Glaukom – Pete Williams forskargrupp

Publikationer

Utvalda publikationer

• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18

  NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

  Tribble JR; Hagstrom A; Jusseaume K; Lardner E; Wong RC-B; Stalhammar G; Williams PA
• Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18

  Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma A Phase 2 Randomized Clinical Trial

  De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
• Article: REDOX BIOLOGY. 2021;43:101988

  Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

  Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Joe M; Lardner E; Venkataraman AP; Dominguez-Vicent A; Kokkali E; Rho S; Johnnesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627

  Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

  Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
• Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914

  Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

  Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
• Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035

  Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma

  Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
• Article: SCIENCE. 2017;355(6326):756-760

  Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

  Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM

Alla gruppmedlemmars publikationer

• Journal article: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53

  Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism.

  Canovai A; Williams PA
• Review: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53

  Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

  Canovai A; Williams PA
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2024;65(12):4

  Ganglion Cell Complex Thickness and Visual Function in Chronic Leber Hereditary Optic Neuropathy.

  Hedström J; Nilsson M; Engvall M; Williams PA; Venkataraman AP
• Review: SURVEY OF OPHTHALMOLOGY. 2024;:S0039-6257(24)00117-6

  Choroidal nevi and melanoma doubling times and implications for delays in treatment: A systematic review and meta-analysis.

  Stålhammar G; Hagström A; Ermedahl Conradi M; Williams PA
• Corrigendum: NATURE COMMUNICATIONS. 2024;15(1):8143

  Author Correction: NMNAT2 is a druggable target to drive neuronal NAD production.

  Tribble JR; Jöe M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Jóhannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
• Journal article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137

  Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma.

  Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
• Editorial comment: NEURAL REGENERATION RESEARCH. 2024;19(8):1637-1638

  Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma

  Williams PA; Casson RJ
• Article: NATURE MEDICINE. 2024;30(8):2362-2370

  Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss

  Petriti B; Rabiolo A; Chau K-Y; Williams PA; Montesano G; Lascaratos G; Garway-Heath DF
• Article: NATURE COMMUNICATIONS. 2024;15(1):6256

  NMNAT2 is a druggable target to drive neuronal NAD production

  Tribble JR; Joee M; Varricchio C; Otmani A; Canovai A; Habchi B; Daskalakis E; Chaleckis R; Loreto A; Gilley J; Wheelock CE; Johannesson G; Wong RCB; Coleman MP; Brancale A; Williams PA
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):79

  Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection

  Rombaut A; Jovancevic D; Wong RC-B; Nicol A; Brautaset R; Finkelstein DI; Nguyen CTO; Tribble JR; Williams PA
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):65

  Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection

  Kim M; Kim JY; Rhim W-K; Cimaglia G; Want A; Morgan JE; Williams PA; Park CG; Han DK; Rho S
• Article: BMC NEUROLOGY. 2024;24(1):111

  Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol

  Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):37

  Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume

  Otmani A; Johannesson G; Brautaset R; Tribble JR; Williams PA
• Preprint: MEDRXIV. 2024

  Evaluating the effect of rapamycin treatment in Alzheimer's Disease and aging usingin vivoimaging: the ERAP phase IIa clinical study protocol

  Svensson J; Bolin M; Thor D; Williams P; Brautaset R; Carlsson M; Sörensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Morén AF; Kivipelto M; Plavén-Sigray P
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):137

  Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma

  Cimaglia G; Tribble JR; Votruba M; Williams PA; Morgan JE
• Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)

  Neuroprotective effects of GLP‐1 receptor agonists and their potential in retinal diseases

  Mouhammad ZA; von Spreckelsen A; Bermudez MYG; Vohra R; Williams P; Kolko M
• Journal article: ACTA OPHTHALMOLOGICA. 2024;102(S279)

  Preventing retinal homocysteine dysregulation protects against retinal ganglion cell death

  Tribble JR; Rutigliani C; Canovai A; Williams PA
• Book chapter: REFERENCE MODULE IN NEUROSCIENCE AND BIOBEHAVIORAL PSYCHOLOGY. 2024;p.

