Yihai Cao

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Professor i vaskulär biologi, särskilt angiogenesreglering

Forskningsbeskrivning

Angiogenes, Cancer, Metastaser, Metabolism, Sjukdomsterapi, Kardiovaskulära sjukdomar, Oftalmologiska sjukdomar.

Undervisning

Grundutbildning
Forskarutbildning
Ph.D utbildning
Postdoktoral utbildning

Artiklar

Article: DIABETES. 2024;:db240393
Long-term nerve regeneration in diabetic keratopathy mediated by a novel NGF delivery system.
Cong L; Qi B; Chen S; Liu R; Li S; Zhou Q; Cao Y; Zhang BN; Xie L
Article: ADVANCED SCIENCE. 2024;:e2409726
Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML
Shao G; Wang X; Zheng Y; Ma J; Wang L; Yan Z; Sun Z; Zhang S; Wu H; Lv Y; Huang H; Li J; Zhu T; Yang B; Wang N; Chen T; Guo X; Jin Y; Kang J; Wang H; Cao Y; Fu C
Article: CELL DISCOVERY. 2024;10(1):106
NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout
Chi J; Chen Y; Li C; Liu S; Che K; Kong Z; Guo Z; Chu Y; Huang Y; Yang L; Sun C; Wang Y; Lv W; Zhang Q; Guo H; Zhao H; Yang Z; Xu L; Wang P; Dong B; Hu J; Liu S; Wang F; Zhao Y; Qi M; Xin Y; Nan H; Zhao X; Zhang W; Xiao M; Si K; Wang Y; Cao Y
Article: REDOX BIOLOGY. 2024;76:103318
ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages
Rui H; Yu H; Chi K; Han Z; Zhu W; Zhang J; Guo H; Zou W; Wang F; Xu P; Zou D; Song X; Liu L; Wu X; Wu W; Qin D; Cao Y; Xu F; Xue L; Chen Y
Article: ADVANCED SCIENCE. 2024;11(38):e2402332
Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues
Chen R; Cheng T; Xie S; Sun X; Chen M; Zhao S; Ruan Q; Ni X; Rao M; Quan X; Chen K; Zhang S; Cheng T; Xu Y; Chen Y; Yang Y; Cao Y
Article: CELL DEATH AND DIFFERENTIATION. 2024;31(6):697-710
Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Liu H; Sun L; Zhao H; Zhao Z; Zhang S; Jiang S; Cheng T; Wang X; Wang T; Shao Y; Zhu H; Han H; Cao Y; Jiang E; Cao Y; Xu Y
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Article: CELLULAR AND MOLECULAR IMMUNOLOGY. 2024;21(5):510-526
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS
Xu C; Zhang L; Xu S; Wang Z; Han Q; Lv Y; Wang X; Zhang X; Zhang Q; Zhang Y; He S; Yuan Q; Bian Y; Li C; Wang J; Xu F; Cao Y; Pang J; Chen Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(6):e2305947121
Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF- macrophage pathway
Yi W; Xue Y; Qing W; Cao Y; Zhou L; Xu M; Sun Z; Li Y; Mai X; Shi L; He C; Zhang F; Duh EJ; Cao Y; Liu X
Article: SCIENCE CHINA LIFE SCIENCES. 2024;67(2):332-344
The role of corneal endothelium in macular corneal dystrophy development and recurrence
Zhang B-N; Qi B; Dong C; Zhang B; Cheng J; Wang X; Li S; Zhuang X; Chen S; Duan H; Li D; Zhu S; Li G; Cao Y; Zhou Q; Xie L
Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1338147
New mechanistic insights of anti-obesity by sleeve gastrectomy-altered gut microbiota and lipid metabolism
Liu C; Xu Q; Dong S; Ding H; Li B; Zhang D; Liang Y; Li L; Liu Q; Cheng Y; Wu J; Zhu J; Zhong M; Cao Y; Zhang G
Article: HOLIST INTEGR ONCOL. 2024;3(1):11
Cancer-triggered systemic disease and therapeutic targets.
Cao Y
Article: NATURE COMMUNICATIONS. 2023;14(1):7610
Mirabegron displays anticancer effects by globally browning adipose tissues
Sun X; Sui W; Mu Z; Xie S; Deng J; Li S; Seki T; Wu J; Jing X; He X; Wang Y; Li X; Yang Y; Huang P; Ge M; Cao Y
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2023;62(41):e202308413
In situ Engineering of Tumor-Associated Macrophages via a Nanodrug-Delivering-Drug (β-Elemene@Stanene) Strategy for Enhanced Cancer Chemo-Immunotherapy
Chen W; Li Y; Liu C; Kang Y; Qin D; Chen S; Zhou J; Liu H-J; Ferdows BE; Patel DN; Huang X; Koo S; Kong N; Ji X; Cao Y; Tao W; Xie T
Journal article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2023;135(41)
Titelbild: In situ Engineering of Tumor‐Associated Macrophages via a Nanodrug‐Delivering‐Drug (β‐Elemene@Stanene) Strategy for Enhanced Cancer Chemo‐Immunotherapy (Angew. Chem. 41/2023)
Chen W; Li Y; Liu C; Kang Y; Qin D; Chen S; Zhou J; Liu H; Ferdows BE; Patel DN; Huang X; Koo S; Kong N; Ji X; Cao Y; Tao W; Xie T
Article: ADVANCED SCIENCE. 2023;10(28):e2301852
Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury
Liu L; Pang J; Qin D; Li R; Zou D; Chi K; Wu W; Rui H; Yu H; Zhu W; Liu K; Wu X; Wang J; Xu P; Song X; Cao Y; Wang J; Xu F; Xue L; Chen Y
Article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):305
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
Lee C; Chen R; Sun G; Liu X; Lin X; He C; Xing L; Liu L; Jensen LD; Kumar A; Langer HF; Ren X; Zhang J; Huang L; Yin X; Kim J; Zhu J; Huang G; Li J; Lu W; Chen W; Liu J; Hu J; Sun Q; Lu W; Fang L; Wang S; Kuang H; Zhang Y; Tian G; Mi J; Kang B-A; Narazaki M; Prodeus A; Schoonjans L; Ornitz DM; Gariepy J; Eelen G; Dewerchin M; Yang Y; Ou J-S; Mora A; Yao J; Zhao C; Liu Y; Carmeliet P; Cao Y; Li X
Article: ADVANCED SCIENCE. 2023;10(24):e2301505
Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism
Wu J; Jing X; Du Q; Sun X; Holgersson K; Gao J; He X; Hosaka K; Zhao C; Tao W; FitzGerald GA; Yang Y; Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(29):e2303740120
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas
Hosaka K; Andersson P; Wu J; He X; Du Q; Jing X; Seki T; Gao J; Zhang Y; Sun X; Huang P; Yang Y; Ge M; Cao Y
Article: MOLECULAR ONCOLOGY. 2023;17(7):1379-1401
A group of novel VEGF splice variants as alternative therapeutic targets in renal cell carcinoma
Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Kamenskaya A; Negrier S; Bernhard J-C; Borchiellini D; Cao Y; Pages G
Article: ADVANCED SCIENCE. 2023;10(16):e2207439
Glutathione-Scavenging Nanoparticle-Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects
Liu H-J; Chen W; Wu G; Zhou J; Liu C; Tang Z; Huang X; Gao J; Xiao Y; Kong N; Joshi N; Cao Y; Abdi R; Tao W
Article: CANCER COMMUNICATIONS. 2023;43(6):637-660
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors
Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
Journal article: CHINESE JOURNAL OF CANCER. 2023;43(4):i
Cover Image, Volume 43, Issue 4
Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: CANCER COMMUNICATIONS. 2023;43(4):415-434
Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors
Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: GUT. 2023;72(4):710-721
Novel TCF21^high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix
Li X; Pan J; Liu T; Yin W; Miao Q; Zhao Z; Gao Y; Zheng W; Li H; Deng R; Huang D; Qiu S; Zhang Y; Qi Q; Deng L; Huang M; Tang PM-K; Cao Y; Chen M; Ye W; Zhang D
Article: CELLS. 2023;12(3):508
Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer
Kowald S; Huge Y; Tandiono D; Ali Z; Vazquez-Rodriguez G; Erkstam A; Fahlgren A; Sherif A; Cao Y; Jensen LD
Article: NATURE METABOLISM. 2022;4(12):1674-1683
