Glaukom – Pete Williams forskargrupp

Publikationer

Utvalda publikationer

• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18

  NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

  Tribble JR; Hagstrom A; Jusseaume K; Lardner E; Wong RC-B; Stalhammar G; Williams PA
• Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18

  Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma A Phase 2 Randomized Clinical Trial

  De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
• Article: REDOX BIOLOGY. 2021;43:101988

  Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

  Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Joe M; Lardner E; Venkataraman AP; Dominguez-Vicent A; Kokkali E; Rho S; Johnnesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627

  Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

  Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
• Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914

  Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

  Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
• Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035

  Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma

  Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
• Article: SCIENCE. 2017;355(6326):756-760

  Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

  Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM

Alla gruppmedlemmars publikationer

• Review: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53

  Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

  Canovai A; Williams PA
• Journal article: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53

  Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism.

  Canovai A; Williams PA
• Review: SURVEY OF OPHTHALMOLOGY. 2025;70(1):38-46

  Choroidal nevi and melanoma doubling times and implications for delays in treatment: A systematic review and meta-analysis.

  Stålhammar G; Hagström A; Ermedahl Conradi M; Williams PA
• Article: MOLECULAR BRAIN. 2024;17(1):84

  Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma

  Rombaut A; Brautaset R; Williams PA; Tribble JR
• Thesis / dissertation: 2024

  Targeting neuronal NAD production through NMNAT2 for neuroprotection

  Jöe M
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2024;65(12):4

  Ganglion Cell Complex Thickness and Visual Function in Chronic Leber Hereditary Optic Neuropathy

  Hedstrom J; Nilsson M; Engvall M; Williams PA; Venkataraman AP
• Corrigendum: NATURE COMMUNICATIONS. 2024;15(1):8143

  Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production.

  Tribble JR; Jöe M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Jóhannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
• Journal article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137

  Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma.

  Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
• Editorial comment: NEURAL REGENERATION RESEARCH. 2024;19(8):1637-1638

  Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

  Williams PA; Casson RJ
• Article: ACTA OPHTHALMOLOGICA. 2024;102(5):e663-e671

  Application frequency - key indicator for the efficiency of severe dry eye disease treatment - evidence for the importance of molecular weight of hyaluronan in lubricating agents

  Medic N; Boldin I; Berisha B; Matijak-Kronschachner B; Aminfar H; Schwantzer G; Mueller-Lierheim WGK; van Setten G-B; Horwath-Winter J
• Article: NATURE MEDICINE. 2024;30(8):2362-2370

  Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

  Petriti B; Rabiolo A; Chau K-Y; Williams PA; Montesano G; Lascaratos G; Garway-Heath DF
• Article: NATURE COMMUNICATIONS. 2024;15(1):6256

  NMNAT2 is a druggable target to drive neuronal NAD production

  Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):79

  Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection

  Rombaut A; Jovancevic D; Wong RC-B; Nicol A; Brautaset R; Finkelstein DI; Nguyen CTO; Tribble JR; Williams PA
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):65

  Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection

  Kim M; Kim JY; Rhim W-K; Cimaglia G; Want A; Morgan JE; Williams PA; Park CG; Han DK; Rho S
• Article: BMC NEUROLOGY. 2024;24(1):111

  Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol

  Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):37

  Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

  Otmani A; Johannesson G; Brautaset R; Tribble JR; Williams PA
• Article: ACTA OPHTHALMOLOGICA. 2024;102(2):135-150

  Guidelines for the management of open-angle glaucoma National Program Area Eye Diseases, National Working Group Glaucoma

  Johannesson G; Stille U; Taube AB; Karlsson M; Kalaboukhova L; Bergstrom A; Peters D; Linden C
• Preprint: MEDRXIV. 2024

  Evaluating the effect of rapamycin treatment in Alzheimer's Disease and aging usingin vivoimaging: the ERAP phase IIa clinical study protocol

  Svensson J; Bolin M; Thor D; Williams P; Brautaset R; Carlsson M; Sörensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Morén AF; Kivipelto M; Plavén-Sigray P
• Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(2):1293

  Benefits and Caveats in the Use of Retinal Pigment Epithelium-Specific Cre Mice.

  Kocherlakota S; Baes M
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137

  Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma

  Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
• Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)

  Neuroprotective effects of GLP‐1 receptor agonists and their potential in retinal diseases

  Mouhammad ZA; von Spreckelsen A; Bermudez MYG; Vohra R; Williams P; Kolko M
• Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)

  Preventing retinal homocysteine dysregulation protects against retinal ganglion cell death

  Tribble JR; Rutigliani C; Canovai A; Williams PA
• Book chapter: REFERENCE MODULE IN NEUROSCIENCE AND BIOBEHAVIORAL PSYCHOLOGY. 2024;p.

  Mitochondria and Primary Open Angle Glaucoma

  Williams PA; Hui F
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(14):10

  DHA Shortage Causes the Early Degeneration of Photoreceptors and RPE in Mice With Peroxisomal β-Oxidation Deficiency.

  Swinkels D; Kocherlakota S; Das Y; Dane AD; Wever EJM; Vaz FM; Bazan NG; Van Veldhoven PP; Baes M
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(14):34

  Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma

  Gustavsson ST; Enz TJ; Tribble JR; Nilsson M; Lindqvist A; Linden C; Hagstrom A; Rutigliani C; Lardner E; Stalhammar G; Williams PA; Johannesson G
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(43):e2301733120

  The murine retinal pigment epithelium requires peroxisomal β-oxidation to maintain lysosomal function and prevent dedifferentiation.

