Lars Maegdefessel

Om mig
Publikationer
Populärvetenskap och samverkan

Forskningsbeskrivning

Min forskning är inriktad på icke-kodande RNA inom vaskulär biologi och
medicin.
Läs mer på min forskargruppsida [1](på engelska)
[1] http://ki.se/en/meds/lars-maegdefessel-group

Artiklar

Article: NATURE COMMUNICATIONS. 2025;16(1):2297
An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis
El Bounkari O; Zan C; Yang B; Ebert S; Wagner J; Bugar E; Kramer N; Bourilhon P; Kontos C; Zarwel M; Sinitski D; Milic J; Jansen Y; Kempf WE; Sachs N; Maegdefessel L; Ji H; Gokce O; Riols F; Haid M; Gerra S; Hoffmann A; Brandhofer M; Avdic M; Bucala R; Megens RTA; Willemsen N; Messerer D; Schulz C; Bartelt A; Harm T; Rath D; Doering Y; Gawaz M; Weber C; Kapurniotu A; Bernhagen J
Article: CIRCULATION. 2025;151(19):1391-1408
Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis
Bonfiglio CA; Lacy M; Triantafyllidou V; Farina FM; Janjic A; Nitz K; Wu Y; Bazioti V; Avcilar-Kuecuekgoeze I; Marques YFS; Joppich M; Kumkum M; Roess K; Venkatasubramani AV; Imhof A; Enard W; Maegdefessel L; de Winther M; Weber C; Santovito D; Lutgens E; Atzler D
Article: CARDIOVASCULAR RESEARCH. 2025;:405-423
CircRNAs increase during vascular cell differentiation and are biomarkers for vascular disease.
Northoff BH; Herbst A; Wenk C; Weindl L; Gäbel G; Brezski A; Zarnack K; Küpper A; Dimmeler S; Moretti A; Laugwitz K-L; Engelhardt S; Maegdefessel L; Boon R; Doppler S; Dreßen M; Lahm H; Lange R; Krane M; Krohn K; Kohlmaier A; Holdt LM; Teupser D
Article: JOURNAL OF CLINICAL INVESTIGATION. 2024;135(1):e182939
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice
Liu W; Hardaway BD; Kim E; Pauli J; Wettich JL; Yalcinkaya M; Hsu C-C; Xiao T; Reilly MP; Tabas I; Maegdefessel L; Schlepckow K; Haass C; Wang N; Tall AR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;327(5):H1296-H1302
Red blood cells as potential materials for microRNA biomarker study: overcoming heparin-related challenges
Kontidou E; Humoud R; Chernogubova E; Alvarsson M; Maegdefessel L; Collado A; Pernow J; Zhou Z
Article: CARDIOVASCULAR RESEARCH. 2024;120(12):1411-1426
Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.
Wang Y; Li G; Chen B; Shakir G; Volz M; van der Vorst EPC; Maas SL; Geiger M; Jethwa C; Bartelt A; Li Z; Wettich J; Sachs N; Maegdefessel L; Nazari Jahantigh M; Hristov M; Lacy M; Lutz B; Weber C; Herzig S; Guillamat Prats R; Steffens S
Article: NATURE COMMUNICATIONS. 2024;15(1):8034
Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis
Bamezai S; Zhang Y; Kumari M; Lotfi M; Alsaigh T; Luo L; Kumar GS; Wang F; Ye J; Puri M; Manchanda R; Paluri S; Adkar SS; Kojima Y; Ingelsson A; Bell CF; Lopez NG; Fu C; Choi RB; Miller Z; Barrios L; Walsh S; Ahmad F; Maegdefessel L; Smith BR; Leeper NJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2024;81(1):331
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
Pourteymour S; Fan J; Majhi RK; Guo S; Sun X; Huang Z; Liu Y; Winter H; Baecklund A; Skenteris N-T; Chernogubova E; Werngren O; Li Z; Skogsberg J; Li Y; Matic L; Hedin U; Maegdefessel L; Ehrenborg E; Tian Y; Jin H
Article: CIRCULATION. 2024;149(24):1885-1898
Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease
Pan H; Ho SE; Xue C; Cui J; Johanson QS; Sachs N; Ross LS; Li F; Solomon RA; Connolly ES; Patel VI; Maegdefessel L; Zhang H; Reilly MP
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(4):930-945
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
Bashore AC; Yan H; Xue C; Zhu LY; Kim E; Mawson T; Coronel J; Chung A; Sachs N; Ho S; Ross LS; Kissner M; Passegue E; Bauer RC; Maegdefessel L; Li M; Reilly MP
Article: MOLECULAR METABOLISM. 2024;82:101912
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(6):e2302907
Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases
