Erik Norberg

Erik Norberg

Anknuten till Forskning | Docent
E-postadress: erik.norberg@ki.se
Telefon: +46852487170
Besöksadress: Solnavägen 9, Biomedicum C5, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa Signalvägar för proteinnedbrytning, 171 77 Stockholm

Om mig

  • *2019*- present: /Assoc. Professor/ of Metabolism (Docent), Karolinska
    Inst.
    *2014*-*2018*: /Asst. Professor, / Karolinska Inst.
    *2011*-*2013*: /PostDoc/, Dana-Farber Cancer Institute, Harvard Medical
    School, Boston, USA.
    *2011*: /Ph.D./ Karolinska Institute, Stockholm, Sweden.
    *2005*: /MSc./ Uppsala University, Uppsala, Sweden.
    (Mer info finner ni under Engelska sidorna.)
    *Dimitris N Chorafas Pris* - för bästa doktorsavhandling vid Karolinska
    Inst 2011.
    *The Lennart Philipson Award *2015 - Delas ut vartannat år till en forskare
    på Karolinska Inst.

Forskningsbeskrivning

  • /*Identifiering samt Blockering av Olikartad Metabolism (Ämnesomsättning) -
    som en ny måltavla för Anti-cancer behandling*/
    Det är numera välkänt att tumörcellernas ämnesomsättning (metabolism)
    skiljer sig avsevärt från den ursprungliga normala vävnaden som
    tumörcellen härstammar ifrån. Tumörcellerna har ett högre behov av
    näringsämnen/energi i jämförselse med normala friska celler. Detta ökade
    energibehov sker eftersom tumörcellerna delar sig snabbare och behöver nya
    byggmaterial såsom proteiner, fetter, DNA, etc. alla komponenter som behövs
    för att bilda en ny cell. Det finns dock väldigt lite kunskap om
    metaboliska skillnader inom en tumörsort.
    Om man upptäcker nya metaboliska särskiljaktigheter hos tumörer,
    förväntas det att om man svälter tumörceller på dessa näringsämnen,
    så leder det till en långsammare tumörtillväxt och i bästa fall
    eliminering av tumören.
    Att påvisa en säregenskap hos tumörer, såsom en förändrad metabolism,
    har stor potential att upptäcka nya diagnostiska redskap såsom terapeutiska
    strategier.
    *Forskargrupp ' Cellulär Metabolism':*
    Vitaly Kaminsky, PhD, Senior Researcher.
    Elena Kochetkova, PhD, PostDoc,
    Boxi Zhang, PhD, PostDoc.
    Lyudmila Krassikova, PhD, PostDoc.
    Divya Nagarajan, PhD, PostDoc.
    Vagelis Samakidis, MSc, Lab technician.
    Anastasiia Krasko, MSc student.
    *Utvalda Publikationer:*
    *1.* The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
    Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E,
    Vakifahmetoglu-Norberg H, * Norberg E.* /Cell Death Differ/. 2020 Oct 20. doi:
    10.1038/s41418-020-00639-1. Online ahead of print.
    />
  • News:
    https://news.ki.se/newly-discovered-mechanism-controls-cancer-cell-grow
    [1] /
    />
  • Selected as the 'Monthly Top pick' by CDD press. /
    *2.* Ambroise G, Yu TT, Zhang B, Kacal M, Hao Y, Queiroz AL, Ouchida AT,