  Kocherlakota S; Das Y; Swinkels D; Vanmunster M; Callens M; Vinckier S; Vaz FM; Sinha D; Van Veldhoven PP; Fransen M; Baes M
• Preprint: RESEARCH SQUARE. 2023

  Mitochondrial respiratory function is strongly associated with progressive glaucomatous vision loss

  Petriti B; Rabiolo A; Chau K-Y; Williams P; Montesano G; Lascaratos G; Garway-Heath D
• Review: MOLECULAR NEURODEGENERATION. 2023;18(1):64

  Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

  Soucy JR; Aguzzi EA; Cho J; Gilhooley MJ; Keuthan C; Luo Z; Monavarfeshani A; Saleem MA; Wang X-W; Wohlschlegel J; Baranov P; Di Polo A; Fortune B; Gokoffski KK; Goldberg JL; Guido W; Kolodkin AL; Mason CA; Ou Y; Reh TA; Ross AG; Samuels BC; Welsbie D; Zack DJ; Johnson TV
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):146

  Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

  Canovai A; Tribble JR; Joe M; Westerlund DY; Amato R; Trounce IA; Dal Monte M; Williams PA
• Article: BIOMOLECULES. 2023;13(8):1246

  Ocular Surface Allostasis-When Homeostasis Is Lost: Challenging Coping Potential, Stress Tolerance, and Resilience

  van Setten G-B
• Review: MOLECULAR ASPECTS OF MEDICINE. 2023;92:101193

  Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering

  Tribble JR; Hui F; Quintero H; El Hajji S; Bell K; Di Polo A; Williams PA
• Article: GENE THERAPY. 2023;30(6):503-519

  Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters

  Nieuwenhuis B; Laperrousaz E; Tribble JR; Verhaagen J; Fawcett JW; Martin KR; Williams PA; Osborne A
• Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2023;159(5):379-387

  Peroxisomes : novel findings and future directions.

  Pedrosa AG; Reglinski K; Lismont C; Kors S; Costello J; Rodrigues TA; Marques M; Linka N; Argyriou C; Weinhofer I; Kocherlakota S; Riccio V; Ferreira V; Di Cara F; Ferreira AR; Francisco T; Azevedo JE; Ribeiro D
• Article: CELLS. 2023;12(9):1228

  Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis.

  Rajaratnam S; Soman AP; Phalguna KS; Pradhan SS; Manjunath M; Rao RK; Dandamudi RB; Bhagavatham SKS; Pulukool SK; Rathnakumar S; Kocherlakota S; Pargaonkar A; Veeranna RP; Arumugam N; Almansour AI; Choudhary B; Sivaramakrishnan V
• Article: BMC CANCER. 2023;23(1):277

  A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival

  Herrspiegel C; Plastino F; Lardner E; Seregard S; Williams PA; Andre H; Stalhammar G
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18

  NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

  Tribble JR; Hagstrom A; Jusseaume K; Lardner E; Wong RC-B; Stalhammar G; Williams PA
• Article: METHODS IN MOLECULAR BIOLOGY. 2023;2643:469-500

  Mouse Models to Study Peroxisomal Functions and Disorders: Overview, Caveats, and Recommendations.

  Kocherlakota S; Swinkels D; Van Veldhoven PP; Baes M
• Article: JOURNAL FRANCAIS D'OPHTALMOLOGIE. 2023;46(1):19-24

  Expression of GPR-68 in Human Corneal and Conjunctival Epithelium. Possible indicator and mediator of attrition associated inflammation at the ocular surface

  van Setten G-B
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Glaucoma: Understanding the biological contributions of Aging and Sex

  Williams P
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Metabolomic profiling of dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

  Komaromy A; Harman C; Anderson A; Williams P
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Effect of short-term nicotinamide supplementation on inner retinal function in dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

  Halsmer EL; DeQuattro C; Wang S; Harman C; Anderson A; Williams P; Komaromy AM
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Primary open angle glaucoma patients have lower systemic mitochondrial function, associated with lower systemic nicotinamide adenine dinucleotide (NAD) levels, compared to Controls

  Petriti B; Rabiolo A; Williams P; Chau K-Y; Lascaratos G; Garway-Heath DF
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  NMNAT2 is a druggable target for neuroprotection in glaucoma

  Williams P; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Development of neuroprotective small molecular drugs targeting NMNAT2

  Joe M; Tribble JR; Varricchio C; Brancale A; Johannesson G; Wheelock C; Williams P
• Review: FRONTIERS IN OPHTHALMOLOGY. 2023;3:1290465

  Glial metabolic alterations during glaucoma pathogenesis.

  Rombaut A; Brautaset R; Williams PA; Tribble JR
• Article: JOURNAL OF BIOPHOTONICS. 2022;15(12):e202200169

  Volume-rendered optical coherence tomography angiography during ocular interventions: Advocating for noninvasive intraoperative retinal perfusion monitoring

  Enz TJ; Maloca PM; Tschopp M; Menke MN; Tribble JR; Williams PA; Inglin N; Steitz U; Scholl HPN; Papazoglou A
• Article: DISCOVER ONCOLOGY. 2022;13(1):116

  The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989

  Stalhammar G; Williams PA; Landelius T
• Article: JOURNAL FRANCAIS D'OPHTALMOLOGIE. 2022;45(8):921-927

  GPR-68 in human lacrimal gland. Detection and possible role in the pathogenesis of dry eye disease

  van Setten G-B
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):118

  Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients

  Rutigliani C; Tribble JR; Hagstrom A; Lardner E; Johannesson G; Stalhammar G; Williams PA
• Editorial comment: FRONTIERS IN BIOSCIENCE-LANDMARK. 2022;27(5):142

  Reflections on the Ocular Surface: Summary of the Presentations at the 4th Coronis Foundation Ophthalmic Symposium Debate: "A Multifactorial Approach to Ocular Surface Disorders" (August 31 2021)

  Bron AJ; Dogru M; Horwath-Winter J; Kojima T; Kovacs I; Mueller-Lierheim WGK; van Setten G-B; Belmonte C
• Review: BMC CANCER. 2022;22(1):398

  The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature

  Hagstrom A; Kal Omar R; Williams PA; Stalhammar G
• Article: JCI INSIGHT. 2022;7(4):e155836

  Renal tubular peroxisomes are dispensable for normal kidney function.