Paloschi V; Pauli J; Winski G; Wu Z; Li Z; Botti L; Meucci S; Conti P; Rogowitz F; Glukha N; Hummel N; Busch A; Chernogubova E; Jin H; Sachs N; Eckstein H-H; Dueck A; Boon RA; Bausch AR; Maegdefessel L
Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(1):60-75
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis
Fidler TP; Dunbar A; Kim E; Hardaway B; Pauli J; Xue C; Abramowicz S; Xiao T; O'Connor K; Sachs N; Wang N; Maegdefessel L; Levine R; Reilly M; Tall AR
Article: CIRCULATION RESEARCH. 2023;133(8):674-686
ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1
Sharifi MA; Wierer M; Dang TA; Milic J; Moggio A; Sachs N; von Scheidt M; Hinterdobler J; Mueller P; Werner J; Stiller B; Aherrahrou Z; Erdmann J; Zaliani A; Graettinger M; Reinshagen J; Gul S; Gribbon P; Maegdefessel L; Bernhagen J; Sager HB; Mann M; Schunkert H; Kessler T
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2023;33:848-865
The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms
Fasolo F; Winski G; Li Z; Wu Z; Winter H; Ritzer J; Glukha N; Roy J; Hultgren R; Pauli J; Busch A; Sachs N; Knappich C; Eckstein H-H; Boon RA; Paloschi V; Maegdefessel L
Article: JCI INSIGHT. 2023;8(17):e170845
Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
Martinez MA; Ritsvall O; Bastrup JA; Celik S; Jakobsson G; Daoud F; Winqvist C; Aspberg A; Rippe C; Maegdefessel L; Schiopu A; Jepps TA; Holmberg J; Sward K; Albinsson S
Article: MEDRXIV. 2023;:2023.07.13.23292633
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.
Bashore AC; Yan H; Xue C; Zhu LY; Kim E; Mawson T; Coronel J; Chung A; Ho S; Ross LS; Kissner M; Passegué E; Bauer RC; Maegdefessel L; Li M; Reilly MP
Article: CIRCULATION. 2023;148(1):47-67
INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10
Zhang W; Zhao J; Deng L; Ishimwe N; Pauli J; Wu W; Shan S; Kempf W; Ballantyne MD; Kim D; Lyu Q; Bennett M; Rodor J; Turner AW; Lu YW; Gao P; Choi M; Warthi G; Kim HW; Barroso MM; Bryant WB; Miller CL; Weintraub NL; Maegdefessel L; Miano JM; Baker AH; Long X
Article: BIOMOLECULES. 2023;13(7):1074
Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease
Pauli J; Reisenauer T; Winski G; Sachs N; Chernogubova E; Freytag H; Otto C; Reeps C; Eckstein H-H; Scholz C-J; Maegdefessel L; Busch A
Article: MOLECULAR THERAPY. 2023;31(6):1775-1790
Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression
Winter H; Winski G; Busch A; Chernogubova E; Fasolo F; Wu Z; Baecklund A; Khomtchouk BB; Booven DJV; Sachs N; Eckstein H-H; Wittig I; Boon RA; Jin H; Maegdefessel L
Article: VASCULAR PHARMACOLOGY. 2023;150:107167
Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification
Skenteris NT; Hemme E; Delfos L; Karadimou G; Karlof E; Lengquist M; Kronqvist M; Zhang X; Maegdefessel L; Schurgers LJ; Arnardottir H; Biessen EAL; Bot I; Matic L
Article: CARDIOVASCULAR RESEARCH. 2023;119(3):867-878
E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1
Mulorz J; Spin JM; Mulorz P; Wagenhaeuser M; Deng A; Mattern K; Rhee YH; Toyama K; Adam M; Schelzig H; Maegdefessel L; Tsao PS
Article: THROMBOSIS AND HAEMOSTASIS. 2023;123(05):545-554
Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging
Ferraro B; Giustetto P; Schengel O; Weckbach LT; Maegdefessel L; Soehnlein O
Article: ATHEROSCLEROSIS. 2023;371:1-13
A comparative gene expression matrix in Apoe-deficient mice identifies unique and atherosclerotic disease stage-specific gene regulation patterns in monocytes and macrophages
Haerdtner C; Kumar A; Ehlert CA; Vico TA; Starz C; von Ehr A; Krebs K; Dufner B; Hoppe N; Stachon P; Heidt T; Wolf D; von zur Muehlen C; Gruening B; Robbins CS; Maegdefessel L; Westermann D; Dederichs T-S; Hilgendorf I
Article: VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. 2023;52(2):124-132
CXCR4 - a possible serum marker for risk stratification of abdominal aortic aneurysms.