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: BIOACTIVE MATERIALS. 2022;18:446-458
A facile and general method for synthesis of antibiotic-free protein-based hydrogel: Wound dressing for the eradication of drug-resistant bacteria and biofilms
Ouyang J; Bu Q; Tao N; Chen M; Liu H; Zhou J; Liu J; Deng B; Kong N; Zhang X; Chen T; Cao Y; Tao W
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(673):eabn9061
Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia
Xie S; Jiang C; Wu M; Ye Y; Wu B; Sun X; Lv X; Chen R; Yu W; Sun Q; Wu Y; Que R; Li H; Yang L; Liu W; Zuo J; Jensen LD; Huang G; Cao Y; Yang Y
Article: ANGIOGENESIS. 2022;25(4):517-533
PDGFD switches on stem cell endothelial commitment
Lu W; Xu P; Deng B; Zhang J; Zhan Y; Lin X; Xu X; Xia Z; Yang X; Zeng X; Huang L; Xie B; Wang C; Wang S; Kuang H; Han X; Mora A; Cao Y; Jiang Q; Li X
Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):251-261
The impact of VEGF on cancer metastasis and systemic disease
Yang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119
Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo
Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308
Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells
Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
Article: CELL REPORTS MEDICINE. 2022;3(9):100659
Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma
Hagege A; Saada-Bouzid E; Ambrosetti D; Rastoin O; Boyer J; He X; Rousset J; Montemagno C; Doyen J; Pedeutour F; Parola J; Bourget I; Luciano F; Bozec A; Cao Y; Pages G; Dufies M
Article: NATURE. 2022;608(7922):421-428
Brown-fat-mediated tumour suppression by cold-altered global metabolism
Seki T; Yang Y; Sun X; Lim S; Xie S; Guo Z; Xiong W; Kuroda M; Sakaue H; Hosaka K; Jing X; Yoshihara M; Qu L; Li X; Chen Y; Cao Y
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CELL CHEMICAL BIOLOGY. 2022;29(4):572-585.e8
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
Liang YY; Bacanu S; Sreekumar L; Ramos AD; Dai L; Michaelis M; Cinatl J; Seki T; Cao Y; Coffill CR; Lane DP; Prabhu N; Nordlund P
Article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2022;27:880-893
Heterogeneity of human corneal endothelium implicates lncRNA NEAT1 in Fuchs endothelial corneal dystrophy
Wang Q; Dou S; Zhang B; Jiang H; Qi X; Duan H; Wang X; Dong C; Zhang BN; Xie L; Cao Y; Zhou Q; Shi W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2112696119
Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
Kong N; Zhang R; Wu G; Sui X; Wang J; Kim NY; Blake S; De D; Xie T; Cao Y; Tao W
Article: CHEMICAL ENGINEERING JOURNAL. 2022;429:132328
Proof of concept for dual anticancer effects by a novel nanomaterial-mediated cancer cell killing and nano-radiosensitization
Duo Y; Quan L; Zhu D; Bin Z; Luo G; Wang F-B; Chen J; Cao Y
Article: SCIENCE ADVANCES. 2022;8(2):eabi8683
Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging
Xu X; Mu L; Li L; Liang J; Zhang S; Jia L; Yang X; Dai Y; Zhang J; Wang Y; Niu S; Xia G; Yang Y; Zhang Y; Cao Y; Zhang H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(1):e146658
Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide
Li Z; Duan H; Jia Y; Zhao C; Li W; Wang X; Gong Y; Dong C; Ma B; Dou S; Bin Z; Li D; Cao Y; Xie L; Zhou Q; Shi W
Article: GUT. 2022;71(1):129-147
Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism
Sun X; He X; Zhang Y; Hosaka K; Andersson P; Wu J; Wu J; Jing X; Du Q; Hui X; Ding B; Guo Z; Hong A; Liu X; Wang Y; Ji Q; Beyaert R; Yang Y; Li Q; Cao Y
Article: GENETICS IN MEDICINE. 2022;24(1):157-169
Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma
Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
Journal article: ADVANCED SCIENCE. 2021;8(21)
Interleukin‐33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage‐Mediated Shedding Mechanism (Adv. Sci. 21/2021)
Wu J; Chen Z; Wickström SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
Article: CANCER LETTERS. 2021;520:48-56
miR-125a-5p impairs the metastatic potential in breast cancer via IP₆K1 targeting
Minini M; Senni A; He X; Proietti S; Liguoro D; Catizone A; Giuliani A; Mancini R; Fuso A; Cucina A; Cao Y; Bizzarri M
Article: ADVANCED SCIENCE. 2021;8(21):e2101936
A Novel Mechanism of Endoplasmic Reticulum Stress- and c-Myc-Degradation-Mediated Therapeutic Benefits of Antineurokinin-1 Receptor Drugs in Colorectal Cancer
Shi Y; Wang X; Meng Y; Ma J; Zhang Q; Shao G; Wang L; Cheng X; Hong X; Wang Y; Yan Z; Cao Y; Kang J; Fu C
Article: ADVANCED SCIENCE. 2021;8(21):e2101029
Interleukin-33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage-Mediated Shedding Mechanism
Wu J; Chen Z; Wickstrom SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
Article: ADVANCED FUNCTIONAL MATERIALS. 2021;31(42)
Nanopoxia: Targeting Cancer Hypoxia by Antimonene-Based Nanoplatform for Precision Cancer Therapy
Qiu M; Duo Y; Liang W; Yang Y; Zhang B; Xie Z; Yang X; Wang G; Xie N; Nie G; Alhartomy OA; ALGhamdi AA; Wageh S; Cao Y; Zhang H
Journal article: EXPLORATION. 2021;1(2):20210051
The impact of the hypoxia-VEGF-vascular permeability on COVID-19-infected patients
Cao Y
Journal article: EMERGENCY AND CRITICAL CARE MEDICINE. 2021;1(1):2-5
Treatment of acute pulmonary edema by blocking VEGF-induced vascular leakage
Cao Y
Article: OCULAR SURFACE. 2021;21:206-220
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege
Dou S; Wang Q; Qi X; Zhang B; Jiang H; Chen S; Duan H; Lu Y; Dong J; Cao Y; Xie L; Zhou Q; Shi W
Article: NANO TODAY. 2021;38:101197
A novel NIR-responsive CO gas-releasing and hyperthermia-generating nanomedicine provides a curative approach for cancer therapy
Jin Z; Duo Y; Li Y; Qiu M; Jiang M; Liu Q; Zhao P; Yang T; Liang W; Zhang H; Cao Y; He Q
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9(6):e002616
Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacy
Xie L; Hu K; Duo Y; Shimokawa T; Kumata K; Zhang Y; Jiang C; Zhang L; Nengaki N; Wakizaka H; Cao Y; Zhang M-R
Article: HELIYON. 2021;7(5):e07134
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death
Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sonnerberg A; Cao Y; Bjornstedt M; Szakos A
Article: JOURNAL OF EXTRACELLULAR VESICLES. 2021;10(7):e12096
Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs
Huang M; Chen M; Qi M; Ye G; Pan J; Shi C; Yang Y; Zhao L; Mo X; Zhang Y; Li Y; Zhong J; Lu W; Li X; Zhang J; Lin J; Luo L; Liu T; Tang PM-K; Hong A; Cao Y; Ye W; Zhang D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2023290118
A specific RIP3⁺ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism
He C; Liu Y; Huang Z; Yang Z; Zhou T; Liu S; Hao Z; Wang J; Feng Q; Liu Y; Cao Y; Liu X
Article: EMBO REPORTS. 2021;22(3):e51329
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells
Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):166
Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma
Dufies M; Verbiest A; Cooley LS; Ndiaye PD; He X; Nottet N; Souleyreau W; Hagege A; Torrino S; Parola J; Giuliano S; Borchiellini D; Schiappa R; Mograbi B; Zucman-Rossi J; Bensalah K; Ravaud A; Auberger P; Bikfalvi A; Chamorey E; Rioux-Leclercq N; Mazure NM; Beuselinck B; Cao Y; Bernhard JC; Ambrosetti D; Pages G
Article: NATURE COMMUNICATIONS. 2021;12(1):814
Efficacy and tolerability of bevacizumab in patients with severe Covid-19
Pang J; Xu F; Aondio G; Li Y; Fumagalli A; Lu M; Valmadre G; Wei J; Bian Y; Canesi M; Damiani G; Zhang Y; Yu D; Chen J; Ji X; Sui W; Wang B; Wu S; Kovacs A; Revera M; Wang H; Jing X; Zhang Y; Chen Y; Cao Y
Article: NANO TODAY. 2021;36:101023
Nano-immunotherapy: Unique mechanisms of nanomaterials in synergizing cancer immunotherapy
Liu Q; Duo Y; Fu J; Qiu M; Sun Z; Adah D; Kang J; Xie Z; Fan T; Bao S; Zhang H; Liu L-P; Cao Y
Article: THERANOSTICS. 2021;11(19):9571-9586
The Polo-like kinase 1 inhibitor onvansertib represents a relevant treatment for head and neck squamous cell carcinoma resistant to cisplatin and radiotherapy
Hagege A; Ambrosetti D; Boyer J; Bozec A; Doyen J; Chamorey E; He X; Bourget I; Rousset J; Saada E; Rastoin O; Parola J; Luciano F; Cao Y; Pages G; Dufies M
Article: ADVANCED SCIENCE. 2020;7(24):2001191
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer
Liu Q; Xie Z; Qiu M; Shim I; Yang Y; Xie S; Yang Q; Wang D; Chen S; Fan T; Ding B; Guo Z; Adah D; Yao X; Zhang Y; Wu H; Wu Z; Wei C; Wang H; Kim HS; Zou Q; Yan Q; Cai Z; Kim JS; Liu L-P; Zhang H; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(46):28667-28677
In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment
Ouyang J; Ji X; Zhang X; Feng C; Tang Z; Kong N; Xie A; Wang J; Sui X; Deng L; Liu Y; Kim JS; Cao Y; Tao W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(37):22910-22919
Visualization of human T lymphocyte-mediated eradication of cancer cells in vivo
He X; Yin X; Wu J; Wickstrom SL; Duo Y; Du Q; Qin S; Yao S; Jing X; Hosaka K; Wu J; Jensen LD; Lundqvist A; Salter AI; Brautigam L; Tao W; Chen Y; Kiessling R; Cao Y
Article: CELL REPORTS. 2020;32(5):107990
Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis
Liu M; Yan M; Lv H; Wang B; Lv X; Zhang H; Xiang S; Du J; Liu T; Tian Y; Zhang X; Zhou F; Cheng T; Zhu Y; Jiang H; Cao Y; Ai D
Article: NATURE COMMUNICATIONS. 2020;11(1):3704
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors
Hosaka K; Yang Y; Seki T; Du Q; Jing X; He X; Wu J; Zhang Y; Morikawa H; Nakamura M; Scherzer M; Sun X; Xu Y; Cheng T; Li X; Liu X; Li Q; Liu Y; Hong A; Chen Y; Cao Y
Article: CANCERS. 2020;12(7):E1883-1883
Fast, In Vivo Model for Drug-Response Prediction in Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
Gauert A; Olk N; Pimentel-Gutierrez H; Astrahantseff K; Jensen LD; Cao Y; Eggert A; Eckert C; Hagemann AIH
Article: SCIENCE ADVANCES. 2020;6(15):eaay6825
Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions
Chen S; Xing C; Huang D; Zhou C; Ding B; Guo Z; Peng Z; Wang D; Zhu X; Liu S; Cai Z; Wu J; Zhao J; Wu Z; Zhang Y; Wei C; Yan Q; Wang H; Fan D; Liu L; Zhang H; Cao Y
Article: NATURE COMMUNICATIONS. 2020;11(1):1211
Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
Ji Q; Zhou L; Sui H; Yang L; Wu X; Song Q; Jia R; Li R; Sun J; Wang Z; Liu N; Feng Y; Sun X; Cai G; Feng Y; Cai J; Cao Y; Cai G; Wang Y; Li Q
Article: DEVELOPMENTAL BIOLOGY. 2020;457(2):206-214
Synchronized tissue-scale vasculogenesis and ubiquitous lateral sprouting underlie the unique architecture of the choriocapillaris
Ali Z; Cui D; Yang Y; Tracey-White D; Vazquez-Rodriguez G; Moosajee M; Ju R; Li X; Cao Y; Jensen LD
Article: AUTOPHAGY. 2020;16(1):106-122
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma
Jiang J; Zhang L; Chen H; Lei Y; Zhang T; Wang Y; Jin P; Lan J; Zhou L; Huang Z; Li B; Liu Y; Gao W; Xie K; Zhou L; Nice EC; Peng Y; Cao Y; Wei Y; Wang K; Huang C
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:373
Aldehyde Dehydrogenase 2 Protects Against Post-Cardiac Arrest Myocardial Dysfunction Through a Novel Mechanism of Suppressing Mitochondrial Reactive Oxygen Species Production
Zhang R; Liu B; Fan X; Wang W; Xu T; Wei S; Zheng W; Yuan Q; Gao L; Yin X; Zheng B; Zhang C; Zhang S; Yang K; Xue M; Wang S; Xu F; Wang J; Cao Y; Chen Y
Article: SCIENTIFIC REPORTS. 2019;9(1):19384
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
Langeback A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Loof S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(39):19635-19645
Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload
Ge C; Huang H; Huang F; Yang T; Zhang T; Wu H; Zhou H; Chen Q; Shi Y; Sun Y; Liu L; Wang X; Pearson RB; Cao Y; Kang J; Fu C
Article: EMBO MOLECULAR MEDICINE. 2019;11(8):e9266
Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy
Uribesalgo I; Hoffmann D; Zhang Y; Kavirayani A; Lazovic J; Berta J; Novatchkova M; Pai T-P; Wimmer RA; Laszlo V; Schramek D; Karim R; Tortola L; Deswal S; Haas L; Zuber J; Szucs M; Kuba K; Dome B; Cao Y; Haubner BJ; Penninger JM
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2019;39(7):1402-1418
Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization
Ali Z; Mukwaya A; Biesemeier A; Ntzouni M; Ramskold D; Giatrellis S; Mammadzada P; Cao R; Lennikov A; Marass M; Gerri C; Hildesjo C; Taylor M; Deng Q; Peebo B; del Peso L; Kvanta A; Sandberg R; Schraermeyer U; Andre H; Steffensen JF; Lagali N; Cao Y; Kele J; Dahl Jensen L
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Bladder drug mirabegron exacerbates atherosclerosis through activation of brown fat-mediated lipolysis
Sui W; Li H; Yang Y; Jing X; Xue F; Cheng J; Dong M; Zhang M; Pan H; Chen Y; Zhang Y; Zhou Q; Shi W; Wang X; Zhang H; Zhang C; Zhang Y; Cao Y
Article: CIRCULATION. 2018;138(23):2698-2712
Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2
Thalgott JH; Dos-Santos-Luis D; Hosman AE; Martin S; Lamande N; Bracquart D; Srun S; Galaris G; de Boer HC; Tual-Chalot S; Kroon S; Arthur HM; Cao Y; Snijder RJ; Disch F; Mager JJ; Rabelink TJ; Mummery CL; Raymond K; Lebrin F
Article: JOURNAL OF PATHOLOGY. 2018;246(4):447-458
Targeting PDGF-mediated recruitment of pericytes blocks vascular mimicry and tumor growth
Thijssen VLJL; Paulis YWJ; Nowak-Sliwinska P; Deumelandt KL; Hosaka K; Soetekouw PMMB; Cimpean AM; Raica M; Pauwels P; van den Oord JJ; Tjan-Heijnen VCG; Hendrix MJ; Heldin C-H; Cao Y; Griffioen AW
Article: JCI INSIGHT. 2018;3(20):e122375
Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(41):10351-10356
VEGF-B is a potent antioxidant
Arjunan P; Lin X; Tang Z; Du Y; Kumar A; Liu L; Yin X; Huang L; Chen W; Chen Q; Ye Z; Wang S; Kuang H; Zhou L; Xu K; Chen X; Zeng H; Lu W; Cao Y; Liu Y; Zhao C; Li X
Article: MOLECULAR CARCINOGENESIS. 2018;57(9):1201-1212
