Gunilla Karlsson Hedestam

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Populärvetenskap och samverkan

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För mer information se den engelska profilsidan

Utvalda publikationer

Article: CELL REPORTS MEDICINE. 2024;5(6):101577

Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies

Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Hedestam GBK; Hallberg BM
Journal article: CURRENT OPINION IN IMMUNOLOGY. 2024;87:102429

Adaptive immune receptor germline gene variation Martin M Corcoran and Gunilla B Karlsson Hedestam

Corcoran MM; Hedestam GBK
Article: NPJ VACCINES. 2024;9(1):58

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

Decamp AC; Corcoran MM; Fulp WJ; Willis JR; Cottrell CA; Bader DLV; Kalyuzhniy O; Leggat DJ; Cohen KW; Hyrien O; Menis S; Finak G; Ballweber-Fleming L; Srikanth A; Plyler JR; Rahaman F; Lombardo A; Philiponis V; Whaley RE; Seese A; Brand J; Ruppel AM; Hoyland W; Mahoney CR; Cagigi A; Taylor A; Brown DM; Ambrozak DR; Sincomb T; Mullen T-M; Maenza J; Kolokythas O; Khati N; Bethony J; Roederer M; Diemert D; Koup RA; Laufer DS; McElrath JM; McDermott AB; Hedestam GBK; Schief WR
Article: NATURE COMMUNICATIONS. 2023;14(1):2249

Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages

Chernyshev M; Sakharkar M; Connor RI; Dugan HL; Sheward DJ; Rappazzo CG; Stalmarck A; Forsell MNE; Wright PF; Corcoran M; Murrell B; Walker LM; Hedestam GKB
Article: IMMUNITY. 2023;56(3):635-652.e6

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

Corcoran M; Chernyshev M; Mandolesi M; Narang S; Kaduk M; Ye K; Sundling C; Farnert A; Kreslavsky T; Bernhardsson C; Larena M; Jakobsson M; Hedestam GBK
Article: IMMUNITY. 2023;56(1):193-206.e7

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
Article: IMMUNITY. 2022;55(12):2405-2418.e7

Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

Moin SM; Boyington JC; Boyoglu-Barnum S; Gillespie RA; Cerutti G; Cheung CS-F; Cagigi A; Gallagher JR; Brand J; Prabhakaran M; Tsybovsky Y; Stephens T; Fisher BE; Creanga A; Ataca S; Rawi R; Corbett KS; Crank MC; Hedestam GBK; Gorman J; McDermott AB; Harris AK; Zhou T; Kwong PD; Shapiro L; Mascola JR; Graham BS; Kanekiyo M
Article: SCIENCE. 2022;378(6623):eadd6502

Vaccination induces HIV broadly neutralizing antibody precursors in humans

Leggat DJ; Cohen KW; Willis JR; Fulp WJ; deCamp AC; Kalyuzhniy O; Cottrell CA; Menis S; Finak G; Ballweber-Fleming L; Srikanth A; Plyler JR; Schiffner T; Liguori A; Rahaman F; Lombardo A; Philiponis V; Whaley RE; Seese A; Brand J; Ruppel AM; Hoyland W; Yates NL; Williams LD; Greene K; Gao H; Mahoney CR; Corcoran MM; Cagigi A; Taylor A; Brown DM; Ambrozak DR; Sincomb T; Hu X; Tingle R; Georgeson E; Eskandarzadeh S; Alavi N; Lu D; Mullen T-M; Kubitz M; Groschel B; Maenza J; Kolokythas O; Khati N; Bethony J; Crotty S; Roederer M; Hedestam GBK; Tomaras GD; Montefiori D; Diemert D; Koup RA; Laufer DS; McElrath MJ; McDermott AB; Schief WR
Editorial comment: IMMUNITY. 2022;55(1):8-10

A family matter: Anti-viral antibody responses

Dopico XC; Hedestam GBK
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates

Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
Article: PLOS PATHOGENS. 2021;17(9):e1009543

Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

Aljedani SS; Liban TJ; Tran K; Phad G; Singh S; Dubrovskaya V; Pushparaj P; Martinez-Murillo P; Rodarte J; Mileant A; Prasad VM; Kinzelman R; O'Dell S; Mascola JR; Lee KK; Hedestam GBK; Wyatt RT; Pancera M
Editorial comment: NATURE METHODS. 2021;18(6):588-591

Diversity in immunogenomics: the value and the challenge

Peng K; Safonova Y; Shugay M; Popejoy AB; Rodriguez OL; Breden F; Brodin P; Burkhardt AM; Bustamante C; Cao-Lormeau V-M; Corcoran MM; Duffy D; Fuentes-Guajardo M; Fujita R; Greiff V; Jonsson VD; Liu X; Quintana-Murci L; Rossetti M; Xie J; Yaari G; Zhang W; Abedalthagafi MS; Adekoya KO; Ahmed RA; Chang W-C; Gray C; Nakamura Y; Lees WD; Khatri P; Alachkar H; Scheepers C; Watson CT; Karlsson Hedestam GB; Mangul S
Article: IMMUNITY. 2021;54(2):355-366.e4

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles

Bernat NV; Corcoran M; Nowak I; Kaduk M; Dopico XC; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Hedestam GBK
Article: CELL HOST & MICROBE. 2020;27(4):531-543.e6

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing

Shen C-H; DeKosky BJ; Guo Y; Xu K; Gu Y; Kilam D; Ko SH; Kong R; Liu K; Louder MK; Ou L; Zhang B; Chao CW; Corcoran MM; Feng E; Huang J; Normandin E; O'Dell S; Ransier A; Rawi R; Sastry M; Schmidt SD; Wang S; Wang Y; Chuang G-Y; Doria-Rose NA; Lin B; Zhou T; Boritz EA; Connors M; Douek DC; Hedestam GBK; Sheng Z; Shapiro L; Mascola JR; Kwong PD
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(2):e20191155

