Mekanismer för proteinaggregering och -inhibering – Axel Abeleins grupp

Publikationer

Utvalda publikationer

• Article: PROTEIN SCIENCE. 2024;33(8):e5091

  Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

  Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstal H; Otzen DE; Johansson J; Abelein A
• Journal article: NATURE COMMUNICATIONS. 2024;15(1):965

  Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain.

  Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
• Review: ACCOUNTS OF CHEMICAL RESEARCH. 2023;56(19):2653-2663

  Metal Binding of Alzheimer's Amyloid-β and Its Effect on Peptide Self-Assembly

  Abelein A
• Review: RSC MEDICINAL CHEMISTRY. 2023;14(5):848-857

  Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo

  Abelein A; Johansson J
• Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511

  Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone

  Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
• Article: JACS AU. 2022;2(11):2571-2584

  Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease

  Abelein A; Ciofi-Baffoni S; Morman C; Kumar R; Giachetti A; Piccioli M; Biverstal H
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234

  Metal ion coordination delays amyloid-? peptide self-assembly by forming an aggregation?inert complex

  Wallin C; Jarvet J; Biverstal H; Warmlander S; Danielsson J; Graslund A; Abelein A
• Article: NATURE COMMUNICATIONS. 2017;8(1):2081

  Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

  Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J

Finansiering

Forskningsbidrag

• Molecular insights into chaperone-amyloid interactions for biomimetic treatment of neurodegenerative diseases

  Swedish Research Council
• Development of novel protein-based biomaterials for sustainable water purification from heavy metals

  Swedish Research Council for Environment Agricultural Sciences and Spatial Planning

Medarbetare och kontakt

Gruppledare

• 

  Axel Abelein

  Biträdande Lektor | Docent

  E-postadress axel.abelein@ki.se

Alla medarbetare i gruppen

• 

  Axel Abelein

  Biträdande Lektor | Docent

  E-postadress axel.abelein@ki.se
• 

  Laurène Adam

  Doktorand

  E-postadress laurene.adam@ki.se
• 

  Rakesh Kumar

  Postdoktor

  E-postadress rakesh.kumar.2@ki.se
• 

  Willem Molenkamp

  Doktorand

  E-postadress willem.molenkamp@ki.se
• 

  Cecilia Mörman

  Postdoktor

  E-postadress cecilia.morman@ki.se

Andra personer med koppling till gruppen

• Kumar, Rakesh