Gefei Chen
Om mig
Jag tog min doktorsexamen i biokemi och molekylärbiologi och utvecklade en gedigen grund inom proteinbiokemi under min postdoktorala utbildning mellan 2014 och 2019. Min karriär fortsatte som biträdande professor i medicinsk proteinbiokemi från 2019 till 2023, där jag fokuserade på molekylära mekanismer och potentiella behandlingar av en molekylär chaperondomän vid neurodegenerativa sjukdomar, bland andra projekt. För närvarande arbetar jag som huvudforskare med inriktning på medicinsk proteinbiokemi och strukturbiologi.
Forskningsbeskrivning
Proteiner kan vecklas ut och samlas i både patogena och funktionella amyloida fibriller, vilka är relevanta för mänskliga sjukdomar, bakteriella infektioner och biomaterial. Vår forskning syftar till att förstå de underliggande mekanismerna bakom dessa olika typer av amyloidbildning samt att identifiera naturliga och ingenjörsmässiga strategier för att hämma amyloidaggregering. Vårt mål är att utveckla terapeutiska metoder för att behandla mänskliga sjukdomar och bekämpa bakteriella infektioner. Parallellt är vi intresserade av mekanismerna och funktionerna hos amyloida strukturer i naturliga silkesfibrer, med fokus på deras potentiella tillämpningar inom biomaterial.
Undervisning
Jag har aktivt bidragit till utbildning på grundnivå och avancerad nivå genom föreläsningar, seminarier, laboratoriekurser samt handledning av kandidatarbeten, masteruppsatser, doktorander och postdoktorala forskare. Under de senaste sex åren har jag genomfört totalt 180+ undervisningstimmar inom kursundervisning och uppsatshandledning. Min undervisningserfarenhet sträcker sig över Karolinska Institutet och Uppsala universitet och omfattar ämnen som biomedicin och molekylär biofysik. Även om min nuvarande tjänst som huvudforskare främst är inriktad på forskning, är jag fortsatt engagerad i utbildning och bidrar frivilligt med cirka 35 undervisningstimmar per år.
Utvalda publikationer
- Article: SCIENCE ADVANCES. 2025;11(24):eads7525Jin Z; Olsen WP; Moerman C; Leppert A; Kumar R; Mollebjerg A; Nielsen LG; Moshynets OV; Frasinyuk MS; Elosua JY; Ferreira D; Abelein A; Landreh M; Knight SD; Johansson J; Otzen DE; Chen G
- Journal article: ADVANCED FUNCTIONAL MATERIALS. 2025;35(15)Qi X; Wei G; Li Y; Xiong S; Chen G
- Article: ADVANCED FUNCTIONAL MATERIALS. 2025;35(15)Qi X; Wei G; Li Y; Xiong S; Chen G
- Article: NEURAL REGENERATION RESEARCH. 2024;19(11):2343-2344Chen G; Johansson J
- Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):453Zhang R; Ohshima M; Brodin D; Wang Y; Morance A; Schultzberg M; Chen G; Johansson J
- Article: MEDCOMM. 2024;5(7):e573Yu H; Chen G; Li L; Wei G; Li Y; Xiong S; Qi X
- Article: PROTEIN SCIENCE. 2024;33(7):e5063Chen G; Wang Y; Zheng Z; Jiang W; Leppert A; Zhong X; Belorusova A; Siegal G; Jegerschold C; Koeck PJB; Abelein A; Hebert H; Knight SD; Johansson J
- Journal article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(23)Qi X; Wang H; Wang K; Wang Y; Leppert A; Iashchishyn I; Zhong X; Zhou Y; Liu R; Rising A; Landreh M; Johansson J; Chen G
- Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(23)Qi X; Wang H; Wang K; Wang Y; Leppert A; Iashchishyn I; Zhong X; Zhou Y; Liu R; Rising A; Landreh M; Johansson J; Chen G
- Article: SMALL. 2023;19(46)Qi X; Wang Y; Yu H; Liu R; Leppert A; Zheng Z; Zhong X; Jin Z; Wang H; Li X; Wang X; Landreh M; Morozova-Roche LA; Johansson J; Xiong S; Iashchishyn I; Chen G
- Article: SMALL. 2023;19(46):e2304031Qi X; Wang Y; Yu H; Liu R; Leppert A; Zheng Z; Zhong X; Jin Z; Wang H; Li X; Wang X; Landreh M; Morozova-Roche LA; Johansson J; Xiong S; Iashchishyn I; Chen G
- Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497Chen G; Leppert A; Poska H; Nilsson HE; Alvira CP; Zhong X; Koeck P; Jegerschold C; Abelein A; Hebert H; Johansson J
- Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366Andrade-Talavera Y; Chen G; Pansieri J; -Garcia LEA; Toleikis Z; Smirnovas V; Johansson J; Morozova-Roche L; Fisahn A
- Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
- Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211Zhong X; Kumar R; Wang Y; Biverstal H; Jegerschoeld CI; Koeck PJB; Johansson J; Abelein A; Chen G
- Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2022;8(1):119-127Li X; Qi X; Cai Y-M; Sun Y; Wen R; Zhang R; Johansson J; Meng Q; Chen G
