Qiaolin Deng

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE MEDICINE. 2025;31(6):1925-1938
Single-cell profiling of the human endometrium in polycystic ovary syndrome
Eriksson G; Li C; Sparovec TG; Dekanski A; Torstensson S; Risal S; Ohlsson C; Hirschberg AL; Petropoulos S; Deng Q; Stener-Victorin E
Journal article: CELL REPORTS MEDICINE. 2025;6(5):102089
CD47-blocking antibody confers metabolic benefits against obesity
Su Y; Sun J; Li X; Huang F; Kong Y; Chen Z; Zhang J; Qin D; Chen X; Wang Z; Pei Y; Gong M; Yang K; Xu M; Dong Y; He Q; Zhang Z-N; Sheng Z; Deng Q; Wang H; Wang G; Hu P; Le R; Gao S; Li W
Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;135(10):e180900
Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes
Collado A; Humoud R; Kontidou E; Eldh M; Swaich J; Zhao A; Yang J; Jiao T; Domingo E; Carlestal E; Mahdi A; Tengbom J; Vegvari A; Deng Q; Alvarsson M; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
Article: ADVANCED SCIENCE. 2025;12(15):e2410533
X-Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome
He W; Luo Q; Zhao J; Wang M; Zhao A; Feng L; Reda A; Lindgren E; Stukenborg J-B; Chen J; Deng Q
Journal article: PLACENTA. 2025;160:147
Gene regulation and intercellular communication at single cell level in placentas from women with polycystic ovary syndrome treated with metformin during pregnancy
Jiang H; Derisoud E; Parreira D; Jannig PR; Vanky E; Stener-Victorin E; Deng Q
Article: NATURE COMMUNICATIONS. 2024;15(1):8894
TGF-β-mediated crosstalk between TIGIT⁺ Tregs and CD226⁺CD8⁺ T cells in the progression and remission of type 1 diabetes
Zhong T; Li X; Lei K; Tang R; Deng Q; Love PE; Zhou Z; Zhao B; Li X
Article: ADVANCED SCIENCE. 2024;11(36):e2309429
Dissecting the Impact of Maternal Androgen Exposure on Developmental Programming through Targeting the Androgen Receptor
Lu H; Jiang H; Li C; Derisoud E; Zhao A; Eriksson G; Lindgren E; Pui H-P; Risal S; Pei Y; Maxian T; Ohlsson C; Benrick A; Haider S; Stener-Victorin E; Deng Q
Article: CELL REPORTS MEDICINE. 2024;5(5):101515
The gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection
Shen S; Wang M; Li X; Wang B; Hong W; Li W; Xu B; Guo Z; Han R; Yi S; Wu Z; He X; Wang L; Zhu Q; Yang G; Wang H; Deng Q; Chen J; Gao S; Jiang C; Gao R
Article: DEVELOPMENTAL CELL. 2024;59(10):1269-1283.e6
Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium
Grommisch D; Wang M; Eenjes E; Svetlicic M; Deng Q; Giselsson P
Article: EMBO REPORTS. 2024;25(4):1752-1772
Appropriate glycemic management protects the germline but not the uterine environment in hyperglycemia
Zhao A; Jiang H; Palomares AR; Larsson A; He W; Grunler J; Zheng X; Wallberg KAR; Catrina S-B; Deng Q
Article: BMC BIOLOGY. 2023;21(1):277
Ovarian ERβ cistrome and transcriptome reveal chromatin interaction with LRH-1
Birgersson M; Indukuri R; Lindquist L; Stepanauskaite L; Luo Q; Deng Q; Archer A; Williams C
Article: CELL REPORTS MEDICINE. 2023;4(5):101035
Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome
Risal S; Li C; Luo Q; Fornes R; Lu H; Eriksson G; Manti M; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; Recabarren S; Petermann TS; Benrick A; Brusselaers N; Qiao J; Deng Q; Stener-Victorin E
Article: CELL DISCOVERY. 2023;9(1):14
Resetting histone modifications during human prenatal germline development
Gao R; Zeng S; Yang D; Li X; Liu W; Gao Y; Bai D; Zhang L; Chen C; Kang Y; Wang B; Hong W; Wang M; Yin J; Wang H; Deng Q; Gao S; Zhang Y; Chen J
Article: CELL REPORTS. 2023;42(1):112021
Epiblast-like stem cells established by Wnt/(3-catenin signaling manifest distinct features of formative pluripotency and germline competence
Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):69
Transcriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome
Pei Y; Risal S; Jiang H; Lu H; Lindgren E; Stener-Victorin E; Deng Q
Article: DIABETOLOGIA. 2022;65(9):1483-1494
A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome
Liu Q; Tang B; Zhu Z; Kraft P; Deng Q; Stener-Victorin E; Jiang X
Article: NATURE COMMUNICATIONS. 2022;13(1):4142
ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes
Ma Q; Xiao Y; Xu W; Wang M; Li S; Yang Z; Xu M; Zhang T; Zhang Z-N; Hu R; Su Q; Yuan F; Xiao T; Wang X; He Q; Zhao J; Chen Z-J; Sheng Z; Chai M; Wang H; Shi W; Deng Q; Cheng X; Li W
Article: NATURE COMMUNICATIONS. 2022;13(1):1854
Elastic dosage compensation by X-chromosome upregulation
Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):705-716
Single-Cell Analysis Reveals Major Histocompatibility Complex II-Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes
Li D; Cheng S; Pei Y; Sommar P; Karner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Landen NX
Article: BMC MEDICINE. 2022;20(1):66
Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis
Liu Q; Zhu Z; Kraft P; Deng Q; Stener-Victorin E; Jiang X
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:235-249
Differentiation of Human-Induced Pluripotent Stem Cells (hiPSCs) into Human Primordial Germ Cell-like Cells (hPGCLCs) In Vitro.
Reda A; Stukenborg J-B; Deng Q
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:213-233
In Vitro Differentiation of Murine Embryonic Stem Cells (ESCs) into Primordial Germ Cell-like Cells (PGCLCs).
Pui H-P; Deng Q
Article: NATURE COMMUNICATIONS. 2021;12(1):5309
Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors
Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
Article: HUMAN REPRODUCTION. 2021;36(8):2382-2391