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses

Phad GE; Pushparaj P; Tran K; Dubrovskaya V; Adori M; Martinez-Murillo P; Bernat NV; Singh S; Dionne G; O'Dell S; Bhullar K; Narang S; Sorini C; Villablanca EJ; Sundling C; Murrell B; Mascola JR; Shapiro L; Pancera M; Martin M; Corcoran M; Wyatt RT; Hedestam GBK
Article: IMMUNITY. 2019;51(5):915-929.e7

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

Dubrovskaya V; Tran K; Ozorowski G; Guenaga J; Wilson R; Bale S; Cottrell CA; Turner HL; Seabright G; O'Dell S; Torres JL; Yang L; Feng Y; Leaman DP; Bernat NV; Liban T; Louder M; McKee K; Bailer RT; Movsesyan A; Doria-Rose NA; Pancera M; Hedestam GBK; Zwick MB; Crispin M; Mascola JR; Ward AB; Wyatt RT
Article: CELL. 2019;178(3):567-584.e19

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

Kong R; Duan H; Sheng Z; Xu K; Acharya P; Chen X; Cheng C; Dingens AS; Gorman J; Sastry M; Shen C-H; Zhang B; Zhou T; Chuang G-Y; Chao CW; Gu Y; Jafari AJ; Louder MK; O'Dell S; Rowshan AP; Viox EG; Wang Y; Choi CW; Corcoran MM; Corrigan AR; Dandey VP; Eng ET; Geng H; Foulds KE; Guo Y; Kwon YD; Lin B; Liu K; Mason RD; Nason MC; Ohr TY; Ou L; Rawi R; Sarfo EK; Schoen A; Todd JP; Wang S; Wei H; Wu W; Mullikin JC; Bailer RT; Doria-Rose NA; Hedestam GBK; Scorpio DG; Overbaugh J; Bloom JD; Carragher B; Potter CS; Shapiro L; Kwong PD; Mascola JR
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:660

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

Bernat NV; Corcoran M; Hardt U; Kaduk M; Phad GE; Martin M; Hedestam GBK
Article: IMMUNITY. 2017;46(5):804-817.e7

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

Martinez-Murillo P; Tran K; Guenaga J; Lindgren G; Adori M; Feng Y; Phad GE; Bernat NV; Bale S; Ingale J; Dubrovskaya V; O'Dell S; Pramanik L; Spangberg M; Corcoran M; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: NATURE COMMUNICATIONS. 2016;7:13642

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

Corcoran MM; Phad GE; Bernat NV; Stahl-Hennig C; Sumida N; Persson MAA; Martin M; Hedestam GBK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(39):E4119-E4126

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS

Pedersen GK; Adori M; Khoenkhoen S; Dosenovic P; Beutler B; Hedestam GBK
Article: PLOS PATHOGENS. 2014;10(8):e1004337

HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization

Navis M; Karen T; Bale S; Phad GE; Guenaga J; Wilson R; Soldemo M; McKee K; Sundling C; Mascola J; Li Y; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3637-3644

Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization

Sundling C; Zhang Z; Phad GE; Sheng Z; Wang Y; Mascola JR; Li Y; Wyatt RT; Shapiro L; Hedestam GBK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):E738-E747

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

Tran K; Poulsen C; Guenaga J; de Val N; Wilson R; Sundling C; Li Y; Stanfield RL; Wilson IA; Ward AB; Hedestam GBK; Wyatt RT
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(142):142ra96

High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site

Sundling C; Li Y; Huynh N; Poulsen C; Wilson R; O'Dell S; Feng Y; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(9):2003-2017

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates

Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Review: NATURE REVIEWS MICROBIOLOGY. 2008;6(2):143-155

The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.

Karlsson Hedestam GB; Fouchier RAM; Phogat S; Burton DR; Sodroski J; Wyatt RT
Visa fler

Artiklar

Article: NATURE COMMUNICATIONS. 2024;15(1):6338

Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

Mandolesi M; Das H; de Vries L; Yang Y; Kim C; Dhinakaran M; Castro Dopico X; Fischbach J; Kim S; Guryleva MV; Adori M; Chernyshev M; Stalmarck A; Hanke L; Mcinerney GM; Sheward DJ; Corcoran M; Haellberg BM; Murrell B; Karlsson Hedestam GB
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1508

Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque

Dopico XC; Guryleva M; Mandolesi M; Corcoran M; Coquet JM; Murrell B; Hedestam GBK
Article: IMMUNITY. 2023;56(10):2425-2441.e14

Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses

Ols S; Lenart K; Cerveira RA; Miranda MC; Brunette N; Kochmann J; Corcoran M; Skotheim R; Philomin A; Cagigi A; Fiala B; Wrenn S; Marcandalli J; Hellgren F; Thompson EA; Lin A; Gegenfurtner F; Kumar A; Chen M; Phad GE; Graham BS; Perez L; Borst AJ; Hedestam GBK; Ruckwardt TJ; King NP; Lore K
Article: JCI INSIGHT. 2023;8(17):e167656

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: IMMUNOLOGY LETTERS. 2023;259:24-29

Untangling associations between immunoglobulin genotypes, repertoires and function

Dopico XC; Mandolesi M; Hedestam GBK
Article: NATURE COMMUNICATIONS. 2023;14(1):3713

Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

Hellgren F; Cagigi A; Cerveira RA; Ols S; Kern T; Lin A; Eriksson B; Dodds MG; Jasny E; Schwendt K; Freuling C; Mueller T; Corcoran M; Hedestam GBK; Petsch B; Lore K
Article: IMMUNOINFORMATICS (AMST). 2023;10:100025

AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets.

