Kaisa Lehti

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: CANCER IMMUNOLOGY RESEARCH. 2025
Adaptive NK Cells Exhibit Tumor-Specific Immune Memory and Cytotoxicity in Ovarian Cancer.
Sun Y; Rodgers Furones A; Gultekin O; Khare S; Neo SY; Shi W; Moyano-Galceran L; Lam K-P; Dasgupta R; Fuxe J; Salehi S; Lehti K; Sarhan D
Article: MOLECULAR ONCOLOGY. 2024;18(4):850-865
MMP14 expression and collagen remodelling support uterine leiomyosarcoma aggressiveness
Gonzalez-Molina J; Hahn P; Falcao RM; Gultekin O; Kokaraki G; Zanfagnin V; Braz Petta T; Lehti K; Carlson JWW
Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(10):e2303481
Attenuating Epithelial-to-Mesenchymal Transition in Cancer through Angiopoietin-Like 4 Inhibition in a 3D Tumor Microenvironment Model
Liao Z; Lim JJH; Lee JXT; Chua D; Vos MIG; Yip YS; Too CB; Cao H; Wang JK; Shou Y; Tay A; Lehti K; Cheng HS; Tay CY; Tan NS
Article: MOLECULAR CANCER THERAPEUTICS. 2023;22(11):1319-1331
Efficacy and Safety of Glycosphingolipid SSEA-4 Targeting CAR-T Cells in an Ovarian Carcinoma Model
Monzo HJ; Kalander K; Hyytiainen MM; Elbasani E; Wall J; Moyano-Galceran L; Tanjore Ramanathan J; Jukonen J; Laakkonen P; Ristimaki A; Carlson JW; Lehti K; Salehi S; Puolakkainen P; Haglund C; Seppanen H; Leppa S; Ojala PM
Article: NPJ PRECISION ONCOLOGY. 2023;7(1):111
The drug efficacy testing in 3D cultures platform identifies effective drugs for ovarian cancer patients
Akerlund E; Gudoityte G; Moussaud-Lamodiere E; Lind O; Bwanika HC; Lehti K; Salehi S; Carlson J; Wallin E; Fernebro J; Ostling P; Kallioniemi O; Joneborg U; Seashore-Ludlow B
Article: ACTA DERMATO-VENEREOLOGICA. 2023;103:adv00883
Tumour Suppressor Neuron Navigator 3 and Matrix Metalloproteinase 14 are Co-expressed in Most Melanomas but Downregulated in Thick Tumours
Bugaeva O; Maliniemi P; Prestvik WS; Leivo E; Kluger N; Salava A; Virtanen S; Jantti K; Saksela O; Lehti K; Kujala P; Krohn K; Ranki A
Article: CELLS. 2022;11(24):4121
An Approach for Systems-Level Understanding of Prostate Cancer from High-Throughput Data Integration to Pathway Modeling and Simulation
Mobashir M; Turunen SP; Izhari MA; Ashankyty IM; Helleday T; Lehti K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(49):e2116220119
PROX1 transcription factor controls rhabdomyosarcoma growth, stemness, myogenic properties and therapeutic targets
Gizaw NY; Kallio P; Punger T; Gucciardo E; Haglund C; Bohling T; Lehti K; Sampo M; Alitalo K; Kivela R
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):207-223
Molecular, cellular and systemic aspects of epithelial ovarian cancer and its tumor microenvironment
Schoutrop E; Moyano-Galceran L; Lheureux S; Mattsson J; Lehti K; Dahlstrand H; Magalhaes I
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):224-236
Chemotherapy as a regulator of extracellular matrix-cell communication: Implications in therapy resistance
Gonzalez-Molina J; Moyano-Galceran L; Single A; Gultekin O; Alsalhi S; Lehti K
Article: ADVANCED SCIENCE. 2022;9(28):e2202552
Mechanical Confinement and DDR1 Signaling Synergize to Regulate Collagen-Induced Apoptosis in Rhabdomyosarcoma Cells
Gonzalez-Molina J; Kirchhof KM; Rathod B; Moyano-Galceran L; Calvo-Noriega M; Kokaraki G; Bjorkoy A; Ehnman M; Carlson JW; Lehti K
Journal article: CLINICAL CANCER RESEARCH. 2022;28(18_Supplement):a026
Abstract A026: PROX1 transcription factor regulates rhabdomyosarcoma growth, myogenic properties and therapeutic targets
Gizaw NY; Kallio P; Gucciardo E; Haglund C; Bohling T; Lehti K; Sampo M; Alitalo K; Kivela R
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):6096
Abstract 6096: The microarchitecture and fibrillar collagen expression of leiomyosarcoma are associated with malignancy
Gonzalez-Molina J; Hahn P; Falcão RM; Kokaraki G; de Souza JE; Lajus TBP; Lehti K; Carlson JW
Article: APMIS. 2021;129(12):717-728
The expression and prognostic relevance of CDH3 in tongue squamous cell carcinoma
Seppala M; Jauhiainen L; Tervo S; Al-Samadi A; Rautiainen M; Salo T; Lehti K; Monni O; Hautaniemi S; Tynninen O; Makitie A; Makinen LK; Paavonen T; Toppila-Salmi S
Article: HUMAN MOLECULAR GENETICS. 2021;30(24):2429-2440
WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas
Aavikko M; Kaasinen E; Andersson N; Pentinmikko N; Sulo P; Donner I; Pihlajamaa P; Kuosmanen A; Bramante S; Katainen R; Sipila LJ; Martin S; Arola J; Carpen O; Heiskanen I; Mecklin J-P; Taipale J; Ristimaki A; Lehti K; Gucciardo E; Katajisto P; Schalin-Jantti C; Vahteristo P; Aaltonen LA