    Lindskog C, *Norberg E#, * Vakifahmetoglu-Norberg H#. Systematic analysis
    reveals a functional role for STAMBPL1 in the epithelial-mesenchymal
    transition process across multiple carcinomas. /British Journal of Cancer/.
    2020 Sep
  • 123(7):1164-1177. *# co-corresponding author*
    *3.* Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M,
    Vakifahmetoglu-Norberg, H, *Norberg E*. PHGDH Defines a metabolic subtype in
    lung adenocarcinomas with poor prognosis. /Cell Reports /2017 Jun
    13
  • 19(11):2289-2303.
    />
  • Selected as 'Issue Highlight' by Cell Reports./
    *4.* Eriksson M, Ambroise G, Ouchida AT, Queiroz AL, Smith D, Gimenez-Cassina
    A, Iwanicki MP, Muller PA, *Norberg E#*, Vakifahmetoglu-Norberg H#. The
    effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism.
    /Mol Cell Biol./ 2017 Nov 28
  • 37(24) * # co-corresponding author.*
    />
  • Selected for the Cover volume 37, issue 24./
    *5.* Zhang B, Tornmalm J, Widengren J, Vakifahmetoglu-Norberg H, *Norberg E*.
    Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell
    Survival. /Journal of Cancer/ 2017
  • 8(11):2088-2096.
    /*Utvalda Samarbetstsartiklar:*/
    *1. *Quantitative proteomic analysis of temporal lysosomal proteome and the
    impact of the KFERQ-like motif and LAMP2A in lysosomal targeting. [2]
    Kacal M, Zhang B, Hao Y, *Norberg E*, Vakifahmetoglu-Norberg H
    /Autophagy 2021 /Jan 14. doi: 10.1080/15548627.2021.1876343. [Online
    ahead of print.]
    *2. *Targetome analysis of chaperone-mediated autophagy in cancer cells.
    [3]Hao Y, Kacal M, Ouchida AT, Zhang B, *Norberg E*, Vakifahmetoglu-Norberg
    H.
    /Autophagy 2019 09
  • 15(9):1558-1571/
    /*Utvalda Översiktsartiklar:*/
    1. Lima Queiroz A, Vakifahmetoglu-Norberg H, *Norberg E*. Resistant to
    Targeted Therapy - Aim for Metabolic Liabilities. /Theranostics/ 2018
  • 8(7):
    2061-2063.
    2. Vakifahmetoglu-Norberg H, Ouchida A, *Norberg E*. The role of Mitochondria
    in Metabolism and Cell Death. /Biochem Biophys Res Commun./ (2017) Jan
    15
  • 482(3):426-431
    /As of July/August 2017, this Review received enough citations to place it in
    the top 1% of the academic field of Biology &
  • Biochemistry (Web of Science)/.
    3. Stanley I, Ribeiro S, Gimenez-Cassina A, *Norberg E*, Danial NN. Changing
    appetites: The adaptive advantages of fuel choice./Trends in Cell Biology./
    2014 Feb
  • 24(2):118-27
    *Examensarbetare sökes:*
    2 Master of Science Projects (Examensarbete) available:
    Doktorand sökes:
    1 doktorandplats tillgänglig (start slutet av 2020 alt början av 2021.)
    [1] https://news.ki.se/newly-discovered-mechanism-controls-cancer-cell-growth-and-metabolism?_ga=2.70076304.168021435.1603384257-969318966.1587422954
    [2] https://pubmed.ncbi.nlm.nih.gov/33446043
    [3] https://pubmed.ncbi.nlm.nih.gov/30821613

