Per Uhlén

Publikationer
CV
Populärvetenskap och samverkan

Utvalda publikationer

Article: NATURE NEUROSCIENCE. 2023;26(6):1008-1020

ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain

Stratoulias V; Ruiz R; Kanatani S; Osman AM; Keane L; Armengol JA; Rodriguez-Moreno A; Murgoci A-N; Garcia-Dominguez I; Alonso-Bellido I; Ibanez FG; Picard K; Vazquez-Cabrera G; Posada-Perez M; Vernoux N; Tejera D; Grabert K; Cheray M; Gonzalez-Rodriguez P; Perez-Villegas EM; Martinez-Gallego I; Lastra-Romero A; Brodin D; Avila-Carino J; Cao Y; Airavaara M; Uhlen P; Heneka MT; Tremblay M-E; Blomgren K; Venero JL; Joseph B
Article: NATURE BIOTECHNOLOGY. 2023;41(2):222-231

Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH

Borm LE; Albiach AM; Mannens CCA; Janusauskas J; Ozgun C; Fernandez-Garcia D; Hodge R; Castillo F; Hedin CRH; Villablanca EJ; Uhlen P; Lein ES; Codeluppi S; Linnarsson S
Preprint: BIORXIV. 2022

Whole-Brain Three-Dimensional Imaging of RNAs at Single-Cell Resolution

Kanatani S; Kreutzmann J; Li Y; West Z; Vougesi Nikou D; Lercke Skytte J; Lydolph Larsen L; Tanaka D; Kaczynska D; Fukumoto K; Uesaka N; Tanabe T; Miyakawa A; Roostalu U; Hecksher-Sørensen J; Uhlén P
Editorial comment: NATURE METHODS. 2022;19(5):527-529

Imaging cleared tissues made easy

Kanatani S; Uhlen P
Article: NATURE COMMUNICATIONS. 2022;13(1):1537

GIT1 protects against breast cancer growth through negative regulation of Notch

Zhang S; Miyakawa A; Wickstrom M; Dyberg C; Louhivuori L; Varas-Godoy M; Kemppainen K; Kanatani S; Kaczynska D; Ellstrom ID; Elfman L; Kronqvist P; Repo H; Mikoshiba K; Sahlgren C; Johnsen JI; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2108768119

Disrupted Cacna1c gene expression perturbs spontaneous Ca²⁺ activity causing abnormal brain development and increased anxiety

Smedler E; Louhivuori L; Romanov RA; Masini D; Ellstrom ID; Wang C; Caramia M; West Z; Zhang S; Rebellato P; Malmersjo S; Brusini I; Kanatani S; Fisone G; Harkany T; Uhlen P
Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies

Tanaka N; Kanatani S; Kaczynska D; Fukumoto K; Louhivuori L; Mizutani T; Kopper O; Kronqvist P; Robertson S; Lindh C; Kis L; Pronk R; Niwa N; Matsumoto K; Oya M; Miyakawa A; Falk A; Hartman J; Sahlgren C; Clevers H; Uhlen P
Editorial comment: TRENDS IN CANCER. 2018;4(5):337-341

Improved Pathological Examination of Tumors with 3D Light-Sheet Microscopy

Uhlen P; Tanaka N
Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity

Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
Article: FRONTIERS IN NEURAL CIRCUITS. 2014;8:111

Network analysis of time-lapse microscopy recordings

Smedler E; Malmersjoe S; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532

Neural progenitors organize in small-world networks to promote cell proliferation

Malmersjo S; Rebellato P; Smedler E; Planert H; Kanatani S; Liste I; Nanou E; Sunner H; Abdelhady S; Zhang S; Andang M; El Manira A; Silberberg G; Arenas E; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(7):2212-2217

Na,K-ATPase signal transduction triggers CREB activation and dendritic growth

Desfrere L; Karlsson M; Hiyoshi H; Malmersjo S; Nanou E; Estrada M; Miyakawa A; Lagercrantz H; El Manira A; Lal M; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(7):2160-2165

Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling

Uhlén P; Burch PM; Zito CL; Estrada M; Ehrlich BE; Bennett AM
Article: NATURE. 2000;405(6787):694-697

α-Haemolysin of uropathogenic E-coli induces Ca²⁺ oscillations in renal epithelial cells

Uhlén P; Laestadius Å; Jahnukainen T; Söderblom T; Bäckhed F; Celsi G; Brismar H; Normark S; Aperia A; Richter-Dahlfors A

Artiklar

Article: WORLD JOURNAL OF UROLOGY. 2023;41(12):3405-3411

Consultation on UTUC II Stockholm 2022: diagnostic and prognostic methods-what's around the corner?