Article: NPJ PRECISION ONCOLOGY. 2021;5(1):97
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson JW
Article: SCIENTIFIC REPORTS. 2021;11(1):18810
Proliferative diabetic retinopathy transcriptomes reveal angiogenesis, anti-angiogenic therapy escape mechanisms, fibrosis and lymphatic involvement
Korhonen A; Gucciardo E; Lehti K; Loukovaara S
Article: NATURE COMMUNICATIONS. 2021;12(1):3904
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
Pietilae EA; Gonzalez-Molina J; Moyano-Galceran L; Jamalzadeh S; Zhang K; Lehtinen L; Turunen SP; Martins TA; Gultekin O; Lamminen T; Kaipio K; Joneborg U; Hynninen J; Hietanen S; Grenman S; Lehtonen R; Hautaniemi S; Carpen O; Carlson JW; Lehti K
Article: CANCER RESEARCH. 2021;81(11):3022-3035
Mesothelin-Specific CAR T Cells Target Ovarian Cancer
Schoutrop E; El-Serafi I; Poiret T; Zhao Y; Gultekin O; He R; Moyano-Galceran L; Carlson JW; Lehti K; Hassan M; Magalhaes I; Mattsson J
Article: JCI INSIGHT. 2021;6(9):141486
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity
Filppu P; Ramanathan JT; Granberg KJ; Gucciardo E; Haapasalo H; Lehti K; Nykter M; Le Joncour V; Laakkonen P
Article: SCIENTIFIC REPORTS. 2021;11(1):8856
Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality
Jukonen J; Moyano-Galceran L; Hopfner K; Pietila EA; Lehtinen L; Huhtinen K; Gucciardo E; Hynninen J; Hietanen S; Grenman S; Ojala PM; Carpen O; Lehti K
Article: CANCERS. 2021;13(5):1175
CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma
Su Y; Tsagkozis P; Papakonstantinou A; Tobin NP; Gultekin O; Malmerfelt A; Ingelshed K; Neo SY; Lundquist J; Chaabane W; Nisancioglu MH; Leiss LW; Ostman A; Bergh J; Sedimbi S; Lehti K; Lundqvist A; Stragliotto CL; Haglund F; Ehnman M
Article: MOLECULAR SYSTEMS BIOLOGY. 2021;17(3):e9526
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Jaiswal A; Gautam P; Pietila EA; Timonen S; Nordstrom N; Akimov Y; Sipari N; Tanoli Z; Fleischer T; Lehti K; Wennerberg K; Aittokallio T
Journal article: CLINICAL CANCER RESEARCH. 2020;26(13_Supplement):a64
Abstract A64: Extracellular matrix proteins increase invasive growth and chemotherapy resistance of ovarian cancer cells
Pietilä EA; Gonzales-Molina J; Moyano-Galceran L; Lehtinen L; Turunen P; Martins TS; Rantanen V; Häkkinen A; Jamalzadeh S; Zhang K; Lamminen T; Kaipio K; Hynninen J; Hietanen S; Grénman S; Lehtonen R; Hautaniemi S; Carpén O; Lehti K
Article: EMBO MOLECULAR MEDICINE. 2020;12(4):e11177
Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
Moyano-Galceran L; Pietila EA; Turunen SP; Corvigno S; Hjerpe E; Bulanova D; Joneborg U; Alkasalias T; Miki Y; Yashiro M; Chernenko A; Jukonen J; Singh M; Dahlstrand H; Carlson JW; Lehti K
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: ISCIENCE. 2020;23(2):100871
PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential
Yadav L; Pietila E; Ohman T; Liu X; Mahato AK; Sidorova Y; Lehti K; Saarma M; Varjosalo M
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2020;1296:319-348
Sarcoma Tumor Microenvironment
Tsagozis P; Gonzalez-Molina J; Georgoudaki A-M; Lehti K; Carlson J; Lundqvist A; Haglund F; Ehnman M
Article: CELL DEATH AND DIFFERENTIATION. 2019;26(12):2577-2593
FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
Turunen SP; von Nandelstadh P; Ohman T; Gucciardo E; Seashore-Ludlow B; Martins B; Rantanen V; Li H; Hopfner K; Ostling P; Varjosalo M; Lehti K
Journal article: CLINICAL CANCER RESEARCH. 2019;25(22_Supplement):gmm-057-gmm-057
Abstract GMM-057: A FUNCTIONAL HOMOLOGOUS RECOMBINATION ASSAY PREDICTS PRIMARY CHEMOTHERAPY RESPONSE AND LONG-TERM SURVIVAL IN OVARIAN CANCER PATIENTS
Tumiati M; Hietanen S; Hynninen J; Pietilä E; Färkkilä A; Alkodsi A; Li Y; Lehtonen R; Erkan EP; Tuominen MM; Lehti K; Hautaniemi SK; Vähärautio A; Grénman S; Carpén O; Kauppi L
Journal article: CLINICAL CANCER RESEARCH. 2019;25(22_Supplement):gmm-041-gmm-041
Abstract GMM-041: OVARIAN CANCER CELLS INDUCE A FEEDBACK RESPONSE TO PLATINUM-BASED CHEMOTHERAPY BY ACTIVATING AN ONCOGENIC RSK-EPHA2-GPRC5A SIGNALING SWITCH
Moyano-Galceran L; Turunen SP; Pietilä E; Alkasalias T; Corvigno S; Hjerpe E; Joneborg U; Bulanova D; Eriksson M; Dahlstrand H; Carlson J; Lehti K
Article: CANCER MEDICINE. 2019;8(16):6995-7005
High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1
Kasurinen A; Gramolelli S; Hagstrom J; Laitinen A; Kokkola A; Miki Y; Lehti K; Yashiro M; Ojala PM; Bockelman C; Haglund C
Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2019;7(8):e802
A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy
Kroger L; Lopponen T; Ala-Kokko L; Kroger H; Jauhonen H-M; Lehti K; Jaaskelainen J
Article: EMBO MOLECULAR MEDICINE. 2019;11(6):e9034
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization
Le Joncour V; Filppu P; Hyvonen M; Holopainen M; Turunen SP; Sihto H; Burghardt I; Joensuu H; Tynninen O; Jaaskelainen J; Weller M; Lehti K; Kakela R; Laakkonen P
Article: CLINICAL CANCER RESEARCH. 2019;25(7):2155-2165
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes
Binzer-Panchal A; Hardell E; Viklund B; Ghaderi M; Bosse T; Nucci MR; Lee C-H; Hollfelder N; Corcoran P; Gonzalez-Molina J; Moyano-Galceran L; Bell DA; Schoolmeester JK; Masback A; Kristensen GB; Davidson B; Lehti K; Isaksson A; Carlson JW
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2019;97(3):341-354
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage
Zeiner J; Loukovaara S; Losenkova K; Zuccarini M; Korhonen AM; Lehti K; Kauppinen A; Kaarniranta K; Mueller CE; Jalkanen S; Yegutkin GG
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(143)
An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy
Gucciardo E; Loukovaara S; Korhonen A; Lehti K
Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2019;(143)
An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy
Gucciardo E; Loukovaara S; Korhonen A; Lehti K
Article: CLINICAL CANCER RESEARCH. 2018;24(18):4482-4493
A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients
Tumiati M; Hietanen S; Hynninen J; Pietila E; Farkkila A; Kaipio K; Roering P; Huhtinen K; Alkodsi A; Li Y; Lehtonen R; Erkan EP; Tuominen MM; Lehti K; Hautaniemi SK; Vaharautio A; Grenman S; Carpen O; Kauppi L
Article: CELL COMMUNICATION AND SIGNALING. 2018;16(1):41
Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton
Pehkonen H; Lento M; von Nandelstadh P; Filippou A; Grenman R; Lehti K; Monni O
Article: SCIENTIFIC REPORTS. 2018;8(1):9531
PROX1 is a transcriptional regulator of MMP14
Gramolelli S; Cheng J; Martinez-Corral I; Vaha-Koskela M; Elbasani E; Kaivanto E; Rantanen V; Tuohinto K; Hautaniemi S; Bower M; Haglund C; Alitalo K; Makinen T; Petrova TV; Lehti K; Ojala PM
Article: JOURNAL OF PATHOLOGY. 2018;245(2):172-185
The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization
Gucciardo E; Loukovaara S; Korhonen A; Repo P; Martins B; Vihinen H; Jokitalo E; Lehti K
Article: ELIFE. 2018;7:e32490
Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation
Pekkonen P; Alve S; Balistreri G; Gramolelli S; Tatti-Bugaeva O; Paatero I; Niiranen O; Tuohinto K; Perala N; Taiwo A; Zinovkina N; Repo P; Icay K; Ivaska J; Saharinen P; Hautaniemi S; Lehti K; Ojala PM
Article: ONCOTARGET. 2017;8(58):98280-98297
Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma
Yin M; Tissari M; Tamminen J; Ylivinkka I; Ronty M; von Nandelstadh P; Lehti K; Hyytiainen M; Myllarniemi M; Koli K
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2017;1864(11):1974-1988
Membrane-type matrix metalloproteases as diverse effectors of cancer progression
Turunen SP; Tatti-Bugaeva O; Lehti K
Article: HUMAN MUTATION. 2017;38(3):269-274
Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry
Heikkinen T; Kaempjaervi K; Keskitalo S; von Nandelstadh P; Liu X; Rantanen V; Pitkaenen E; Kinnunen M; Kuusanmaeki H; Kontro M; Turunen M; Maekinen N; Taipale J; Heckman C; Lehti K; Mustjoki S; Varjosalo M; Vahteristo P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(8):E1413-E1421
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo
Alkasalias T; Alexeyenko A; Hennig K; Danielsson F; Lebbink RJ; Fielden M; Turunen SP; Lehti K; Kashuba V; Madapura HS; Bozoky B; Lundberg E; Balland M; Guven H; Klein G; Gad AKB; Pavlova T
Journal article: EUROPEAN JOURNAL OF CANCER. 2016;61:s88
417 Somatic MED12 exon 1 nonsense mutation in T-cell acute lymphoblastic leukemia escapes nonsense-mediated mRNA decay and prevents protein nuclear localization
Kämpjärvi K; Heikkinen T; Keskitalo S; Von Nandelstadh P; Rantanen V; Pitkänen E; Lehti K; Mustjoki S; Varjosalo M; Vahteristo P
Article: SCIENTIFIC REPORTS. 2016;6:24486
Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery
Pehkonen H; von Nandelstadh P; Karhemo P-R; Lepikhova T; Grenman R; Lehti K; Monni O
Article: JOURNAL OF PROTEOME RESEARCH. 2015;14(12):5131-5143
Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients
Loukovaara S; Nurkkala H; Tamene F; Gucciardo E; Liu X; Repo P; Lehti K; Varjosalo M