Artiklar

Alla övriga publikationer

  • Preprint: BIORXIV. 2024;BIORXIV
    Centeno D; Farsinejad S; Kochetkova E; Volpari T; Gladych-Macioszek A; Klupczynska-Gabryszak A; Polotaye T; Greenberg M; Kung D; Hyde E; Alshehri S; Pavlovic T; Sullivan W; Plewa S; Vakifahmetoglu-Norberg H; Monsma FJ; Muller PAJ; Matysiak J; Zaborowski M; DiFeo A; Norberg E; Martin LA; Iwanicki M
  • Preprint: BIORXIV. 2022
    Zhou X; Shi Y; Shirokova V; Kochetkova E; Becirovic T; Zhang B; Kaminskyy VO; Lindskog C; Hydbring P; Ekman S; Genander M; Norberg E; Vakifahmetoglu-Norberg H
  • Review: FRONTIERS IN ONCOLOGY. 2020;10:607149
    Shi Y; Norberg E; Vakifahmetoglu-Norberg H
  • Editorial comment: THERANOSTICS. 2018;8(7):2061-2063
    Queiroz AL; Vakifahmetoglu-Norberg H; Norberg E
  • Review: AUTOPHAGY. 2016;12(1):1-222
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Alguel H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Awale S; Azad N; Bachetti T; Backer JM; Bae D-H; Bae J-S; Bae O-N; Bae SH; Baehrecke EH; Baek S-H; Baghdiguian S; Bagniewska-Zadworna A; Bai H; Bai J; Bai X-Y; Bailly Y; Balaji KN; Balduini W; Ballabio A; Balzan R; Banerjee R; Banhegyi G; Bao H; Barbeau B; Barrachina MD; Barreiro E; Bartel B; Bartolome A; Bassham DC; Bassi MT; Bast RCJ; Basu A; Batista MT; Batoko H; Battino M; Bauckman K; Baumgarner BL; Bayer KU; Beale R; Beaulieu J-F; Beck GRJ; Becker C; Beckham JD; Bedard P-A; Bednarski PJ; Begley TJ; Behl C; Behrends C; Behrens GMN; Behrns KE; Bejarano E; Belaid A; Belleudi F; Benard G; Berchem G; Bergamaschi D; Bergami M; Berkhout B; Berliocchi L; Bernard A; Bernard M; Bernassola F; Bertolotti A; Bess AS; Besteiro S; Bettuzzi S; Bhalla S; Bhattacharyya S; Bhutia SK; Biagosch C; Bianchi MW; Biard-Piechaczyk M; Billes V; Bincoletto C; Bingol B; Bird SW; Bitoun M; Bjedov I; Blackstone C; Blanc L; Blanco GA; Blomhoff HK; Boada-Romero E; Boeckler S; Boes M; Boesze-Battaglia K; Boise LH; Bolino A; Boman A; Bonaldo P; Bordi M; Bosch J; Botana LM; Botti J; Bou G; Bouche M; Bouchecareilh M; Boucher M-J; Boulton ME; Bouret SG; Boya P; Boyer-Guittaut M; Bozhkov PV; Brady N; Braga VMM; Brancolini C; Braus GH; Bravo-San Pedro JM; Brennan LA; Bresnick EH; Brest P; Bridges D; Bringer M-A; Brini M; Brito GC; Brodin B; Brookes PS; Brown EJ; Brown K; Broxmeyer HE; Bruhat A; Brum PC; Brumell JH; Brunetti-Pierri N; Bryson-Richardson RJ; Buch S; Buchan AM; Budak H; Bulavin DV; Bultman SJ; Bultynck G; Bumbasirevic V; Burelle Y; Burke RE; Burmeister M; Buetikofer P; Caberlotto L; Cadwell K; Cahova M; Cai D; Cai J; Cai Q; Calatayud S; Camougrand N; Campanella M; Campbell GR; Campbell M; Campello S; Candau R; Caniggia I; Cantoni L; Cao L; Caplan AB; Caraglia M; Cardinali C; Cardoso SM; Carew JS; Carleton LA; Carlin CR; Carloni S; Carlsson SR; Carmona-Gutierrez D; Carneiro LAM; Carnevali O; Carra S; Carrier A; Carroll B; Casas C; Casas J; Cassinelli G; Castets