Silvia Maioli

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Utvalda publikationer

Article: SCIENCE ADVANCES. 2024;10(4):eadj1354

CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.

Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-García LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Björkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S

Artiklar

Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300

Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression.

Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-García LE
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1347535

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol.

Spanos F; Gerenu G; Goikolea J; Latorre-Leal M; Balleza-Tapia H; Gomez K; Álvarez-Jiménez L; Piras A; Gómez-Galán M; Fisahn A; Cedazo-Minguez A; Maioli S; Loera-Valencia R
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):220

Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study.

Petek B; Häbel H; Xu H; Villa-Lopez M; Kalar I; Hoang MT; Maioli S; Pereira JB; Mostafaei S; Winblad B; Gregoric Kramberger M; Eriksdotter M; Garcia-Ptacek S
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387

Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison.

Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Björkhem I; Rodriguez Rodriguez P; Maioli S
Article: JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 2023;18(3):529-550

SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer's Disease.

Sola-Sevilla N; Mesa-Lombardo A; Aleixo M; Expósito S; Diaz-Perdigón T; Azqueta A; Zamani F; Suzuki T; Maioli S; Eroli F; Matton A; Ramírez MJ; Solas M; Tordera RM; Martín ED; Puerta E
Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228

Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities.

Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):141

A metagenomic study of gut viral markers in amyloid-positive Alzheimer's disease patients.

Ghorbani M; Ferreira D; Maioli S
Article: GLIA. 2023;71(6):1414-1428

27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes.

Alanko V; Gaminde-Blasco A; Quintela-López T; Loera-Valencia R; Solomon A; Björkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245

Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice.

Emre C; Arroyo-García LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):37

Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer's disease: a potential early sign of AD.

Goikolea J; Gerenu G; Daniilidou M; Mangialasche F; Mecocci P; Ngandu T; Rinne J; Solomon A; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A; Maioli S
Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076

Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration.

Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Björkhem I; Puerta E; Romão MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
Article: AGING-US. 2021;13(11):14729-14744

Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice.

Eroli F; Johnell K; Latorre-Leal M; Hilmer S; Wastesson J; Cedazo-Minguez A; Maioli S
Article: AGING-US. 2020;12(11):10147-10161

Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice.

Eroli F; Johnell K; Latorre Leal M; Adamo C; Hilmer S; Wastesson JW; Cedazo-Minguez A; Maioli S
Article: SCIENTIFIC REPORTS. 2019;9(1):3965

Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases.

Caberlotto L; Nguyen T-P; Lauria M; Priami C; Rimondini R; Maioli S; Cedazo-Minguez A; Sita G; Morroni F; Corsi M; Carboni L
Article: CEREBRAL CORTEX. 2019;29(1):429-446

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons.

Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Björkhem I; DeFelipe J; Cedazo-Minguez A
Article: PLOS ONE. 2018;13(3):e0194892

The composition of polypharmacy: A register-based study of Swedes aged 75 years and older.

Wastesson JW; Cedazo Minguez A; Fastbom J; Maioli S; Johnell K
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(3):699-717

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.

Ismail M-A; Mateos L; Maioli S; Merino-Serrais P; Ali Z; Lodeiro M; Westman E; Leitersdorf E; Gulyás B; Olof-Wahlund L; Winblad B; Savitcheva I; Björkhem I; Cedazo-Mínguez A
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328

Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions.

Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Rönnbäck A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(2):601-617

Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis.

Persson T; Lattanzio F; Calvo-Garrido J; Rimondini R; Rubio-Rodrigo M; Sundström E; Maioli S; Sandebring-Matton A; Cedazo-Mínguez Á
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(1):349-361

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.

Tajeddinn W; Persson T; Calvo-Garrido J; Seed Ahmed M; Maioli S; Vijayaraghavan S; Kazokoglu MS; Parrado-Fernández C; Yoshitake T; Kehr J; Francis P; Winblad B; Höglund K; Cedazo-Minguez A; Aarsland D
Article: NEUROSCIENCE LETTERS. 2015;594:137-143

5-HT1B and other related serotonergic proteins are altered in APPswe mutation.

Tajeddinn W; Persson T; Maioli S; Calvo-Garrido J; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Höglund K; Cedazo-Minguez A; Aarsland D
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;278:356-359

27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice.

Heverin M; Maioli S; Pham T; Mateos L; Camporesi E; Ali Z; Winblad B; Cedazo-Minguez A; Björkhem I
Article: AGING CELL. 2015;14(1):122-129

Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease.

Maioli S; Lodeiro M; Merino-Serrais P; Falahati F; Khan W; Puerta E; Codita A; Rimondini R; Ramirez MJ; Simmons A; Gil-Bea F; Westman E; Cedazo-Minguez A; Alzheimer's Disease Neuroimaging Initiative
Article: FEBS OPEN BIO. 2014;4:393-406

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.

Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlström H
Article: PLOS ONE. 2013;8(7):e68534

Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain?

Maioli S; Båvner A; Ali Z; Heverin M; Ismail M-A; Puerta E; Olin M; Saeed A; Shafaati M; Parini P; Cedazo-Minguez A; Björkhem I
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;32(2):341-355

Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice.

Maioli S; Puerta E; Merino-Serrais P; Fusari L; Gil-Bea F; Rimondini R; Cedazo-Minguez A
Article: BEHAVIOURAL BRAIN RESEARCH. 2012;230(2):349-354

Excitotoxic lesion of the perirhinal cortex impairs spatial working memory in a delayed-alternation task.

Maioli S; Gangarossa G; Locchi F; Andrioli A; Bertini G; Rimondini R
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Alla övriga publikationer

Preprint: BIORXIV. 2024

Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression

Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-García LE
Preprint: BIORXIV. 2022

Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia

Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925

Estrogen receptors and the aging brain.

Maioli S; Leander K; Nilsson P; Nalvarte I
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(18):10139

Brain Renin-Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer's Disease.

Loera-Valencia R; Eroli F; Garcia-Ptacek S; Maioli S
Preprint: BIORXIV. 2021

Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging

Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Daniilidou M; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths W; Björkhem I; Sandebring Matton A; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:104-114

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment.

Loera-Valencia R; Goikolea J; Parrado-Fernandez C; Merino-Serrais P; Maioli S

Forskningsbidrag

Finansieringsförslag för en kryostat inom inom Avdelningen för Neurogeriatrik

Olle Engkvists Stiftelse

1 January 2024
The interaction between APOE, menopause, and estrogen in Alzheimer’s disease

Swedish Research Council

1 January 2024 - 31 December 2026
Cholesterol metabolism and sex hormones in Alzheimer’s Disease: from basic mechanisms to precision medicine.

The private initiative “Innovative ways to fight Alzheimer’s disease - Leif Lundblad Family and others”

1 November 2023 - 31 October 2026
Cholesterol metabolism and risk factors in men and women: from pathogenic mechanisms to precision medicine in Alzheimer’s Disease.

Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse

1 January 2023 - 31 December 2024
Sex specific effects of CYP46A1 up regulation in brain: roles and implication for cholesterol turnover in neurodegenerative diseases.

KID funding

1 January 2022 - 31 December 2025
Understanding the role of menopause and estrogen receptor activation for Alzheimer's disease risk.

National Institutes of Health

30 September 2020 - 31 May 2024

Anställningar

Senior Forskningsspecialist, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Neurovetenskap, Karolinska Institutet, 2023

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