Reutersberg B; Metschl S; Salvermoser M; Eckstein H-H; Knappich C; Maegdefessel L; Jaroslav P; Busch A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(2):286-299
Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1)
Cynn E; Li DY; O'Reilly ME; Wang Y; Bashore AC; Jha A; Foulkes AS; Zhang H; Winter H; Maegdefessel L; Yan H; Li M; Ross L; Xue C; Reilly MP
Article: JVS - VASCULAR SCIENCE. 2023;4:100093
Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth.
Zschäpitz D; Bohmann B; Lutz B; Eckstein H-H; Reeps C; Maegdefessel L; Gasser CT; Busch A
Article: SCIENTIFIC REPORTS. 2022;12(1):20990
Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms
Lim C; Pratama MY; Rivera C; Silvestro M; Tsao PSS; Maegdefessel L; Gallagher KAA; Maldonado T; Ramkhelawon B
Article: CELL REPORTS. 2022;41(7):111670
Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2.
Oo JA; Pálfi K; Warwick T; Wittig I; Prieto-Garcia C; Matkovic V; Tomašković I; Boos F; Izquierdo Ponce J; Teichmann T; Petriukov K; Haydar S; Maegdefessel L; Wu Z; Pham MD; Krishnan J; Baker AH; Günther S; Ulrich HD; Dikic I; Leisegang MS; Brandes RP
Article: NATURE CARDIOVASCULAR RESEARCH. 2022;1(11):1056-1071
GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation
Guillamat-Prats R; Hering D; Derle A; Rami M; Haerdtner C; Santovito D; Rinne P; Bindila L; Hristov M; Pagano S; Vuilleumier N; Schmid S; Janjic A; Enard W; Weber C; Maegdefessel L; Faussner A; Hilgendorf I; Steffens S
Article: CARDIOVASCULAR RESEARCH. 2022;118(13):2792-2804
Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells
Wang Y; Gao H; Wang F; Ye Z; Mokry M; Turner AW; Ye J; Koplev S; Luo L; Alsaigh T; Adkar SS; Elishaev M; Gao X; Maegdefessel L; Bjorkegren JLM; Pasterkamp G; Miller CL; Ross EG; Leeper NJ
Article: PLOS ONE. 2022;17(9):e0265160
Aging-regulated TUG1 is dispensable for endothelial cell function
Gimbel AT; Koziarek S; Theodorou K; Schulz JF; Stanicek L; Kremer V; Ali T; Guenther S; Kumar S; Jo H; Huebner N; Maegdefessel L; Dimmeler S; van Heesch S; Boon RA
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(10):512
Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation.
Brandhofer M; Hoffmann A; Blanchet X; Siminkovitch E; Rohlfing A-K; El Bounkari O; Nestele JA; Bild A; Kontos C; Hille K; Rohde V; Fröhlich A; Golemi J; Gokce O; Krammer C; Scheiermann P; Tsilimparis N; Sachs N; Kempf WE; Maegdefessel L; Otabil MK; Megens RTA; Ippel H; Koenen RR; Luo J; Engelmann B; Mayo KH; Gawaz M; Kapurniotu A; Weber C; von Hundelshausen P; Bernhagen J
Article: METABOLITES. 2022;12(9):840
Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR
Bauer S; Eigenmann J; Zhao Y; Fleig J; Hawe JS; Pan C; Bongiovanni D; Wengert S; Ma A; Lusis AJ; Kovacic JC; Bjoerkegren JLM; Maegdefessel L; Schunkert H; von Scheidt M
Article: THROMBOSIS AND HAEMOSTASIS. 2022;122(9):1513-1523
Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture.