Lees WD; Christley S; Peres A; Kos JT; Corrie B; Ralph D; Breden F; Cowell LG; Yaari G; Corcoran M; Karlsson Hedestam GB; Ohlin M; Collins AM; Watson CT; Busse CE; AIRR Community
Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2023;1524(1):65-86

Progress in vaccine development for infectious diseases-a Keystone Symposia report

Cable J; Graham BS; Koup RA; Seder RA; Kariko K; Pardi N; Barouch DH; Sharma B; Rauch S; Nachbagauer R; Forsell MNE; Schotsaert M; Ellebedy AH; Lore K; Irvine DJ; Pilkington E; Tahtinen S; Thompson EA; Feraoun Y; King NP; Saunders K; Alter G; Moin SM; Sliepen K; Karlsson Hedestam GB; Wardemann H; Pulendran B; Doria-Rose NA; He W-T; Juno JA; Ataca S; Wheatley AK; McLellan JS; Walker LM; Lederhofer J; Lindesmith LC; Wille H; Hotez PJ; Bekker L-G
Article: CELLS. 2023;12(9):1229

Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

Adori M; Khoenkhoen S; Zhang J; Dopico XC; Karlsson Hedestam GB
Article: EUROSURVEILLANCE. 2023;28(13):2200432

At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study

Bystrom JW; Vikstrom L; Rosendal E; Groning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Hedestam GBK; Thunberg T; Monsen T; Elgh F; Evander M; Johansson AF; Overby AK; Ahim C; Normark J; Forsell MNE
Article: FRONTIERS IN VIROLOGY. 2023;3:1128253

Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

Pushparaj P; Nicoletto A; Castro Dopico X; Sheward DJ; Kim S; Ekstrom S; Murrell B; Corcoran M; Karlsson Hedestam GB
Journal article: BIOPHYSICAL JOURNAL. 2023;122(3):541a-542a

Structural basis of antibodies targeting neutralizing epitopes revealed by cryoempem

Zhang S; Ozorowski G; Antanasijevic A; van Schooten J; Richey S; Copps J; Hedestam GK; Sanders RW; Ward A
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1073414

Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity

Hardt U; Corcoran MM; Narang S; Malmstrom V; Padyukov L; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1125884

Adaptive immune receptor genotyping using the corecount program

Narang S; Kaduk M; Chernyshev M; Hedestam GBKB; Corcoran MM
Article: NPJ VACCINES. 2022;7(1):152

Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

Reiss EIMM; van Haaren MM; van Schooten J; Claireaux MAF; Maisonnasse P; Antanasijevic A; Allen JD; Bontjer I; Torres JL; Lee W-H; Ozorowski G; Bernat NV; Kaduk M; Aldon Y; Burger JA; Chawla H; Aartse A; Tolazzi M; Gao H; Mundsperger P; Crispin M; Montefiori DC; Hedestam GBK; Scarlatti G; Ward AB; Le Grand R; Shattock R; Dereuddre-Bosquet N; Sanders RW; van Gils MJ
Article: SCIENTIFIC REPORTS. 2022;12(1):11876

Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

Hardt U; Carlberg K; af Klint E; Sahlstrom P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Stahl PL; Malmstrom V
Article: LANCET INFECTIOUS DISEASES. 2022;22(6):813-820

Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study

Sheward DJ; Kim C; Ehling RA; Pankow A; Dopico XC; Dyrdak R; Martin DP; Reddy ST; Dillner J; Hedestam GBK; Albert J; Murrell B
Article: CELLULAR IMMUNOLOGY. 2022;375:104516

Impaired plasma cell differentiation associates with increased oxidative metabolism in I?BNS-deficient B cells

Erikson E; Adori M; Khoenkhoen S; Zhang J; Rorbach J; Dopico XC; Hedestam GK
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(6):965-970

Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms

Cunningham JL; Virhammar J; Ronnberg B; Dopico XC; Kolstad L; Albinsson B; Kumlien E; Naas A; Klang A; Westman G; Zetterberg H; Frithiof R; Lundkvist A; Hedestam GBK; Rostami E
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1026951

Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies

Aartse A; Mortier D; Mooij P; Hofman S; van Haaren MM; Corcoran M; Karlsson Hedestam GB; Eggink D; Claireaux M; Bogers WMJM; van Gils MJ; Koopman G
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1000755

IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens

Khoenkhoen S; Adori M; Solis-Sayago D; Soulier J; Russell J; Beutler B; Pedersen GK; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:818440

Addressing IGHV Gene Structural Diversity Enhances Immunoglobulin Repertoire Analysis: Lessons From Rhesus Macaque

Kaduk M; Corcoran M; Hedestam GBK
Article: CELL REPORTS MEDICINE. 2021;2(11):100450

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models

Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden

Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2021;2(4):100252

SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses

Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: JOURNAL OF IMMUNOLOGY. 2021;206(5):999-1012

Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor

Spencer DA; Malherbe DC; Bernat NV; Adori M; Goldberg B; Dambrauskas N; Henderson H; Pandey S; Cheever T; Barnette P; Sutton WF; Ackerman ME; Kobie JJ; Sather DN; Hedestam GBK; Haigwood NL; Hessell AJ
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(2):445-458

Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine

Valeri V; Tonon S; Vibhushan S; Gulino A; Belmonte B; Adori M; Karlsson Hedestam GB; Gautier G; Tripodo C; Blank U; Mion F; Pucillo CEM
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243

GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens

Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:815680

VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques

Chernyshev M; Kaduk M; Corcoran M; Hedestam GBK
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312

Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay

Hober S; Hellstrom C; Olofsson J; Andersson E; Bergstrom S; Jernbom Falk A; Bayati S; Mravinacova S; Sjoberg R; Yousef J; Skoglund L; Kanje S; Berling A; Svensson A-S; Jensen G; Enstedt H; Afshari D; Xu LL; Zwahlen M; von Feilitzen K; Hanke L; Murrell B; McInerney G; Karlsson Hedestam GB; Lendel C; Roth RG; Skoog I; Svenungsson E; Olsson T; Fogdell-Hahn A; Lindroth Y; Lundgren M; Maleki KT; Lagerqvist N; Klingstrom J; Da Silva Rodrigues R; Muschiol S; Bogdanovic G; Arroyo Muhr LS; Eklund C; Lagheden C; Dillner J; Sivertsson A; Havervall S; Thalin C; Tegel H; Pin E; Manberg A; Hedhammar M; Nilsson P
Article: EBIOMEDICINE. 2021;63:103197

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice

Worzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GBK; Murrell B; Christensen D; Pedersen GK
Article: NATURE COMMUNICATIONS. 2020;11(1):4420

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
Article: CELL REPORTS. 2020;30(12):3964-3971.e7

Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity

Ols S; Yang L; Thompson EA; Pushparaj P; Tran K; Liang F; Lin A; Eriksson B; Hedestam GBK; Wyatt RT; Lore K
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:571321

Flow Cytometry-Based Protocols for the Analysis of Human Plasma Cell Differentiation

Khoenkhoen S; Adori M; Pedersen GK; Hedestam GBK
Journal article: JOURNAL OF IMMUNOLOGY. 2019;202(1_Supplement):72.9

Characterization of heterologous HIV-1 Tier 2 neutralizing mAbs cloned from a macaque immunized with viral quasispecies present in a human subject with neutralization breadth

Spencer DA; Malherbe DC; Henderson H; Pandy S; Bernat NV; Àdori M; Goldberg B; Dambrauskas N; Sutton W; Sather N; Kobie J; Ackerman ME; Karlsson Hedestam GB; Haigwood NL; Hessell AJ
Article: IMMUNOLOGY AND CELL BIOLOGY. 2019;97(5):485-497

TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS

Khoenkhoen S; Erikson E; Adori M; Stark JM; Scholz JL; Cancro MP; Pedersen GK; Hedestam GBK
Article: JCI INSIGHT. 2018;3(5):97018

Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site

Cheng HD; Grimm SK; Gilman MSA; Gwom LC; Sok D; Sundling C; Donofrio G; Hedestam GBK; Bonsignori M; Haynes BF; Lahey TP; Maro I; von Reyn CF; Gorny MK; Zolla-Pazner S; Walker BD; Alter G; Burton DR; Robb ML; Krebs SJ; Seaman MS; Bailey-Kellogg C; Ackerman ME
Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787

Altered Marginal Zone B Cell Selection in the Absence of IκBNS

Adori M; Pedersen GK; Adori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1738

B-1a cell Development in splenectomized neonatal Mice

Pedersen GK; Li X; Khoenkhoen S; Adori M; Beutler B; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2017;91(21):e00910-e00917

HIV-1 Cross-Reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Nonhuman Primates

Wang Y; O'Dell S; Turner HL; Chiang C-I; Lei L; Guenaga J; Wilson R; Martinez-Murillo P; Doria-Rose N; Ward AB; Mascola JR; Wyatt RT; Hedestam GBK; Li Y
Article: PLOS PATHOGENS. 2017;13(9):e1006614

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

Dubrovskaya V; Guenaga J; de Val N; Wilson R; Feng Y; Movsesyan A; Hedestam GBK; Ward AB; Wyatt RT
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196

PPAR-γ promotes type 2 immune responses in allergy and nematode infection

Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1654

Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

Soldemo M; Adori M; Stark JM; Feng Y; Tran K; Wilson R; Yang L; Guenaga J; Wyatt RT; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2016;90(10):5031-5046

Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds

Madani N; Princiotto AM; Easterhoff D; Bradley T; Luo K; Williams WB; Liao H-X; Moody MA; Phad GE; Bernat NV; Melillo B; Santra S; Smith ABIII; Hedestam GBK; Haynes B; Sodroski J
Article: JOURNAL OF IMMUNOLOGY. 2016;196(9):3729-3743

High-Resolution Longitudinal Study of HIV-1 Env Vaccine-Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence

Wang Y; Sundling C; Wilson R; O'Dell S; Chen Y; Dai K; Phad GE; Zhu J; Xiao Y; Mascola JR; Hedestam GBK; Wyatt RT; Li Y
Article: SCIENTIFIC REPORTS. 2016;6:20987

HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

Dai K; Khan SN; Wang Y; He L; Guenaga J; Ingale J; Sundling C; O'Dell S; McKee K; Phad G; Corcoran M; Wilson R; Mascola JR; Zhu J; Li Y; Hedestam GBK; Wyatt RT
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:242-10

CD138 and CD31 Double-Positive Cells Comprise the Functional Antibody-Secreting Plasma Cell compartment in Primate Bone Marrow

Martinez-Murillo P; Pramanik L; Sundling C; Hultenby K; Wretenberg P; Spangberg M; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:65

Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens

Pedersen GK; Adori M; Stark JM; Khoenkhoen S; Arnold C; Beutler B; Hedestam GBK
Article: MBIO. 2015;6(6):e01375-e01315

Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis

Dai K; He L; Khan SN; O'Dell S; McKee K; Tran K; Li Y; Sundling C; Morris CD; Mascola JR; Hedestam GBK; Wyatt RT; Zhu J
Article: IMMUNITY. 2015;43(2):318-330

Interleukin-21-Producing CD4⁺ T Cells Promote Type 2 Immunity to House Dust Mites