Article: ACTA OPHTHALMOLOGICA. 2015;93(6):512-523
Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy
Loukovaara S; Gucciardo E; Repo P; Vihinen H; Lohi J; Jokitalo E; Salven P; Lehti K
Article: CANCER RESEARCH. 2015;75(10):2083-2094
MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
Tatti O; Gucciardo E; Pekkonen P; Holopainen T; Louhimo R; Repo P; Maliniemi P; Lohi J; Rantanen V; Hautaniemi S; Alitalo K; Ranki A; Ojala PM; Keski-Oja J; Lehti K
Article: BRITISH JOURNAL OF CANCER. 2014;111(8):1657-1662
Identification of 33 candidate oncogenes by screening for base-specific mutations
Tuupanen S; Hanninen UA; Kondelin J; von Nandelstadh P; Cajuso T; Gylfe AE; Katainen R; Tanskanen T; Ristolainen H; Bohm J; Mecklin J-P; Jarvinen H; Renkonen-Sinisalo L; Andersen CL; Taipale M; Taipale J; Vahteristo P; Lehti K; Pitkanen E; Aaltonen LA
Article: MOLECULAR BIOLOGY OF THE CELL. 2014;25(17):2556-2570
Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton
von Nandelstadh P; Gucciardo E; Lohi J; Li R; Sugiyama N; Carpen O; Lehti K
Article: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2014;252(6):881-888
Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment
Loukovaara S; Lehti K; Robciuc A; Pessi T; Holopainen JM; Koli K; Immonen I; Keski-Oja J
Article: ACTA OPHTHALMOLOGICA. 2013;91(6):531-539
Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy
Loukovaara S; Robciuc A; Holopainen JM; Lehti K; Pessi T; Liinamaa J; Kukkonen K-T; Jauhiainen M; Koli K; Keski-Oja J; Immonen I
Article: JOURNAL OF CELL BIOLOGY. 2013;201(3):467-484
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion
Sugiyama N; Gucciardo E; Tatti O; Varjosalo M; Hyytiainen M; Gstaiger M; Lehti K
Article: JOURNAL OF PROTEOMICS. 2012;77:87-100
An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis
Karhemo P-R; Ravela S; Laakso M; Ritamo I; Tatti O; Makinen S; Goodison S; Stenman U-H; Holtta E; Hautaniemi S; Valmu L; Lehti K; Laakkonen P
Article: DEVELOPMENTAL CELL. 2012;22(6):1176-1190
MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: CELL HOST & MICROBE. 2011;10(6):577-590
KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition
Cheng F; Pekkonen P; Laurinavicius S; Sugiyama N; Henderson S; Guenther T; Rantanen V; Kaivanto E; Aavikko M; Sarek G; Hautaniemi S; Biberfeld P; Aaltonen L; Grundhoff A; Boshoff C; Alitalo K; Lehti K; Ojala PM
Article: BLOOD. 2011;118(4):1154-1162
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Zheng W; Tammela T; Yamamoto M; Anisimov A; Holopainen T; Kaijalainen S; Karpanen T; Lehti K; Yla-Herttuala S; Alitalo K
Article: MATRIX BIOLOGY. 2011;30(3):207-217
Syndecan-1 and-4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP
Vuoriluoto K; Hognas G; Meller P; Lehti K; Ivaska J
Article: PLOS ONE. 2011;6(12):e28325
Membrane-Type-3 Matrix Metalloproteinase (MT3-MMP) Functions as a Matrix Composition-Dependent Effector of Melanoma Cell Invasion
Tatti O; Arjama M; Ranki A; Weiss SJ; Keski-Oja J; Lehti K
Article: CANCER RESEARCH. 2010;70(20):7851-7861
Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation
Sugiyama N; Varjosalo M; Meller P; Lohi J; Hyytiainen M; Kilpinen S; Kallioniemi O; Ingvarsen S; Engelholm LH; Taipale J; Alitalo K; Keski-Oja J; Lehti K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15786-15791
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex
Sugiyama N; Varjosalo M; Meller P; Lohi J; Chan KM; Zhou Z; Alitalo K; Taipale J; Keski-Oja J; Lehti K
Article: JOURNAL OF CELL SCIENCE. 2009;122(1):126-135
MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing
Lehti K; Rose NF; Valavaara S; Weiss SJ; Keski-Oja J
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2008;105(5):1211-1218
Secretion of Active Membrane Type 1 Matrix Metalloproteinase (MMP-14) Into Extracellular Space in Microvesicular Exosomes
Hakulinen J; Sankkila L; Sugiyama N; Lehti K; Keski-Oja J
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(13):2501-2514
MT1-MMP releases latent TGF-β1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1
Tatti O; Vehvilainen P; Lehti K; Keski-Oja J
Article: JOURNAL OF CELL SCIENCE. 2006;119(18):3856-3865
Epilysin (MMP-28) induces TGF-β mediated epithelial to mesenchymal transition in lung carcinoma cells
Illman SA; Lehti K; Keski-Oja J; Lohi J
Article: GENES & DEVELOPMENT. 2005;19(8):979-991
An MT1-MMP-PDGF receptor-β axis regulates mural cell investment of the microvasculature
Lehti K; Allen E; Birkedal-Hansen H; Holmbeck K; Miyake Y; Chun TH; Weiss SJ