P; Castro-Obregon S; Cavallini G; Ceccherini I; Cecconi F; Cederbaum AI; Cena V; Cenci S; Cerella C; Cervia D; Cetrullo S; Chaachouay H; Chae H-J; Chagin AS; Chai C-Y; Chakrabarti G; Chamilos G; Chan EYW; Chan MTV; Chandra D; Chandra P; Chang C-P; Chang RC-C; Chang TY; Chatham JC; Chatterjee S; Chauhan S; Che Y; Cheetham ME; Cheluvappa R; Chen C-J; Chen G; Chen G-C; Chen G; Chen H; Chen JW; Chen J-K; Chen M; Chen M; Chen P; Chen Q; Chen Q; Chen S-D; Chen S; Chen SS-L; Chen W; Chen W-J; Chen WQ; Chen W; Chen X; Chen Y-H; Chen Y-G; Chen Y; Chen Y; Chen Y; Chen Y-J; Chen Y-Q; Chen Y; Chen Z; Chen Z; Cheng A; Cheng CHK; Cheng H; Cheong H; Cherry S; Chesney J; Cheung CHA; Chevet E; Chi HC; Chi S-G; Chiacchiera F; Chiang H-L; Chiarelli R; Chiariello M; Chieppa M; Chin L-S; Chiong M; Chiu GNC; Cho D-H; Cho S-G; Cho WC; Cho Y-Y; Cho Y-S; Choi AMK; Choi E-J; Choi E-K; Choi J; Choi ME; Choi S-I; Chou T-F; Chouaib S; Choubey D; Choubey V; Chow K-C; Chowdhury K; Chu CT; Chuang T-H; Chun T; Chung H; Chung T; Chung Y-L; Chwae Y-J; Cianfanelli V; Ciarcia R; Ciechomska IA; Ciriolo MR; Cirone M; Claerhout S; Clague MJ; Claria J; Clarke PGH; Clarke R; Clementi E; Cleyrat C; Cnop M; Coccia EM; Cocco T; Codogno P; Coers J; Cohen EEW; Colecchia D; Coletto L; Coll NS; Colucci-Guyon E; Comincini S; Condello M; Cook KL; Coombs GH; Cooper CD; Cooper JM; Coppens I; Corasaniti MT; Corazzari M; Corbalan R; Corcelle-Termeau E; Cordero MD; Corral-Ramos C; Corti O; Cossarizza A; Costelli P; Costes S; Costes S; Coto-Montes A; Cottet S; Couve E; Covey LR; Cowart LA; Cox JS; Coxon FP; Coyne CB; Cragg MS; Craven RJ; Crepaldi T; Crespo JL; Criollo A; Crippa V; Cruz MT; Cuervo AM; Cuezva JM; Cui T; Cutillas PR; Czaja MJ; Czyzyk-Krzeska MF; Dagda RK; Dahmen U; Dai C; Dai W; Dai Y; Dalby KN; Valle LD; Dalmasso G; D'Amelio M; Damme M; Darfeuille-Michaud A; Dargemont C; Darley-Usmar VM; Dasarathy S; Dasgupta B; Dash S; Dass CR; Davey HM; Davids LM; Davila D; Davis RJ; Dawson TM; Dawson VL; Daza P; de Belleroche J; de Figueiredo P; Bressan Queiroz de Figueiredo RC; de la Fuente J; De Martino L; De Matteis A; De Meyer GRY; De Milito A; De Santi M; de Souza W; De Tata V; De Zio D; Debnath J; Dechant R; Decuypere J-P; Deegan S; Dehay B; Del Bello B; Del Re DP; Delage-Mourroux R; Delbridge LMD; Deldicque L; Delorme-Axford E; Deng Y; Dengjel J; Denizot M; Dent P; Der CJ; Deretic V; Derrien B; Deutsch E; Devarenne TP; Devenish RJ; Di Bartolomeo S; Di Daniele N; Di Domenico F; Di Nardo A; Di Paola S; Di Pietro A; Di Renzo L; DiAntonio A; Diaz-Araya G; Diaz-Laviada I; Diaz-Meco MT; Diaz-Nido J; Dickey CA; Dickson RC; Diederich M; Digard P; Dikic I; Dinesh-Kumar SP; Ding C; Ding W-X; Ding Z; Dini L; Distler JHW; Diwan A; Djavaheri-Mergny M; Dmytruk K; Dobson RCJ; Doetsch V; Dokladny K; Dokudovskaya S; Donadelli M; Dong XC; Dong X; Dong Z; Donohue TMJ; Doran KS; D'Orazi G; Dorn GWII; Dosenko