Is there a shared genetic basis and causal relationship between polycystic ovary syndrome and psychiatric disorders: evidence from a comprehensive genetic analysis
Jiang X; Deng Q; Stener-Victorin E
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021;14:699562
Spatial RNA Sequencing Identifies Robust Markers of Vulnerable and Resistant Human Midbrain Dopamine Neurons and Their Expression in Parkinson's Disease
Aguila J; Cheng S; Kee N; Cao M; Wang M; Deng Q; Hedlund E
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):45
Prenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders
Risal S; Manti M; Lu H; Fornes R; Larsson H; Benrick A; Deng Q; Cesta CE; Rosenqvist MA; Stener-Victorin E
Article: FASEB JOURNAL. 2020;34(11):14440-14457
Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice
Manti M; Pui H-P; Edstrom S; Risal S; Lu H; Lindgren E; Ohlsson C; Jerlhag E; Benrick A; Deng Q; Stener-Victorin E
Article: GENOME RESEARCH. 2020;30(8):1083-1096
LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy
Nichterwitz S; Nijssen J; Storvall H; Schweingruber C; Comley LH; Allodi I; van der Lee M; Deng Q; Sandberg R; Hedlund E
Article: NATURE MEDICINE. 2019;25(12):1894-1904
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
Risal S; Pei Y; Lu H; Manti M; Fornes R; Pui H-P; Zhao Z; Massart J; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; de Guevara AL; Sir-Petermann T; Larsson H; Rosenqvist MA; Cesta CE; Benrick A; Deng Q; Stener-Victorin E
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39(7):1402-1418
Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization
Ali Z; Mukwaya A; Biesemeier A; Ntzouni M; Ramskold D; Giatrellis S; Mammadzada P; Cao R; Lennikov A; Marass M; Gerri C; Hildesjo C; Taylor M; Deng Q; Peebo B; del Peso L; Kvanta A; Sandberg R; Schraermeyer U; Andre H; Steffensen JF; Lagali N; Cao Y; Kele J; Dahl Jensen L
Article: CELL REPORTS. 2019;26(10):2593-2607.e3
Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development
Cheng S; Pei Y; He L; Peng G; Reinius B; Tam PPL; Jing N; Deng Q
Article: EBIOMEDICINE. 2018;30:283-294
GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes
Bhandage AK; Jin Z; Korol SV; Shen Q; Pei Y; Deng Q; Espes D; Carlsson P-O; Kamali-Moghaddam M; Birnir B
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1649:95-110
LCM-Seq: A Method for Spatial Transcriptomic Profiling Using Laser Capture Microdissection Coupled with PolyA-Based RNA Sequencing.
Nichterwitz S; Benitez JA; Hoogstraaten R; Deng Q; Hedlund E
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2017;90:155-160
Revealing allele-specific gene expression by single-cell transcriptomics
Benitez JA; Cheng S; Deng Q
Article: NATURE GENETICS. 2016;48(11):1430-1435
Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq
Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
Article: GENOME RESEARCH. 2016;26(10):1342-1354
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4387-E4396
Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons
Doucet-Beaupre H; Gilbert C; Profes MS; Chabrat A; Pacelli C; Giguere N; Rioux V; Charest J; Deng Q; Laguna A; Ericson J; Perlmann T; Ang S-L; Cicchetti F; Parent M; Trudeau L-E; Levesque M
Article: NATURE COMMUNICATIONS. 2016;7:12139
Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling
Nichterwitz S; Chen G; Benitez JA; Yilmaz M; Storvall H; Cao M; Sandberg R; Deng Q; Hedlund E
Article: SCIENTIFIC REPORTS. 2016;6:26448
Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
Article: STEM CELL REPORTS. 2016;6(5):643-651
Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells
Braune E-B; Tsoi YL; Phoon YP; Landor S; Cascales HS; Ramskold D; Deng Q; Lindqvist A; Lian X; Sahlgren C; Jin S-B; Lendahl U
Article: CELL. 2016;165(4):1012-1026
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Article: NATURE BIOTECHNOLOGY. 2016;34(2):199-203
Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq
Cadwell CR; Palasantza A; Jiang X; Berens P; Deng Q; Yilmaz M; Reimer J; Shen S; Bethge M; Tolias KF; Sandberg R; Tolias AS
Article: NATURE NEUROSCIENCE. 2015;18(6):826-835
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease
Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
Article: CANCER CELL. 2014;25(6):794-808
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
Article: SCIENCE. 2014;343(6167):193-196
Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells
Deng Q; Ramskold D; Reinius B; Sandberg R
Article: CELL STEM CELL. 2013;13(5):535-548
Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells
Boiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
Article: NATURE BIOTECHNOLOGY. 2012;30(8):777-782
Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells
Ramskold D; Luo S; Wang Y-C; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R
Article: DEVELOPMENT. 2011;138(16):3399-3408
Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development
Deng Q; Andersson E; Hedlund E; Alekseenko Z; Coppola E; Panman L; Millonig JH; Brunet J-F; Ericson J; Perlmann T
Article: CELL STEM CELL. 2011;8(6):663-675
Transcription Factor-Induced Lineage Selection of Stem-Cell-Derived Neural Progenitor Cells
Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T
Article: CELL. 2006;124(2):393-405
Identification of intrinsic determinants of midbrain dopamine neurons
Andersson E; Tryggvason U; Deng QL; Friling S; Alekseenko Z; Robert B; Perlmann T; Ericson J
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Alla övriga publikationer

Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2025;36(5):472-481
Epigenetic inheritance of PCOS by developmental programming and germline transmission
Stener-Victorin E; Deng Q
Preprint: BIORXIV. 2025
Decoding human placental cellular and molecular responses to obesity and fetal growth
Jiang H; Derisoud E; Parreira D; Taebnia N; Jannig P; Shafagh RZ; Zhao A; Li C; Ortiz M; Maliqueo MA; Stener-Victorin E; Lauschke V; Deng Q
Review: HUMAN REPRODUCTION UPDATE. 2024;30(4):410-441
Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies
Derisoud E; Jiang H; Zhao A; Chavatte-Palmer P; Deng Q
Review: NATURE REVIEWS ENDOCRINOLOGY. 2021;17(9):521-533
Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment
Stener-Victorin E; Deng Q
Editorial comment: TRENDS IN MOLECULAR MEDICINE. 2021;27(8):723-724
Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance
Stener-Victorin E; Deng Q
Review: MOLECULAR ASPECTS OF MEDICINE. 2018;59:36-46
Single-cell RNA sequencing: Technical advancements and biological applications
Hedlund E; Deng Q
Corrigendum: CELL. 2016;167(1):285
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos (vol 165, pg 1012, 2016)
Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
Corrigendum: CANCER CELL. 2015;27(4):603-605
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo (vol 25, pg 794, 2014)
Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
Doctoral thesis: 2010
The role of Lmx1a and Lmx1b in regulating mesencephalon development and dopamine neuron specification
Deng Q

Forskningsbidrag

A programming perspective of the germline cycle on origin of germ cell tumors and epigenetic inheritance of diseases
Vetenskapsrådet
1 January 2021 - 1 January 2026

Anställningar

Senior Forskare, Fysiologi och farmakologi, Karolinska Institutet, 2021-

Examina och utbildning

Docent, Utvecklingsbiologi, Karolinska Institutet, 2019
Medicine Doktorsexamen, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2010

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Nyheter från KI

Kalenderhändelser från KI