  Ansermet C; Centeno G; Pradervand S; Harmacek D; Garcia A; Daraspe J; Kocherlakota S; Baes M; Bignon Y; Firsov D
• Preprint: RESEARCH SQUARE. 2022

  The Rationale For Treating Uveal Melanoma With Adjuvant Melatonin: A Review of The Literature

  Hagström A; Omar RK; Williams P; Stålhammar G
• Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2022;11(2):1-13

  Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging

  Enz TJ; Bittner M; Tribble JR; Williams PA; Thiel MA; Schmid MK; Bachmann LM; Bochmann F
• Article: CELLS. 2022;11(1):161

  Cell Type-Selective Loss of Peroxisomal β-Oxidation Impairs Bipolar Cell but Not Photoreceptor Survival in the Retina.

  Swinkels D; Das Y; Kocherlakota S; Vinckier S; Wever E; van Kampen AHC; Vaz FM; Baes M
• Review: FRONTIERS IN NEUROSCIENCE. 2022;16:824054

  Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?

  Mouhammad ZA; Vohra R; Horwitz A; Thein A-S; Rovelt J; Cvenkel B; Williams PA; Azuara-Blanco A; Kolko M
• Article: BRAIN AND BEHAVIOR. 2022;12(1):e2472

  Serum concentration of zinc is elevated in clinically stable bipolar disorder patients

  Jonsson BH; Orhan F; Bruno S; Oliveira AO; Sparding T; Landen M; Sellgren CM
• Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18

  Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma A Phase 2 Randomized Clinical Trial

  De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
• Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:903436

  Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model

  Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2022;63(7)

  Valproic acid reduces resident neuroinflammation and provides neuroprotection following retinal ganglion cell axotomy

  Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2022;63(7)

  Targeting NMNAT2 for neuroprotection in glaucoma

  Williams PA; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
• Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(17):3938

  Comparison of Glaucoma-Relevant Transcriptomic Datasets Identifies Novel Drug Targets for Retinal Ganglion Cell Neuroprotection

  Enz TJ; Tribble JR; Williams PA
• Article: REDOX BIOLOGY. 2021;43:101988

  Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

  Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Joe M; Lardner E; Venkataraman AP; Dominguez-Vicent A; Kokkali E; Rho S; Johnnesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
• Review: CELLS. 2021;10(6):1402

  Neuroprotection in Glaucoma: NAD⁺/NADH Redox State as a Potential Biomarker and Therapeutic Target

  Petriti B; Williams PA; Lascaratos G; Chau K-Y; Garway-Heath DF
• Article: OPHTHALMOLOGY AND THERAPY. 2021;10(2):321-335

  The Enduring Experience in Dry Eye Diagnosis: A Non-Interventional Study Comparing the Experiences of Patients Living With and Without Sjogren's Syndrome

  Figueiredo FC; Baudouin C; Rolando M; Messmer EM; van Setten G; Garrigue J-S; Garrigos G; Labetoulle M
• Review: PROGRESS IN RETINAL AND EYE RESEARCH. 2021;81:100881

  Retinal energy metabolism in health and glaucoma

  Casson RJ; Chidlow G; Crowston JG; Williams PA; Wood JPM
• Review: CELLS. 2021;10(2):295

  Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

  Tribble JR; Hui F; Joe M; Bell K; Chrysostomou V; Crowston JG; Williams PA
• Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):21

  Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma

  Tribble JR; Otmani A; Kokkali E; Lardner E; Morgan JE; Williams PA
• Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):22

  When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma

  Tribble JR; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; Andre H; Morgan JE; Williams PA
• Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:632930

  Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

  Das Y; Swinkels D; Kocherlakota S; Vinckier S; Vaz FM; Wever E; van Kampen AHC; Jun B; Do KV; Moons L; Bazan NG; Van Veldhoven PP; Baes M
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627

  Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

  Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):216

  Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease

  Bevan RJ; Hughes TR; Williams PA; Good MA; Morgan BP; Morgan JE
• Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(12):E3799-3799

  High Molecular Weight Hyaluronan Promotes Corneal Nerve Growth in Severe Dry Eyes

  Van Setten G-B; Stachs O; Dupas B; Turhan SA; Seitz B; Reitsamer H; Winter K; Horwath-Winter J; Guthoff RF; Mueller-Lierheim WGK
• Article: JOURNAL OF NEUROINFLAMMATION. 2020;17(1):336

  Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

  Harder JM; Williams PA; Braine CE; Yang HS; Thomas JM; Foxworth NE; John SWM; Howell GR
• Article: NATURE COMMUNICATIONS. 2020;11(1):5614

  Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

  Petrova V; Pearson CS; Ching J; Tribble JR; Solano AG; Yang Y; Love FM; Watt RJ; Osborne A; Reid E; Williams PA; Martin KR; Geller HM; Eva R; Fawcett JW
• Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(11):E3536-3536

  The HYLAN M Study: Efficacy of 0.15% High Molecular Weight Hyaluronan Fluid in the Treatment of Severe Dry Eye Disease in a Multicenter Randomized Trial

  van Setten G-B; Baudouin C; Horwath-Winter J; Boehringer D; Stachs O; Toker E; Al-Zaaidi S; Benitez-del-Castillo JM; Beck R; Al-Sheikh O; Seitz B; Barabino S; Reitsamer HA; Mueller-Lierheim WGK
• Article: JOURNAL FRANCAIS D'OPHTALMOLOGIE. 2020;43(9):879-883

