Laenger F; Gossler T; Stubbendorff M; Rakovic A; Klein C; Sutendra G; Dromparis P; Maegdefessel L; Tsao PS; Velden J; Reichenspurner H; Robbins RC; Haddad F; Michelakis E; Schrepfer S
Review: VASCULAR HEALTH AND RISK MANAGEMENT. 2010;6:339-349
New options with dabigatran etexilate in anticoagulant therapy
Maegdefessel L; Spin JM; Azuma J; Tsao PS
Review: VASCULAR HEALTH AND RISK MANAGEMENT. 2010;6:95-103
Modern role for clopidogrel in management of atrial fibrillation and stroke reduction
Maegdefessel L; Azuma J; Tsao PS
Letter: THROMBOSIS RESEARCH. 2009;124(2):242-243
INR matters: A case on managing argatroban for bridging oral anticoagulation in a patient with heparin induced thrombocytopenia type II after mechanical heart valve replacement
Raaz U; Maegdefessel L; Buerke M; Janusch M; Werdan K; Schlitt A
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