  Mitochondria and Primary Open Angle Glaucoma

  Williams PA; Hui F
• Article: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(14):34

  Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma

  Gustavsson ST; Enz TJ; Tribble JR; Nilsson M; Lindqvist A; Linden C; Hagstrom A; Rutigliani C; Lardner E; Stalhammar G; Williams PA; Johannesson G
• Preprint: RESEARCH SQUARE. 2023

  Mitochondrial respiratory function is strongly associated with progressive glaucomatous vision loss

  Petriti B; Rabiolo A; Chau K-Y; Williams P; Montesano G; Lascaratos G; Garway-Heath D
• Review: MOLECULAR NEURODEGENERATION. 2023;18(1):64

  Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

  Soucy JR; Aguzzi EA; Cho J; Gilhooley MJ; Keuthan C; Luo Z; Monavarfeshani A; Saleem MA; Wang X-W; Wohlschlegel J; Baranov P; Di Polo A; Fortune B; Gokoffski KK; Goldberg JL; Guido W; Kolodkin AL; Mason CA; Ou Y; Reh TA; Ross AG; Samuels BC; Welsbie D; Zack DJ; Johnson TV
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):146

  Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

  Canovai A; Tribble JR; Joe M; Westerlund DY; Amato R; Trounce IA; Dal Monte M; Williams PA
• Review: MOLECULAR ASPECTS OF MEDICINE. 2023;92:101193

  Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering

  Tribble JR; Hui F; Quintero H; El Hajji S; Bell K; Di Polo A; Williams PA
• Article: GENE THERAPY. 2023;30(6):503-519

  Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters

  Nieuwenhuis B; Laperrousaz E; Tribble JR; Verhaagen J; Fawcett JW; Martin KR; Williams PA; Osborne A
• Article: BMC CANCER. 2023;23(1):277

  A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival

  Herrspiegel C; Plastino F; Lardner E; Seregard S; Williams PA; Andre H; Stalhammar G
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18

  NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve

  Tribble JR; Hagstrom A; Jusseaume K; Lardner E; Wong RC-B; Stalhammar G; Williams PA
• Review: FRONTIERS IN OPHTHALMOLOGY. 2023;3:1290465

  Glial metabolic alterations during glaucoma pathogenesis.

  Rombaut A; Brautaset R; Williams PA; Tribble JR
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Glaucoma: Understanding the biological contributions of Aging and Sex

  Williams P
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Metabolomic profiling of dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

  Komaromy A; Harman C; Anderson A; Williams P
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Effect of short-term nicotinamide supplementation on inner retinal function in dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

  Halsmer EL; DeQuattro C; Wang S; Harman C; Anderson A; Williams P; Komaromy AM
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Primary open angle glaucoma patients have lower systemic mitochondrial function, associated with lower systemic nicotinamide adenine dinucleotide (NAD) levels, compared to Controls

  Petriti B; Rabiolo A; Williams P; Chau K-Y; Lascaratos G; Garway-Heath DF
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  NMNAT2 is a druggable target for neuroprotection in glaucoma

  Williams P; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2023;64(8)

  Development of neuroprotective small molecular drugs targeting NMNAT2

  Joe M; Tribble JR; Varricchio C; Brancale A; Johannesson G; Wheelock C; Williams P
• Article: JOURNAL OF BIOPHOTONICS. 2022;15(12):e202200169

  Volume-rendered optical coherence tomography angiography during ocular interventions: Advocating for noninvasive intraoperative retinal perfusion monitoring

  Enz TJ; Maloca PM; Tschopp M; Menke MN; Tribble JR; Williams PA; Inglin N; Steitz U; Scholl HPN; Papazoglou A
• Article: DISCOVER ONCOLOGY. 2022;13(1):116

  The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989

  Stalhammar G; Williams PA; Landelius T
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):118

  Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients

  Rutigliani C; Tribble JR; Hagstrom A; Lardner E; Johannesson G; Stalhammar G; Williams PA
• Review: BMC CANCER. 2022;22(1):398

  The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature

  Hagstrom A; Kal Omar R; Williams PA; Stalhammar G
• Preprint: RESEARCH SQUARE. 2022

  The Rationale For Treating Uveal Melanoma With Adjuvant Melatonin: A Review of The Literature

  Hagström A; Omar RK; Williams P; Stålhammar G
• Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2022;11(2):1-13

  Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging

  Enz TJ; Bittner M; Tribble JR; Williams PA; Thiel MA; Schmid MK; Bachmann LM; Bochmann F
• Review: FRONTIERS IN NEUROSCIENCE. 2022;16:824054

  Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?