  Detection of TSG-6 like protein n human corneal epithelium. Simultaneous presence with CD44 and hyaluronic acid

  Lardner E; van Setten G-B
• Preprint: BIORXIV. 2020

  Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

  Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Jöe M; Lardner E; Venkataraman AP; Domínguez-Vicent A; Kokkali E; Rho S; Jóhannesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
• Editorial comment: KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE. 2020;237(10):1235-1236

  Dry Eye Etiology: Focus on Friction

  van Setten GB; Mueller-Lierheim W; Baudouin C
• Review: NUTRIENTS. 2020;12(9):E2871-2871

  Potential Therapeutic Benefit of NAD⁺Supplementation for Glaucoma and Age-Related Macular Degeneration

  Cimaglia G; Votruba M; Morgan JE; Andre H; Williams PA
• Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914

  Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

  Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
• Letter: ACTA OPHTHALMOLOGICA. 2020;98(5):e659-e661

  Survival of the best? - Why some surgical techniques such as deep sclerectomy 'fail'

  van Setten GB
• Preprint: BIORXIV. 2020

  Computational approaches towards reducing contamination in single-cell RNA-seq data

  Yousefi S; Chen H; Ingels J; McCarty M; Centeno A; Chintalapudi S; Mulligan M; Williams P; John S; Jones B; Jablonski M; Hollingsworth TJ; Geisert E; Lu L; Williams R
• Preprint: RESEARCH SQUARE. 2020

  Anaphylatoxin Receptor C3AR1 Promotesoptic Nerve Degeneration in DBA/2J Mice

  Harder JM; Williams P; Braine C; Yang H; Thomas J; Foxworth N; John S; Howell G
• Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa101

  OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory

  Bevan RJ; Williams PA; Waters CT; Thirgood R; Mui A; Seto S; Good M; Morgan JE; Votruba M; Erchova I
• Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(12):E4333-4333

  Impact of Attrition, Intercellular Shear in Dry Eye Disease: When Cells are Challenged and Neurons are Triggered

  van Setten G-B
• Article: MOLECULAR BRAIN. 2020;13(1):81

  Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

  Tribble J; Harder JM; Williams P; John SWM
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(10):E3516-3516

  The Effects of High Molecular Weight Hyaluronic Acid Eye Drop Application in Environmental Dry Eye Stress Model Mice

  Kojima T; Nagata T; Kudo H; Mueller-Lierheim WGK; van Setten G-B; Dogru M; Tsubota K
• Preprint: BIORXIV. 2020

  Oral pyruvate prevents glaucomatous neurodegeneration

  Williams P; Harder J; Guymer C; Wood J; Daskalaki E; Chidlow G; Cardozo B; Foxworth N; Cochran K; Ouellette T; Wheelock C; Casson R; John S
• Article: KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE. 2020;237(5):644-648

  Osmokinetics: Defining the Characteristics of Osmotic Challenge to the Ocular Surface

  van Setten GB
• Preprint: MEDRXIV. 2020

  Improvement in Inner Retinal Function in Glaucoma with Nicotinamide (Vitamin B3) Supplementation: A Crossover Randomised Clinical Trial

  Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
• Preprint: BIORXIV. 2020

  Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system

  Petrova V; Pearson C; Tribble J; Solano A; Reid E; Williams P; Geller H; Eva R; Fawcett J
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2020;61(7)

  Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial

  Hui F; Tang J; Williams P; McGuinness M; Hadoux X; Casson RJ; Coote M; Trounce I; Martin KR; van Wijngaarden P; Crowston JG
• Preprint: BIORXIV. 2019

  Suppression of homeostatic gene expression and increased expression of metabolism-related genes are early features of glaucoma in optic nerve head microglia

  Tribble J; Harder J; Williams P; John S
• Preprint: BIORXIV. 2019

  When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma

  Tribble J; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; André H; Morgan J; Williams P
• Article: BRITISH JOURNAL OF OPHTHALMOLOGY. 2019;103(8):1190-1194

  Proteomic analysis of the aqueous humour in eyes with pseudoexfoliation syndrome.

  Botling Taube A; Konzer A; Alm A; Bergquist J
• Review: PROGRESS IN RETINAL AND EYE RESEARCH. 2019;71:68-87

  Reconsidering the central role of mucins in dry eye and ocular surface diseases.

  Baudouin C; Rolando M; Benitez Del Castillo JM; Messmer EM; Figueiredo FC; Irkec M; Van Setten G; Labetoulle M
• Other: CASE REPORTS IN OPHTHALMOLOGY. 2019;10(2):244-255

  Hyaluronic Acid as an Alternative to Autologous Human Serum Eye Drops: Initial Clinical Results with High-Molecular-Weight Hyaluronic Acid Eye Drops

  Beck R; Stachs O; Koschmieder A; Mueller-Lierheim WGK; Peschel S; van Setten G-B
• Article: JOURNAL FRANCAIS D'OPHTALMOLOGIE. 2019;42(3):221-225

  Osmokinetics: A new dynamic concept in dry eye disease

  van Setten G-B
• Article: MOLECULAR NEURODEGENERATION. 2019;14(1):6

  Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

  Williams PA; Braine CE; Kizhatil K; Foxworth NE; Tolman NG; Harder JM; Scott RA; Sousa GL; Panitch A; Howell GR; John SWM
• Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035

  Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma

  Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
• Article: MOLECULAR BRAIN. 2018;11(1):69

  Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

  Tribble JR; Williams PA; Caterson B; Sengpiel F; Morgan JE
• Article: CELL DEATH AND DISEASE. 2018;9(6):705

  Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice

  Harder JM; Williams PA; Soto I; Foxworth NE; Fernandes KA; Freeburg NF; Libby RT; John SWM
• Article: NATURE COMMUNICATIONS. 2018;9(1):2278

  A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

  Choquet H; Paylakhi S; Kneeland SC; Thai KK; Hoffmann TJ; Yin J; Kvale MN; Banda Y; Tolman NG; Williams PA; Schaefer C; Melles RB; Risch N; John SWM; Nair KS; Jorgenson E
• Letter: PSYCHOLOGICAL MEDICINE. 2018;48(7):1218-1219

  Are older studies lost in database searches for systematic reviews?