Coquet JM; Schuijs MJ; Smyth MJ; Deswarte K; Beyaert R; Braun H; Boon L; Hedestam GBK; Nutt SL; Hammad H; Lambrecht BN
Article: JOURNAL OF IMMUNOLOGY. 2015;194(12):5903-5914

Diverse Antibody Genetic and Recognition Properties Revealed following HIV-1 Envelope Glycoprotein Immunization

Phad GE; Bernat NV; Feng Y; Ingale J; Murillo PAM; O'Dell S; Li Y; Mascola JR; Sundling C; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4422-4430

Protection of Human Myeloid Dendritic Cell Subsets against Influenza A Virus Infection Is Differentially Regulated upon TLR Stimulation

Baharom F; Thomas S; Bieder A; Hellmer M; Volz J; Sandgren KJ; McInerney GM; Hedestam GBK; Mellman I; Smed-Sorensen A
Article: SCIENTIFIC REPORTS. 2015;5:8925

Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation

Martinez P; Sundling C; O'Dell S; Mascola JR; Wyatt RT; Hedestam GBK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(5):E440-E449

Real-time resolution of point mutations that cause phenovariance in mice

Wang T; Zhan X; Bu C-H; Lyon S; Pratt D; Hildebrand S; Choi JH; Zhang Z; Zeng M; Wang K-W; Turer E; Chen Z; Zhang D; Yue T; Wang Y; Shi H; Wang J; Sun L; SoRelle J; McAlpine W; Hutchins N; Zhan X; Fina M; Gobert R; Quan J; Kreutzer M; Arnett S; Hawkins K; Leach A; Tate C; Daniel C; Reyna C; Prince L; Davis S; Purrington J; Bearden R; Weatherly J; White D; Russell J; Sun Q; Tang M; Li X; Scott L; Moresco EMY; McInerney GM; Hedestam GBK; Xie Y; Beutler B
Article: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(2):136-146

Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation

Dosenovic P; Adori M; Adams WC; Pedersen GK; Soldemo M; Beutler B; Hedestam GBK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(12):2361-2372

Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants

Klein F; Nogueira L; Nishimura Y; Phad G; West APJ; Halper-Stromberg A; Horwitz JA; Gazumyan A; Liu C; Eisenreich TR; Lehmann C; Faetkenheuer G; Williams C; Shingai M; Martin MA; Bjorkman PJ; Seaman MS; Zolla-Pazner S; Hedestam GBK; Nussenzweig MC
Article: VIRUSES-BASEL. 2014;6(9):3400-3414

HIV-1 Env-Specific Memory and Germinal Center B Cells in C57BL/6 Mice

Soldemo M; Pedersen GK; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2014;408:137-141

A simple and safe technique for longitudinal bone marrow aspiration in cynomolgus and rhesus macaques

Spangberg M; Martinez P; Fredlund H; Hedestam GBK; Sundling C
Article: JOURNAL OF VIROLOGY. 2013;87(24):13239-13251

Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates

Chakrabarti BK; Feng Y; Sharma SK; McKee K; Hedestam GBK; LaBranche CC; Montefiori DC; Mascola JR; Wyatt RT
Article: VIROLOGY. 2013;446(1-2):56-65

Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants

Feng Y; Forsell MNE; Flynn B; Adams W; Lore K; Seder R; Wyatt RT; Hedestam GBK
Article: CELLULAR MICROBIOLOGY. 2013;15(8):1385-1400

Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae

Kuri T; Sorensen AS; Thomas S; Hedestam GBK; Normark S; Henriques-Normark B; McInerney GM; Plant L
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51

Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization

Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):60-69

Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation

Sandgren KJ; Smed-Sorensen A; Forsell MN; Soldemo M; Adams WC; Liang F; Perbeck L; Koup RA; Wyatt RT; Hedestam GBK; Lore K
Article: JOURNAL OF INFECTIOUS DISEASES. 2013;207(3):426-431

Immunization of Macaques With Soluble HIV Type 1 and Influenza Virus Envelope Glycoproteins Results in a Similarly Rapid Contraction of Peripheral B-Cell Responses After Boosting

Sundling C; Martinez P; Soldemo M; Spangberg M; Bengtsson KL; Stertman L; Forsell MNE; Hedestam GBK
Article: MOLECULAR BIOLOGY OF THE CELL. 2012;23(24):4701-4712

Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection

Panas MD; Varjak M; Lulla A; Eng KE; Merits A; Hedestam GBK; McInerney GM
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;386(1-2):85-93

Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells

Sundling C; Phad G; Douagi I; Navis M; Hedestam GBK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(31):12286-12293

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

Arnold CN; Pirie E; Dosenovic P; McInerney GM; Xia Y; Wang N; Li X; Siggs OM; Hedestam GBK; Beutler B
Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026

BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses

Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Hedestam GBK
Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 6):1339-1344

Attenuation of CD4⁺ T-cell function by human adenovirus type 35 is mediated by the knob protein

Adams WC; Berenson RJ; Hedestam GBK; Lieber A; Koup RA; Lore K
Article: JOURNAL OF VIROLOGY. 2012;86(10):5674-5685

Accumulation of Autophagosomes in Semliki Forest Virus-Infected Cells Is Dependent on Expression of the Viral Glycoproteins

Eng KE; Panas MD; Murphy D; Hedestam GBK; McInerney GM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(8):5673-5686

Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site

Feng Y; Mckee K; Tran K; O'Dell S; Schmidt SD; Phogat A; Forsell MN; Hedestam GBK; Mascola JR; Wyatt RT
Article: IMMUNOLOGY. 2011;134(3):257-269

Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation

Gujer C; Sundling C; Seder RA; Hedestam GBK; Lore K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(18):7499-7504

