Onur Dagliyan

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Vår forskargrupp är intresserad av de molekylära mekanismer genom vilka erfarenheter påverkar dynamiken i neuronala kretsar i mushjärnan. Vi studerar detta ämne genom att bygga nya molekylära teknologier som möjliggör visualisering och kontroll av proteinaktivitet in vivo.

Forskningsbeskrivning

synaptisk plasticitet, proteinteknik, optogenetik, biosensorer, inlärning och minne.

Undervisning

Jag undervisar i biokemi, neurobiologi, metabolism, DNA/RNA/proteinstruktur och dynamik.

Artiklar

Journal article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268
Ernest Arenas (1962-2024)
Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
Article: SCIENCE ADVANCES. 2023;9(46):eadh1110
Engineering memory with an extrinsically disordered kinase
Ripoli C; Dagliyan O; Renna P; Pastore F; Paciello F; Sollazzo R; Rinaudo M; Battistoni M; Martini S; Tramutola A; Sattin A; Barone E; Saneyoshi T; Fellin T; Hayashi Y; Grassi C
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(2):917
A Bioengineering Strategy to Control ADAM10 Activity in Living Cells
Pastore F; Battistoni M; Sollazzo R; Renna P; Paciello F; Li Puma DD; Barone E; Dagliyan O; Ripoli C; Grassi C
Journal article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2022;7(2):e10292
Engineering a switchable single-chain TEV protease to control protein maturation in living neurons
Renna P; Ripoli C; Dagliyan O; Pastore F; Rinaudo M; Re A; Paciello F; Grassi C
Article: NATURE COMMUNICATIONS. 2022;13(1):430
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
Cakir B; Tanaka Y; Kiral FR; Xiang Y; Dagliyan O; Wang J; Lee M; Greaney AM; Yang WS; DuBoulay C; Kural MH; Patterson B; Zhong M; Kim J; Bai Y; Min W; Niklason LE; Patra P; Park I-H
Article: CELL. 2021;184(22):5670-5685.e23
Biosensors based on peptide exposure show single molecule conformations in live cells
Liu B; Stone OJ; Pablo M; Herron JC; Nogueira AT; Dagliyan O; Grimm JB; Lavis LD; Elston TC; Hahn KM
Article: NATURE. 2021;590(7844):115-121
Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network.
Yap E-L; Pettit NL; Davis CP; Nagy MA; Harmin DA; Golden E; Dagliyan O; Lin C; Rudolph S; Sharma N; Griffith EC; Harvey CD; Greenberg ME
Article: NATURE METHODS. 2020;17(9):928-936
Rational design and implementation of a chemically inducible heterotrimerization system
Wu HD; Kikuchi M; Dagliyan O; Aragaki AK; Nakamura H; Dokholyan NV; Umehara T; Inoue T
Article: CELL REPORTS. 2020;31(11):107764
Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.
Ozkan-Dagliyan I; Diehl JN; George SD; Schaefer A; Papke B; Klotz-Noack K; Waters AM; Goodwin CM; Gautam P; Pierobon M; Peng S; Gilbert TSK; Lin KH; Dagliyan O; Wennerberg K; Petricoin EF; Tran NL; Bhagwat SV; Tiu RV; Peng S-B; Herring LE; Graves LM; Sers C; Wood KC; Cox AD; Der CJ
Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2019;57:17-22
Controlling protein conformation with light
Dagliyan O; Hahne KM
Article: NATURE PROTOCOLS. 2019;14(6):1863-1883
Engineering proteins for allosteric control by light or ligands
Dagliyan O; Dokholyan NV; Hahn KM
Article: NATURE COMMUNICATIONS. 2018;9(1):4042
Computational design of chemogenetic and optogenetic split proteins
Dagliyan O; Krokhotin A; Ozkan-Dagliyan I; Deiters A; Der CJ; Hahn KM; Dokholyan NV
Article: PLOS COMPUTATIONAL BIOLOGY. 2018;14(8):e1006321
Profiling cellular morphodynamics by spatiotemporal spectrum decomposition
Ma X; Dagliyan O; Hahn KM; Danuser G
Article: ACS SYNTHETIC BIOLOGY. 2017;6(7):1257-1262
Engineering Pak1 Allosteric Switches
Dagliyan O; Karginov AV; Yagishita S; Gale ME; Wang H; DerMardirossian C; Wells CM; Dokholyan NV; Kasai H; Hahn KM