Grahn A; Coleman JA; Eriksson Y; Gabrielsson S; Madsen JS; Tham E; Thomas K; Turney B; Uhlen P; Vollmer T; Zieger K; Osther PJS; Brehmer M
Article: EXPERIMENTAL EYE RESEARCH. 2023;237:109674

Anatomy of the complete mouse eye vasculature explored by light-sheet fluorescence microscopy exposes subvascular-specific remodeling in development and pathology

Krimpenfort LT; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; Andre H; Uhlen P; Jakobsson L
Article: ACS APPLIED BIO MATERIALS. 2023;6(9):3790-3797

Live Detection of Neural Progenitors and Glioblastoma Cells by an Oligothiophene Derivative

Ilkhanizadeh S; Gracias A; Aslund AKO; Back M; Simon R; Kavanagh E; Migliori B; Neofytou C; Nelander S; Westermark B; Uhrbom L; Forsberg-Nilsson K; Konradsson P; Teixeira AI; Uhlen P; Joseph B; Hermanson O; Nilsson KPR
Article: ENVIRONMENTAL TOXICOLOGY. 2022;37(8):2044-2057

Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation

Reis L; Raciti M; Rodriguez PG; Joseph B; Al Rayyes I; Uhlen P; Falk A; Lima STDC; Ceccatelli S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(18):e2118927119

Small-world connectivity dictates collective endothelial cell signaling

Lee MD; Buckley C; Zhang X; Louhivuori L; Uhlen P; Wilson C; McCarron JG
Article: FRONTIERS IN MATERIALS. 2021;7:560372

Recombinant Spider Silk Protein Matrices Facilitate Differentiation of Neural Stem Cells Into Mature and Functional Neurons

Lewicka M; Rebellato P; Lewicki J; Uhlen P; Rising A; Hermanson O
Article: EXPERIMENTAL CELL RESEARCH. 2020;395(1):112156

Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes

Phoon YP; Chivukula IV; Tsoi YL; Kanatani S; Uhlen P; Kuiper R; Lendahl U
Article: STEM CELLS AND DEVELOPMENT. 2020;29(17):1160-1177

Neurotransmitters and Endothelins Acting on Radial Glial G-Protein-Coupled Receptors Are, Through Proteolytic NRG/ErbB4 Activation, Able to Modify the Migratory Behavior of Neocortical Cells and Mediate Bipolar-to-Multipolar Transition

Louhivuori LM; Turunen PM; Louhivuori V; Al Rayyes I; Nordstrom T; Uhlen P; Akerman KE
Article: STEM CELL RESEARCH & THERAPY. 2020;11(1):320

Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy

Lin C; Calzarossa C; Fernandez-Zafra T; Liu J; Li X; Ekblad-Nordberg A; Vazquez-Juarez E; Codeluppi S; Holmberg L; Lindskog M; Uhlen P; Akesson E
Article: CELL REPORTS. 2020;31(9):107699

Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain

Osman AM; Sun Y; Burns TC; He L; Kee N; Oliva-Vilarnau N; Alevyzaki A; Zhou K; Louhivuori L; Uhlen P; Hedlund E; Betsholtz C; Lauschke VM; Kele J; Blomgren K
Article: CELL CALCIUM. 2020;88:102210

Mending Fences: Na,K-ATPase signaling via Ca²⁺ in the maintenance of epithelium integrity

Aperia A; Brismar H; Uhlen P
Article: WORLD JOURNAL OF UROLOGY. 2019;37(11):2297-2302

Volumetric imaging: a potential tool to stage upper tract urothelial carcinoma

Grahn A; Tanaka N; Uhlen P; Brehmer M
Article: EXPERIMENTAL CELL RESEARCH. 2019;383(1):111469

Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality

Lam M; Moslem M; Bryois J; Pronk RJ; Uhlin E; Ellstrom ID; Laan L; Olive J; Morse R; Ronnholm H; Louhivuori L; Korol SV; Dahl N; Uhlen P; Anderlid B-M; Kele M; Sullivan PF; Falk A
Article: NEUROSCIENCE. 2019;402:78-89

