Onur Dagliyan

Onur Dagliyan

Biträdande Lektor
E-postadress: onur.dagliyan@ki.se
Besöksadress: Solnavägen 9, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Dagliyan, 171 77 Stockholm

Om mig

  • Vår forskargrupp är intresserad av de molekylära mekanismer genom vilka erfarenheter påverkar dynamiken i neuronala kretsar i mushjärnan. Vi studerar detta ämne genom att bygga nya molekylära teknologier som möjliggör visualisering och kontroll av proteinaktivitet in vivo.

Forskningsbeskrivning

  • synaptisk plasticitet, proteinteknik, optogenetik, biosensorer, inlärning och minne.

Undervisning

  • Jag undervisar i biokemi, neurobiologi, metabolism, DNA/RNA/proteinstruktur och dynamik.

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2022 - 31 December 2025
    Upon the arrival of stimuli with new experiences, neuronal circuits regulate a large set of molecular adaptation programs at the DNA, RNA, and protein levels to store the necessary information and to perform computations. Many of these molecular events have been shown to be involved in the excitation of neuronal circuits responsible for a particular behavior, learning ability, and memory. However an activated neuronal circuit has to be balanced with inhibitory events, and the molecular mechanisms of such inhibition are mostly unknown. This excitatory-inhibitory balance is particularly important to develop innovative therapeutic approaches for brain disorders including epilepsy, depression, schizophrenia, autism, and learning disorders. The two-third of my research program here will unravel two molecular mechanisms by which the inhibitory arm of the excitatory-inhibitory balance is established. The last part of the research program will focus on the development of technologies that enable the building of causal links between the spatiotemporal role of a protein and neuronal circuits. Overall this research program will allow us to better understand sensory-experience dependent circuit modulations at the molecular level and will pave the way to develop new therapeutic approaches for brain disorders.

Anställningar

  • Research Fellow, Neurobiology, Department of Neurobiology, Harvard Medical School, 2016-
  • Biträdande Lektor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2022-2028

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