A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis
Wang R; Jin Y; Yao X-H; Fan W; Zhang J; Cao Y; Li J
Article: CELL METABOLISM. 2018;28(1):104-117.e5
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(3):1106-1124
CD163⁺ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
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Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2018;215(2):611-626
Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning
Seki T; Hosaka K; Fischer C; Lim S; Andersson P; Abe M; Iwamoto H; Gao Y; Wang X; Fong G-H; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(3):501-506
Novel concept of the smart NIR-light-controlled drug release of black phosphorus nanostructure for cancer therapy
Qiu M; Wang D; Liang W; Liu L; Zhang Y; Chen X; Sang DK; Xing C; Li Z; Dong B; Xing F; Fan D; Bao S; Zhang H; Cao Y
Article: CELL DISCOVERY. 2018;4:3
Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling
Hosaka K; Yang Y; Nakamura M; Andersson P; Yang X; Zhang Y; Seki T; Scherzer M; Dubey O; Wang X; Cao Y
Article: NATURE COMMUNICATIONS. 2017;8(1):2079
A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning
Fischer C; Seki T; Lim S; Nakamura M; Andersson P; Yang Y; Honek J; Wang Y; Gao Y; Chen F; Samani NJ; Zhang J; Miyake M; Oyadomari S; Yasue A; Li X; Zhang Y; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9635-E9644
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(40):10737-10742
Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK
Jiang Y; Lin X; Tang Z; Lee C; Tian G; Du Y; Yin X; Ren X; Huang L; Ye Z; Chen W; Zhang F; Mi J; Gao Z; Wang S; Chen Q; Xing L; Wang B; Cao Y; Sessa WC; Ju R; Liu Y; Li X
Article: CLINICAL CANCER RESEARCH. 2017;23(16):4769-4779
A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis
Liu C; Zhang Y; Lim S; Hosaka K; Yang Y; Pavlova T; Alkasalias T; Hartman J; Jensen L; Xing X; Wang X; Lu Y; Nie G; Cao Y
Article: CELL DEATH AND DIFFERENTIATION. 2017;24(8):1431-1442
MicroRNA-26a and-26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway
Chen X; Xiao W; Chen W; Liu X; Wu M; Bo Q; Luo Y; Ye S; Cao Y; Liu Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(26):E5226-E5235
Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy
Zhang Y; Sun M; Huang G; Yin L; Lai Q; Yang Y; Xing X; Yu G; Sun Y; Wang X; Nie G; Liu Y; Cao Y
Article: JCI INSIGHT. 2017;2(4):e89044
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
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Article: CANCER RESEARCH. 2016;76(19):5634-5646
Estrogen Receptor a Promotes Breast Cancer by Reprogramming Choline Metabolism
Jia M; Andreassen T; Jensen L; Bathen TF; Sinha I; Gao H; Zhao C; Haldosen L-A; Cao Y; Girnita L; Moestue SA; Dahlman-Wright K
Article: ONCOGENE. 2016;35(39):5155-5169
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
Carmona G; Perera U; Gillett C; Naba A; Law A-L; Sharma VP; Wang J; Wyckoff J; Balsamo M; Mosis F; De Piano M; Monypenny J; Woodman N; McConnell RE; Mouneimne G; Van Hemelrijck M; Cao Y; Condeelis J; Hynes RO; Gertler FB; Krause M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627
Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12680
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Yang Y; Zhang Y; Iwamoto H; Hosaka K; Seki T; Andersson P; Lim S; Fischer C; Nakamura M; Abe M; Cao R; Skov PV; Chen F; Chen X; Lu Y; Nie G; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12152
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T; Hosaka K; Lim S; Fischer C; Honek J; Yang Y; Andersson P; Nakamura M; Naslund E; Yla-Herttuala S; Sun M; Iwamoto H; Li X; Liu Y; Samani NJ; Cao Y
Article: ONCOTARGET. 2016;7(25):38282-38291
Co-option of pre-existing vascular beds in adipose tissue controls tumor growth rates and angiogenesis
Lim S; Hosaka K; Nakamura M; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:11385
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages
Yang Y; Andersson P; Hosaka K; Zhang Y; Cao R; Iwamoto H; Yang X; Nakamura M; Wang J; Zhuang R; Morikawa H; Xue Y; Braun H; Beyaert R; Samani N; Nakae S; Hams E; Dissing S; Fallon PG; Langer R; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(15):4158-4163
Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy
Zhang Y; Yang Y; Hosaka K; Huang G; Zang J; Chen F; Zhang Y; Samani NJ; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:10824
MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
Wong HLX; Jin G; Cao R; Zhang S; Cao Y; Zhou Z
Article: SCIENTIFIC REPORTS. 2016;6:19973
Resveratrol analogue 4,4′-dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis
Savio M; Ferraro D; Maccario C; Vaccarone R; Jensen LD; Corana F; Mannucci B; Bianchi L; Cao Y; Stivala LA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(44):E5944-E5953
VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish
Jensen LD; Nakamura M; Brautigam L; Li X; Liu Y; Samani NJ; Cao Y
Article: ELIFE. 2015;4:e08422
Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain
Hameed LS; Berg DA; Belnoue L; Jensen LD; Cao Y; Simon A
Article: ONCOGENE. 2015;34(37):4867-4878
MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes
Keklikoglou I; Hosaka K; Bender C; Bott A; Koerner C; Mitra D; Will R; Woerner A; Muenstermann E; Wilhelm H; Cao Y; Wiemann S
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Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis
Singleton DC; Rouhi P; Zois CE; Haider S; Li J-L; Kessler BM; Cao Y; Harris AL
Article: CLINICAL CANCER RESEARCH. 2015;21(16):3794-3805
CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer
Svensson S; Abrahamsson A; Rodriguez GV; Olsson A-K; Jensen L; Cao Y; Dabrosin C
Article: SCIENTIFIC REPORTS. 2015;5:10351
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model
Chen X; Wang J; Cao Z; Hosaka K; Jensen L; Yang H; Sun Y; Zhuang R; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(22):E2900-E2909
VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
Yang X; Zhang Y; Hosaka K; Andersson P; Wang J; Tholander F; Cao Z; Morikawa H; Tegner J; Yang Y; Iwamoto H; Lim S; Cao Y
Article: SCIENCE ADVANCES. 2015;1(3):e1400244
PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors
Iwamoto H; Zhang Y; Seki T; Yang Y; Nakamura M; Wang J; Yang X; Torimura T; Cao Y
Article: CANCER RESEARCH. 2015;75(2):306-315
Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Wang J; Cao Z; Zhang X-M; Nakamura M; Sun M; Hartman J; Harris RA; Sun Y; Cao Y
Article: CELL REPORTS. 2014;9(2):569-580
VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization
Lim S; Zhang Y; Zhang D; Chen F; Hosaka K; Feng N; Seki T; Andersson P; Li J; Zang J; Sun B; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14906-14911
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