The T-type Ca²⁺ Channel Ca_v3.2 Regulates Differentiation of Neural Progenitor Cells during Cortical Development via Caspase-3

Rebellato P; Kaczynska A; Kanatani S; Al Rayyes I; Zhang S; Villaescusa C; Falk A; Arenas E; Hermanson O; Louhivuori L; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(6):2328-2337

Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy

Bernard-Marissal N; van Hameren G; Juneja M; Pellegrino C; Louhivuori L; Bartesaghi L; Rochat C; El Mansour O; Medard J-J; Croisier M; Maclachlan C; Poirot O; Uhlen P; Timmerman V; Tricaud N; Schneider BL; Chrast R
Article: MOLECULAR ONCOLOGY. 2019;13(2):202-211

BCG-induced cytokine release in bladder cancer cells is regulated by Ca²⁺ signaling

Ibarra C; Karlsson M; Codeluppi S; Varas-Godoy M; Zhang S; Louhivuori L; Mangsbo S; Hosseini A; Soltani N; Kaba R; Lundgren TK; Hosseini A; Tanaka N; Oya M; Wiklund P; Miyakawa A; Uhlen P
Article: JOURNAL OF NEUROSCIENCE METHODS. 2019;311:259-266

Spinal cord injury in zebrafish induced by near-infrared femtosecond laser pulses

Ellstrom ID; Spulber S; Hultin S; Norlin N; Ceccatelli S; Hultling C; Uhlen P
Article: CANCER MEDICINE. 2018;7(12):6193-6204

Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63

Tanaka N; Katayama S; Reddy A; Nishimura K; Niwa N; Hongo H; Ogihara K; Kosaka T; Mizuno R; Kikuchi E; Mikami S; Miyakawa A; Arenas E; Kere J; Oya M; Uhlen P
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2018;97(3):190-203

Glycosylation controls sodium-calcium exchanger 3 sub-cellular localization during cell cycle

Liu T; Zhao J; Ibarra C; Garcia MU; Uhlen P; Nister M
Article: BRITISH JOURNAL OF CANCER. 2018;118(7):995-999

Mapping of the three-dimensional lymphatic microvasculature in bladder tumours using light-sheet microscopy

Tanaka N; Kaczynska D; Kanatani S; Sahlgren C; Mitura P; Stepulak A; Miyakawa A; Wiklund P; Uhlen P
Article: GLIA. 2018;66(1):94-107

Regulation of radial glial process growth by glutamate via mGluR5/TRPC3 and neuregulin/ErbB4

Louhivuori LM; Turunen PM; Louhivuori V; Yellapragada V; Nordstrom T; Uhlen P; Akerman KE
Article: COMMUNICATIONS BIOLOGY. 2018;1:75

A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration

Yang S; Toledo EM; Rosmaninho P; Peng C; Uhlen P; Castro DS; Arenas E
Article: PLOS PATHOGENS. 2017;13(12):e1006739

Voltage-dependent calcium channel signaling mediates GABA_A receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

Kanatani S; Fuks JM; Olafsson EB; Westermark L; Chambers B; Varas-Godoy M; Uhlen P; Barragan A
Article: EXPERIMENTAL CELL RESEARCH. 2017;357(2):236-242

An ex vivo spinal cord injury model to study ependymal cells in adult mouse tissue

Fernandez-Zafra T; Codeluppl S; Uhlen P
Article: BIOINFORMATICS. 2017;33(16):2547-2554

Mapping genes for calcium signaling and their associated human genetic disorders

Hortenhuber M; Toledo EM; Smedler E; Arenas E; Malmersjo S; Louhivuori L; Uhlen P
Article: STEM CELLS AND DEVELOPMENT. 2017;26(12):876-887

Expression of Pluripotency Markers in Nonpluripotent Human Neural Stem and Progenitor Cells

Vincent PH; Benedikz E; Uhlen P; Hovatta O; Sundstrom E
Article: CANCER RESEARCH. 2017;77(7):1741-1752

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Niklasson M; Maddalo G; Sramkova Z; Mutlu E; Wee S; Sekyrova P; Schmidt L; Fritz N; Dehnisch I; Kyriatzis G; Krafcikova M; Carson BB; Feenstra JM; Marinescu VD; Segerman A; Haraldsson M; Gustavsson A-L; Hammarstrom LGJ; Jensen AJ; Uhrbom L; Altelaar AFM; Linnarsson S; Uhlen P; Trantirek L; Vincent CT; Nelander S; Enger PO; Andang M
Article: JCI INSIGHT. 2016;1(18):e83654

