Könscellsbiologi och utvecklingsprogrammering i epigenetisk nedärvning av sjukdom – Qiaolin Dengs forskargrupp

Publikationer

Alla gruppmedlemmars publikationer

• Review: HUMAN REPRODUCTION UPDATE. 2024;30(4):410-441

  Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies

  Derisoud E; Jiang H; Zhao A; Chavatte-Palmer P; Deng Q
• Article: CELL REPORTS MEDICINE. 2024;5(5):101515

  The gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection

  Shen S; Wang M; Li X; Wang B; Hong W; Li W; Xu B; Guo Z; Han R; Yi S; Wu Z; He X; Wang L; Zhu Q; Yang G; Wang H; Deng Q; Chen J; Gao S; Jiang C; Gao R
• Article: DEVELOPMENTAL CELL. 2024;59(10):1269-1283.e6

  Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium

  Grommisch D; Wang M; Eenjes E; Svetlicic M; Deng Q; Giselsson P
• Article: EMBO REPORTS. 2024;25(4):1752-1772

  Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia

  Zhao A; Jiang H; Palomares AR; Larsson A; He W; Grunler J; Zheng X; Wallberg KAR; Catrina S-B; Deng Q
• Article: BMC BIOLOGY. 2023;21(1):277

  Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1

  Birgersson M; Indukuri R; Lindquist L; Stepanauskaite L; Luo Q; Deng Q; Archer A; Williams C
• Article: CELL REPORTS MEDICINE. 2023;4(5):101035

  Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome

  Risal S; Li C; Luo Q; Fornes R; Lu H; Eriksson G; Manti M; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; Recabarren S; Petermann TS; Benrick A; Brusselaers N; Qiao J; Deng Q; Stener-Victorin E
• Article: CELL DISCOVERY. 2023;9(1):14

  Resetting histone modifications during human prenatal germline development

  Gao R; Zeng S; Yang D; Li X; Liu W; Gao Y; Bai D; Zhang L; Chen C; Kang Y; Wang B; Hong W; Wang M; Yin J; Wang H; Deng Q; Gao S; Zhang Y; Chen J
• Article: CELL REPORTS. 2023;42(1):112021

  Epiblast-like stem cells established by Wnt/(3-catenin signaling manifest distinct features of formative pluripotency and germline competence

  Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
• Article: COMMUNICATIONS BIOLOGY. 2023;6(1):69

  Transcriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome

  Pei Y; Risal S; Jiang H; Lu H; Lindgren E; Stener-Victorin E; Deng Q
• Article: DIABETOLOGIA. 2022;65(9):1483-1494

  A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome

  Liu Q; Tang B; Zhu Z; Kraft P; Deng Q; Stener-Victorin E; Jiang X
• Article: NATURE COMMUNICATIONS. 2022;13(1):4142

  ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes

  Ma Q; Xiao Y; Xu W; Wang M; Li S; Yang Z; Xu M; Zhang T; Zhang Z-N; Hu R; Su Q; Yuan F; Xiao T; Wang X; He Q; Zhao J; Chen Z-J; Sheng Z; Chai M; Wang H; Shi W; Deng Q; Cheng X; Li W
• Article: NATURE COMMUNICATIONS. 2022;13(1):1854

  Elastic dosage compensation by X-chromosome upregulation

  Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
• Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):705-716

  Single-Cell Analysis Reveals Major Histocompatibility Complex II-Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes

  Li D; Cheng S; Pei Y; Sommar P; Karner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Landen NX
• Article: BMC MEDICINE. 2022;20(1):66

  Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis

  Liu Q; Zhu Z; Kraft P; Deng Q; Stener-Victorin E; Jiang X
• Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:235-249

  Differentiation of Human-Induced Pluripotent Stem Cells (hiPSCs) into Human Primordial Germ Cell-like Cells (hPGCLCs) In Vitro.