V; Dridi S; Drucker L; Du J; Du L-L; Du L; du Toit A; Dua P; Duan L; Duann P; Dubey VK; Duchen MR; Duchosal MA; Duez H; Dugail I; Dumit VI; 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Harris AL; Harris J; Hasler U; Hasselblatt P; Hasui K; Hawley RG; Hawley TS; He C; He CY; He F; He G; He R-R; He X-H; He Y-W; He Y-Y; Heath JK; Hebert M-J; Heinzen RA; Helgason GV; Hensel M; Henske EP; Her C; Herman PK; Hernandez A; Hernandez C; Hernandez-Tiedra S; Hetz C; Hiesinger PR; Higaki K; Hilfiker S; Hill BG; Hill JA; Hill WD; Hino K; Hofius D; Hofman P; Hoeglinger GU; Hoehfeld J; Holz MK; Hong Y; Hood DA; Hoozemans JJM; Hoppe T; Hsu C; Hsu C-Y; Hsu L-C; Hu D; Hu G; Hu H-M; Hu H; Hu MC; Hu Y-C; Hu Z-W; Hua F; Hua Y; Huang C; Huang H-L; Huang K-H; Huang K-Y; Huang S; Huang S; Huang W-P; Huang Y-R; Huang Y; Huang Y; Huber TB; Huebbe P; Huh W-K; Hulmi JJ; Hur GM; Hurley JH; Husak Z; Hussain SNA; Hussain S; Hwang JJ; Hwang S; Hwang TIS; Ichihara A; Imai Y; Imbriano C; Inomata M; Into T; Iovane V; Iovanna JL; Iozzo RV; Ip NY; Irazoqui JE; Iribarren P; Isaka Y; Isakovic AJ; Ischiropoulos H; Isenberg JS; Ishaq M; Ishida H; Ishii I; Ishmael JE; Isidoro C; Isobe K-I; Isono E; Issazadeh-Navikas S; Itahana K; Itakura E; Ivanov AI; Iyer AKV; Izquierdo JM; Izumi Y; Izzo V; Jaeaettelae M; Jaber N; Jackson DJ; Jackson WT; Jacob TG; Jacques TS; Jagannath C; Jain A; Jana NR; Jang BK; Jani A; Janji B; Jannig PR; Jansson PJ; Jean S; Jendrach M; Jeon J-H; Jessen N; Jeung E-B; Jia K; Jia L; Jiang H; Jiang H; Jiang L; Jiang T; Jiang X; Jiang X; Jiang Y; Jiang Y; Jimenez A; Jin C; Jin H; Jin L; Jin M; Jin S; Jinwal UK; Jo E-K; Johansen T; Johnson DE; Johnson GVW; Johnson JD; Jonasch E; Jones C; Joosten LAB; Jordan J; Joseph A-M; Joseph B; Joubert AM; Ju D; Ju J; Juan H-F; Juenemann K; Juhasz G; Jung HS; Jung JU; Jung Y-K; Jungbluth H; Justice MJ; Jutten B; Kaakoush NO; Kaarniranta K; Kaasik A; Kabuta T; Kaeffer B; Kagedal K; Kahana A; Kajimura S; Kakhlon O; Kalia M; Kalvakolanu DV; Kamada Y; Kambas K; Kaminskyy VO; Kampinga HH; Kandouz M; Kang C; Kang R; Kang T-C; Kanki T; Kanneganti T-D; Kanno H; Kanthasamy AG; Kantorow M; Kaparakis-Liaskos M; Kapuy O; Karantza V; Karim MR; Karmakar P; Kaser A; 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  • Corrigendum: FREE RADICAL BIOLOGY AND MEDICINE. 2013;65:895-896
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  • Review: CELL DEATH AND DIFFERENTIATION. 2009;16(8):1075-1082
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Anställningar

  • Anknuten till Forskning, Fysiologi och farmakologi, Karolinska Institutet, 2024-2026
  • Senior Forskare, Fysiologi och farmakologi, Karolinska Institutet, 2021-2024

Examina och utbildning

  • Docent, metabolism, Karolinska Institutet, 2019
  • Medicine Doktorsexamen, Institutet för miljömedicin, Karolinska Institutet, 2011

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