Metschl S; Bruder L; Paloschi V; Jakob K; Reutersberg B; Reeps C; Maegdefessel L; Gee M; Eckstein H-H; Pelisek J
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2022;64(2-3):255-264
Radiation and Chemotherapy are Associated with Altered Aortic Aneurysm Growth in Patients with Cancer: Impact of Synchronous Cancer and Aortic Aneurysm
von Rose AB; Kobus K; Bohmann B; Lindquist-Lilljequist M; Eilenberg W; Bassermann F; Reeps C; Eckstein H-H; Trenner M; Maegdefessel L; Neumayer C; Brostjan C; Roy J; Hultgren R; Schwaiger BJ; Busch A
Article: CIRCULATION RESEARCH. 2022;131(1):42-58
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages
My-Anh N; Huy-Dung H; Rasheed A; Duchez A-C; Wyatt H; Cottee ML; Graber TE; Susser L; Robichaud S; Berber I; Geoffrion M; Ouimet M; Kazan H; Maegdefessel L; Mulvihill EE; Alain T; Rayner KJ
Article: JOURNAL OF CELL SCIENCE. 2022;135(12):jcs259671
The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and-494 processing
Kremer V; Stanicek L; van Ingen E; Bink DI; Hilderink S; Tijsen AJ; Wittig I; Maegdefessel L; Nossent AY; Boon RA
Article: NATURE COMMUNICATIONS. 2022;13(1):2867
ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.
Kaufmann JO; Brangsch J; Kader A; Saatz J; Mangarova DB; Zacharias M; Kempf WE; Schwaar T; Ponader M; Adams LC; Möckel J; Botnar RM; Taupitz M; Mägdefessel L; Traub H; Hamm B; Weller MG; Makowski MR
Article: EUROPEAN HEART JOURNAL. 2022;43(19):1864-1877
Interferon regulatory factor-5-dependent CD11c⁺ macrophages contribute to the formation of rupture-prone atherosclerotic plaques
Edsfeldt A; Swart M; Singh P; Dib L; Sun J; Cole JE; Park I; Al-Sharify D; Persson A; Nitulescu M; Borges PDN; Kassiteridi C; Goddard ME; Lee R; Volkov P; Orho-Melander M; Maegdefessel L; Nilsson J; Udalova I; Goncalves I; Monaco C
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):197
PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle
Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Roell W; Pfeifer A
Article: NATURE CARDIOVASCULAR RESEARCH. 2022;1(3):253-262
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis
Jarr K-U; Ye J; Kojima Y; Ye Z; Gao H; Schmid S; Luo L; Baylis RA; Lotfi M; Lopez N; Eberhard AV; Smith BR; Weissman IL; Maegdefessel L; Leeper NJ
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(2):e682
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification
Skenteris NT; Seime T; Witasp A; Karlof E; Wasilewski GB; Heuschkel MA; Jaminon AMG; Oduor L; Dzhanaev R; Kronqvist M; Lengquist M; Peeters FECM; Soderberg M; Hultgren R; Roy J; Maegdefessel L; Arnardottir H; Bengtsson E; Goncalves I; Quertermous T; Goettsch C; Stenvinkel P; Schurgers LJ; Matic L
Article: DIABETES. 2022;71(2):285-297
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes
Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: CARDIOVASCULAR RESEARCH. 2021;117(14):2767-2780
Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability
Tsantilas P; Lao S; Wu Z; Eberhard A; Winski G; Vaerst M; Nanda V; Wang Y; Kojima Y; Ye J; Flores A; Jarr K-U; Pelisek J; Eckstein H-H; Matic L; Hedin U; Tsao PS; Paloschi V; Maegdefessel L; Leeper NJ
Article: BIOMOLECULES. 2021;11(11):1683
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.