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation

Tanaka N; Kosaka T; Miyazaki Y; Mikami S; Niwa N; Otsuka Y; Minamishima YA; Mizuno R; Kikuchi E; Miyajima A; Sabe H; Okada Y; Uhlen P; Suematsu M; Oya M
Article: ELIFE. 2016;5:e14170

CO₂-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

Forsberg D; Horn Z; Tserga E; Smedler E; Silberberg G; Shvarev Y; Kaila K; Uhlen P; Herlenius E
Article: STEM CELL REPORTS. 2016;6(4):607-617

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells

Mansson-Broberg A; Rodin S; Bulatovic I; Ibarra C; Lofling M; Genead R; Wardell E; Felldin U; Granath C; Alici E; Le Blanc K; Smith CIE; Salasova A; Westgren M; Sundstrom E; Uhlen P; Arenas E; Sylven C; Tryggvason K; Corbascio M; Simonson OE; Osterholm C; Grinnemo K-H
Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlen P; Kogner P; Schlisio S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(36):E4985-E4994

The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain

Kanatani S; Honda T; Aramaki M; Hayashi K; Kubo K-I; Ishida M; Tanaka DH; Kawauchi T; Sekine K; Kusuzawa S; Kawasaki T; Hirata T; Tabata H; Uhlen P; Nakajima K
Article: DEVELOPMENTAL NEUROBIOLOGY. 2015;75(4):360-368

Calcium Signaling in Neocortical Development

Uhlen P; Fritz N; Smedler E; Malmersjoe S; Kanatani S
Article: PLOS ONE. 2015;10(9):e0139104

Infection by Toxoplasma gondii Induces Amoeboid-Like Migration of Dendritic Cells in a Three-Dimensional Collagen Matrix

Kanatani S; Uhlen P; Barragan A
Article: PLOS ONE. 2015;10(3):e0120176

Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells

Bulatovic I; Ibarra C; Osterholm C; Wang H; Beltran-Rodriguez A; Varas-Godoy M; Mansson-Broberg A; Uhlen P; Simon A; Grinnemo K-H
Article: NATURE PROTOCOLS. 2014;9(9):2164-2179

Tracheal tissue engineering in rats

Jungebluth P; Haag JC; Sjoqvist S; Gustafsson Y; Rodriguez AB; Del Gaudio C; Bianco A; Dehnisch I; Uhlen P; Baiguera S; Lemon G; Lim ML; Macchiarini P
Article: FASEB JOURNAL. 2014;28(8):3456-3467

Cathelicidin LL-37 induces time-resolved release of LTB₄ and TXA₂ by human macrophages and triggers eicosanoid generation in vivo

Wan M; Soehnlein O; Tang X; van der Does AM; Smedler E; Uhlen P; Lindbom L; Agerberth B; Haeggstrom JZ
Article: NATURE COMMUNICATIONS. 2014;5:4557

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion

Mojallal M; Zheng Y; Hultin S; Audebert S; van Harn T; Johnsson P; Lenander C; Fritz N; Mieth C; Corcoran M; Lembo F; Hallstroem M; Hartman J; Mazure NM; Weide T; Grander D; Borg J-P; Uhlen P; Holmgren L
Article: NATURE COMMUNICATIONS. 2014;5:3743

AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion

Hultin S; Zheng Y; Mojallal M; Vertuani S; Gentili C; Balland M; Milloud R; Belting H-G; Affolter M; Helker CSM; Adams RH; Herzog W; Uhlen P; Majumdar A; Holmgren L
Article: EMBO REPORTS. 2014;15(4):383-391

MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division

Zinin N; Adameyko I; Wilhelm M; Fritz N; Uhlen P; Ernfors P; Henriksson MA
Article: PLOS ONE. 2014;9(3):e92649

Interleukin-6 Secretion by Astrocytes Is Dynamically Regulated by PI3K-mTOR-Calcium Signaling

Codeluppi S; Fernandez-Zafra T; Sandor K; Kjell J; Liu Q; Abrams M; Olson L; Gray NS; Svensson CI; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062

Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1

Brautigam L; Jensen LDE; Poschmann G; Nystrom S; Bannenberg S; Dreij K; Lepka K; Prozorovski T; Montano SJ; Aktas O; Uhlen P; Stuehler K; Cao Y; Holmgren A; Berndt C
Journal article: JOURNAL OF CELL SCIENCE. 2013;126(22):e1

Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons

Yang S; Edman LC; Sánchez-Alcañiz JA; Fritz N; Bonilla S; Hecht J; Uhlén P; Pleasure SJ; Carlos Villaescusa J; Marín O; Arenas E
Article: DEVELOPMENT. 2013;140(22):4554-4564

Cxcl12/Cxcr4 signaling controls the migration and process orientation of A9-A10 dopaminergic neurons

Yang S; Edman LC; Antonio Sanchez-Alcaniz J; Fritz N; Bonilla S; Hecht J; Uhlen P; Pleasure SJ; Villaescusa JC; Marin O; Arenas E
Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2013;6(4):e24788

Small-world networks of spontaneous Ca(2+) activity.

Malmersjö S; Rebellato P; Smedler E; Uhlén P
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;269(1):51-60

Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPARγ in vitro and in vivo

Ibrahim WNW; Tofighi R; Onishchenko N; Rebellato P; Bose R; Uhlen P; Ceccatelli S
Article: BMC NEPHROLOGY. 2013;14:34

Intracellular calcium release modulates polycystin-2 trafficking

Miyakawa A; Ibarra C; Malmersjo S; Aperia A; Wiklund P; Uhlen P
Article: CIRCULATION RESEARCH. 2013;112(2):236-245

Local Control of Nuclear Calcium Signaling in Cardiac Myocytes by Perinuclear Microdomains of Sarcolemmal Insulin-Like Growth Factor 1 Receptors

Ibarra C; Vicencio JM; Estrada M; Lin Y; Rocco P; Rebellato P; Munoz JP; Garcia-Prieto J; Quest AFG; Chiong M; Davidson SM; Bulatovic I; Grinnemo K-H; Larsson O; Szabadkai G; Uhlen P; Jaimovich E; Lavandero S
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: BRITISH JOURNAL OF CANCER. 2012;106(11):1807-1815

Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase

Hiyoshi H; Abdelhady S; Segerstrom L; Sveinbjornsson B; Nuriya M; Lundgren TK; Desfrere L; Miyakawa A; Yasui M; Kogner P; Johnsen JI; Andang M; Uhlen P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(14):5511-5516

Origin of excitation underlying locomotion in the spinal circuit of zebrafish

Eklof-Ljunggren E; Haupt S; Ausborn J; Dehnisch I; Uhlen P; Higashijima S-I; El Manira A
Article: BMC PHYSIOLOGY. 2012;12:3

Small molecule screening platform for assessment of cardiovascular toxicity on adult zebrafish heart.

Kitambi SS; Nilsson ES; Sekyrova P; Ibarra C; Tekeoh GN; Andäng M; Ernfors P; Uhlén P
Article: PLOS ONE. 2012;7(2):e31258

RET PLCγ Phosphotyrosine Binding Domain Regulates Ca²⁺ Signaling and Neocortical Neuronal Migration

Lundgren TK; Nakahata K; Fritz N; Rebellato P; Zhang S; Uhlen P
Article: TOXICOLOGICAL SCIENCES. 2011;124(1):192-201

Non-Dioxin-like Polychlorinated Biphenyls Interfere with Neuronal Differentiation of Embryonic Neural Stem Cells

Tofighi R; Ibrahim WNW; Rebellato P; Andersson PL; Uhlen P; Ceccatelli S
Article: NEUROCHEMICAL RESEARCH. 2011;36(7):1175-1185

Inositol 1,4,5-Trisphosphate Receptor Subtype-Specific Regulation of Calcium Oscillations

Zhang S; Fritz N; Ibarra C; Uhlen P
Article: EMBO JOURNAL. 2011;30(14):2762-2778

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

Zhao J; Liu T; Jin S; Wang X; Qu M; Uhlen P; Tomilin N; Shupliakov O; Lendahl U; Nister M
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2011;47(1):10-18

Noggin and Wnt3a enable BMP4-dependent differentiation of telencephalic stem cells into GluR-agonist responsive neurons