Adenovirus type-35 vectors block human CD4⁺ T-cell activation via CD46 ligation

Adams WC; Gujer C; McInerney G; Gall JGD; Petrovas C; Hedestam GBK; Koup RA; Lore K
Article: PLOS ONE. 2011;6(1):e16074

Heterologous Epitope-Scaffold Prime:Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

Guenaga J; Dosenovic P; Ofek G; Baker D; Schief WR; Kwong PD; Hedestam GBK; Wyatt RT
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;89(6):811-821

IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation

Gujer C; Sandgren KJ; Douagi I; Adams WC; Sundling C; Smed-Sorensen A; Seder RA; Hedestam GBK; Lore K
Article: JOURNAL OF VIROLOGY. 2010;84(18):9086-9095

Immunization with Wild-Type or CD4-Binding-Defective HIV-1 Env Trimers Reduces Viremia Equivalently following Heterologous Challenge with Simian-Human Immunodeficiency Virus

Sundling C; O'Dell S; Douagi I; Forsell MN; Morner A; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: AUTOPHAGY. 2010;6(5):634-641

A novel quantitative flow cytometry-based assay for autophagy

Eng KE; Panas MD; Hedestam GBK; McInerney GM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(7):3046-3051

A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα

Siggs OM; Berger M; Krebs P; Arnold CN; Eidenschenk C; Huber C; Pirie E; Smart NG; Khovananth K; Xia Y; McInerney G; Hedestam GBK; Nemazee D; Beutler B
Article: JOURNAL OF VIROLOGY. 2010;84(4):1683-1695

Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates

Douagi I; Forsell MNE; Sundling C; O'Dell S; Feng Y; Dosenovic P; Li Y; Seder R; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2009;183(5):3373-3382

Selective Expansion of HIV-1 Envelope Glycoprotein-Specific B Cell Subsets Recognizing Distinct Structural Elements Following Immunization

Dosenovic P; Chakrabarti B; Soldemo M; Douagi I; Forsell MNE; Li Y; Phogat A; Paulie S; Hoxie J; Wyatt RT; Hedestam GBK
Article: CURRENT OPINION IN HIV AND AIDS. 2009;4(5):441-446

Novel adjuvants for B cell immune responses

Lore K; Hedestam GBK
Article: JOURNAL OF GENERAL VIROLOGY. 2009;90(Pt 7):1600-1610

Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN

Adams WC; Bond E; Havenga MJE; Holterman L; Goudsmit J; Hedestam GBK; Koup RA; Lore K
Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):1991-2001

Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Hedestam GBK; Lore K
Article: JOURNAL OF VIROLOGY. 2009;83(2):540-551

Human Immunodeficiency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein

Moerner A; Douagi I; Forsell MNE; Sundling C; Dosenovic P; O'Dell S; Dey B; Kwong PD; Voss G; Thorstensson R; Mascola JR; Wyatt RT; Hedestam GBK
Article: JOURNAL OF GENERAL VIROLOGY. 2008;89(Pt 12):2954-2964

CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization

Sundling C; Schon K; Morner A; Forsell MNE; Wyatt RT; Thorstensson R; Hedestam GBK; Lycke NY
Article: PLOS PATHOGENS. 2008;4(10):e1000171

B Cell Recognition of the Conserved HIV-1 Co-Receptor Binding Site Is Altered by Endogenous Primate CD4

Forsell MNE; Dey B; Moerner A; Svehla K; O'dell S; Hoegerkorp C-M; Voss G; Thorstensson R; Shaw GM; Mascola JR; Hedestam GBK; Wyatt RT
Article: JOURNAL OF GENERAL VIROLOGY. 2007;88(Pt 10):2774-2779

Increased human immunodeficiency virus type 1 Env expression and antibody induction using an enhanced alphavirus vector

Forsell MNE; McInerney GM; Dosenovic P; Hidmark AS; Eriksson C; Liljestorm P; Grundner C; Hedestam GBK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;372(1):150-159

Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP

Hogbom M; Collins R; van den Berg S; Jenvert R-M; Karlberg T; Kotenyova T; Flores A; Hedestam GBK; Schiavone LH
Article: JOURNAL OF VIROLOGY. 2007;81(16):8677-8684

Semliki forest virus nonstructural protein 2 is involved in suppression of the type I interferon response

Breakwell L; Dosenovic P; Hedestam GBK; D'Amato M; Liljestrom P; Fazakerley J; McInerney GM
Article: JOURNAL OF VIROLOGY. 2007;81(6):2758-2768

Role of interferon regulatory factor 3 in type I interferon responses in rotavirus-infected dendritic cells and fibroblasts

Douagi I; McInerney GA; Hidmark AS; Miriallis V; Johansen K; Svensson L; Hedestam GBK
Article: JOURNAL OF IMMUNOLOGY. 2006;177(5):2908-2916

DAP12 signalling regulates plasmacytoid ddendritic cell homeostasis and down-modulates their function during viral infection

Sjolin H; Robbins SH; Bessou G; Hidmark A; Tomasello E; Johansson M; Hall H; Charifi F; Hedestam GBK; Biron CA; Karre K; Hoglund P; Vivier E; Dalod M
Article: JOURNAL OF VIROLOGY. 2006;80(14):7100-7110

Humoral responses against coimmunized protein antigen but not against alphavirus-encoded antigens require alpha/beta interferon signaling

Hidmark AS; Nordstrom EKL; Dosenovic P; Forsell MNE; Liljestrom P; Hedestam GBK
Article: VIROLOGY. 2005;341(2):190-202

Efficient expansion of HIV-1-specific T cell responses by homologous immunization with recombinant Semliki Forest virus particles

