Molecular mapping of the nervous system in health and disease – Jan Mulder group

The Human Protein Atlas (HPA) is an international core data resource for biological data identified by Elixir (EU) and the Global Biodata Coalition. The mission of HPA is to profile the expression and distribution of all proteins in all major organs and tissues, and our research group has been involved in brain profiling efforts since 2004.

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Traditionally our research group has utilized HPA antibodies to map protein distribution in the human and rodent brain. During the recent years the focus has shifted toward transcriptomics analysis of the human brain and we have released a ‘bulk’ transcriptomics dataset covering nearly 200 regions of the human brain.

Currently the group is performing high resolution spatial transcriptomics analysis to get a detailed overview of the location of transcripts in tissue and cells, and is a founding member of the SpatioTemporal Omics Consortium (STOC) that aims to organize and advance global scientific efforts to create spatiotemporally-resolved cellular atlases of all living things.