Research
Research in the Bartek lab focuses on various mechanistic aspects of the DDR and DNA repair pathways. Of particular interest is discovery of targets and markers for personalized cancer treatment and finding novel components or mechanisms of genome integrity maintenance. Another of our long-term goals is to further unravel the principles of ribosome biogenesis surveillance and to understand the dynamics and the finer details of the p53 pathway in sensing ribosome dysfunction, and how ribosomal stress crosstalk with the DNA damage response.
Examples of projects currently running in the lab include: the search for new treatments and markers for malignant brain tumors with a focus on the nucleolus and ribosome biogenesis; characterization of proteins involved in the DNA damage response in particular in R loop formation and resolution; characterization of proteins involved in rRNA processing and mRNA translation; and the exploration of novel links between the nucleolus and the protein degradation machinery.