  Jonsson BH; Winzer R; Gornitzki C
• Review: ACTA OPHTHALMOLOGICA. 2018;96(2):111-119

  Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting.

  Baudouin C; Irkeç M; Messmer EM; Benítez-Del-Castillo JM; Bonini S; Figueiredo FC; Geerling G; Labetoulle M; Lemp M; Rolando M; Van Setten G; Aragona P; ODISSEY European Consensus Group Members
• Article: NUTRIENTS. 2018;10(2):134

  Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency

  Jonsson BH
• Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2018;11(1):e1356956

  Nicotinamide treatment robustly protects from inherited mouse glaucoma.

  Williams PA; Harder JM; Cardozo BH; Foxworth NE; John SWM
• Review: JOURNAL OF GLAUCOMA. 2017;26(12):1161-1168

  Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma

  Williams PA; Harder JM; John SWM
• Letter: EUROPEAN JOURNAL OF OPHTHALMOLOGY. 2017;27(6):e194-e195

  Author's Reply to: "Concerns Over: Efficacy and Safety of 0.1% Cyclosporine a Cationic Emulsion in the Treatment of Severe Dry Eye Disease".

  Leonardi A; Van Setten G; Amrane M; Ismail D; Garrigue J-S; Figueiredo FC; Baudouin C
• Article: BRITISH JOURNAL OF OPHTHALMOLOGY. 2017;101(8):1100-1105

  Patients' perception of DED and its relation with time to diagnosis and quality of life: an international and multilingual survey.

  Labetoulle M; Rolando M; Baudouin C; van Setten G
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3839-E3848

  Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

  Harder JM; Braine CE; Williams PA; Zhu X; MacNicoll KH; Sousa GL; Buchanan RA; Smith RS; Libby RT; Howell GR; John SWM
• Article: JOURNAL OF NEUROINFLAMMATION. 2017;14(1):93

  GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma

  Williams PA; Braine CE; Foxworth NE; Cochran KE; John SWM
• Article: EXPERIMENTAL EYE RESEARCH. 2017;157:20-27

  Neuroinflammation in glaucoma: A new opportunity

  Williams PA; Marsh-Armstrong N; Howell GR
• Article: JOURNAL FRANCAIS D'OPHTALMOLOGIE. 2017;40(3):187-195

  Pan-European survey of the topical ocular use of cyclosporine A

  Labbe A; Baudouin C; Ismail D; Amrane M; Garrigue J-S; Leonardi A; Figueiredo FC; Van Setten G; Labetoulle M
• Article: SCIENCE. 2017;355(6326):756-760

  Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

  Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM
• Article: EYE. 2017;31(2):199-205

  The optical detection of retinal ganglion cell damage

  Morgan JE; Tribble J; Fergusson J; White N; Erchova I
• Article: JOURNAL OF CATARACT AND REFRACTIVE SURGERY. 2017;43(1):87-94

  Comparison of the performance and safety of 2 ophthalmic viscosurgical devices in cataract surgery.

  Auffarth GU; Auerbach FN; Rabsilber T; Gegúndez JA; Cuiña R; Renard Y; Vinciguerra P; Camesasca F; Van Cauwenberge F; Amzallag T; Van Setten G; Holzer MP
• Article: FRONTIERS IN NEUROSCIENCE. 2017;11:232

  Nicotinamide and WLD^S Act Together to Prevent Neurodegeneration in Glaucoma

  Williams PA; Harder JM; Foxworth NE; Cardozo BH; Cochran KE; John SWM
• Article: CURRENT EYE RESEARCH. 2016;41(12):1571-1579

  Immunohistochemical Detection of CTGF in the Human Eye

  van Setten GB; Trost A; Schroedl F; Kaser-Eichberger A; Bogner B; van Setten M; Heindl LM; Grabner G; Reitsamer HA
• Article: ACTA OPHTHALMOLOGICA. 2016;94(5):499-506

  Evidence of seasonality and effects of psychrometry in dry eye disease

  van Setten G; Labetoulle M; Baudouin C; Rolando M
• Article: EUROPEAN JOURNAL OF OPHTHALMOLOGY. 2016;26(4):287-296

  Efficacy and safety of 0.1% cyclosporine A cationic emulsion in the treatment of severe dry eye disease: a multicenter randomized trial.

  Leonardi A; Van Setten G; Amrane M; Ismail D; Garrigue J-S; Figueiredo FC; Baudouin C
• Article: MOLECULAR NEURODEGENERATION. 2016;11:26

  Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

  Williams PA; Tribble JR; Pepper KW; Cross SD; Morgan BP; Morgan JE; John SWM; Howell GR
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2016;57(12)

  The yin and yang of the complement cascade in glaucoma - the importance of timing and location

  Howell GR; Williams P; Harder J; Tribble J; Pepper K; Cross S; Morgan P; Morgan JE; John SW
• Article: ACTA OPHTHALMOLOGICA. 2015;93(8):774-777

  Pseudoexfoliation and cataract surgery: a population-based 30-year follow-up study.