Andersson T; Duckworth JK; Fritz N; Lewicka M; Sodersten E; Uhlen P; Hermanson O
Article: PLOS ONE. 2011;6(9):e23875

PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms

Ferreira PE; Holmgren G; Veiga MI; Uhlen P; Kaneko A; Gil JP
Article: EMBO JOURNAL. 2010;29(22):3869-3878

Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis

Norberg E; Karlsson M; Korenovska O; Szydlowski S; Silberberg G; Uhlen P; Orrenius S; Zhivotovsky B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(37):16336-16341

En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons

Usoskin D; Zilberter M; Linnarsson S; Hjerling-Leffler J; Uhlen P; Harkany T; Ernfors P
Article: STEM CELLS AND DEVELOPMENT. 2010;19(9):1355-1364

Ca²⁺ and cAMP Signaling in Human Embryonic Stem Cell-Derived Dopamine Neurons

Malmersjo S; Liste I; Dyachok O; Tengholm A; Arenas E; Uhlen P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):28-32

Biochemistry of calcium oscillations

Uhlen P; Fritz N
Article: JOURNAL OF ENDOCRINOLOGY. 2009;202(2):299-307

Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway

Altamirano F; Oyarce C; Silva P; Toyos M; Wilson C; Lavandero S; Uhlen P; Estrada M
Article: CIRCULATION RESEARCH. 2009;105(3):260-270

Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis

Zheng Y; Vertuani S; Nystrom S; Audebert S; Meijer I; Tegnebratt T; Borg J-P; Uhlen P; Majumdar A; Holmgren L
Article: CELL DEATH AND DIFFERENTIATION. 2008;15(12):1857-1864

An increase in intracellular Ca²⁺ is required for the activation of mitochondrial calpain to release AIF during cell death

Norberg E; Gogvadze V; Ott M; Uhlen P; Orrenius S; Zhivotovsky B
Article: STEM CELLS. 2008;26(7):1891-1900

α-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres

Edman LC; Mira H; Erices A; Malmersjo S; Andersson E; Uhlen P; Arenas E
Article: MATHEMATICAL BIOSCIENCES. 2006;204(2):232-249

Modeling the impact of store-operated Ca²⁺ entry on intracellular Ca²⁺ oscillations

Kowalewski JM; Uhlen P; Kitano H; Brismar H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21954-21962

Distinct role of the N-terminal tail of the Na,K-ATPase catalytic subunit as a signal transducer

Zhang S; Malmersjo S; Li J; Ando H; Aizman O; Uhlen P; Mikoshiba K; Aperia A
Journal article: JOURNAL OF CELL SCIENCE. 2006;119(4):733-743

Ca²⁺ oscillations induced by testosterone enhance neurite outgrowth

Estrada M; Uhlen P; Ehrlich BE
Article: CELLULAR MICROBIOLOGY. 2005;7(6):779-788

Effects of the Escherichia coli toxin cytolysin A on mucosal immunostimulation via epithelial Ca²⁺ signalling and Toll-like receptor 4

Söderblom T; Oxhamre C; Wai SN; Uhlén P; Aperia A; Uhlin BE; Richter-Dahlfors A
Journal article: JOURNAL OF NEUROSCIENCE. 2005;25(11):2853-2864

Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons

Jacob SN; Choe CU; Uhlen P; DeGray B; Yeckel MF; Ehrlich BE
Journal article: JOURNAL OF ENDOCRINOLOGY. 2005;184(2):371-379

Capacitative calcium entry in testosterone-induced intracellular calcium oscillations in myotubes

Estrada M; Espinosa A; Gibson CJ; Uhlen P; Jaimovich E
Journal article: SCIENCES STKE [ELECTRONIC RESOURCE] : SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT. 2004;2004(258):pl15

Spectral analysis of calcium oscillations.

