Gefei Chen

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Utvalda publikationer

Article: NEURAL REGENERATION RESEARCH. 2024;19(11):2343-2344
Potential of molecular chaperones for treating Alzheimer's disease
Chen G; Johansson J
Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(23)
Spiders Use Structural Conversion of Globular Amyloidogenic Domains to Make Strong Silk Fibers
Qi X; Wang H; Wang K; Wang Y; Leppert A; Iashchishyn I; Zhong X; Zhou Y; Liu R; Rising A; Landreh M; Johansson J; Chen G
Article: SMALL. 2023;19(46):e2304031
Spider Silk Protein Forms Amyloid-Like Nanofibrils through a Non-Nucleation-Dependent Polymerization Mechanism
Qi X; Wang Y; Yu H; Liu R; Leppert A; Zheng Z; Zhong X; Jin Z; Wang H; Li X; Wang X; Landreh M; Morozova-Roche LA; Johansson J; Xiong S; Iashchishyn I; Chen G
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497
Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation
Chen G; Leppert A; Poska H; Nilsson HE; Alvira CP; Zhong X; Koeck P; Jegerschold C; Abelein A; Hebert H; Johansson J
Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366
S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS
Andrade-Talavera Y; Chen G; Pansieri J; -Garcia LEA; Toleikis Z; Smirnovas V; Johansson J; Morozova-Roche L; Fisahn A
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue
Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain
Zhong X; Kumar R; Wang Y; Biverstal H; Jegerschoeld CI; Koeck PJB; Johansson J; Abelein A; Chen G
Article: ACS BIOMATERIALS SCIENCE AND ENGINEERING. 2022;8(1):119-127
Customized Flagelliform Spidroins Form Spider Silk-like Fibers at pH 8.0 with Outstanding Tensile Strength
Li X; Qi X; Cai Y-M; Sun Y; Wen R; Zhang R; Johansson J; Meng Q; Chen G
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808
Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro
Oliveira DV; Svensson J; Zhong X; Biverstal H; Chen G; Karlstrom H
Preprint: BIORXIV. 2021
Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue
Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: BMC BIOTECHNOLOGY. 2020;20(1):37
One-step heating strategy for efficient solubilization of recombinant spider silk protein from inclusion bodies
Cai H; Chen G; Yu H; Tang Y; Xiong S; Qi X
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
Article: NATURE COMMUNICATIONS. 2017;8(1):2081
Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
Article: BIOPOLYMERS. 2016;105(7):385-392
Chimeric Spider Silk Proteins Mediated by Intein Result in Artificial Hybrid Silks
Lin S; Chen G; Liu X; Meng Q
Article: CHEMBIOCHEM. 2015;16(12):1720-1724
Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains
Otikovs M; Chen G; Nordling K; Landreh M; Meng Q; Joernvall H; Kronqvist N; Rising A; Johansson J; Jaudzems K
Journal article: CHEMBIOCHEM. 2015;16(12):1824
Back Cover: Diversified Structural Basis of a Conserved Molecular Mechanism for pH‐Dependent Dimerization in Spider Silk N‐Terminal Domains (ChemBioChem 12/2015)
Otikovs M; Chen G; Nordling K; Landreh M; Meng Q; Jörnvall H; Kronqvist N; Rising A; Johansson J; Jaudzems K
Article: PLOS BIOLOGY. 2014;12(8):e1001921
Carbonic Anhydrase Generates CO₂ and H⁺ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains
Andersson M; Chen G; Otikovs M; Landreh M; Nordling K; Kronqvist N; Westermark P; Jornvall H; Knight S; Ridderstrale Y; Holm L; Meng Q; Jaudzems K; Chesler M; Johansson J; Rising A
Article: PLOS ONE. 2012;7(12):e52293
Full-Length Minor Ampullate Spidroin Gene Sequence
Chen G; Liu X; Zhang Y; Lin S; Yang Z; Johansson J; Rising A; Meng Q