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(38):40246
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain (vol 275, pg 15006, 2000)
Lehti K; Valtanen H; Wickström SA; Lohi J; Keski-Oja J
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2002;192(2):160-170
Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism
Monea S; Lehti K; Keski-Oja J; Mignatti P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(10):8440-8448
Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane type 1 matrix metalloproteinase
Lehti K; Lohi J; Juntunen MM; Pei DQ; Keski-Oja J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(24):13693-13698
Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis
Jiang AX; Lehti K; Wang X; Weiss SJ; Keski-Oja J; Pei DQ
Article: PROTEIN EXPRESSION AND PURIFICATION. 2000;19(1):66-73
Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase
Valtanen H; Lehti K; Lohi J; Keski-Oja J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(20):15006-15013
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain
Lehti K; Valtanen H; Wickström SA; Lohi J; Keski-Oja J
Article: HEPATOLOGY. 1999;30(2):462-468
MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells
Théret N; Lehti K; Musso O; Clément B
Article: BRITISH JOURNAL OF CANCER. 1999;80(5-6):733-743
Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas
Airola K; Karonen T; Vaalamo M; Lehti K; Lohi J; Kariniemi AL; Keski-Oja J; Saarialho-Kere UK
Article: BIOCHEMICAL JOURNAL. 1998;334(Pt 2):345-353
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface
Lehti K; Lohi J; Valtanen H; Keski-Oja J
Journal article: FIBRINOLYSIS AND PROTEOLYSIS. 1997;11:36
129 Cooperation between plasmin and membrane-type 1 metalloproteinase (MT1-MMP) in the activation of 72 kDa type IV collagenase (MMP-2) on the cell surface
Monea S; Lehti K; Shamamian P; Marcus S; Galloway AC; Keski-Oja J; Mignatti P
Article: FEBS JOURNAL. 1996;239(2):239-247
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate
Lohi J; Lehti K; Westermarck J; Kahari VM; KeskiOja J
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Preprint: BIORXIV. 2025
BooLEVARD: Boolean Logical Evaluation of Activation and Repression in Directed pathways
Fariñas M; Tsirvouli E; Zobolas J; Aittokallio T; Flobak Å; Lehti K
Preprint: MEDRXIV. 2024
A 3D ovarian cancer metastasis model using a decellularized peritoneal matrix to study therapy response
Gjerde CH; Kleinmanns K; Langer A; de Garibay Ponce GR; Rozmus E; Stangeland GN; Leitch C; Elnour R; Dongre HN; Berger C; Gultekin O; Forcados C; Stensland M; Nyman TA; Lehti K; Davidson B; Wälchli S; Gelebart P; Costea DE; Kotopoulis S; Bjørge L; McCormack E
Preprint: BIORXIV. 2024
The mechanical anisotropy of adipose tissues regulates ovarian cancer invasion
Gonzalez-Molina J; Nabili P; Marciano D; Abdelnabi S; Gultekin O; Rasul MF; Zhang Y; Nadal C; Chrysanthou A; Alkasalias T; Salehi S; Balkwill F; Lehti K; Gautrot JE
Preprint: BIORXIV. 2024
Advancing Adoptive Cell Therapy: Optimized Expansion of Adaptive NK Cells for Solid Tumors
Almazán NM; Román S; Sun Y; Bräutigam L; Pantalone MR; Stragliotto G; Gultekin O; Saheli S; Lehti K; Nauclér CS; Sarhan D
Preprint: BIORXIV. 2024
CXCR2-mediated recruitment of adaptive NK cells with NKG2C/HLA-E dependent antigen-specific memory enhances tumor killing in ovarian cancer
Sun Y; Rodgers-Furones A; Gultekin O; Khare S; Neo SY; Shi W; Galceran LM; Lam K-P; Dasgupta R; Fuxe J; Salehi S; Lehti K; Sarhan D
Conference publication: 2023;:a1108
1000 Adaptive NK cells with distinct features possess immune memory towards ovarian tumors
Sun Y; Rodgers-Furones A; Suzuki S; Gultekin O; Galceran L; Salehi S; Lehti K; Sarhan D
Review: MATRIX BIOLOGY. 2023;121:217-228
The extracellular matrix-immune microenvironment crosstalk in cancer therapy: Challenges and opportunities
Closset L; Gultekin O; Salehi S; Sarhan D; Lehti K; Gonzalez-Molina J
Preprint: RESEARCH SQUARE. 2023
The Drug Efficacy Testing in Ex Vivo 3D Cultures (DETECt) platform enables rapid identification of effective drugs and drug combinations for ovarian cancer patients
Seashore-Ludlow B; Åkerlund E; Gudoityte G; Moussaud-Lamodière E; Lind O; Bwanika HC; Lehti K; Saheli S; Carlson J; Wallin E; Fernebro J; Ostling P; Kallioniemi O; Joneborg U
Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
Data from Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindström MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Conference publication: LABORATORY INVESTIGATION. 2023;103(3):S81