  Ekström C; Botling Taube A
• Article: EXPERIMENTAL EYE RESEARCH. 2015;141:9-14

  Microbead models in glaucoma

  Morgan JE; Tribble JR
• Article: EXPERIMENTAL EYE RESEARCH. 2015;141:42-56

  Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

  Fernandes KA; Harder JM; Williams PA; Rausch RL; Kiernan AE; Nair KS; Anderson MG; John SWM; Howell GR; Libby RT
• Article: IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING. 2015;23(4):655-664

  A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator

  Lee ST; Williams PA; Braine CE; Lin D-T; John SWM; Irazoqui PP
• Letter: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. 2015;143(6):908-910

  What Is Hidden in Tattoos?

  Jonsson BH; Winzer R
• Article: VISUAL NEUROSCIENCE. 2014;31(6):373-380

  A novel system for the classification of diseased retinal ganglion cells

  Tribble JR; Cross SD; Samsel PA; Sengpiel F; Morgan JE
• Review: BRITISH JOURNAL OF OPHTHALMOLOGY. 2014;98(9):1168-1176

  Diagnosing the severity of dry eye: a clear and practical algorithm.

  Baudouin C; Aragona P; Van Setten G; Rolando M; Irkeç M; Benítez del Castillo J; Geerling G; Labetoulle M; Bonini S; ODISSEY European Consensus Group members
• Article: JOURNAL OF NEUROSCIENCE METHODS. 2014;225:65-70

  Sholl analysis: A quantitative comparison of semi-automated methods

  Binley KE; Ng WS; Tribble JR; Song B; Morgan JE
• Article: NEUROBIOLOGY OF AGING. 2013;34(7):1799-1806

  Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease

  Williams PA; Thirgood RA; Oliphant H; Frizzati A; Littlewood E; Votruba M; Good MA; Williams J; Morgan JE
• Article: PLOS ONE. 2013;8(8):e72282

  Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

  Williams PA; Howell GR; Barbay JM; Braine CE; Sousa GL; John SWM; Morgan JE
• Other: LAKARTIDNINGEN. 2012;109(9-10):486-487

  [The risks with a high-fat diet are exaggerated].

  Ravnskov U; Jonsson BH
• Article: BRAIN. 2012;135(Pt 2):493-505

  Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity

  Williams PA; Piechota M; von Ruhland C; Taylor E; Morgan JE; Votruba M
• Article: EUROPEAN JOURNAL OF MASS SPECTROMETRY. 2012;18(6):531-541

  Proteins in aqueous humor from cataract patients with and without pseudoexfoliation syndrome.

  Taube AB; Hardenborg E; Wetterhall M; Artemenko K; Hanrieder J; Andersson M; Alm A; Bergquist J
• Article: EXPERIMENTAL EYE RESEARCH. 2011;93(5):771-777

  Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy

  Barnard AR; Issa PC; Perganta G; Williams PA; Davies VJ; Sekaran S; Votruba M; MacLaren RE
• Published conference paper: VISION RESEARCH. 2011;51(2):229-234

  Mouse models of dominant optic atrophy: What do they tell us about the pathophysiology of visual loss?

  Williams PA; Morgan JE; Votruba M
• Letter: JOURNAL OF CATARACT AND REFRACTIVE SURGERY. 2010;36(10):1794-1796

  Increasing the safety of cataract surgery of hard lenses: phaco-on-top technique.

  van Setten G
• Article: BRAIN. 2010;133(10):2942-2951

  Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy

  Williams PA; Morgan JE; Votruba M
• Letter: SCIENCE. 2010;327(5963):268

  The Potential of Nutritional Therapy

  Gardner A; Kaplan BJ; Rucklidge JJ; Jonsson BH; Humble MB
• Article: ACTA OPHTHALMOLOGICA. 2009;87(5):524-528

  Trabeculectomy with an active postoperative regimen: results and resource utilization.

  Taube AB; Niemelä P; Alm A
• Article: PROTEOMICS - CLINICAL APPLICATIONS. 2009;3(3):299-306

  Protein content in aqueous humor from patients with pseudoexfoliation (PEX) investigated by capillary LC MALDI-TOF/TOF MS.

  Hardenborg E; Botling-Taube A; Hanrieder J; Andersson M; Alm A; Bergquist J
• Letter: ACTA OPHTHALMOLOGICA. 2009;87(1):107-109

  Bimanual implantation of the capsular tension ring: minimizing capsular stress, optimizing surgical outcome and efficacy.

  van Setten G
• Article: OPHTHALMIC RESEARCH. 2008;40(1):16-18

  Antiangiogenic activity in tears: Presence of pigment-epithelium-derived factor

  Abdiu O; Van Setten G
• Article: CORNEA. 2006;25(8):900-907

  Dysfunctional tear syndrome: a Delphi approach to treatment recommendations.

  Behrens A; Doyle JJ; Stern L; Chuck RS; McDonnell PJ; Azar DT; Dua HS; Hom M; Karpecki PM; Laibson PR; Lemp MA; Meisler DM; Del Castillo JM; O'Brien TP; Pflugfelder SC; Rolando M; Schein OD; Seitz B; Tseng SC; van Setten G; Wilson SE; Yiu SC; Dysfunctional tear syndrome study group
• Article: OPHTHALMIC RESEARCH. 2006;38(4):189-192

  Detection of PEDF in subretinal fluid of retinal detachment: Possible role in the prevention of subretinal neovascularization - Preliminary results

  Abdiu O; Olivestedt G; Berglin L; van Setten G
• Article: EUROPEAN JOURNAL OF OPHTHALMOLOGY. 2005;15(6):660-667

  The triple classification of dry eye for practical clinical use.

  Murube J; Németh J; Höh H; Kaynak-Hekimhan P; Horwath-Winter J; Agarwal A; Baudouin C; Benítez del Castillo JM; Cervenka S; ChenZhuo L; Ducasse A; Durán J; Holly F; Javate R; Nepp J; Paulsen F; Rahimi A; Raus P; Shalaby O; Sieg P; Soriano H; Spinelli D; Ugurbas SH; Van Setten G
• Article: OPHTHALMIC RESEARCH. 2005;37(6):289-292

  Detection of connective tissue growth factor in subretinal fluid following retinal detachment: Possible contribution to subretinal scar formation, preliminary results

  van Setten G; Berglin L; Blalock TD; Schultz G
• Article: LAKARTIDNINGEN. 2005;102(20):1559-1560

  [The lack of interest within health care for the effects of nutrients must be broken off].