  Mouhammad ZA; Vohra R; Horwitz A; Thein A-S; Rovelt J; Cvenkel B; Williams PA; Azuara-Blanco A; Kolko M
• Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:903436

  Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model

  Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
• Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18

  Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma A Phase 2 Randomized Clinical Trial

  De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2022;63(7)

  Valproic acid reduces resident neuroinflammation and provides neuroprotection following retinal ganglion cell axotomy

  Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2022;63(7)

  Targeting NMNAT2 for neuroprotection in glaucoma

  Williams PA; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
• Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(17):3938

  Comparison of Glaucoma-Relevant Transcriptomic Datasets Identifies Novel Drug Targets for Retinal Ganglion Cell Neuroprotection

  Enz TJ; Tribble JR; Williams PA
• Article: REDOX BIOLOGY. 2021;43:101988

  Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

  Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Joe M; Lardner E; Venkataraman AP; Dominguez-Vicent A; Kokkali E; Rho S; Johnnesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
• Review: CELLS. 2021;10(6):1402

  Neuroprotection in Glaucoma: NAD⁺/NADH Redox State as a Potential Biomarker and Therapeutic Target

  Petriti B; Williams PA; Lascaratos G; Chau K-Y; Garway-Heath DF
• Review: PROGRESS IN RETINAL AND EYE RESEARCH. 2021;81:100881

  Retinal energy metabolism in health and glaucoma

  Casson RJ; Chidlow G; Crowston JG; Williams PA; Wood JPM
• Review: CELLS. 2021;10(2):295

  Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma

  Tribble JR; Hui F; Joe M; Bell K; Chrysostomou V; Crowston JG; Williams PA
• Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):22

  When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma

  Tribble JR; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; Andre H; Morgan JE; Williams PA
• Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):21

  Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma

  Tribble JR; Otmani A; Kokkali E; Lardner E; Morgan JE; Williams PA
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627

  Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin

  Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):216

  Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease

  Bevan RJ; Hughes TR; Williams PA; Good MA; Morgan BP; Morgan JE
• Article: JOURNAL OF NEUROINFLAMMATION. 2020;17(1):336

  Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

  Harder JM; Williams PA; Braine CE; Yang HS; Thomas JM; Foxworth NE; John SWM; Howell GR
• Article: NATURE COMMUNICATIONS. 2020;11(1):5614

  Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

  Petrova V; Pearson CS; Ching J; Tribble JR; Solano AG; Yang Y; Love FM; Watt RJ; Osborne A; Reid E; Williams PA; Martin KR; Geller HM; Eva R; Fawcett JW
• Preprint: BIORXIV. 2020

  Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

  Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Jöe M; Lardner E; Venkataraman AP; Domínguez-Vicent A; Kokkali E; Rho S; Jóhannesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
• Review: NUTRIENTS. 2020;12(9):E2871-2871

  Potential Therapeutic Benefit of NAD⁺Supplementation for Glaucoma and Age-Related Macular Degeneration

  Cimaglia G; Votruba M; Morgan JE; Andre H; Williams PA
• Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914

  Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

  Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
• Preprint: BIORXIV. 2020

  Computational approaches towards reducing contamination in single-cell RNA-seq data

  Yousefi S; Chen H; Ingels J; McCarty M; Centeno A; Chintalapudi S; Mulligan M; Williams P; John S; Jones B; Jablonski M; Hollingsworth TJ; Geisert E; Lu L; Williams R
• Preprint: RESEARCH SQUARE. 2020

  Anaphylatoxin Receptor C3AR1 Promotesoptic Nerve Degeneration in DBA/2J Mice

  Harder JM; Williams P; Braine C; Yang H; Thomas J; Foxworth N; John S; Howell G
• Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa101

  OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory

  Bevan RJ; Williams PA; Waters CT; Thirgood R; Mui A; Seto S; Good M; Morgan JE; Votruba M; Erchova I
• Article: MOLECULAR BRAIN. 2020;13(1):81

  Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

  Tribble J; Harder JM; Williams P; John SWM
• Preprint: BIORXIV. 2020

  Oral pyruvate prevents glaucomatous neurodegeneration

  Williams P; Harder J; Guymer C; Wood J; Daskalaki E; Chidlow G; Cardozo B; Foxworth N; Cochran K; Ouellette T; Wheelock C; Casson R; John S
• Preprint: MEDRXIV. 2020

  Improvement in Inner Retinal Function in Glaucoma with Nicotinamide (Vitamin B3) Supplementation: A Crossover Randomised Clinical Trial

  Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
• Preprint: BIORXIV. 2020

  Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system

  Petrova V; Pearson C; Tribble J; Solano A; Reid E; Williams P; Geller H; Eva R; Fawcett J
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2020;61(7)

  Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial

  Hui F; Tang J; Williams P; McGuinness M; Hadoux X; Casson RJ; Coote M; Trounce I; Martin KR; van Wijngaarden P; Crowston JG
• Preprint: BIORXIV. 2019

  Suppression of homeostatic gene expression and increased expression of metabolism-related genes are early features of glaucoma in optic nerve head microglia

  Tribble J; Harder J; Williams P; John S
• Preprint: BIORXIV. 2019

  When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma

  Tribble J; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; André H; Morgan J; Williams P
• Article: MOLECULAR NEURODEGENERATION. 2019;14(1):6

  Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

  Williams PA; Braine CE; Kizhatil K; Foxworth NE; Tolman NG; Harder JM; Scott RA; Sousa GL; Panitch A; Howell GR; John SWM
• Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035

  Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma

  Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
• Article: MOLECULAR BRAIN. 2018;11(1):69

  Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma

  Tribble JR; Williams PA; Caterson B; Sengpiel F; Morgan JE
• Article: CELL DEATH AND DISEASE. 2018;9(6):705

  Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice

  Harder JM; Williams PA; Soto I; Foxworth NE; Fernandes KA; Freeburg NF; Libby RT; John SWM
• Article: NATURE COMMUNICATIONS. 2018;9(1):2278

  A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

  Choquet H; Paylakhi S; Kneeland SC; Thai KK; Hoffmann TJ; Yin J; Kvale MN; Banda Y; Tolman NG; Williams PA; Schaefer C; Melles RB; Risch N; John SWM; Nair KS; Jorgenson E
• Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2018;11(1):e1356956

  Nicotinamide treatment robustly protects from inherited mouse glaucoma.

  Williams PA; Harder JM; Cardozo BH; Foxworth NE; John SWM
• Review: JOURNAL OF GLAUCOMA. 2017;26(12):1161-1168

  Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma

  Williams PA; Harder JM; John SWM
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3839-E3848

  Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective

  Harder JM; Braine CE; Williams PA; Zhu X; MacNicoll KH; Sousa GL; Buchanan RA; Smith RS; Libby RT; Howell GR; John SWM
• Article: JOURNAL OF NEUROINFLAMMATION. 2017;14(1):93

  GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma

  Williams PA; Braine CE; Foxworth NE; Cochran KE; John SWM
• Article: EXPERIMENTAL EYE RESEARCH. 2017;157:20-27

  Neuroinflammation in glaucoma: A new opportunity

  Williams PA; Marsh-Armstrong N; Howell GR
• Article: SCIENCE. 2017;355(6326):756-760

  Vitamin B₃ modulates mitochondrial vulnerability and prevents glaucoma in aged mice

  Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM
• Article: FRONTIERS IN NEUROSCIENCE. 2017;11:232

  Nicotinamide and WLD^S Act Together to Prevent Neurodegeneration in Glaucoma

  Williams PA; Harder JM; Foxworth NE; Cardozo BH; Cochran KE; John SWM
• Article: MOLECULAR NEURODEGENERATION. 2016;11:26

  Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

  Williams PA; Tribble JR; Pepper KW; Cross SD; Morgan BP; Morgan JE; John SWM; Howell GR
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2016;57(12)

  The yin and yang of the complement cascade in glaucoma - the importance of timing and location