  Reda A; Stukenborg J-B; Deng Q
• Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:213-233

  In Vitro Differentiation of Murine Embryonic Stem Cells (ESCs) into Primordial Germ Cell-like Cells (PGCLCs).

  Pui H-P; Deng Q
• Article: NATURE COMMUNICATIONS. 2021;12(1):5309

  Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Review: NATURE REVIEWS ENDOCRINOLOGY. 2021;17(9):521-533

  Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment

  Stener-Victorin E; Deng Q
• Editorial comment: TRENDS IN MOLECULAR MEDICINE. 2021;27(8):723-724

  Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance

  Stener-Victorin E; Deng Q
• Article: HUMAN REPRODUCTION. 2021;36(8):2382-2391

  Is there a shared genetic basis and causal relationship between polycystic ovary syndrome and psychiatric disorders: evidence from a comprehensive genetic analysis

  Jiang X; Deng Q; Stener-Victorin E
• Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):45

  Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders

  Risal S; Manti M; Lu H; Fornes R; Larsson H; Benrick A; Deng Q; Cesta CE; Rosenqvist MA; Stener-Victorin E
• Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021;14:699562

  Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease

  Aguila J; Cheng S; Kee N; Cao M; Wang M; Deng Q; Hedlund E
• Article: THE FASEB JOURNAL. 2020;34(11):14440-14457

  Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice

  Manti M; Pui H-P; Edstrom S; Risal S; Lu H; Lindgren E; Ohlsson C; Jerlhag E; Benrick A; Deng Q; Stener-Victorin E
• Article: GENOME RESEARCH. 2020;30(8):1083-1096

  LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy

  Nichterwitz S; Nijssen J; Storvall H; Schweingruber C; Comley LH; Allodi I; van der Lee M; Deng Q; Sandberg R; Hedlund E
• Article: NATURE MEDICINE. 2019;25(12):1894-1904

  Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome

  Risal S; Pei Y; Lu H; Manti M; Fornes R; Pui H-P; Zhao Z; Massart J; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; de Guevara AL; Sir-Petermann T; Larsson H; Rosenqvist MA; Cesta CE; Benrick A; Deng Q; Stener-Victorin E
• Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39(7):1402-1418

  Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization

  Ali Z; Mukwaya A; Biesemeier A; Ntzouni M; Ramskold D; Giatrellis S; Mammadzada P; Cao R; Lennikov A; Marass M; Gerri C; Hildesjo C; Taylor M; Deng Q; Peebo B; del Peso L; Kvanta A; Sandberg R; Schraermeyer U; Andre H; Steffensen JF; Lagali N; Cao Y; Kele J; Dahl Jensen L
• Article: CELL REPORTS. 2019;26(10):2593-2607.e3

  Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development

  Cheng S; Pei Y; He L; Peng G; Reinius B; Tam PPL; Jing N; Deng Q
• Article: EBIOMEDICINE. 2018;30:283-294

  GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes

  Bhandage AK; Jin Z; Korol SV; Shen Q; Pei Y; Deng Q; Espes D; Carlsson P-O; Kamali-Moghaddam M; Birnir B
• Review: MOLECULAR ASPECTS OF MEDICINE. 2018;59:36-46

  Single-cell RNA sequencing: Technical advancements and biological applications

  Hedlund E; Deng Q
• Article: METHODS IN MOLECULAR BIOLOGY. 2018;1649:95-110

  LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing.

  Nichterwitz S; Benitez JA; Hoogstraaten R; Deng Q; Hedlund E
• Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2017;90:155-160

  Revealing allele-specific gene expression by single-cell transcriptomics

  Benitez JA; Cheng S; Deng Q
• Article: NATURE GENETICS. 2016;48(11):1430-1435

  Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq

  Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
• Article: GENOME RESEARCH. 2016;26(10):1342-1354

  Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation

  Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
• Corrigendum: CELL. 2016;167(1):285

  Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos (vol 165, pg 1012, 2016)

  Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4387-E4396

  Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

  Doucet-Beaupre H; Gilbert C; Profes MS; Chabrat A; Pacelli C; Giguere N; Rioux V; Charest J; Deng Q; Laguna A; Ericson J; Perlmann T; Ang S-L; Cicchetti F; Parent M; Trudeau L-E; Levesque M
• Article: NATURE COMMUNICATIONS. 2016;7:12139

  Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling

  Nichterwitz S; Chen G; Benitez JA; Yilmaz M; Storvall H; Cao M; Sandberg R; Deng Q; Hedlund E
• Article: SCIENTIFIC REPORTS. 2016;6:26448

  Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors

  Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
• Article: STEM CELL REPORTS. 2016;6(5):643-651

  Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

  Braune E-B; Tsoi YL; Phoon YP; Landor S; Cascales HS; Ramskold D; Deng Q; Lindqvist A; Lian X; Sahlgren C; Jin S-B; Lendahl U
• Article: CELL. 2016;165(4):1012-1026

  Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

  Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
• Article: NATURE BIOTECHNOLOGY. 2016;34(2):199-203

  Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

  Cadwell CR; Palasantza A; Jiang X; Berens P; Deng Q; Yilmaz M; Reimer J; Shen S; Bethge M; Tolias KF; Sandberg R; Tolias AS
• Article: NATURE NEUROSCIENCE. 2015;18(6):826-835

  Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

  Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
• Corrigendum: CANCER CELL. 2015;27(4):603-605

  Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)

  Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
• Article: CANCER CELL. 2014;25(6):794-808

  Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

  Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
• Article: SCIENCE. 2014;343(6167):193-196

  Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells

  Deng Q; Ramskold D; Reinius B; Sandberg R
• Article: CELL STEM CELL. 2013;13(5):535-548

  Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells

  Boiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
• Article: NATURE BIOTECHNOLOGY. 2012;30(8):777-782

  Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

  Ramskold D; Luo S; Wang Y-C; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R
• Article: DEVELOPMENT. 2011;138(16):3399-3408

  Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

  Deng Q; Andersson E; Hedlund E; Alekseenko Z; Coppola E; Panman L; Millonig JH; Brunet J-F; Ericson J; Perlmann T
• Article: CELL STEM CELL. 2011;8(6):663-675

  Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells

  Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T
• Thesis / dissertation: 2010

  The role of Lmx1a and Lmx1b in regulating mesencephalon development and dopamine neuron specification

  Deng, Qiaolin
• Article: CELL. 2006;124(2):393-405

  Identification of intrinsic determinants of midbrain dopamine neurons

  Andersson E; Tryggvason U; Deng QL; Friling S; Alekseenko Z; Robert B; Perlmann T; Ericson J
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Medarbetare och kontakt

Gruppledare

• 

  Qiaolin Deng

  Senior Forskare | Docent

  Telefon +46852483933

  E-postadress qiaolin.deng@ki.se

Alla medarbetare i gruppen

• 

  Andrea Del Valle

  Postdoktor

  E-postadress andrea.del.valle@ki.se
• 

  Qiaolin Deng

  Senior Forskare | Docent

  Telefon +46852483933

  E-postadress qiaolin.deng@ki.se
• 

  Emilie Derisoud

  E-postadress emilie.derisoud@ki.se
• 

  Wenteng He

  Postdoktor

  E-postadress wenteng.he@ki.se
• 

  Paulo Jannig

  Forskningsspecialist

  E-postadress paulo.jannig@ki.se
• 

  Hong Jiang

  E-postadress hong.jiang@ki.se
• 

  Qing Luo

  Anknuten till Forskning

  E-postadress qing.luo@ki.se
• 

  Allan Zhao

  Doktorand

  E-postadress allan.zhao@ki.se

Besöksadress

Karolinska Institutet, Physiology and Pharmacology, Biomedicum B5, Solnaväg 9, Stockholm, Stockholm, 17177, Sweden

Postadress

Karolinska Institutet, Physiology and Pharmacology, Biomedicum B5, Solnaväg 9, Stockholm, Stockholm, 17177, Sweden