Morphometric Analysis Reveals Prognostically Distinct Groups of Undifferentiated Soft Tissue Sarcomas
Zanfagnin V; Gultekin O; Falcao RM; Lehti K; Petta TB; Carlson J
Conference publication: INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER. 2022;32:a406
2022-RA-717-ESGO Establishment of peritoneal dECM scaffolds for 3D culture of ovarian cancer organoids
Gjerde CH; Langer A; de Garibay Ponce GR; Kleinmanns K; Dongre HN; Mustafa RE; Berger C; Willoughby R; de Jalón EG; Gultekin O; Bozluolcay E; Davidson B; Gelebart P; Costea DE; Lehti K; McCormack E; Bjørge L
Preprint: BIORXIV. 2022
Efficacy and safety of glycosphingolipid SSEA-4 targeting CAR-T cells in an ovarian carcinoma model
Monzo HJ; Hyytiäinen M; Elbasani E; Kalander K; Wall J; Moyano-Galceran L; Tanjore-Ramanathan J; Jukonen J; Laakkonen P; Ristimäki A; Carlson JW; Lehti K; Salehi S; Puolakkainen P; Haglund C; Seppänen H; Leppä S; Ojala PM
Letter: ACTA OPHTHALMOLOGICA. 2022;100(5):e1187-e1188
Phosphodiesterase type 5 inhibitor (sildenafil) - impact in proliferative diabetic retinopathy?
Korhonen A; Gucciardo E; Lehti K; Loukovaara S
Preprint: BIORXIV. 2022
YAP and collagen remodelling support cell proliferation and tumour aggressiveness in uterine leiomyosarcoma
Gonzalez-Molina J; Hahn P; Falcão RM; Gultekin O; Kokaraki G; Zanfagnin V; Petta TB; Lehti K; Carlson J
Preprint: BIORXIV. 2022
Mechanical confinement and DDR1 signalling synergise to regulate collagen-induced apoptosis in rhabdomyosarcoma cells
Gonzalez-Molina J; Kirchhof KM; Rathod B; Moyano-Galceran L; Calvo-Noriega M; Kokaraki G; Bjørkøy A; Ehnman M; Carlson J; Lehti K
Conference publication: CANCER RESEARCH. 2022;82(12)
The microarchitecture and fibrillar collagen expression of leiomyosarcoma are associated with malignancy.
Gonzalez-Molina J; Hahn P; Falcao RM; Kokaraki G; de Souza JE; Petta Lajus TB; Lehti K; Carlson JW
Conference publication: CANCER RESEARCH. 2022;82(12)
The microarchitecture and fibrillar collagen expression of leiomyosarcoma are associated with malignancy
Gonzalez-Molina J; Hahn P; Falcao RM; Kokaraki G; de Souza JE; Petta Lajus TB; Lehti K; Carlson JW
Conference publication: CLINICAL CANCER RESEARCH. 2022;28(18)
PROX1 transcription factor regulates rhabdomyosarcoma growth, myogenic properties and therapeutic targets
Gizaw NY; Kallio P; Gucciardo E; Haglund C; Bohling T; Lehti K; Sampo M; Alitalo K; Kivela R
Preprint: BIORXIV. 2021
Regulatory FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson J
Conference publication: CANCER RESEARCH. 2021;81(5):po050
EphA2 signaling segregation and modulation by diverse tumor microenvironment components differentially regulates cancer cell invasion and survival
Moyano-Galceran L; Turunen PS; Sugiyama N; von Nandelstadh P; Gucciardo E; Varjosalo M; Lehti K
Conference publication: CANCER RESEARCH. 2020;80(16):lb-055-lb-055
Novel therapeutic option targeting the tumor cell lysosomes
Le Joncour V; Filppu P; Holopainen M; Hyvonen M; Turunen SP; Sihto H; Burghardt I; Jaaskelainen J; Weller M; Lehti K; Kakela R; Laakkonen P
Preprint: BIORXIV. 2020
PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma
Gizaw NY; Kallio P; Punger T; Kinnunen M; Gucciardo E; Lehti K; Haglund C; Böhling T; Varjosalo M; Sampo M; Alitalo K; Kivelä R
Preprint: BIORXIV. 2020
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Jaiswal A; Gautam P; Pietilä E; Timonen S; Nordström N; Sipari N; Tanoli Z; Lehti K; Wennerberg K; Aittokallio T
Review: FRONTIERS IN ONCOLOGY. 2020;10:568557
Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer
Miki Y; Yashiro M; Moyano-Galceran L; Sugimoto A; Ohira M; Lehti K
Conference publication: LABORATORY INVESTIGATION. 2020;100(SUPPL 1):1065-1066
The Immune Microenvironment in Low-Grade Endometrial Stromal Sarcomas: The Ratio of CD8+T-Cells/FOXP3+Tregs (T Regulatory Cells) is a Significant Prognostic Factor
Hardell E; Gonzalez-Molina J; Gultekin O; Lehti K; Carlson J
Conference publication: MODERN PATHOLOGY. 2020;33(SUPPL 2):1065-1066
The Immune Microenvironment in Low-Grade Endometrial Stromal Sarcomas: The Ratio of CD8+T-Cells/FOXP3+Tregs (T Regulatory Cells) is a Significant Prognostic Factor
Hardell E; Gonzalez-Molina J; Gultekin O; Lehti K; Carlson J
Conference publication: CLINICAL CANCER RESEARCH. 2020;26(13):71
Extracellular matrix proteins increase invasive growth and chemotherapy resistance of ovarian cancer cells.