Neiburga KD; Vilne B; Bauer S; Bongiovanni D; Ziegler T; Lachmann M; Wengert S; Hawe JS; Güldener U; Westerlund AM; Li L; Pang S; Yang C; Saar K; Huebner N; Maegdefessel L; DigiMed Bayern Consortium; Lange R; Krane M; Schunkert H; von Scheidt M
Article: CIRCULATION. 2021;144(19):1567-1583
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Baecklund A; Bergmark C; Paloschi V; Maegdefessel L
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2021;62(5):716-726
Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling
Karlof E; Buckler A; Liljeqvist ML; Lengquist M; Kronqvist M; Toonsi MA; Maegdefessel L; Matic LP; Hedin U
Article: EUROPEAN HEART JOURNAL. 2021;42(39):4077-4088
Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
Hinterdobler J; Schott S; Jin H; Meesmann A; Steinsiek A-L; Zimmermann A-S; Wobst J; Mueller P; Mauersberger C; Vilne B; Baecklund A; Chen C-S; Moggio A; Braster Q; Molitor M; Krane M; Kempf WE; Ladwig K-H; Hristov M; Hulsmans M; Hilgendorf I; Weber C; Wenzel P; Scheiermann C; Maegdefessel L; Soehnlein O; Libby P; Nahrendorf M; Schunkert H; Kessler T; Sager HB
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(17):e020231
Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression
Gabel G; Northoff BH; Balboa A; Becirovic-Agic M; Petri M; Busch A; Maegdefessel L; Mahlmann A; Ludwig S; Teupser D; de Waard V; Golledge J; Wanhainen A; Wagsater D; Holdt LM; Lindeman JHN
Article: JCI INSIGHT. 2021;6(15):140364
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility
Busch A; Pauli J; Winski G; Bleichert S; Chernogubova E; Metschl S; Winter H; Trenner M; Wiegering A; Otto C; Fischer J; Reiser J; Werner J; Roy J; Brostjan C; Knappich C; Eckstein H-H; Paloschi V; Maegdefessel L
Article: TRANSLATIONAL RESEARCH. 2021;233:32-46
Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms
Eilenberg W; Zagrapan B; Bleichert S; Ibrahim N; Knobl V; Brandau A; Martelanz L; Grasl M-T; Hayden H; Nawrozi P; Rajic R; Hausler C; Potolidis A; Schirwani N; Scheuba A; Klopf J; Teubenbacher P; Weigl MP; Kirchweger P; Beitzke D; Stiglbauer-Tscholakoff A; Panzenbock A; Lang I; Mauracher L-M; Hell L; Pabinger I; Bailey MA; Scott DJA; Maegdefessel L; Busch A; Huk I; Neumayer C; Brostjan C
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2021;24:188-199
MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening
Schellinger IN; Wagenhaeuser M; Chodisetti G; Mattern K; Dannert A; Petzold A; Jakubizka-Smorag J; Emrich F; Haunschild J; Schuster A; Schwob E; Schulz K; Maegdefessel L; Spin JM; Stumvoll M; Hasenfuss G; Tsao PS; Raaz U
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(6):2038-2048
Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability
Georgakis MK; van der Laan SW; Asare Y; Mekke JM; Haitjema S; Schoneveld AH; de Jager SCA; Nurmohamed NS; Kroon J; Stroes ESG; de KDPV; de Borst GJ; Maegdefessel L; Soehnlein O; Pasterkamp G; Dichgans M
Article: CELLS. 2021;10(6):1276
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification
Seime T; Akbulut AC; Liljeqvist ML; Siika A; Jin H; Winski G; van Gorp RH; Karlof E; Lengquist M; Buckler AJ; Kronqvist M; Waring OJ; Lindeman JHN; Biessen EAL; Maegdefessel L; Razuvaev A; Schurgers LJ; Hedin U; Matic L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(5):1738-1750
Virtual Transcriptomics Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging
Buckler AJ; Karlof E; Lengquist M; Gasser TC; Maegdefessel L; Perisic Matic L; Hedin U
Article: REDOX BIOLOGY. 2021;41:101903
MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
Gao P; Gao P; Zhao J; Shan S; Luo W; Slivano OJ; Zhang W; Tabuchi A; LeMaire SA; Maegdefessel L; Shen YH; Miano JM; Singer HA; Long X
Article: CIRCULATION. 2021;143(3):254-266
Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion
Schumski A; Ortega-Gomez A; Wichapong K; Winter C; Lemnitzer P; Viola JR; Pinilla-Vera M; Folco E; Solis-Mezarino V; Volker-Albert M; Maas SL; Pan C; Olivares LP; Winter J; Hackeng T; Karlsson MCI; Zeller T; Imhof A; Baron RM; Nicolaes GAF; Libby P; Maegdefessel L; Kamp F; Benoit M; Doring Y; Soehnlein O
Journal article: CIRCULATION. 2021;144(19):1567-1583
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization
Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DYY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Backlund A; Bergmark C; Paloschi V; Maegdefessel L
Article: ATHEROSCLEROSIS. 2020;314:1-9
A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?