Sundbäck M; Douagi I; Dayaraj C; Forsell MNE; Nordström EKL; McInerney GM; Spångberg K; Tjäder L; Bonin E; Sundström M; Liljeström P; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2005;79(17):10902-10914

Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by Semliki Forest virus

Forsell MNE; Li YX; Sundbäck M; Svehla K; Liljeström P; Mascola JR; Wyatt R; Hedestam GBK
Article: JOURNAL OF VIROLOGY. 2005;79(16):10376-10385

Early alpha/beta interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88

Hidmark Å; McInerney GM; Nordström EKL; Douagi I; Werner KM; Liljeström P; Hedestam GBK
Article: JOURNAL OF GENERAL VIROLOGY. 2005;86(Pt 2):349-354

Enhanced immunogenicity using an alphavirus replicon DNA vaccine against human immunodeficiency virus type 1

Nordström EKL; Forsell MNE; Barnfield C; Bonin E; Hanke T; Sundström M; Karlsson GB; Liljeström P
Article: BRITISH JOURNAL OF CANCER. 2004;91(8):1488-1494

Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level

Karlsson GB; Jensen A; Stevenson LF; Woods YL; Lane DP; Sorensen MS
Article: METHODS IN MOLECULAR BIOLOGY. 2004;246:543-557

Delivery and expression of heterologous genes in mammalian cells using self-replicating alphavirus vectors.

Karlsson GB; Liljeström P
Article: METHODS IN MOLECULAR MEDICINE. 2003;87:69-82

Live viral vectors: Semliki Forest virus.

Karlsson GB; Liljeström P
Article: JOURNAL OF VIROLOGY. 1999;73(10):8873-8879

Determinants of neutralization resistance in the envelope glycoproteins of a simian-human immunodeficiency virus passaged in vivo.

Etemad-Moghadam B; Sun Y; Nicholson EK; Karlsson GB; Schenten D; Sodroski J
Article: JOURNAL OF VIROLOGY. 1999;73(7):5373-5380

Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells.

Schenten D; Marcon L; Karlsson GB; Parolin C; Kodama T; Gerard N; Sodroski J
Article: VIROLOGY. 1999;256(1):15-21

Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses.

Reimann KA; Watson A; Dailey PJ; Lin W; Lord CI; Steenbeke TD; Parker RA; Axthelm MK; Karlsson GB
Article: JOURNAL OF VIROLOGY. 1999;73(2):976-984

Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2).

Cayabyab M; Karlsson GB; Etemad-Moghadam BA; Hofmann W; Steenbeke T; Halloran M; Fanton JW; Axthelm MK; Letvin NL; Sodroski JG
Article: JOURNAL OF VIROLOGY. 1998;72(10):8437-8445

Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys.

Etemad-Moghadam B; Karlsson GB; Halloran M; Sun Y; Schenten D; Fernandes M; Letvin NL; Sodroski J
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1998;188(6):1159-1171

The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.

Karlsson GB; Halloran M; Schenten D; Lee J; Racz P; Tenner-Racz K; Manola J; Gelman R; Etemad-Moghadam B; Desjardins E; Wyatt R; Gerard NP; Marcon L; Margolin D; Fanton J; Axthelm MK; Letvin NL; Sodroski J
Article: JOURNAL OF VIROLOGY. 1997;71(11):8582-8591

Immunoglobulin V(H) usage during primary infection of rhesus monkeys with chimeric simian-human immunodeficiency viruses.

Margolin DH; Reimann KA; Sodroski J; Karlsson GB; Tenner-Racz K; Racz P; Letvin NL
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1997;186(3):405-411

Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.

Farzan M; Choe H; Martin K; Marcon L; Hofmann W; Karlsson G; Sun Y; Barrett P; Marchand N; Sullivan N; Gerard N; Gerard C; Sodroski J
Article: JOURNAL OF VIROLOGY. 1997;71(6):4218-4225

Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.

Karlsson GB; Halloran M; Li J; Park IW; Gomila R; Reimann KA; Axthelm MK; Iliff SA; Letvin NL; Sodroski J
Article: JOURNAL OF VIROLOGY. 1996;70(10):7153-7160

N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with impaired gp120 shedding and gp41 exposure.

Fischer PB; Karlsson GB; Dwek RA; Platt FM
Article: JOURNAL OF VIROLOGY. 1996;70(10):7143-7152

N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120.

Fischer PB; Karlsson GB; Butters TD; Dwek RA; Platt FM
Article: JOURNAL OF VIROLOGY. 1996;70(10):6922-6928

A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.

Reimann KA; Li JT; Veazey R; Halloran M; Park IW; Karlsson GB; Sodroski J; Letvin NL
Article: JOURNAL OF VIROLOGY. 1996;70(9):6136-6142

Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses.

Karlsson GB; Gao F; Robinson J; Hahn B; Sodroski J
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Coleman S; Nicholls K; Nicholls K; Dopico XC; Karlsson Hedestam G; Kirk PDW; Wallace C
Preprint: BIORXIV. 2022

Structural basis of Omicron neutralization by affinity-matured public antibodies

Sheward D; Pushparaj P; Das H; Kim C; Kim S; Hanke L; Dyrdak R; McInerney G; Albert J; Murrell B; Karlsson Hedestam G; Hällberg M
Review: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):32-50

Immunity to SARS-CoV-2 induced by infection or vaccination

Castro Dopico X; Ols S; Lore K; Karlsson Hedestam GB
Preprint: BIORXIV. 2021

Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

Sheward D; Kim C; Ehling R; Pankow A; Dopico XC; Martin D; Reddy S; Dillner J; Karlsson Hedestam G; Albert J; Murrell B
Preprint: MEDRXIV. 2021

Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
Preprint: MEDRXIV. 2021

Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis

Hardt U; Carlberg K; Klint EA; Sahlström P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Ståhl PL; Malmström V
Preprint: BIORXIV. 2021

Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

Aljedani SS; Liban TJ; Tran K; Phad G; Singh S; Dubrovskaya V; Pushparaj P; Martinez-Murillo P; Rodarte J; Mileant A; Prasad VM; Kinzelman R; O’Dell S; Mascola JR; Lee KK; Hedestam GBK; Wyatt RT; Pancera M
Preprint: BIORXIV. 2020

SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
Preprint: MEDRXIV. 2020

Probabilistic approaches for classifying highly variable anti-SARS-CoV-2 antibody responses

Dopico X; Hanke L; Sheward D; Muschiol S; Aleman S; Grinberg N; Adori M; Christian M; Vidakovics LP; Kim C; Khoenkhoen S; Pushparaj P; Morro AM; Mandolesi M; Ahl M; Forsell M; Coquet J; Corcoran M; Rorbach J; Dillner J; Bogdanovic G; McInerney G; Allander T; Murrell B; Wallace C; Albert J; Karlsson Hedestam G
Preprint: SSRN. 2020

Adjuvanted SARS-CoV-2 Spike Protein Elicits Neutralizing Antibodies and CD4 T Cell Responses after a Single Immunization in Mice

Wørzner K; Sheward D; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GK; Murrel B; Christensen D; Pedersen G
Preprint: SSRN ELECTRONIC JOURNAL. 2020

Rhesus and Cynomolgus IGH Genotyping Yields Comprehensive Databases of Germline VDJ Alleles for In-Depth Immunological Studies

Bernat NV; Corcoran M; Nowak I; Kaduk M; Dopico XC; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Hedestam GBK
Conference publication: JOURNAL OF MEDICAL PRIMATOLOGY. 2019;48(5):301

Native HIV-1 Env circulating during the development of breadth in human subjects elicits Tier 2 heterologous neutralizing monoclonal antibodies in macaques

Spencer D; Malherbe D; Henderson H; Pandey S; Adori M; Bernat N; Kobie J; Karlsson-Hedestam G; Haigwood N; Hessell A
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2018;34:37

Native HIV-1 Env Circulating During the Development of Breadth in Human Subjects Elicits Tier 2 Heterologous Neutralizing Monoclonal Antibodies in NHP

Hessell A; Malherbe D; Henderson H; Pandey S; Adori M; Vazquez N; Kobie J; Karlsson-Hedestam G; Haigwood N
Review: FRONTIERS IN IMMUNOLOGY. 2017;8:1057

Env-Specific Antibodies in Chronic Infection versus in Vaccination

Soldemo M; Hedestam GBK
Review: IMMUNOLOGICAL REVIEWS. 2017;275(1):183-202

Evolution of B cell analysis and Env trimer redesign

Hedestam GBK; Guenaga J; Corcoran M; Wyatt RT
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2015;1362:39-47

NF-κB signaling in B-1 cell development

Pedersen GK; Adori M; Hedestam GBK
Corrigendum: JOURNAL OF VIROLOGY. 2015;89(1):887

Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates (vol 87, pg 13239, 2013)

Chakrabarti BK; Feng Y; Sharma SK; Mckee K; Hedestam GBK; LaBranche CC; Montefiori DC; Mascola JR; Wyatt RT
Conference publication: JOURNAL OF IMMUNOLOGY. 2014;192:131.5

Potentially neutralizing B cell clonotypes are eliminated at peripheral selection checkpoints

Scholz J; Soldemo M; Dosenovic P; Naradikiani M; Zhou L; Wilson R; Wyatt R; Lackner A; Hedestam GK; Cancro M
Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(10):2283

Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates (vol 207, pg 2003, 2010)

Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
Meeting abstract: RETROVIROLOGY. 2009;6:p178

Analysis of antibody and B cell responses following inoculation with computationally designed HIV-1 2F5 epitope scaffold proteins

Dosenovic P; Guenaga J; Ofek G; Baker D; Schief W; Kwong PD; Hedestam GBK; Wyatt RT
Review: JOURNAL OF INNATE IMMUNITY. 2009;1(6):599-606

Direct cleavage, proteasomal degradation and sequestration: three mechanisms of viral subversion of type I interferon responses.

McInerney GM; Karlsson Hedestam GB
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):238

Human B cell responses to toll-like receptor ligands are differentially modulated by myloid and plasmacytoid dendritic cells

Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Karlsson-Hedestam G; Lore K
Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2007;262(1):26-43

Inhibition of HIV-1 entry by antibodies: potential viral and cellular targets.

Phogat S; Wyatt RT; Karlsson Hedestam GB
Review: HUMAN GENE THERAPY. 2006;17(11):1051-1061

DNA vaccines: Recent developments and future possibilities

Liu MA; Wahren B; Hedestam GBK
Corrigendum: JOURNAL OF IMMUNOLOGY. 2006;177(8):5748

DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection (vol 177, pg 2908, 2006)

Sjolin H; Robbins SH; Bessou G; Hidmark A; Tomasello E; Johansson M; Hall H; Charifi F; Hedestam GBK; Biron CA; Karre K; Hoglund P; Vivier E; Dalod M
Review: JOURNAL OF VIROLOGY. 1996;70(3):1651-1667

Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization.

Gao F; Morrison SG; Robertson DL; Thornton CL; Craig S; Karlsson G; Sodroski J; Morgado M; Galvao-Castro B; von Briesen H; Beddows S; Weber J; Sharp PM; Shaw GM; Hahn BH
Other: JOURNAL OF VIROLOGY. 1995;69(9):5791-5797

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding.

Fischer PB; Collin M; Karlsson GB; James W; Butters TD; Davis SJ; Gordon S; Dwek RA; Platt FM
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