  Jonsson BH; Dalén P; Arfors K-E
• Article: VETERINARY OPHTHALMOLOGY. 2004;7(6):397-405

  Profiles of matrix metalloproteinase activity in equine tear fluid during corneal healing in 10 horses with ulcerative keratitis.

  Ollivier FJ; Brooks DE; Van Setten GB; Schultz GS; Gelatt KN; Stevens GR; Blalock TD; Andrew SE; Komaromy AM; Lassaline ME; Kallberg ME; Cutler TJ
• Article: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY. 2004;98(3):324-326

  Basic fibroblast growth factor (bFGF) in saliva and oral mucosa in patients with oral lichen planus:: Preliminary observations

  Magnusson M; Pyykkö I; van Setten G; Norlander T; Nastri A; Westermark A
• Article: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2004;242(2):165-171

  Connective tissue growth factor in tear film of the horse: detection, identification and origin.

  Ollivier FJ; Brooks DE; Schultz GS; Blalock TD; Andrew SE; Komaromy AM; Cutler TJ; Lassaline ME; Kallberg ME; Van Setten GB
• Letter: ACTA OPHTHALMOLOGICA. 2003;81(6):661-662

  The immediate approach anterior capsulorhexis (IAAC) in cataract surgery: contribution to safety and efficacy

  van Setten G; Al Ahmary AM
• Article: AMERICAN JOURNAL OF VETERINARY RESEARCH. 2003;64(9):1081-1087

  Evaluation of various compounds to inhibit activity of matrix metalloproteinases in the tear film of horses with ulcerative keratitis.

  Ollivier FJ; Brooks DE; Kallberg ME; Komaromy AM; Lassaline ME; Andrew SE; Gelatt KN; Stevens GR; Blalock TD; van Setten G-B; Schultz GS
• Article: ACTA OPHTHALMOLOGICA. 2003;81(1):51-53

  Detection of connective tissue growth factor (CTGF) in human tear fluid: preliminary results.

  van Setten GB; Blalock TD; Grotendorst G; Schultz GS
• Article: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2003;241(2):135-139

  Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring

  van Setten G; Aspiotis M; Blalock TD; Grotendorst G; Schultz G
• Article: OPHTHALMIC RESEARCH. 2002;34(5):306-308

  Detection of connective tissue growth factor in human aqueous humor.

  van Setten G-B; Blalock TD; Grotendorst G; Schultz GS
• Article: ORBIT. 2002;21(2):161-167

  Elevated intraocular levels of insulin-like growth factor I in a diabetic patient with acromegaly.

  van Setten G; Brismar K; Algvere P
• Article: THE LARYNGOSCOPE. 2002;112(5):887-889

  Basic fibroblast growth factor in human saliva decreases with aging

  Westermark A; Pyykkö I; Magnusson M; Ishizaki H; Jäntti P; van Setten G
• Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2002;506(Pt A):611-615

  Immunodacryochemistry (immunoferning): A new screening method for proteins in tears

  van Setten G
• Article: ACTA OPHTHALMOLOGICA. 2001;79(5):488-492

  Cellular proliferation and leukocyte infiltration in the rabbit cornea after photorefractive keratectomy

  Gan L; Hamberg-Nyström H; Fagerholm P; Van Setten G
• Article: JOURNAL OF CATARACT AND REFRACTIVE SURGERY. 2001;27(7):1071-1075

  Anterior lenticonus: Histological evaluation and approach for cataract surgery

  van Setten G
• Article: RHINOLOGY. 2001;39(2):88-92

  Basic fibroblast growth factor in nasal polyps immunohistochemical and quantitative findings

  Norlander T; Westermark A; van Setten G; Valtonen H; Ishizaki H; Pyykkö I
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2000;41(13):4158-4162

  Enhanced short-term plasmid transfection of filtration surgery tissues

  Angella GJ; Sherwood MB; Balasubramanian L; Doyle JW; Smith MF; van Setten G; Goldstein M; Schultz GS
• Article: INTEGRATIVE PSYCHOLOGICAL AND BEHAVIORAL SCIENCE. 2000;35(4):256-265

  Motilin- and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia

  Jonsson BH; Hellström PM
• Published conference paper: ACTA OTO-LARYNGOLOGICA, SUPPLEMENT. 2000;543:193-195

  Basic fibroblast growth factor (bFGF) in saliva-physiological acid clinical implications

  Ishizaki H; Westermark A; Van Setten G; Pyykkö I
• Thesis / dissertation: 1999

  Psychophysiological study of functional dyspepsia

  Jonsson, Bo H
• Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE. 1999;17(2):131-134

  Levels of transforming growth factor alpha (TGF-alpha) in human cerebrospinal fluid.