Artiklar

Article: BIOORGANIC CHEMISTRY. 2024;147:107373
Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer's disease
Das B; Baidya ATK; Chakrabarti S; Chouhan D; Thakur B; Darreh-Shori T; Chen G; Tiwari V; Kumar R
Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease
Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
Journal article: JOURNAL OF FUNCTIONAL FOODS. 2024;113:106041
Eriodictyol downregulates UBA52 to promote autophagy and upregulates Nrf2/HO-1 to inhibit oxidative stress to ameliorate non-alcoholic fatty liver disease
Cai Y; Yuan L; Wang K; Liu Q; Xing H; Zhong P; Lin J; Liang Y; Chen G; Li W; Chen J; Li X
Journal article: NATURE COMMUNICATIONS. 2024;15(1):965
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain.
Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: NATURE COMMUNICATIONS. 2024;15(1):965
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: SMALL. 2023;19(46)
Spider Silk Protein Forms Amyloid-Like Nanofibrils through a Non-Nucleation-Dependent Polymerization Mechanism (Small 46/2023)
Qi X; Wang Y; Yu H; Liu R; Leppert A; Zheng Z; Zhong X; Jin Z; Wang H; Li X; Wang X; Landreh M; Morozova-Roche LA; Johansson J; Xiong S; Iashchishyn I; Chen G
Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545
Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity
Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
Journal article: IBRO REPORTS. 2023;15:s447
PRO-NEUROGENIC THERAPEUTIC APPROACHES BASED ON BRI2 MODULATION
Martins F; Chen G; Zhao H; Nilsson P; Tambaro S; Rebelo S
Article: BIOLOGY. 2023;12(6):805
The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in App^NL-G-F Knock-In Mice
Medina-Vera D; Zhao H; Bereczki E; Rosell-Valle C; Shimozawa M; Chen G; de Fonseca FR; Nilsson P; Tambaro S
Article: PNAS NEXUS. 2023;2(2):pgac303
A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1
Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmae M; Chen G; Elofsson A; Allison TM; Arsenian-Henriksson M; Johansson J; Lane DP; Hallberg BM; Landreh M
Article: MOLECULAR THERAPY. 2023;31(2):487-502
Intravenous treatment with a molecular chaperone designed against f3-amyloid toxicity improves Alzheimer?s disease pathology in mouse models
Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
Article: NATURE COMMUNICATIONS. 2022;13(1):4695
Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Stromberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;188:194-205
Resolution of inflammation is disturbed in acute ischemic stroke with diabetes mellitus and rescued by resolvin D2 treatment
Tang X; Liu L; Miao Z; Zhang J; Cai X; Zhao B-Q; Chen G; Schultzberg M; Zhao Y; Wang X
Article: PROTEIN SCIENCE. 2022;31(8):e4378
ATP-independent molecular chaperone activity generated under reducing conditions
Leppert A; Chen G; Lianoudaki D; Williams C; Zhong X; Gilthorpe JD; Landreh M; Johansson J
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis
Jiang R; Smailovic U; Haytural H; Tijms BM; Li H; Haret RM; Shevchenko G; Chen G; Abelein A; Gobom J; Frykman S; Sekiguchi M; Fujioka R; Watamura N; Sasaguri H; Nystrom S; Hammarstrom P; Saido TC; Jelic V; Syvanen S; Zetterberg H; Winblad B; Bergquist J; Visser PJ; Nilsson P
Article: STRUCTURE. 2022;30(5):733-742.e7
A "spindle and thread"mechanism unblocks p53 translation N-terminal disorder
Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514
Bri2 BRICHOS chaperone rescues impaired fast-spiking interneuron behavior and neuronal network dynamics in an AD mouse model in vitro
Andrade-Talavera Y; Chen G; Kurudenkandy FR; Johansson J; Fisahn A
Article: SCIENTIFIC REPORTS. 2021;11(1):21069
AA amyloid in human food chain is a possible biohazard
Rising A; Gherardi P; Chen G; Johansson J; Oskarsson ME; Westermark GT; Westermark P
Article: MICROBIAL CELL FACTORIES. 2021;20(1):150
Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture
Schmuck B; Chen G; Pelcman J; Kronqvist N; Rising A; Johansson J
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996
The synthesis and characterization of Bri2 BRICHOS coated magnetic particles and their application to protein fishing: Identification of novel binding proteins
Tigro H; Kronqvist N; Abelein A; Galan-Acosta L; Chen G; Landreh M; Lyashkov A; Aon MA; Ferrucci L; Shimmo R; Johansson J; Moaddel R
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212
Ablation of p75^NTR signaling strengthens gamma-theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro
Andrade-Talavera Y; Balleza-Tapia H; Dolz-Gaiton P; Chen G; Johansson J; Fisahn A
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:650848
Echocardiographic Prognosis Relevance of Attenuated Right Heart Remodeling in Idiopathic Pulmonary Arterial Hypertension
Zhao Q-H; Gong S-G; Jiang R; Li C; Chen G-F; Luo C-J; Qiu H-L; Liu J-M; Wang L; Zhang R
Article: JOURNAL OF PHYSIOLOGY. 2020;598(17):3711-3725
Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ-induced desynchronization of fast-spiking interneuron firing in an AD mouse modelin vitro
Andrade-Talavera Y; Arroyo-Garcia LE; Chen G; Johansson J; Fisahn A
Article: THE FEBS JOURNAL. 2020;287(13):2823-2833
High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry
Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
Article: SCIENTIFIC REPORTS. 2020;10(1):9817
Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation
Poska H; Leppert A; Tigro H; Zhong X; Kaldmae M; Nilsson HE; Hebert H; Chen G; Johansson J
Article: SCIENTIFIC REPORTS. 2020;10(1):235
High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstal H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice
Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstal H; Presto J; Nilsson P; Johansson J
Article: ELIFE. 2018;7:e37703
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro
Balleza-Tapia H; Crux S; Andrade-Talavera Y; Dolz-Gaiton P; Papadia D; Chen G; Johansson J; Fisahn A
Article: THE FEBS JOURNAL. 2018;285(10):1873-1885
A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein
Sarr M; Kronqvist N; Chen G; Aleksis R; Purhonen P; Hebert H; Jaudzems K; Rising A; Johansson J
Article: SHENGWU GONGCHENG XUEBAO/CHINESE JOURNAL OF BIOTECHNOLOGY. 2016;32(12):1704-1714
[Construction of spider silk functional platform via intein trans-splicing].
Lin S; Chen G; Meng Q
Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila
Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
Article: SHENGWU GONGCHENG XUEBAO/CHINESE JOURNAL OF BIOTECHNOLOGY. 2014;30(8):1308-1317
[Effect of salt on minor ampullate silk spidroin modules].
Wang J; Chen G; Meng Q
Article: NATURE COMMUNICATIONS. 2014;5:3254
Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation
Kronqvist N; Otikovs M; Chmyrov V; Chen G; Andersson M; Nordling K; Landreh M; Sarr M; Jornvall H; Wennmalm S; Widengren J; Meng Q; Rising A; Otzen D; Knight SD; Jaudzems K; Johansson J
Article: SHENGWU GONGCHENG XUEBAO/CHINESE JOURNAL OF BIOTECHNOLOGY. 2013;29(9):1323-1331
[Expression of Araneus ventricosus minor ampullate spidroin].
Yang Z; Chen G; Meng Q
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Letter: NANO LETTERS. 2023;23(12):5836-5841
Liquid-Liquid Phase Separation Primes Spider Silk Proteins for Fiber Formation via a Conditional Sticker Domain
Leppert A; Chen G; Lama D; Sahin C; Railaite V; Shilkova O; Arndt T; Marklund EG; Lane DP; Rising A; Landreh M
Review: PROTEIN SCIENCE. 2023;32(6):e4645
A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain
Leppert A; Poska H; Landreh M; Abelein A; Chen G; Johansson J
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S54
Structural insights into aggregation hotspots on Alzheimer's associated amyloid-β fibrils blocked by the BRICHOS chaperone
Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
Preprint: BIORXIV. 2022
Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer’s disease
Maccioni R; Travisan C; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schröder B; Nilsson P; Tambaro S
Preprint: BIORXIV. 2022
A “grappling hook” interaction balances self-assembly and chaperone activity of Nucleophosmin 1
Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmäe M; Chen G; Elofsson A; Allison T; Arsenian-Henriksson M; Johansson J; Lane D; Hällberg M; Landreh M
Preprint: RESEARCH SQUARE. 2021
Resolution of Inflammation is Disturbed in Acute Ischemic Stroke With Diabetes Mellitus and Rescued By Resolvin D2 Treatment
Tang X; Liu L; Miao Z; Zhang J; Cai X; Zhao B-Q; Chen G; Schultzberg M; Zhao Y; Wang X
Preprint: BIORXIV. 2021
A “spindle and thread”-mechanism unblocks translation of N-terminally disordered proteins
Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy F; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag L; Väänänen V; Sedimbi S; Zubarev R; Nilsson L; Koeck P; Rising A; Fritz N; Johansson J; Lane D; Landreh M
Preprint: SSRN ELECTRONIC JOURNAL. 2021
A 'Spindle and Thread'-Mechanism Unblocks p53 Translation by Modulating N-Terminal Disorder
Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Sau JW; Ng AS; Ghadessy F; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag L; Väänänen V; Sedimbi S; Arsenain-Henriksson M; Zubarev R; Nilsson L; Koeck P; Rising A; Abelein A; Fritz N; johansson J; Lane DP; Landreh M
Preprint: RESEARCH SQUARE. 2020
One-step heating strategy for efficient solubilization of recombinant spider silk protein from inclusion bodies
Cai H; Chen G; Yu H; Tang Y; Xiong S; Qi X
Preprint: RESEARCH SQUARE. 2020
One-Step Heating Strategy for Efficient Solubilization of Recombinant Spider Silk Protein From Inclusion Bodies
Cai H; Chen G; Yu H; Tang Y; Xiong S; Qi X
Preprint: RESEARCH SQUARE. 2019
One-step heating strategy for efficient solubilization of recombinant spider silk protein from inclusion bodies
Cai H; Chen G; Tang Y; Yu H; Xiong S; Qi X
Meeting abstract: AMYLOID : THE INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF AMYLOIDOSIS. 2019;26(sup1):152-153
BRICHOS: a chaperone with different activities depending on quaternary structure and cellular location?
Leppert A; Chen G; Johansson J
Conference publication: PROTEIN SCIENCE. 2017;26:18-19
Exploring Amyloid-like Aggregation Using a Mutant Domain of a Spidroin as a Solubility Tag
Sarr M; Kronqvist N; Reifenrath M; Chen G; Rising A; Johansson J
Conference publication: PROTEIN SCIENCE. 2017;26:31-32
Bri2 BRICHOS molecular chaperone activity is decoupled from its ability to inhibit amyloid fibril formation
Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J

Forskningsbidrag

BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s Disease
Fundação para a Ciência e Tecnologia
1 January 2022 - 31 December 2025

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