Pietila EA; Gonzales-Molina J; Moyano-Galceran L; Lehtinen L; Turunen P; Martins TS; Rantanen V; Hakkinen A; Jamalzadeh S; Zhang K; Lamminen T; Kaipio K; Hynninen J; Hietanen S; Grenman S; Lehtonen R; Hautaniemi S; Carpen O; Lehti K
Review: CELLS. 2019;8(9):E991-991
MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues
Gonzalez-Molina J; Gramolelli S; Liao Z; Carlson JW; Ojala PM; Lehti K
Conference publication: CLINICAL CANCER RESEARCH. 2019;25(22):104
OVARIAN CANCER CELLS INDUCE A FEEDBACK RESPONSE TO PLATINUM-BASED CHEMOTHERAPY BY ACTIVATING AN ONCOGENIC RSK-EPHA2-GPRC5A SIGNALING SWITCH
Moyano-Galceran L; Turunen SP; Pietila E; Alkasalias T; Corvigno S; Hjerpe E; Joneborg U; Bulanova D; Eriksson M; Dahlstrand H; Carlson J; Lehti K
Conference publication: CLINICAL CANCER RESEARCH. 2019;25(22):120
A FUNCTIONAL HOMOLOGOUS RECOMBINATION ASSAY PREDICTS PRIMARY CHEMOTHERAPY RESPONSE AND LONG-TERM SURVIVAL IN OVARIAN CANCER PATIENTS
Tumiati M; Hietanen S; Hynninen J; Pietila E; Farkkila A; Alkodsi A; Li Y; Lehtonen R; Erkan EP; Tuominen MM; Lehti K; Hautaniemi SK; Vaharautio A; Grenman S; Carpen O; Kauppi L
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Novel Tumor Suppressor PTPRA Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential
Yadav L; Pietilä E; Öhman T; Liu X; Mahato AK; Lehti K; Saarma M; Varjosalo M
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(12):E4034-4034
Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy
Gucciardo E; Loukovaara S; Salven P; Lehti K
Preprint: BIORXIV. 2018
FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
Turunen P; von Nandelstadh P; Öhman T; Gucciardo E; Martins B; Rantanen V; Li H; Höpfner K; Varjosalo M; Lehti K
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(5):E1532-1532
Fibroblasts in the Tumor Microenvironment: Shield or Spear?
Alkasalias T; Moyano-Galceran L; Arsenian-Henriksson M; Lehti K
Preprint: BIORXIV. 2018
Vulnerability of invasive glioma cells to lysosomal membrane instabilization
Joncour VL; Hyvönen M; Filppu P; Turunen P; Sihto H; Burghardt I; Joensuu H; Tynninen O; Jääskeläinen J; Weller M; Lehti K; Laakkonen P
Conference publication: CANCER RESEARCH. 2017;77:1894
Gremlin-1 is an important regulator of invasiveness in malignant mesothelioma
Yin M; Tissari M; Joensuu EI; Tamminen J; Ylivinkka I; Ronty M; Lehti K; Hyytiainen M; Myllarniemi M; Koli K
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2017;12(1):S246-S247
Gremlin-1 is a Key Regulator of the Invasive Phenotype in Mesothelioma
Yin M; Tissari M; Tamminen J; Ylivinkka I; Ronty M; Lehti K; Hyytiainen M; Myllarniemi M; Koli K
Conference publication: EUROPEAN JOURNAL OF CANCER. 2016;61:S88-S89
The role of CD109 in glioma progression
Filppu P; Le Joncour V; Hyvonen M; Sihto H; Joensuu H; Lehti K; Laakkonen P
Editorial comment: JOURNAL OF CELL BIOLOGY. 2016;213(1):11-13
Proactive for invasion: Reuse of matrix metalloproteinase for structural memory
Gucciardo E; Mobashir M; Lehti K
Conference publication: EUROPEAN JOURNAL OF CANCER. 2016;61:S88
Somatic MED12 exon 1 nonsense mutation in T-cell acute lymphoblastic leukemia escapes nonsense-mediated mRNA decay and prevents protein nuclear localization
Kampjarvi K; Heikkinen T; Keskitalo S; Von Nandelstadh P; Rantanen V; Pitkanen E; Lehti K; Mustjoki S; Varjosalo M; Vahteristo P
Conference publication: ACTA OPHTHALMOLOGICA. 2015;93
Abnormal lymphatic-like differentiation and endothelial progenitor cell activation in hemi retinal vein occlusion
Loukovaara S; Gucciardo E; Repo P; Lohi J; Salven P; Lehti K
Conference publication: CANCER RESEARCH. 2015;75:2744
Familial multiple metastatic small intestine neuroendocrine tumors: searching for genetic susceptibility
Aavikko M; Kaasinen E; Donner I; Lehti K; Gucciardo E; Shrestha B; Mecklin J-P; Johannes J; Landerholm K; Pukkala E; Schalin-Jantti C; Ristimaki A; Vahteristo P; Aaltonen LA
Other: CASE REPORTS IN OPHTHALMOLOGY. 2015;6(2):228-238
A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion
Loukovaara S; Gucciardo E; Repo P; Lohi J; Salven P; Lehti K
Conference publication: CLINICAL & EXPERIMENTAL METASTASIS. 2015;32(3):228-229
Crosstalk of tumor cells and lymphatic endothelium in melanoma metastasis
Pekkonen P; Balistreri G; Zinovkina N; Perala N; Tatti O; Lehti K; Ojala PM
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2014;71(19):3685-3710
Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics
Gucciardo E; Sugiyama N; Lehti K
Editorial comment: CELL CYCLE. 2013;12(18):2927-2928
EphA2 bears plasticity to tumor invasion
Sugiyama N; Gucciardo E; Lehti K