  Van Setten GB; Edström L; Stibler H; Rasmussen S; Schultz G
• Article: PSYCHOTHERAPY AND PSYCHOSOMATICS. 1999;68(3):151-156

  Low plasma prolactin levels in patients with functional dyspepsia

  Jonsson BH; Theorell T
• Article: PSYCHOSOMATIC MEDICINE. 1998;60(3):331-337

  Gastrin, cholecystokinin, and somatostatin in a laboratory experiment of patients with functional dyspepsia

  Jonsson BH; Uvnäs-Moberg K; Theorell T; Gotthard R
• Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1998;438:537-540

  Growth factor interaction with contact lenses: evidence for and possible effects of storage of basic FGF in contact lenses. Preliminary results.

  van Setten GB; Zengin N
• Article: ACTA OPHTHALMOLOGICA. 1997;75(6):649-652

  Vascular endothelial growth factor (VEGF) in normal human corneal epithelium: detection and physiological importance.

  van Setten GB
• Review: CURRENT OPINION IN OPHTHALMOLOGY. 1997;8(4):41-45

  Dry eye syndrome, tear film, pharmacology of eye drops, and toxicity.

  van Setten GB
• Article: JOURNAL OF REFRACTIVE SURGERY. 1997;13(3):263-267

  Comparison of corneal epithelial wound healing after photorefractive keratectomy in the rabbit with two types of excimer lasers.

  Hamberg-Nyström H; van Setten GB; Fagerholm P
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 1996;37(13):2585-2593

  beta-amyloid protein precursor expression in lacrimal glands and tear fluid

  vanSetten GB; Nilsson L; Hahne S; Johnston JA; Kvanta A; Gandy SE; Naslund J; Nordstedt C
• Review: CURRENT OPINION IN OPHTHALMOLOGY. 1996;7(4):17-21

  The clinical use of contact lenses and collagen shields.

  van Setten GB
• Article: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 1996;234(4):275-277

  Basic fibroblast growth factor in human tear fluid: detection of another growth factor.

  van Setten GB
• Article: OPHTHALMIC RESEARCH. 1996;28(6):361-364

  Growth factors and their receptors in the anterior chamber. Absence of epidermal growth factor and transforming growth factor alpha in human aqueous humor.

  van Setten GB; Fagerholm P; Philipson B; Schultz G
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 1996;37(1):20-28

  Inhibition of pseudomonal ulceration in rabbit corneas by a synthetic matrix metalloproteinase inhibitor.

  Barletta JP; Angella G; Balch KC; Dimova HG; Stern GA; Moser MT; van Setten GB; Schultz GS
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 1996;37(1):166-173

  Detection of transforming growth factor-alpha mRNA and protein in rat lacrimal glands and characterization of transforming growth factor-alpha in human tears.

  van Setten GB; Macauley S; Humphreys-Beher M; Chegini N; Schultz G
• Article: ACTA OPHTHALMOLOGICA. 1995;73(6):491-495

  Proliferating cell nuclear antigen colocalization with corneal epithelial stem cells and involvement in physiological cell turnover

  Gan LS; vanSetten G; Seregard S; Fagerholm P
• Article: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 1995;233(12):792-794

  Proliferating cell nuclear antigen: contradictory results regarding its presence in the lens.

  Gan L; van Setten G; Fagerholm P
• Article: THE LARYNGOSCOPE. 1995;105(6):610-612

  Basic fibroblast growth factor in human saliva: detection and physiological implications.

  van Setten GB
• Article: OPHTHALMIC RESEARCH. 1995;27(6):317-321

  Presence of basic fibroblast growth factor in corneal epithelium.

  van Setten G; Fagerholm P; Cuevas-Sanchez P
• Article: JOURNAL OF PSYCHOSOMATIC RESEARCH. 1995;39(1):93-102

  SYMPTOMS AND PERSONALITY IN PATIENTS WITH CHRONIC FUNCTIONAL DYSPEPSIA

  JONSSON BH; THEORELL T; GOTTHARD R
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  Pete Williams

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  E-postadress pete.williams@ki.se

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  E-postadress amelie.botling.taube@ki.se
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  E-postadress bo.jonsson@ki.se
• Melissa Jöe

  Doktorand

  E-postadress melissa.joe@ki.se
• Sai Kocherlakota

  Postdoktor

  E-postadress sai.kocherlakota@ki.se
• Zaynab Mouhammad

  Anknuten till Forskning

  E-postadress zaynab.mouhammad@ki.se
• 

  Amin Otmani

  Doktorand

  E-postadress amin.otmani@ki.se
• Anne Rombaut

  Doktorand

  E-postadress anne.rombaut@ki.se
• 

  James Tribble

  Biträdande Lektor

  E-postadress james.tribble@ki.se
• 

  Pete Williams

  Lektor | Docent

  E-postadress pete.williams@ki.se
• 

  Gysbert van Setten

  Anknuten till Forskning | Docent

  E-postadress gysbert.van.setten@ki.se

Forskningsprojekt

Nyheter

Stort anslag till forskning om den obotliga sjukdomen glaukom

Foto: Kommunikationsavdelningen S:t Eriks Ögonsjukhus

Glaukom

Stort anslag till forskning om den obotliga sjukdomen glaukom

Tre forskare vid S:t Eriks Ögonsjukhus och Karolinska Institutet, får totalt 1, 5 miljoner kronor i anslag från Stiftelsen Kronprinsessan Margaretas Arbetsnämnd för synskadade och Synskadades Vänner i Gävleborg för forskning kring behandling av glaukom.

Jakten på en bättre behandling mot grön starr

Foto: Stefan Zimmerman

Jakten på en bättre behandling mot grön starr

Pete Williams är en av få i Sverige som forskar på glaukom eller grön starr som det också kallas. Målet är en effektivare behandling. Ett läkemedel som kan förhindra den nedbrytande processen i ögats nervceller.

600 000 kronor i anslag från stiftelsen Promobilia till forskning om glaukom

Foto: Johan Gunseus

Glaukom

600 000 kronor i anslag från stiftelsen Promobilia till forskning om glaukom

Pete Williams, forskargruppsledare och lektor vid Karolinska Institutet och S:t Eriks Ögonsjukhus, har beviljats 600 000 kronor i anslag från stiftelsen Promobilia för sitt projekt med titeln Dubbel inriktning av neuroprotektion och neuroregeneration i synnerven. Projektet kommer att pågå i två år.

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