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
- Article: NATURE COMMUNICATIONS. 2017;8(1):2081Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
- Journal article: CHEMBIOCHEM. 2015;16(12):1824Otikovs M; Chen G; Nordling K; Landreh M; Meng Q; Jörnvall H; Kronqvist N; Rising A; Johansson J; Jaudzems K
- Article: CHEMBIOCHEM. 2015;16(12):1720-1724Otikovs M; Chen G; Nordling K; Landreh M; Meng Q; Joernvall H; Kronqvist N; Rising A; Johansson J; Jaudzems K
- Article: PLOS BIOLOGY. 2014;12(8):e1001921Andersson M; Chen G; Otikovs M; Landreh M; Nordling K; Kronqvist N; Westermark P; Jornvall H; Knight S; Ridderstrale Y; Holm L; Meng Q; Jaudzems K; Chesler M; Johansson J; Rising A
- Article: PLOS ONE. 2012;7(12):e52293Chen G; Liu X; Zhang Y; Lin S; Yang Z; Johansson J; Rising A; Meng Q
- Visa fler
Artiklar
- Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2025;147(27):23504-23518Morman C; Leppert A; Pizzirusso G; Zheng Z; Sun X; Kumar R; Biverstal H; Landreh M; Johansson J; Arroyo-Garcia LE; Luo J; Chen G; Abelein A
- Journal article: ALZHEIMERS & DEMENTIA. 2024;20(Suppl 9):e093828Badman J; Chen G; Garcia SP; Nilsson P; Tambaro S
- Journal article: ALZHEIMERS & DEMENTIA. 2024;20 Suppl 1:e089371Badman J; Chen G; Garcia SP; Nilsson P; Tambaro S
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;101(3):787-796Oasa S; Chen G; Schultzberg M; Terenius L
- Article: BIOORGANIC CHEMISTRY. 2024;147:107373Das B; Baidya ATK; Chakrabarti S; Chouhan D; Thakur B; Darreh-Shori T; Chen G; Tiwari V; Kumar R
- Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
- Journal article: NATURE COMMUNICATIONS. 2024;15(1):965Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
- Article: NATURE COMMUNICATIONS. 2024;15(1):965Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
- Article: JOURNAL OF FUNCTIONAL FOODS. 2024;113:106041Cai Y; Yuan L; Wang K; Liu Q; Xing H; Zhong P; Lin J; Liang Y; Chen G; Li W; Chen J; Li X
- Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
- Journal article: IBRO REPORTS. 2023;15:s447Martins F; Chen G; Zhao H; Nilsson P; Tambaro S; Rebelo S
- Journal article: NANO LETTERS. 2023;23(12):5836-5841Leppert A; Chen G; Lama D; Sahin C; Railaite V; Shilkova O; Arndt T; Marklund EG; Lane DP; Rising A; Landreh M
- Article: BIOLOGY-BASEL. 2023;12(6):805Medina-Vera D; Zhao H; Bereczki E; Rosell-Valle C; Shimozawa M; Chen G; de Fonseca FR; Nilsson P; Tambaro S
- Article: PNAS NEXUS. 2023;2(2):pgac303Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmae M; Chen G; Elofsson A; Allison TM; Arsenian-Henriksson M; Johansson J; Lane DP; Hallberg BM; Landreh M
- Article: MOLECULAR THERAPY. 2023;31(2):487-502Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
- Article: NATURE COMMUNICATIONS. 2022;13(1):4695Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Stromberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;188:194-205Tang X; Liu L; Miao Z; Zhang J; Cai X; Zhao B-Q; Chen G; Schultzberg M; Zhao Y; Wang X
- Article: PROTEIN SCIENCE. 2022;31(8):e4378Leppert A; Chen G; Lianoudaki D; Williams C; Zhong X; Gilthorpe JD; Landreh M; Johansson J
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96Jiang R; Smailovic U; Haytural H; Tijms BM; Li H; Haret RM; Shevchenko G; Chen G; Abelein A; Gobom J; Frykman S; Sekiguchi M; Fujioka R; Watamura N; Sasaguri H; Nystrom S; Hammarstrom P; Saido TC; Jelic V; Syvanen S; Zetterberg H; Winblad B; Bergquist J; Visser PJ; Nilsson P
- Article: STRUCTURE. 2022;30(5):733-742.e7Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
- Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808Oliveira DV; Svensson J; Zhong X; Biverstal H; Chen G; Karlstrom H
- Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514Andrade-Talavera Y; Chen G; Kurudenkandy FR; Johansson J; Fisahn A
- Article: SCIENTIFIC REPORTS. 2021;11(1):21069Rising A; Gherardi P; Chen G; Johansson J; Oskarsson ME; Westermark GT; Westermark P
- Article: MICROBIAL CELL FACTORIES. 2021;20(1):150Schmuck B; Chen G; Pelcman J; Kronqvist N; Rising A; Johansson J
- Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996Tigro H; Kronqvist N; Abelein A; Galan-Acosta L; Chen G; Landreh M; Lyashkov A; Aon MA; Ferrucci L; Shimmo R; Johansson J; Moaddel R
- Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:650848Zhao Q-H; Gong S-G; Jiang R; Li C; Chen G-F; Luo C-J; Qiu H-L; Liu J-M; Wang L; Zhang R
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212Andrade-Talavera Y; Balleza-Tapia H; Dolz-Gaiton P; Chen G; Johansson J; Fisahn A
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(17):3711-3725Andrade-Talavera Y; Arroyo-Garcia LE; Chen G; Johansson J; Fisahn A
- Article: BMC BIOTECHNOLOGY. 2020;20(1):37Cai H; Chen G; Yu H; Tang Y; Xiong S; Qi X
- Article: FEBS JOURNAL. 2020;287(13):2823-2833Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
- Article: SCIENTIFIC REPORTS. 2020;10(1):9817Poska H; Leppert A; Tigro H; Zhong X; Kaldmae M; Nilsson HE; Hebert H; Chen G; Johansson J
- Article: SCIENTIFIC REPORTS. 2020;10(1):235Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstal H
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstal H; Presto J; Nilsson P; Johansson J
- Article: ELIFE. 2018;7:e37703Balleza-Tapia H; Crux S; Andrade-Talavera Y; Dolz-Gaiton P; Papadia D; Chen G; Johansson J; Fisahn A
- Article: FEBS JOURNAL. 2018;285(10):1873-1885Sarr M; Kronqvist N; Chen G; Aleksis R; Purhonen P; Hebert H; Jaudzems K; Rising A; Johansson J
- Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2016;32(12):1704-1714Lin S; Chen G; Meng Q
- Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
- Article: BIOPOLYMERS. 2016;105(7):385-392Lin S; Chen G; Liu X; Meng Q
- Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2014;30(8):1308-1317Wang J; Chen G; Meng Q
- Article: NATURE COMMUNICATIONS. 2014;5:3254Kronqvist N; Otikovs M; Chmyrov V; Chen G; Andersson M; Nordling K; Landreh M; Sarr M; Jornvall H; Wennmalm S; Widengren J; Meng Q; Rising A; Otzen D; Knight SD; Jaudzems K; Johansson J
- Article: CHINESE JOURNAL OF BIOTECHNOLOGY. 2013;29(9):1323-1331Yang Z; Chen G; Meng Q
- Visa fler
Alla övriga publikationer
- Review: COMMUNICATIONS CHEMISTRY. 2024;7(1):260Landreh M; Osterholz H; Chen G; Knight SD; Rising A; Leppert A
- Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S54Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
- Review: PROTEIN SCIENCE. 2023;32(6):e4645Leppert A; Poska H; Landreh M; Abelein A; Chen G; Johansson J
- Preprint: BIORXIV. 2022Maccioni R; Travisan C; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schröder B; Nilsson P; Tambaro S
- Preprint: BIORXIV. 2022Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmäe M; Chen G; Elofsson A; Allison T; Arsenian-Henriksson M; Johansson J; Lane D; Hällberg M; Landreh M
- Preprint: BIORXIV. 2021Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
- Preprint: RESEARCH SQUARE. 2021Tang X; Liu L; Miao Z; Zhang J; Cai X; Zhao B-Q; Chen G; Schultzberg M; Zhao Y; Wang X
- Preprint: BIORXIV. 2021Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy F; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag L; Väänänen V; Sedimbi S; Zubarev R; Nilsson L; Koeck P; Rising A; Fritz N; Johansson J; Lane D; Landreh M
- Preprint: SSRN ELECTRONIC JOURNAL. 2021Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Sau JW; Ng AS; Ghadessy F; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag L; Väänänen V; Sedimbi S; Arsenain-Henriksson M; Zubarev R; Nilsson L; Koeck P; Rising A; Abelein A; Fritz N; johansson J; Lane DP; Landreh M
- Preprint: RESEARCH SQUARE. 2020Cai H; Chen G; Yu H; Tang Y; Xiong S; Qi X
- Preprint: RESEARCH SQUARE. 2020Cai H; Chen G; Yu H; Tang Y; Xiong S; Qi X
- Preprint: RESEARCH SQUARE. 2019Cai H; Chen G; Tang Y; Yu H; Xiong S; Qi X
- Conference publication: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 2019;26(sup1):152-153Leppert A; Chen G; Johansson J
- Conference publication: PROTEIN SCIENCE. 2017;26:18-19Sarr M; Kronqvist N; Reifenrath M; Chen G; Rising A; Johansson J
- Conference publication: PROTEIN SCIENCE. 2017;26:31-32Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
Forskningsbidrag
- U.S. Alzheimer's Association Research GrantAlzheimer's Association, U.S.1 September 2022 - 31 August 2025
- BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s DiseaseFundação para a Ciência e Tecnologia1 January 2022 - 31 December 2025
Anställningar
- Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2024-
Examina och utbildning
- Docent, Cell- och molekylärbiologi, Karolinska Institutet, 2025