  Howell GR; Williams P; Harder J; Tribble J; Pepper K; Cross S; Morgan P; Morgan JE; John SW
• Article: EXPERIMENTAL EYE RESEARCH. 2015;141:42-56

  Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

  Fernandes KA; Harder JM; Williams PA; Rausch RL; Kiernan AE; Nair KS; Anderson MG; John SWM; Howell GR; Libby RT
• Article: IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING. 2015;23(4):655-664

  A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator

  Lee ST; Williams PA; Braine CE; Lin D-T; John SWM; Irazoqui PP
• Article: NEUROBIOLOGY OF AGING. 2013;34(7):1799-1806

  Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease

  Williams PA; Thirgood RA; Oliphant H; Frizzati A; Littlewood E; Votruba M; Good MA; Williams J; Morgan JE
• Article: PLOS ONE. 2013;8(8):e72282

  Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma

  Williams PA; Howell GR; Barbay JM; Braine CE; Sousa GL; John SWM; Morgan JE
• Article: BRAIN. 2012;135(Pt 2):493-505

  Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity

  Williams PA; Piechota M; von Ruhland C; Taylor E; Morgan JE; Votruba M
• Article: EXPERIMENTAL EYE RESEARCH. 2011;93(5):771-777

  Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy

  Barnard AR; Issa PC; Perganta G; Williams PA; Davies VJ; Sekaran S; Votruba M; MacLaren RE
• Published conference paper: VISION RESEARCH. 2011;51(2):229-234

  Mouse models of dominant optic atrophy: What do they tell us about the pathophysiology of visual loss?

  Williams PA; Morgan JE; Votruba M
• Article: BRAIN. 2010;133(10):2942-2951

  Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy

  Williams PA; Morgan JE; Votruba M
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Medarbetare och kontakt

Gruppledare

• 

  Pete Williams

  Lektor | Docent

  E-postadress pete.williams@ki.se

Alla medarbetare i gruppen

• Amelie Botling Taube

  E-postadress amelie.botling.taube@ki.se
• Navid Golpour

  Doktorand

  E-postadress navid.golpour@ki.se
• Steffi Jonk

  Doktorand

  E-postadress steffi.jonk@ki.se
• Bo Jonsson

  Anknuten till Forskning

  E-postadress bo.jonsson@ki.se
• Melissa Jöe

  Doktorand

  E-postadress melissa.joe@ki.se
• Sai Kocherlakota

  Postdoktor

  E-postadress sai.kocherlakota@ki.se
• Zaynab Mouhammad

  Anknuten till Forskning

  E-postadress zaynab.mouhammad@ki.se
• Alan Nicol

  Forskningsassistent

  E-postadress alan.nicol@ki.se
• 

  Amin Otmani

  Doktorand

  E-postadress amin.otmani@ki.se
• Anne Rombaut

  Doktorand

  E-postadress anne.rombaut@ki.se
• 

  James Tribble

  Biträdande Lektor

  E-postadress james.tribble@ki.se
• 

  Pete Williams

  Lektor | Docent

  E-postadress pete.williams@ki.se
• 

  Gysbert van Setten

  Anknuten till Forskning | Docent

  E-postadress gysbert.van.setten@ki.se

Forskningsprojekt

Nyheter

Jakten på en bättre behandling mot grön starr

Foto: Stefan Zimmerman

Jakten på en bättre behandling mot grön starr

Pete Williams är en av få i Sverige som forskar på glaukom eller grön starr som det också kallas. Målet är en effektivare behandling. Ett läkemedel som kan förhindra den nedbrytande processen i ögats nervceller.

600 000 kronor i anslag från stiftelsen Promobilia till forskning om glaukom

Foto: Johan Gunseus

Glaukom

600 000 kronor i anslag från stiftelsen Promobilia till forskning om glaukom

Pete Williams, forskargruppsledare och lektor vid Karolinska Institutet och S:t Eriks Ögonsjukhus, har beviljats 600 000 kronor i anslag från stiftelsen Promobilia för sitt projekt med titeln Dubbel inriktning av neuroprotektion och neuroregeneration i synnerven. Projektet kommer att pågå i två år.

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