Article: SCIENCE. 2016;354(6318):1441-1444
Engineering extrinsic disorder to control protein activity in living cells
Dagliyan O; Tarnawski M; Chu P-H; Shirvanyants D; Schlichting I; Dokholyan NV; Hahn KM
Article: NATURE CHEMICAL BIOLOGY. 2016;12(10):802-809
FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions
Hodgson L; Spiering D; Sabouri-Ghomi M; Dagliyan O; DerMardirossian C; Danuser G; Hahn KM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(8):3682-3692
Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling
Shobair M; Dagliyan O; Kota P; Dang YL; He H; Stutts MJ; Dokholyan NV
Article: JOURNAL OF MOLECULAR BIOLOGY. 2014;426(10):2082-2097
Intrinsic Disorder Mediates Cooperative Signal Transduction in STIM1
Furukawa Y; Teraguchi S; Ikegami T; Dagliyan O; Jin L; Hall D; Dokholyan NV; Namba K; Akira S; Kurosaki T; Baba Y; Standley DM
Article: BIOCHEMISTRY. 2013;52(40):7082-7090
Identification of Novel Integrin Binding Partners for Calcium and Integrin Binding Protein 1 (CIB1): Structural and Thermodynamic Basis of CIB1 Promiscuity
Freeman TCJ; Black JL; Bray HG; Dagliyan O; Wu YI; Tripathy A; Dokholyan NV; Leisner TM; Parise LV
Article: CHEMISTRY AND BIOLOGY. 2013;20(6):847-856
Knowledge-Based Design of a Biosensor to Quantify Localized ERK Activation in Living Cells
Kummer L; Hsu C-W; Dagliyan O; MacNevin C; Kaufholz M; Zimmermann B; Dokholyan NV; Hahn KM; Plueckthun A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(17):6800-6804
Rational design of a ligand-controlled protein conformational switch
Dagliyan O; Shirvanyants D; Karginov AV; Ding F; Fee L; Chandrasekaran SN; Freisinger CM; Smolen GA; Huttenlocher A; Hahn KM; Dokholyan NV
Article: PLOS ONE. 2012;7(2):e31787
Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme
Cakir B; Dagliyan O; Dagyildiz E; Baris I; Kavakli IH; Kizilel S; Turkay M
Article: STRUCTURE. 2011;19(12):1837-1845
Structural and Dynamic Determinants of Protein-Peptide Recognition
Dagliyan O; Proctor EA; D'Auria KM; Ding F; Dokholyan NV
Article: PLOS ONE. 2011;6(2):e14579
Optimization Based Tumor Classification from Microarray Gene Expression Data
Dagliyan O; Uney-Yuksektepe F; Kavakli IH; Turkay M
Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2009;49(10):2403-2411
Classification of Cytochrome P450 Inhibitors with Respect to Binding Free Energy and pIC₅₀ Using Common Molecular Descriptors
Dagliyan O; Kavakli IH; Turkay M
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Alla övriga publikationer

Dataset: 2016
Faculty Opinions recommendation of High-Throughput, High-Resolution Mapping of Protein Localization in Mammalian Brain by In Vivo Genome Editing.
Dokholyan N; Dagliyan O
Dataset: 2014
Faculty Opinions recommendation of Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes.
Dokholyan N; Dagliyan O
Dataset: 2014
Faculty Opinions recommendation of Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells.
Dokholyan N; Dagliyan O
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2014;6(2):104-115
Computational approaches to understanding protein aggregation in neurodegeneration
Redler RL; Shirvanyants D; Dagliyan O; Ding F; Kim DN; Kota P; Proctor EA; Ramachandran S; Tandon A; Dokholyan NV

Forskningsbidrag

Molecular mechanisms of excitatory-inhibitory balance in neuronal circuits
Swedish Research Council
1 January 2022 - 31 December 2025

Anställningar

Research Fellow, Neurobiology, Department of Neurobiology, Harvard Medical School, 2016-
Biträdande Lektor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2022-2028

Om mig

Forskningsbeskrivning

Undervisning

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Nyheter från KI

Kalenderhändelser från KI