Utforskar olika cellsignaleringsfenomen och deras inverkan på kritiska biologiska och medicinska processer med avancerad ljusmikroskopi – Per Uhléns grupp

Publikationer

Utvalda publikationer

• Article: SCIENCE. 2024;386(6724):907-915

  Whole-brain spatial transcriptional analysis at cellular resolution

  Kanatani S; Kreutzmann JC; Li Y; West Z; Larsen LL; Nikou DV; Eidhof I; Walton A; Zhang S; Rodriguez-Kirby LR; Skytte JL; Salinas CG; Takamatsu K; Li X; Tanaka DH; Kaczynska D; Fukumoto K; Karamzadeh R; Xiang Y; Uesaka N; Tanabe T; Adner M; Hartman J; Miyakawa A; Sundstrom E; Castelo-Branco G; Roostalu U; Hecksher-Sorensen J; Uhlen P
• Journal article: NATURE METHODS. 2022;19(5):527-529

  Imaging cleared tissues made easy

  Kanatani S; Uhlen P
• Article: NATURE COMMUNICATIONS. 2022;13(1):1537

  GIT1 protects against breast cancer growth through negative regulation of Notch

  Zhang S; Miyakawa A; Wickstrom M; Dyberg C; Louhivuori L; Varas-Godoy M; Kemppainen K; Kanatani S; Kaczynska D; Ellstrom ID; Elfman L; Kronqvist P; Repo H; Mikoshiba K; Sahlgren C; Johnsen JI; Uhlen P
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2108768119

  Disrupted Cacna1c gene expression perturbs spontaneous Ca²⁺ activity causing abnormal brain development and increased anxiety

  Smedler E; Louhivuori L; Romanov RA; Masini D; Ellstrom ID; Wang C; Caramia M; West Z; Zhang S; Rebellato P; Malmersjo S; Brusini I; Kanatani S; Fisone G; Harkany T; Uhlen P
• Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888

  Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

  Tanaka N; Kanatani S; Kaczynska D; Fukumoto K; Louhivuori L; Mizutani T; Kopper O; Kronqvist P; Robertson S; Lindh C; Kis L; Pronk R; Niwa N; Matsumoto K; Oya M; Miyakawa A; Falk A; Hartman J; Sahlgren C; Clevers H; Uhlen P
• Journal article: NATURE BIOMEDICAL ENGINEERING. 2018;2(10):717-718

  Predicting a tumour's drug uptake

  Louhivuori L; Kanatani S; Uhlen P
• Journal article: TRENDS IN CANCER. 2018;4(5):337-341

  Improved Pathological Examination of Tumors with 3D Light-Sheet Microscopy

  Uhlen P; Tanaka N
• Article: BRITISH JOURNAL OF CANCER. 2018;118(7):995-999

  Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy

  Tanaka N; Kaczynska D; Kanatani S; Sahlgren C; Mitura P; Stepulak A; Miyakawa A; Wiklund P; Uhlen P
• Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806

  Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

  Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
• Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(3):964-969

  Frequency decoding of calcium oscillations

  Smedler E; Uhlen P
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532

  Neural progenitors organize in small-world networks to promote cell proliferation

  Malmersjo S; Rebellato P; Smedler E; Planert H; Kanatani S; Liste I; Nanou E; Sunner H; Abdelhady S; Zhang S; Andang M; El Manira A; Silberberg G; Arenas E; Uhlen P
• Journal article: SCIENCES STKE [ELECTRONIC RESOURCE] : SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT. 2004;2004(258):pl15

  Spectral analysis of calcium oscillations.

  Uhlén P
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(23):13420-13424

  Ouabain, a steroid hormone that signals with slow calcium oscillations

  Aizman O; Uhlén P; Lal M; Brismar H; Aperia A
• Article: NATURE. 2000;405(6787):694-697

  α-Haemolysin of uropathogenic E-coli induces Ca²⁺ oscillations in renal epithelial cells

  Uhlén P; Laestadius Å; Jahnukainen T; Söderblom T; Bäckhed F; Celsi G; Brismar H; Normark S; Aperia A; Richter-Dahlfors A
• Article: NATURE NEUROSCIENCE. 2000;3(3):226-230

  Anatomical and physiological evidence for D₁ and D₂ dopamine receptor colocalization in neostriatal neurons

  Aizman O; Brismar H; Uhlén P; Zettergren E; Levey AI; Forssberg H; Greengard P; Aperia A

Finansiering

Forskningsbidrag

• Three-Dimensional Mapping of Molecular Mechanisms After Spinal Cord Injury

  Hjärnfonden

  1 July 2024 - 30 June 2027
• Spatial Single-Cell Analysis of Proteins and RNAs in the Tumor Microenvironment by 3D Imaging

  Cancerfonden

  1 January 2023 - 31 December 2025
• Exploration of Intratumoral Heterogeneity with Multimodal 3D Imaging at Single-Cell Resolution to Improve Precision Medicine for Cancer

  Vetenskapsrådet

  1 January 2022 - 31 December 2025

Medarbetare och kontakt

Gruppledare

• 

  Per Uhlén

  Professor

  E-postadress per.uhlen@ki.se

Alla medarbetare i gruppen

• Ibrahim Al Rayyes

  Assistent Klinisk

  E-postadress ibrahim.al.rayyes@ki.se
• Ivar Dehnisch Ellström

  Anknuten till Forskning

  E-postadress ivar.dehnisch.ellstrom@ki.se
• 

  Connla Edwards

  Forskningsingenjör

  Telefon +46852486978

  E-postadress connla.edwards@ki.se
• Ilse Eidhof

  Forskningsspecialist

  E-postadress ilse.eidhof@ki.se
• Eleni Gelali

  Postdoktor

  E-postadress eleni.gelali@ki.se
• 

  Shigeaki Kanatani

  Forskningsspecialist

  Telefon +46852487159

  E-postadress shigeaki.kanatani@ki.se
• 

  Yue Li

  Doktorand

  E-postadress yue.li@ki.se
• Ayako Miyakawa

  Anknuten till Forskning

  E-postadress ayako.miyakawa@ki.se
• 

  Göran Månsson

  Forskningsingenjör

  Telefon +46852487977

  E-postadress goran.mansson@ki.se
• Kimiharu Takamatsu

  Postdoktorala Studier

  E-postadress kimiharu.takamatsu@ki.se
• 

  Per Uhlén

  Professor

  E-postadress per.uhlen@ki.se
• 

  Abigail Walton

  Doktorand

  E-postadress abigail.walton@ki.se
• 

  Songbai Zhang

  Senior Lab Manager

  E-postadress songbai.zhang@ki.se