Axel Abelein

Axel Abelein

Biträdande Lektor | Docent
E-postadress: axel.abelein@ki.se
Besöksadress: Blickagången 16, Neo, Flemingsberg, 14152 Hudding
Postadress: H7 Medicin, Huddinge, H7 BioNut Abelein, 171 77 Stockholm
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Forskningsbeskrivning

  • My research concerns protein self-assembly related to neurodegenerative
    diseases with the focus on characterization of protein structure and
    molecular mechanisms of self-assembly. The studies in our lab include a
    broad range of different techniques within biophysics, protein
    biochemistry and biomedicine. My current research focuses on the
    aggregation mechanisms of amyloid-β peptide (Aβ) fibril formation,
    associated to Alzheimer’s disease and inhibition mechanisms by the
    BRICHOS domain, a chaperone-like protein that is potential candidate to be
    implemented in Alzheimer’s disease treatment. Furthermore, another research
    line is the development of new expression and purification protocols for
    aggregation-prone proteins using a spider silk-derived solubility tag, where
    one possible application is the generation of new biomaterials.
    Please visit our group homepage for more information:
    https://ki.se/en/bionut/laboratory-for-protein-misfolding-and-assembly

Utvalda publikationer

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Anställningar

  • Biträdande Lektor, Medicin, Huddinge, Karolinska Institutet, 2024-2025

Examina och utbildning

  • Docent, Biofysik, Karolinska Institutet, 2024

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