Forskargrupp Stephen Malin

Aterogen dyslipidemi

Vår forskning fokuserar på hur aterogen dyslipidemi provocerar immunsystemet, särskilt B-lymfocyter, och hur detta kan leda till vävnadsskador.

Samarbeten

Kardiovaskulär sjukdom:
Christoph Binder, Vienna
Esther Lutgens, Amsterdam
Carolina Hagberg, Göran Hansson och Peder Olofsson, Stockholm

Immunförsvar och inflammation:
Meinrad Busslinger, Vienna
Mikael Karlsson, Jonathan Coquet och Rikard Holmdahl, Stockholm

Finansiering

Internationell finansiering:
Leducq Foundation, EU FP7, EU-COST, Novo Nordisk

Nationell finansiering:
Vetenskapsrådet Starting and Project grants
Hjärt-Lungfonden
Åke Wibergs Stiftelse

KI-finansiering:
KID
Dr Åke Olssons stiftelse
VR Linne Center CERIC

Gruppmedlemmar

Stephen Malin

Senior forskare/forskargruppsledare

Utvalda publikationer

Animal Models of Atherosclerosis-Supportive Notes and Tricks of the Trade.
Gisterå A, Ketelhuth DFJ, Malin SG, Hansson GK
Circ Res 2022 Jun;130(12):1869-1887.

The PAX5-JAK2 translocation acts as dual-hit mutation that promotes aggressive B-cell leukemia via nuclear STAT5 activation.
Jurado S, Fedl AS, Jaritz M, Kostanova-Poliakova D, Malin SG, Mullighan CG, Strehl S, Fischer M, Busslinger M
EMBO J 2022 04;41(7):e108397.

Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation.
Calderón L, Schindler K, Malin SG, Schebesta A, Sun Q, Schwickert T, Alberti C, Fischer M, Jaritz M, Tagoh H, Ebert A, Minnich M, Liston A, Cochella L, Busslinger M
Sci Immunol 2021 07;6(61):eabg5003.

Repression of the B cell identity factor Pax5 is not required for plasma cell development.
Liu GJ, Jaritz M, Wöhner M, Agerer B, Bergthaler A, Malin SG, Busslinger M
J Exp Med 2020 11;217(11):e20200147.

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG
Circulation 2019 05;139(21):2466-2482.

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis.
Centa M, Prokopec KE, Garimella MG, Habir K, Hofste L, Stark JM, Dahdah A, Tibbitt CA, Polyzos KA, Gisterå A, Johansson DK, Maeda NN, Hansson GK, Ketelhuth DFJ, Coquet JM, Binder CJ, Karlsson MCI, Malin S
Arterioscler Thromb Vasc Biol 2018 08;38(8):e145-e158.

Germinal Center B Cells Are Essential for Collagen-Induced Arthritis.
Dahdah A, Habir K, Nandakumar KS, Saxena A, Xu B, Holmdahl R, Malin S
Arthritis Rheumatol 2018 02;70(2):193-203.

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene.
Centa M, Gruber S, Nilsson D, Polyzos KA, Johansson DK, Hansson GK, Ketelhuth DF, Binder CJ, Malin S
Arterioscler Thromb Vasc Biol 2016 Jan;36(1):25-36.

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M
Nat Immunol 2010 Feb;11(2):171-9.

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development.
Kwon K, Hutter C, Sun Q, Bilic I, Cobaleda C, Malin S, Busslinger M
Immunity 2008 Jun;28(6):751-62.