Uhlén P
Journal article: BIOCHEMICAL JOURNAL. 2004;382(Pt 2):687-694

InsP₃-mediated intracellular calcium signalling is altered by expression of synaptojanin-1

Johenning FW; Wenk MR; Uhlén P; DeGray B; Lee E; Camilli PD; Ehrlich BE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(50):50355-50361

Cell signaling Microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations

Miyakawa-Naito A; Uhlén P; Lal M; Aizman O; Mikoshiba K; Brismar H; Zelenin S; Aperia A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(23):13420-13424

Ouabain, a steroid hormone that signals with slow calcium oscillations

Aizman O; Uhlén P; Lal M; Brismar H; Aperia A
Article: NATURE NEUROSCIENCE. 2000;3(3):226-230

Anatomical and physiological evidence for D₁ and D₂ dopamine receptor colocalization in neostriatal neurons

Aizman O; Brismar H; Uhlén P; Zettergren E; Levey AI; Forssberg H; Greengard P; Aperia A
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Preprint: BIORXIV. 2023

Defined human PSC culture conditions robustly maintain human PSC pluripotency through Ca²⁺signaling

Eidhof I; Kele M; Shasavani M; Ulfenborg B; Winn D; Uhlén P; Falk A
Preprint: BIORXIV. 2022

Anatomy of the complete mouse eye vasculature in development and pathology explored by light-sheet fluorescence microscopy

Krimpenfort L; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; André H; Uhlén P; Jakobsson L
Preprint: BIORXIV. 2021

Arg1⁺ microglia are critical for shaping cognition in female mice

Stratoulias V; Ruiz R; Kanatani S; Osman A; Armengol J; Rodríguez-Moreno A; Murgoci A-N; García-Domínguez I; Keane L; Vázquez-Cabrera G; Alonso-Bellido I; Vernoux N; Tejera D; Grabert K; Cheray M; González-Rodríguez P; Pérez-Villegas E; Martinez-Gallego I; Brodin D; Avila-Cariño J; Airavaara M; Uhlén P; Heneka M; Tremblay M-È; Blomgren K; Venero J; Joseph B
Corrigendum: STEM CELL RESEARCH & THERAPY. 2020;11(1):369

Human ex vivo spinal cord slice culture as a useful model of neural development, lesion, and allogeneic neural cell therapy (vol 11, 320, 2020)

Lin C; Calzarossa C; Fernandez-Zafra T; Liu J; Li X; Ekblad-Nordberg A; Vazquez-Juarez E; Codeluppi S; Holmberg L; Lindskog M; Uhlen P; Akesson E
Editorial comment: NATURE BIOMEDICAL ENGINEERING. 2018;2(10):717-718

Predicting a tumour's drug uptake

Louhivuori L; Kanatani S; Uhlen P
Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity (vol 1, pg 796, 2017)

Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2014;75:40-48

An integrated mechanism of cardiomyocyte nuclear Ca²⁺ signaling

Ibarra C; Vicencio JM; Varas-Godoy M; Jaimovich E; Rothermel BA; Uhlen P; Hill JA; Lavandero S
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(3):964-969

Frequency decoding of calcium oscillations

Smedler E; Uhlen P
Letter: BRITISH JOURNAL OF CANCER. 2013;108(10):2191

Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer

Hiyoshi H; Johnsen JI; Andang M; Uhlen P
Conference publication: ANGIOGENESIS. 2013;16(1):246-247

The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2

Gaengel K; Niaudet C; Hagikura K; Siemsen LB; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2 (vol 23, pg 587, 2012)

Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Review: CELL CALCIUM. 2011;49(5):350-356

Calcium signaling in placenta

Baczyk D; Kingdom JCP; Uhlen P
Conference publication: FASEB JOURNAL. 2006;20(5):A1238

Binding between a highly conserved Na,K-ATPase domain and the InsP3R protects from serum-deprivation triggered apoptosis

Malmersjö S; Zhang SB; Uhlen P; Mikoshiba K; Aperia A
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;986:514-518

Visualization of Na,K-ATPase interacting proteins using FRET technique

Uhlén P
Published conference paper: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. 2002;477(1-3):82-87

A TOF-PET system for educational purposes

Bäck T; Cederkäll J; Cederwall B; Johnson A; Kerek A; Klamra W; van der Marel J; Molnár J; Novák D; Sohler D; Steén M; Uhlén P
Published conference paper: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT. 2001;471(1-2):200-204

An educational tool for demonstrating the TOF-PET technique

Bäck T; Cederkäll J; Cederwall B; Johnson A; Kerek A; Klamra W; van der Marel J; Molnár J; Novák D; Sohler D; Steèn M; Uhlèn P

Anställningar

Professor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2014-

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Docent, Cellbiologi, Karolinska Institutet, 2008
MEDICINE DOKTORSEXAMEN, Institutionen för kvinnors och barns hälsa, Karolinska Institutet, 2002

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