Conference publication: EUROPEAN JOURNAL OF CANCER. 2012;48:S52-S53
The Role of MDGI in Glioma Progression
Hyvonen M; Virtanen J; Rivinoja A; Enback J; Joensuu H; Mari B; Tavi P; Lehti K; Laakkonen P
Conference publication: CANCER RESEARCH. 2012;72:2976
KSHV-initiated Notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition
Pekkonen P; Cheng F; Sugiyama N; Henderson S; Rantanen V; Aavikko M; Hautaniemi S; Aaltonen L; Boshoff C; Alitalo K; Lehti K; Ojala PM
Conference publication: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2012;30:S41
The role of CoR in glioma progression
Ilvyonen MLK; Virtanen J; Rivinoja A; Enbaek J; Joensuu H; Mari B; Tavi P; Lehti K; Laakkonen P
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130:S52
Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition -dependent effector of MT1-MMP activity and tumor cell invasion
Tatti O; Arjama M; Keski-Oja J; Lehti K
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129:S82
Interplay between MT1-MMP and MT3-MMP regulates melanoma cell invasion
Tatti O; Arjama M; Keski-Oja J; Lehti K
Conference publication: ANTICANCER RESEARCH. 2008;28(5C):3345-3346
LATENT TGF-BETA BINDING PROTEINS (LTBPS) IN TARGETING TGF-BETA ACTION
Keski-Oja J; Hyytiainen M; Vehvilainen P; Tatti O; Kantola AK; Lehti K; von Melchner H; Koli K
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2006;126:86
Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells
Illman SA; Lehti K; Lohi J; Keski-Oja J
Published conference paper: GENE. 2000;242(1-2):75-86
Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene
Lohi J; Lehti K; Valtanen H; Parks WC; Keski-Oja J
Conference publication: HEPATOLOGY. 1999;30(4):488A
MMP2 activation by collagen I and concavalin A in cultured human hepatic stellate cells.
Theret N; Lehti K; Musso O; Clement B
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;113(3):435
Targeting of membrane-type-1 matrix metalloproteinase activity in melanoma cell invasion and inactivation by cleavage of 20-kDa N-terminal domain
Lehti K; Valtanen H; Wickström S; Keski-Oja J
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;112(4):535
Membrane-type-1 matrix metalloproteinase targeting in melanoma cell invasion:: Identification of a 20-kDa cleavage product
Lehti K; Valtanen H; Wickström S; Lohi J; Keski-Oja J
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1998;9:175A
Structure and promoter characterization of the human membrane-type-1 matrix metalloproteinase (MT1-MMP) gene
Lohi J; Lehti K; Valtanen H; Parks WC; Keski-Oja J
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1997;8:434
Requirement for plasmin and membrane type I matrix metalloproteinase in the cell surface activation of gelatinase A (MMP-2).
Monea S; Lehti K; Schwartz J; Shamamian P; Marcus S; Galloway AC; KeskiOja J; Mignatti P
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 1996;7:343
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with 72-KDA gelatinase activation at the cell surface.
Lehti K; Lohi J; KeskiOja J
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1996;107(3):282
Proteolytic processing of membrane-type matrix metalloproteinase-I (MT-MMP-1).
Lehti K; Lohi J; KeskiOja J
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Forskningsbidrag

Inflammation “the fuel for cancer” - adding precision to patient stratification and therapy
Central Norway Regional Health Authority
1 January 2023
Lehti, Kaisa – Signals and proteolytic effectors of invasion, metastasis and anti-cancer drug resistance in ovarian cancer
Swedish Cancer Society
1 January 2022
Rethinking Ovarian Cancer: Development of New Preclinical Tools and the Design of Innovative Multimodal Treatment Strategies
Western Norway Regional Health Authority
1 January 2021 - 31 December 2024
Molecular mechanism, ex vivo tumor testing and clinical data guided combinatorial treatment strategies to eradicate ovarian cancer metastasis
Swedish Research Council
1 January 2020 - 31 December 2022
Tumor cell-microenvironment communication in cancer invasion, metastasis, and drug resistance
Swedish Research Council
1 January 2016 - 31 December 2018

Anställningar

Forskare, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2015-

Examina och utbildning

Docent, Cell and Molecular Biology, University of Helsinki, 2009
PhD, Biochemistry, Membrane-type-1 matrix metalloproteinase in pericellular proteolysis and cell migration, University of Helsinki, 2002
MSc, Biochemistry, Pertussis toxin and filamentous hemagglutinin as components of an acellular pertussis vaccine, University of Helsinki, 1994

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