Honek J; Seki T; Iwamoto H; Fischer C; Li J; Lim S; Samani NJ; Zang J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14806-14811
Vasoprotective effect of PDGF-CC mediated by HMOX1 rescues retinal degeneration
He C; Zhao C; Kumar A; Lee C; Chen M; Huang L; Wang J; Ren X; Jiang Y; Chen W; Wang B; Gao Z; Zhong Z; Huang Z; Zhang F; Huang B; Ding H; Ju R; Tang Z; Liu Y; Cao Y; Li X; Liu X
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Targeting filamin B induces tumor growth and metastasis via enhanced activity of matrix metalloproteinase-9 and secretion of VEGF-A
Bandaru S; Zhou A-X; Rouhi P; Zhang Y; Bergo MO; Cao Y; Akyurek LM
Article: NATURE COMMUNICATIONS. 2014;5:4944
TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling
Ji H; Cao R; Yang Y; Zhang Y; Iwamoto H; Lim S; Nakamura M; Andersson P; Wang J; Sun Y; Dissing S; He X; Yang X; Cao Y
Article: CANCER RESEARCH. 2014;74(14):3983-3994
Genome-wide Profiling of AP-1-Regulated Transcription Provides Insights into the Invasiveness of Triple-Negative Breast Cancer
Zhao C; Qiao Y; Jonsson P; Wang J; Xu L; Rouhi P; Sinha I; Cao Y; Williams C; Dahlman-Wright K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(3):1069-1082
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis
Arjonen A; Kaukonen R; Mattila E; Rouhi P; Hognas G; Sihto H; Miller BW; Morton JP; Bucher E; Taimen P; Virtakoivu R; Cao Y; Sansom OJ; Joensuu H; Ivaska J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):2560-2565
Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response
Zheng X; Zhou A-X; Rouhi P; Uramoto H; Boren J; Cao Y; Pereira T; Akyurek LM; Poellinger L
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(2):90-97
Angiostatic Effects of NK Cell-Derived IFN-γ Counteracted by Tumour Cell Bcl-x_L Expression
Wallin RPA; Sundquist VS; Brakenhielm E; Cao Y; Ljunggren H-G; Grandien A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20057-20062
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1
Brautigam L; Jensen LDE; Poschmann G; Nystrom S; Bannenberg S; Dreij K; Lepka K; Prozorovski T; Montano SJ; Aktas O; Uhlen P; Stuehler K; Cao Y; Holmgren A; Berndt C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(34):13932-13937
Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth
Yang X; Zhang Y; Yang Y; Lim S; Cao Z; Rak J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(29):12018-12023
Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues
Yang Y; Zhang Y; Cao Z; Ji H; Yang X; Iwamoto H; Wahlberg E; Lanne T; Sun B; Cao Y
Article: SCIENCE. 2013;341(6141):84-87
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
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Article: CELL METABOLISM. 2013;18(1):118-129
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong M; Yang X; Lim S; Cao Z; Honek J; Lu H; Zhang C; Seki T; Hosaka K; Wahlberg E; Yang J; Zhang L; Lanne T; Sun B; Li X; Liu Y; Zhang Y; Cao Y
Journal article: CANCER RESEARCH. 2013;73(8_Supplement):1623
Abstract 1623: PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.
Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E; Andersson P; Sasahara M; Larsson O; Galter D; Cao R; Hosaka K; Cao Y
Article: CELL CYCLE. 2013;12(3):405-408
Clock controls angiogenesis
Jensen LD; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):654-659
Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs
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Article: NATURE COMMUNICATIONS. 2013;4:2129
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
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VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
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Article: CELL REPORTS. 2012;2(5):1272-1285
Proliferative and Survival Effects of PUMA Promote Angiogenesis
Zhang F; Li Y; Tang Z; Kumar A; Lee C; Zhang L; Zhu C; Klotzsche-von Ameln A; Wang B; Gao Z; Zhang S; Langer HF; Hou X; Jensen L; Ma W; Wong W; Chavakis T; Liu Y; Cao Y; Li X
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(39):15894-15899
Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis
Cao R; Ji H; Feng N; Zhang Y; Yang X; Andersson P; Sun Y; Tritsaris K; Hansen AJ; Dissing S; Cao Y
Article: CELL REPORTS. 2012;2(2):231-241
Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish
Jensen LD; Cao Z; Nakamura M; Yang Y; Brautigam L; Andersson P; Zhang Y; Wahlberg E; Lanne T; Hosaka K; Cao Y
Article: MOLECULAR CANCER. 2012;11:50
Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice
Nallapalli RK; Ibrahim MX; Zhou AX; Bandaru S; Sunkara SN; Redfors B; Pazooki D; Zhang Y; Boren J; Cao Y; Bergo MO; Akyurek LM
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When MT1-MMP meets ADAMs
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Article: DEVELOPMENTAL CELL. 2012;22(6):1176-1190
MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis
Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: NATURE PROTOCOLS. 2012;7(3):606-615
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
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Article: NATURE MEDICINE. 2011;18(1):100-110
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
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Article: CIRCULATION. 2011;124(9):1059-U170
Arteriogenic Therapy by Intramyocardial Sustained Delivery of a Novel Growth Factor Combination Prevents Chronic Heart Failure
Banquet S; Gomez E; Nicol L; Edwards-Levy F; Henry J-P; Cao R; Schapman D; Dautreaux B; Lallemand F; Bauer F; Cao Y; Thuillez C; Mulder P; Richard V; Brakenhielm E
Article: NATURE PROTOCOLS. 2011;6(6):817-826
Mouse corneal lymphangiogenesis model
Cao R; Lim S; Ji H; Zhang Y; Yang Y; Honek J; Hedlund E-M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(10):4117-4122
Antiangiogenic agents significantly improve survival in tumor-bearing mice by increasing tolerance to chemotherapy-induced toxicity
Zhang D; Hedlund E-ME; Lim S; Chen F; Zhang Y; Sun B; Cao Y
Journal article: VASCULAR CELL. 2011;3(1):1
It's hard to keep all things angiogenic in one JAR!
Kitajewski J; Cao Y; Slevin M
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2011;55(4-5):557-562
Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?
Cao Y
Article: NATURE PROTOCOLS. 2010;5(12):1911-1918
Hypoxia-induced metastasis model in embryonic zebrafish
Rouhi P; Jensen LD; Cao Z; Hosaka K; Lanne T; Wahlberg E; Steffensen JF; Cao Y
Article: NATURE PROTOCOLS. 2010;5(12):1903-1910
Hypoxia-induced retinopathy model in adult zebrafish
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Article: PHYSICAL BIOLOGY. 2010;7(4):046007
Collective cell motion in endothelial monolayers
Szabo A; Uennep R; Mehes E; Twal WO; Argraves WS; Cao Y; Czirok A
Article: NATURE REVIEWS CLINICAL ONCOLOGY. 2010;7(10):604-608
Off-tumor target-beneficial site for antiangiogenic cancer therapy?
Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15886-15891
Angiotensin-converting enzyme 2 attenuates atherosclerotic lesions by targeting vascular cells
Zhang C; Zhao YX; Zhang YH; Zhu L; Deng BP; Zhou ZL; Li SY; Lu XT; Song LL; Lei XM; Tang WB; Wang N; Pan CM; Song HD; Liu CX; Dong B; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(27):12216-12221
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
Hou X; Kumar A; Lee C; Wang B; Arjunan P; Dong L; Maminishkis A; Tang Z; Li Y; Zhang F; Zhang S-Z; Wardega P; Chakrabarty S; Liu B; Wu Z; Colosi P; Fariss RN; Lennartsson J; Nussenblatt R; Gutkind JS; Cao Y; Li X
Article: CELL CYCLE. 2010;9(10):1882-1885
Cancer-associated retinopathy A new mechanistic insight on vascular remodeling
Cao R; Cao Y
Article: NATURE PROTOCOLS. 2010;5(5):912-920
Adipose angiogenesis: quantitative methods to study microvessel growth, regression and remodeling in vivo
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Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(4):867-880
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation
Tang Z; Arjunan P; Lee C; Li Y; Kumar A; Hou X; Wang B; Wardega P; Zhang F; Dong L; Zhang Y; Zhang S-Z; Ding H; Fariss RN; Becker KG; Lennartsson J; Nagai N; Cao Y; Li X
Article: DISCOVERY MEDICINE. 2010;9(46):179-184
Therapeutic Angiogenesis for Ischemic Disorders: What Is Missing for Clinical Benefits?
Cao Y
Article: CELL CYCLE. 2010;9(5):913-917
Pathological angiogenesis facilitates tumor cell dissemination and metastasis
Rouhi P; Lee SLC; Cao Z; Hedlund E-M; Jensen LD; Cao Y
Article: NATURE REVIEWS DRUG DISCOVERY. 2010;9(2):107-115
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
Cao Y
Article: SCIENCE TRANSLATIONAL MEDICINE. 2010;2(15):15ps3
Optimizing the Delivery of Cancer Drugs that Block Angiogenesis
Cao Y; Langer R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(2):856-861
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy
Cao R; Xue Y; Hedlund E-M; Zhong Z; Tritsaris K; Tondelli B; Lucchini F; Zhu Z; Dissing S; Cao Y
Article: JOURNAL OF ANGIOGENESIS RESEARCH. 2009;1:9
Tumor-derived VEGF modulates hematopoiesis.
Xue Y; Chen F; Zhang D; Lim S; Cao Y
Article: PLOS ONE. 2009;4(11):e7867
Selective inhibition of retinal angiogenesis by targeting PI3 kinase.
Alvarez Y; Astudillo O; Jensen L; Reynolds AL; Waghorne N; Brazil DP; Cao Y; O'Connor JJ; Kennedy BN
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(46):19485-19490
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
Lee SLC; Rouhi P; Jensen LD; Zhang D; Ji H; Hauptmann G; Ingham P; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(43):18408-18413
Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
Jensen LDE; Cao R; Hedlund E-M; Soll I; Lundberg JO; Hauptmann G; Steffensen JF; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(41):17505-17510
Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature
Hedlund E-M; Hosaka K; Zhong Z; Cao R; Cao Y
Journal article: JOURNAL OF ANGIOGENESIS RESEARCH. 2009;1:1
Welcome to Journal of Angiogenesis Research.
Slevin M; Cao Y; Kitajewski J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(15):6152-6157
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Zhang F; Tang Z; Hou X; Lennartsson J; Li Y; Koch AW; Scotney P; Lee C; Arjunan P; Dong L; Kumar A; Rissanen TT; Wang B; Nagai N; Fons P; Fariss R; Zhang Y; Wawrousek E; Tansey G; Raber J; Fong G-H; Ding H; Greenberg DA; Becker KG; Herbert J-M; Nash A; Yla-Herttuala S; Cao Y; Watts RJ; Li X
Article: CELL METABOLISM. 2009;9(1):99-109
Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation
Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
Article: FRONTIERS IN BIOSCIENCE-LANDMARK. 2009;14(10):3962-3973
Tumor angiogenesis and molecular targets for therapy
Cao Y
Article: THE FASEB JOURNAL. 2009;23(1):153-163
Differential roles of PDGFR-α and PDGFR-β in angiogenesis and vessel stability
Zhang J; Cao R; Zhang Y; Jia T; Cao Y; Wahlberg E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18513-18518
Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome
Xue Y; Religa P; Cao R; Hansen AJ; Lucchini F; Jones B; Wu Y; Zhu Z; Pytowski B; Liang Y; Zhong W; Vezzoni P; Rozell B; Cao Y
Article: CIRCULATION RESEARCH. 2008;103(10):1092-1U71
Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels
Korpisalo P; Karvinen H; Rissanen TT; Kilpijoki J; Marjomaki V; Baluk P; McDonald DM; Cao Y; Eriksson U; Alitalo K; Yla-Herttuala S
Article: CANCER RESEARCH. 2008;68(18):7293-7303
A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasis
Clasper S; Royston D; Baban D; Cao Y; Ewers S; Butz S; Vestweber D; Jackson DG
Article: PLOS ONE. 2008;3(7):e2748
Hypoxia-Induced Retinal Angiogenesis in Zebrafish as a Model to Study Retinopathy
Cao R; Jensen LDE; Soell I; Hauptmann G; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(29):10167-10172
FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue
Xue Y; Cao R; Nilsson D; Chen S; Westergren R; Hedlund E-M; Martijn C; Rondahl L; Krauli P; Walum E; Enerback S; Cao Y
Article: JOURNAL OF CLINICAL INVESTIGATION. 2008;118(3):913-923
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats
Li Y; Zhang F; Nagai N; Tang Z; Zhang S; Scotney P; Lennartsson J; Zhu C; Qu Y; Fang C; Hua J; Matsuo O; Fong G-H; Ding H; Cao Y; Becker KG; Nash A; Heldin C-H; Li X
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;37(3):507-518
Characterization of neuroprogenitor cells expressing the PDGF β-receptor within the subventricular zone of postnatal mice
Ishii Y; Matsumoto Y; Watanabe R; Elmi M; Fujimori T; Nissen J; Cao Y; Nabeshima Y-I; Sasahara M; Funa K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(10):2766-2777
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
Nissen LJ; Cao R; Hedlund E-M; Wang Z; Zhao X; Wetterskog D; Funa K; Brakenhielm E; Cao Y
Article: BIOMEDICINE & PHARMACOTHERAPY. 2007;61(9):534-539
Tumor-derived lymphangiogenic factors and lymphatic metastasis
Cao Y; Zhong W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(39):15364-15369
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
Tritsaris K; Myren M; Ditlev SB; Hubschmann MV; van der Blom I; Hansen AJ; Olsen UB; Cao R; Zhang J; Jia T; Wahlberg E; Dissing S; Cao Y
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(13):2896-2909
Intra- and extracellular signaling by endothelial neuregulin-1
Iivanainen E; Paatero I; Heikkinen S-M; Junttila TT; Cao R; Klint P; Jaakkola PM; Cao Y; Elenius K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(29):12140-12145
Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs
Lu H; Xu X; Zhang M; Cao R; Brakenhielm E; Li C; Lin H; Yao G; Sun H; Qi L; Tang M; Dai H; Zhang Y; Su R; Bi Y; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(10):3919-3924
Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
Zhou X; Tian F; Sandzen J; Cao R; Flaberg E; Szekely L; Cao Y; Ohlsson C; Bergo MO; Boren J; Akyurek LM
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641
Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α:: Role of subcellular compartmentalization
Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: BLOOD. 2006;107(9):3531-3536
Hepatocyte growth factor is a lymphanoiogenic factor with an indirect mechanism of action
Cao RH; Björndahl MA; Gallego MI; Chen SH; Religa P; Hansen AJ; Cao YH
Article: GASTROENTEROLOGY. 2006;130(4):1301-1310
Gene transfer of kringle 1-5 suppresses tumor development and improves prognosis of mice with hepatocellular carcinoma
Torimura T; Ueno T; Kin M; Taniguchi E; Nakamura T; Inoue K; Sakata R; Hashimoto O; Sakamoto M; Ohira H; Kumashiro R; Sata M; Yano H; Kojiro M; Veitonmaki N; Cao YH
Article: BLOOD. 2005;106(13):4184-4190
Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
Religa P; Cao RH; Bjorndahl M; Zhou ZJ; Zhu ZP; Cao YH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(43):15593-15598
Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.