Rakipovski G; Rolin B; Barascuk N; Lund HE; Bonde MFB; Djordjevic D; Wulff-Larsen PG; Petersen M; Kirk RK; Hultman K; Manfe V; Blume N; Zahn S; Lengquist M; Maegdefessel L; Hovingh GK; Conde-Knape K; Hedin U; Matic L; Nyberg M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(12):2821-2828
18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.
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Article: NATURE COMMUNICATIONS. 2020;11(1):5981
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.
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Functional investigation of the coronary artery disease gene SVEP1
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Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15818-15826
Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade
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Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(6):1464-1478
Macrophage-Enriched lncRNA RAPIA: A Novel Therapeutic Target for Atherosclerosis.
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Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2020;75(15):1788-1800
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MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice
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The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment
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Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA
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Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis
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Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability
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Therapeutic Targeting of Neutrophil Extracellular Traps in Atherogenic Inflammation
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Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129
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Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation
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Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank.
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Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm Possible Therapeutic Targets?
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Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(1):72-82
miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease
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The long noncoding RNA CHROME regulates cholesterol homeostasis in primates
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Article: JOURNAL OF VASCULAR RESEARCH. 2019;56(5):217-229
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Article: CARDIOVASCULAR RESEARCH. 2019;115(1):230-242
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Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms
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Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion
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Article: MOLECULAR THERAPY. 2018;26(4):1040-1055
Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions
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Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm
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Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration
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Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A
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Guidelines for the functional annotation of microRNAs using the Gene Ontology
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miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux
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Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression
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Local MicroRNA Modulation Using a Novel Anti-miR21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis
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Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus
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Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Article: PLOS GENETICS. 2014;10(3):e1004263
Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
Miller CL; Haas U; Diaz R; Leeper NJ; Kundu RK; Patlolla B; Assimes TL; Kaiser FJ; Perisic L; Hedin U; Maegdefessel L; Schunkert H; Erdmann J; Quertermous T; Sczakiel G
Article: VASCULAR MEDICINE. 2014;19(1):3-8
The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model
Downing KP; Nead KT; Kojima Y; Assimes T; Maegdefessel L; Quertermous T; Cooke JP; Leeper NJ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(1):e1-e10
Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Leeper NJ; Raiesdana A; Kojima Y; Kundu RK; Cheng H; Maegdefessel L; Toh R; Ahn G-O; Ali ZA; Anderson DR; Miller CL; Roberts SC; Spin JM; de Almeida PE; Wu JC; Xu B; Cheng K; Quertermous M; Kundu S; Kortekaas KE; Berzin E; Downing KP; Dalman RL; Tsao PS; Schadt EE; Owens GK; Quertermous T
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2012;(63):e3663
Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis
Hua X; Deuse T; Michelakis ED; Haromy A; Tsao PS; Maegdefessel L; Erben RG; Bergow C; Behnisch BB; Reichenspurner H; Robbins RC; Schrepfer S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(122):122ra22
MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Maegdefessel L; Azuma J; Toh R; Deng A; Merk DR; Raiesdana A; Leeper NJ; Raaz U; Schoelmerich AM; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):497-506
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development
Maegdefessel L; Azuma J; Toh R; Merk DR; Deng A; Chin JT; Raaz U; Schoelmerich AM; Raiesdana A; Leeper NJ; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: CIRCULATION RESEARCH. 2012;110(2):312-324
miR-29b Participates in Early Aneurysm Development in Marfan Syndrome
Merk DR; Chin JT; Dake BA; Maegdefessel L; Miller MO; Kimura N; Tsao PS; Iosef C; Berry GJ; Mohr FW; Spin JM; Alvira CM; Robbins RC; Fischbein MP
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2011;32(4):417-425
Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study
Kaeberich A; Reindl I; Raaz U; Maegdefessel L; Vogt A; Linde T; Steinseifer U; Perzborn E; Hauroeder B; Buerke M; Werdan K; Schlitt A
Article: PHYSIOLOGICAL GENOMICS. 2011;43(17):993-1003
Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm
Spin JM; Hsu M; Azuma J; Tedesco MM; Deng A; Dyer JS; Maegdefessel L; Dalman RL; Tsao PS
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2011;226(4):1035-1043
MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function
Leeper NJ; Raiesdana A; Kojima Y; Chun HJ; Azuma J; Maegdefessel L; Kundu RK; Quertermous T; Tsao PS; Spin JM
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(2):270-279
Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms
Goergen CJ; Azuma J; Barr KN; Magdefessel L; Kallop DY; Gogineni A; Grewall A; Weimer RM; Connolly AJ; Dalman RL; Taylor CA; Tsao PS; Greve JM
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2011;7:693-699
Comparison of outcome in 1809 patients treated with drug-eluting stents or bare-metal stents in a real-world setting
Vogt A; Schoelmerich A; Pollner F; Schlitt M; Raaz U; Maegdefessel L; Reindl I; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2011;2011:252141
Assessment of Elastase-Induced Murine Abdominal Aortic Aneurysms: Comparison of Ultrasound Imaging with In Situ Video Microscopy
Azuma J; Maegdefessel L; Kitagawa T; Dalman RL; McConnell MV; Tsao PS
Article: THROMBOSIS RESEARCH. 2010;126(3):e196-e200
In vitro comparison of dabigatran, unfractionated heparin, and low-molecular-weight heparin in preventing thrombus formation on mechanical heart valves
Maegdefessel L; Linde T; Krapiec F; Hamilton K; Steinseifer U; van Ryn J; Raaz U; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2010;29(3):265-270
Efficacy of enoxaparin, certoparin and dalteparin in preventing cardiac catheter thrombosis: an in vitro approach
Raaz U; Buerke M; Busshardt M; Maegdefessel L; Plehn A; Hauroeder B; Werdan K; Schlitt A
Article: THROMBOSIS AND HAEMOSTASIS. 2010;103(4):808-814
The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro
Raaz U; Kaeberich A; Maegdefessel L; Buerke M; Busshardt M; Schubert S; Russ M; Plehn A; Ebelt H; Werdan K; Schlitt A
Article: LIPIDS. 2010;45(2):129-135
Serum Phospholipid Transfer Protein Activity After a High Fat Meal in Patients with Insulin-Treated Type 2 Diabetes
Schlitt A; Schwaab B; Fingscheidt K; Lackner KJ; Heine GH; Vogt A; Buerke M; Maegdefessel L; Raaz U; Werdan K; Jiang X-C
Article: THROMBOSIS AND HAEMOSTASIS. 2009;101(6):1163-1169
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves Results of an in-vitro study
Maegdefessel L; Linde T; Michel T; Hamilton K; Steinseifer U; Friedrich I; Schubert S; Hauroeder B; Raaz U; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF LIPID RESEARCH. 2009;50(4):723-729
PLTP activity is a risk factor for subsequent cardiovascular events in CAD patients under statin therapy: the AtheroGene Study
Schlitt A; Blankenberg S; Bickel C; Lackner KJ; Heine GH; Buerke M; Werdan K; Maegdefessel L; Raaz U; Rupprecht HJ; Munzel T; Jiang X-C
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2009;5:849-857
Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects
Maegdefessel L; Schlitt A; Pippig S; Schwaab B; Fingscheidt K; Raaz U; Buerke M; Loppnow H
Article: THROMBOSIS AND HAEMOSTASIS. 2008;100(4):693-698
Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis Results of an in-vitro study
Maegdefessel L; Buerke M; Schubert S; Reindl I; Michel T; Hauroeder B; Carter JM; Peetz D; Werdan K; Schlitt A
Article: MEDIZINISCHE KLINIK. 2008;103(9):628-632
Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention
Maegdefessel L; Schlitt A; Faerber J; Bond SP; Messow C-M; Buerke M; Raaz U; Werdan K; Munzel T; Weiss C
Article: INTERNIST. 2008;49(7):868-872
27-year old pregnant woman with syncope and dyspnea after aortic alloplastic heart valve replacement 15 years ago
Maegdefessel L; Issa H; Scheler C; Thaele V; Schlitt A; Hartelt U; Grabitz R; Buerke M
Article: CORONARY ARTERY DISEASE. 2008;19(4):279-284
In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus
Schlitt A; Rupprecht HJ; Reindl I; Schubert S; Hauroeder B; Carter JM; Peetz D; Kropff SS; Maegdefessel L; Russ M; Schmidt H; Ebelt H; Werdan K; Buerke M
Article: JOURNAL OF HEART VALVE DISEASE. 2006;15(6):809-814
Comparison of fondaparinux, low molecular-weight heparin and unfractionated heparin in preventing thrombus formation on mechanical heart valves: Results of an in-vitro study
Schlitt A; Hamilton K; Maegdefessel L; Dahm M; Theis C; Eichler M; Brockmann O; Steinseifer U; Hauroeder B; Hitzler WE; Rupprecht HJ
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