Dagliyans grupp

Journal article: SCIENCE ADVANCES. 2023;9(46):eadh1110

Engineering memory with an extrinsically disordered kinase.

Ripoli C; Dagliyan O; Renna P; Pastore F; Paciello F; Sollazzo R; Rinaudo M; Battistoni M; Martini S; Tramutola A; Sattin A; Barone E; Saneyoshi T; Fellin T; Hayashi Y; Grassi C

Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(2):917

A Bioengineering Strategy to Control ADAM10 Activity in Living Cells.

Pastore F; Battistoni M; Sollazzo R; Renna P; Paciello F; Li Puma DD; Barone E; Dagliyan O; Ripoli C; Grassi C

Journal article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2022;7(2):e10292

Engineering a switchable single-chain TEV protease to control protein maturation in living neurons.

Renna P; Ripoli C; Dagliyan O; Pastore F; Rinaudo M; Re A; Paciello F; Grassi C

Journal article: NATURE COMMUNICATIONS. 2022;13(1):430

Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.

Cakir B; Tanaka Y; Kiral FR; Xiang Y; Dagliyan O; Wang J; Lee M; Greaney AM; Yang WS; duBoulay C; Kural MH; Patterson B; Zhong M; Kim J; Bai Y; Min W; Niklason LE; Patra P; Park I-H

Journal article: CELL. 2021;184(22):5670-5685.e23

Biosensors based on peptide exposure show single molecule conformations in live cells.

Liu B; Stone OJ; Pablo M; Herron JC; Nogueira AT; Dagliyan O; Grimm JB; Lavis LD; Elston TC; Hahn KM

Journal article: NATURE. 2021;590(7844):115-121

Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network.

Yap E-L; Pettit NL; Davis CP; Nagy MA; Harmin DA; Golden E; Dagliyan O; Lin C; Rudolph S; Sharma N; Griffith EC; Harvey CD; Greenberg ME

Journal article: NATURE METHODS. 2020;17(9):928-936

Rational design and implementation of a chemically inducible heterotrimerization system.

Wu HD; Kikuchi M; Dagliyan O; Aragaki AK; Nakamura H; Dokholyan NV; Umehara T; Inoue T

Journal article: CELL REPORTS. 2020;31(11):107764

Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.

Ozkan-Dagliyan I; Diehl JN; George SD; Schaefer A; Papke B; Klotz-Noack K; Waters AM; Goodwin CM; Gautam P; Pierobon M; Peng S; Gilbert TSK; Lin KH; Dagliyan O; Wennerberg K; Petricoin EF; Tran NL; Bhagwat SV; Tiu RV; Peng S-B; Herring LE; Graves LM; Sers C; Wood KC; Cox AD; Der CJ

Journal article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2019;57:17-22

Controlling protein conformation with light.

Dagliyan O; Hahn KM

Journal article: NATURE PROTOCOLS. 2019;14(6):1863-1883

Engineering proteins for allosteric control by light or ligands.

Dagliyan O; Dokholyan NV; Hahn KM

Journal article: NATURE COMMUNICATIONS. 2018;9(1):4042

Computational design of chemogenetic and optogenetic split proteins.

Dagliyan O; Krokhotin A; Ozkan-Dagliyan I; Deiters A; Der CJ; Hahn KM; Dokholyan NV

Journal article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(8):e1006321

Profiling cellular morphodynamics by spatiotemporal spectrum decomposition.

Ma X; Dagliyan O; Hahn KM; Danuser G

Journal article: ACS SYNTHETIC BIOLOGY. 2017;6(7):1257-1262

Engineering Pak1 Allosteric Switches.

Dagliyan O; Karginov AV; Yagishita S; Gale ME; Wang H; DerMardirossian C; Wells CM; Dokholyan NV; Kasai H; Hahn KM

Journal article: SCIENCE. 2016;354(6318):1441-1444

Engineering extrinsic disorder to control protein activity in living cells.

Dagliyan O; Tarnawski M; Chu P-H; Shirvanyants D; Schlichting I; Dokholyan NV; Hahn KM

Journal article: NATURE CHEMICAL BIOLOGY. 2016;12(10):802-809

FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions.

Hodgson L; Spiering D; Sabouri-Ghomi M; Dagliyan O; DerMardirossian C; Danuser G; Hahn KM

Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(8):3682-3692

Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling.

Shobair M; Dagliyan O; Kota P; Dang YL; He H; Stutts MJ; Dokholyan NV

Journal article: JOURNAL OF MOLECULAR BIOLOGY. 2014;426(10):2082-2097

Intrinsic disorder mediates cooperative signal transduction in STIM1.

Furukawa Y; Teraguchi S; Ikegami T; Dagliyan O; Jin L; Hall D; Dokholyan NV; Namba K; Akira S; Kurosaki T; Baba Y; Standley DM

Journal article: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(2):104-115

Computational approaches to understanding protein aggregation in neurodegeneration.

Redler RL; Shirvanyants D; Dagliyan O; Ding F; Kim DN; Kota P; Proctor EA; Ramachandran S; Tandon A; Dokholyan NV

Journal article: BIOCHEMISTRY. 2013;52(40):7082-7090

Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.

Freeman TC; Black JL; Bray HG; Dagliyan O; Wu YI; Tripathy A; Dokholyan NV; Leisner TM; Parise LV

Journal article: CHEMISTRY AND BIOLOGY. 2013;20(6):847-856

Knowledge-based design of a biosensor to quantify localized ERK activation in living cells.

Kummer L; Hsu C-W; Dagliyan O; MacNevin C; Kaufholz M; Zimmermann B; Dokholyan NV; Hahn KM; Plückthun A

Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(17):6800-6804

Rational design of a ligand-controlled protein conformational switch.

Dagliyan O; Shirvanyants D; Karginov AV; Ding F; Fee L; Chandrasekaran SN; Freisinger CM; Smolen GA; Huttenlocher A; Hahn KM; Dokholyan NV

Journal article: PLOS ONE. 2012;7(2):e31787

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.

Çakir B; Dağliyan O; Dağyildiz E; Bariş İ; Kavakli IH; Kizilel S; Türkay M

Journal article: STRUCTURE. 2011;19(12):1837-1845

Structural and dynamic determinants of protein-peptide recognition.

Dagliyan O; Proctor EA; D'Auria KM; Ding F; Dokholyan NV

Journal article: PLOS ONE. 2011;6(2):e14579

Optimization based tumor classification from microarray gene expression data.

Dagliyan O; Uney-Yuksektepe F; Kavakli IH; Turkay M

Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2009;49(10):2403-2411

Classification of cytochrome P450 inhibitors with respect to binding free energy and pIC50 using common molecular descriptors.

Dagliyan O; Kavakli IH; Turkay M

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