Björndahl M; Cao R; Nissen LJ; Clasper S; Johnson LA; Xue Y; Zhou Z; Jackson D; Hansen AJ; Cao Y
Article: CANCER RESEARCH. 2005;65(20):9261-9268
Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
Björndahl MA; Cao R; Burton JB; Brakenhielm E; Religa P; Galter D; Wu L; Cao YH
Article: NATURE MEDICINE. 2005;11(7):780-785
Genomic instability in laminopathy-based premature aging
Liu BH; Wang JM; Chan KM; Tjia WM; Deng W; Guan XY; Huang JD; Li KM; Chau PY; Chen DJ; Pei DQ; Pendas AM; Cadiñanos J; López-Otín C; Tse HF; Hutchison C; Chen JJ; Cao YH; Cheah KSE; Tryggvason K; Zhou ZJ
Article: CELL CYCLE. 2005;4(2):228-230
Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis.
Cao Y
Article: CANCER CELL. 2004;6(4):333-345
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Galter D; Meister B; Ikomi F; Tritsaris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Article: CANCER RESEARCH. 2004;64(14):4699-4702
Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice
Zhou ZJ; Wang JM; Cao RH; Morita H; Soininen R; Chan KM; Liu B; Cao YH; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(12):1579-1588
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
Bråkenhielm E; Cao RH; Gao BH; Angelin B; Cannon B; Parini P; Cao YH
Article: CANCER RESEARCH. 2004;64(12):4059-4063
Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice
Zhou ZJ; Doi M; Wang JM; Cao RH; Liu BH; Chan KM; Kortesmaa J; Sorokin L; Cao YH; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(11):1443-1450
Blockage of VEGF-induced angiogenesis by preventing VEGF secretion
Björndahl M; Cao RH; Eriksson A; Cao YH
Article: CANCER RESEARCH. 2004;64(10):3679-3686
Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-Induced antiangiogenesis
Veitonmäki N; Cao R; Wu LH; Moser TL; Li B; Pizzo SV; Boris ZY; Cao YH
Article: SEMINARS IN CANCER BIOLOGY. 2004;14(2):139-145
Antiangiogenic cancer therapy.
Cao Y
Article: CIRCULATION RESEARCH. 2004;94(5):664-670
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability
Cao RH; Eriksson A; Kubo H; Alitalo K; Cao YH; Thyberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(8):2476-2481
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
Bråkenhielm E; Veitonmäki N; Cao RH; Kihara S; Matsuzawa YJ; Zhivotovsky B; Funahashi T; Cao YH
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2004;30(1):83-93
Angiostatin.
Cao Y; Xue L
Journal article: EJC SUPPLEMENTS. 2003;1(5):s175
579 Significant tumor growth inhibition of glioblastoma xenografts by NNC 47-0011 — a low molecular weight tricyclic tyrosine kinase modulator with anti-angiogenic activity
Cao R; Cao Y; Dissing S; Hansen AJ; Kristjansen PEG; Olsen UB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(10):6033-6038
Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing
Ekstrand AJ; Cao RH; Björndahl M; Nyström S; Jönsson-Rylander AC; Hassani H; Hallberg B; Nordlander M; Cao YH
Article: NATURE MEDICINE. 2003;9(5):604-613
Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
Cao RH; Bråkenhielm E; Pawliuk R; Wariaro D; Post MJ; Wahlberg E; Leboulch P; Cao YH
Article: THE FASEB JOURNAL. 2003;17(2):764-766
Immortalization of bovine capillary endothelial cells by hTERT alone involves inactivation of endogenous p16^INK4A/pRb
Veitonmäki N; Fuxe J; Hultdin M; Roos G; Pattersson RF; Cao Y
Article: CIRCULATION. 2003;107(11):1532-1538
Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability
Eriksson A; Cao RH; Roy J; Tritsaris K; Wahlestedt C; Dissing S; Thyberg J; Cao YH
Article: ARTHRITIS RESEARCH & THERAPY. 2003;5(1):r32-R39
The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.
Sumariwalla PF; Cao Y; Wu H-L; Feldmann M; Paleolog EM
Article: NEUROSCIENCE. 2003;120(4):951-960
Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
Widenfalk J; Lipson A; Jubran M; Hofstetter C; Ebendal T; Cao Y; Olson L
Article: THE FASEB JOURNAL. 2002;16(12):1575-1583
Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-αα and -αβ receptors
Cao RH; Bråkenhielm E; Li XR; Pietras K; Widenfalk J; Östman A; Eriksson U; Cao YH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8868-8873
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.
Kubo H; Cao R; Brakenhielm E; Mäkinen T; Cao Y; Alitalo K
Article: MOLECULAR THERAPY. 2002;5(4):345-351
Continuous intravascular secretion of endostatin in mice from transduced hematopoietic stem cells
Pawliuk R; Bachelot T; Zurkiya O; Eriksson A; Cao YH; Leboulch P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(4):1194-1202
Deletion of the laminin α4 chain leads to impaired microvessel maturation
Thyboll J; Kortesmaa J; Cao RH; Soininen R; Wang L; Iivanainen A; Sorokin L; Risling M; Cao YH; Tryggvason K
Article: CANCER CELL. 2002;1(1):99-108
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers
Eriksson A; Cao RH; Pawliuk R; Berg SM; Tsang M; Zhou D; Fleet C; Tritsaris K; Dissing S; Leboulch P; Cao YH
Article: LABORATORY INVESTIGATION. 2001;81(12):1669-1681
Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis.
Feraud O; Cao Y; Vittet D
Article: NATURE. 2001;414(6863):550-554
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
Makino Y; Cao RH; Svensson K; Bertilsson GR; Åsman M; Tanaka H; Cao YH; Berkenstam A; Poellinger L
Article: ONCOGENE. 2001;20(34):4685-4695
The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.
Ambartsumian N; Klingelhöfer J; Grigorian M; Christensen C; Kriajevska M; Tulchinsky E; Georgiev G; Berezin V; Bock E; Rygaard J; Cao R; Cao Y; Lukanidin E
Article: THE FASEB JOURNAL. 2001;15(10):1798-1800
Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes.
Bråkenhielm E; Cao R; Cao Y
Article: CIRCULATION. 2001;104(3):358-364
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Article: CANCER RESEARCH. 2001;61(14):5441-5446
Effects of angiostatin gene transfer on functional properties and in vivo growth of Kaposi's sarcoma cells.
Indraccolo S; Morini M; Gola E; Carrozzino F; Habeler W; Minghelli S; Santi L; Chieco-Bianchi L; Cao Y; Albini A; Noonan DM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(11):6390-6395
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
Cao RH; Brakenhielm E; Wahlestedt C; Thyberg J; Cao YH
Article: MOLECULAR THERAPY. 2001;3(2):186-196
Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice
Scappaticci FA; Smith R; Pathak A; Schloss D; Lum B; Cao YH; Johnson F; Engleman EG; Nolan GP
Article: ANGIOGENESIS. 2001;4(4):263-268
Statin-AE: a novel angiostatin-endostatin fusion protein with enhanced antiangiogenic and antitumor activity.
Scappaticci FA; Contreras A; Smith R; Bonhoure L; Lum B; Cao Y; Engleman EG; Nolan GP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(38):29383-29390
Human plasmin enzymatic activity is inhibited by chemically modified dextrans.
Ledoux D; Papy-Garcia D; Escartin Q; Sagot MA; Cao Y; Barritault D; Courtois J; Hornebeck W; Caruelle JP
Journal article: GENE THERAPY AND REGULATION. 2000;1(2):123-139
Antiangiogenic gene therapy
Cao Y
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2000;5(5):547-551
Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients
Cao YH; Veitonmäki N; Keough K; Cheng H; Lee LS; Cao YM; Zurakowski D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(8):4052-4057
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Zhou ZJ; Apte SS; Soininen R; Cao RH; Baaklini GY; Rauser RW; Wang JM; Cao YH; Tryggvason K
Article: THE FASEB JOURNAL. 1999;13(15):2195-2202
Interleukin-18 acts as an angiogenesis and tumor suppressor.
Cao R; Farnebo J; Kurimoto M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(10):5728-5733
Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis
Cao RH; Wu HL; Veitonmäki N; Linden P; Farnebo J; Shi GY; Cao YH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(19):13338-13344
Systemic gene delivery expands the repertoire of effective antiangiogenic agents
Liu Y; Thor A; Shtivelman E; Cao YH; Tu GH; Heath TD; Debs RJ
Article: AIDS. 1999;13(11):A5-A9
IAS position paper on prevention of HIV1 mother-to-child transmission
Hirsch MS; Wilfert C; Ammann A; Coovadia HM; Cu-Uvin S; Dabis F; Ekpini RAE; Kallings LO; Mofenson L; Tess B; Bryson Y; Cao Y; Chotpitayasunondh T; Nduati R; Solomon S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(24):14389-14394
Vascular endothelial growth factor C induces angiogenesis in vivo
Cao YH; Linden P; Farnebo J; Cao RH; Eriksson A; Kumar V; Qi JH; Claesson-Welsh L; Alitalo K
Article: LABORATORY INVESTIGATION. 1998;78(8):1029-1030
Microbead assay: a novel assay that detects endothelial cell proliferation and inhibition.
Cao Y; Ji RW; Folkman J
Article: CANCER RESEARCH. 1998;58(15):3362-3369
Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA.
Tanaka T; Cao Y; Folkman J; Fine HA
Article: JOURNAL OF CLINICAL INVESTIGATION. 1998;101(5):1055-1063
Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.
Cao Y; O'Reilly MS; Marshall B; Flynn E; Ji RW; Folkman J
Article: ONCOGENE. 1998;16(3):359-367
Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-gamma and migration of endothelial cells expressing Flt 1.
Landgren E; Schiller P; Cao Y; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(36):22924-22928
Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth
Cao YH; Chen A; An SSA; Ji RWD; Davidson D; Cao YM; Llinas M
Article: EMBO JOURNAL. 1997;16(13):3898-3911
Proteolytic processing regulates receptor specificity and activity of VEGF-C
Joukov V; Sorsa T; Kumar V; Jeltsch M; ClaessonWelsh L; Cao YH; Saksela O; Kalkkinen N; Alitalo K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;235(3):493-498
Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing.
Cao Y; Ji WR; Qi P; Rosin A; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(3):861-866
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.
Arbiser JL; Moses MA; Fernandez CA; Ghiso N; Cao Y; Klauber N; Frank D; Brownlee M; Flynn E; Parangi S; Byers HR; Folkman J
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(11):2507-2511
In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor.
Cao Y; Linden P; Shima D; Browne F; Folkman J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(46):29461-29467
Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.
Cao Y; Ji RW; Davidson D; Schaller J; Marti D; Söhndel S; McCance SG; O'Reilly MS; Llinás M; Folkman J
Article: SCIENCE. 1996;273(5274):510-513
Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function
Cheng H; Cao YH; Olson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(6):3154-3162
Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR.
Cao Y; Chen H; Zhou L; Chiang MK; Anand-Apte B; Weatherbee JA; Wang Y; Fang F; Flanagan JG; Tsang ML
Article: BRAIN RESEARCH. 1996;707(1):81-87
Distribution of acidic fibroblast growth factor-like immunoreactivity in rat skeletal muscle fibers
Junttila T; Rechardt L; Cao YH; Hokfelt T; PeltoHuikko M
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1995;182(6):2069-2077
gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.
Cao Y; Chen C; Weatherbee JA; Tsang M; Folkman J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(20):9269-9273
The site of action of neuronal acidic fibroblast growth factor is the organ of Corti of the rat cochlea.
Pirvola U; Cao Y; Oellig C; Suoqiang Z; Pettersson RF; Ylikoski J
Journal article: NEUROSCIENCE. 1994;61(4):891-910
TEMPORAL AND SPATIAL INCREASE OF ASTROGLIAL BASIC FIBROBLAST GROWTH-FACTOR SYNTHESIS AFTER 6-HYDROXYDOPAMINE-INDUCED DEGENERATION OF THE NIGROSTRIATAL DOPAMINE NEURONS
CHADI G; CAO Y; PETTERSSON RF; FUXE K
Journal article: BRAIN RESEARCH. 1993;625(1):45-56
PHOTOCHEMICALLY INDUCED FOCAL CEREBRAL-ISCHEMIA IN RAT - TIME-DEPENDENT AND GLOBAL INCREASE IN EXPRESSION OF BASIC FIBROBLAST GROWTH-FACTOR MESSENGER-RNA
LIPPOLDT A; ANDBJER B; ROSEN L; RICHTER E; GANTEN D; CAO Y; PETTERSSON RF; FUXE K
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(10):1321-1333
GAP-43, AFGF, CCK AND ALPHA-CGRP AND BETA-CGRP IN RAT SPINAL MOTONEURONS SUBJECTED TO AXOTOMY AND OR DORSAL-ROOT SEVERANCE
PIEHL F; ARVIDSSON U; JOHNSON H; CULLHEIM S; DAGERLIND A; ULFHAKE B; CAO Y; ELDE R; PETTERSSON RF; TERENIUS L; HOKFELT T
Journal article: DEVELOPMENTAL BRAIN RESEARCH. 1993;75(1):65-73
FIBROBLAST GROWTH-FACTORS ENHANCE DOPAMINE FIBER FORMATION FROM NIGRAL GRAFTS
GIACOBINI MMJ; STROMBERG I; ALMSTROM S; CAO YH; OLSON L
Journal article: JOURNAL OF NEUROSCIENCE RESEARCH. 1993;35(4):419-427
PENTYLENETETRAZOL SEIZURES INCREASE PRO-NERVE GROWTH FACTOR-LIKE IMMUNOREACTIVITY IN THE RETICULAR THALAMIC NUCLEUS AND NERVE GROWTH-FACTOR MESSENGER-RNA IN THE DENTATE GYRUS
HUMPEL C; EBENDAL T; CAO Y; OLSON L
Journal article: JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY. 1993;41(4):521-533
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) PEPTIDE ANTIBODIES - CHARACTERIZATION USING A VACCINIA VIRUS EXPRESSION SYSTEM
WETMORE CJ; CAO YH; PETTERSSON RF; OLSON L
Journal article: GROWTH FACTORS. 1993;8(4):277-290
Release and subcellular localization of acidic fibroblast growth factor expressed to high levels in HeLa cells.
Cao Y; Pettersson RF
Journal article: JOURNAL OF CELL SCIENCE. 1993;104:77-87
CHARACTERIZATION OF THE NUCLEAR TRANSLOCATION OF ACIDIC FIBROBLAST GROWTH-FACTOR
CAO Y; EKSTROM M; PETTERSSON RF
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(22):10237-10241
EXPRESSION OF ACIDIC AND BASIC FIBROBLAST GROWTH-FACTORS IN THE SUBSTANTIA-NIGRA OF RAT, MONKEY, AND HUMAN
BEAN AJ; ELDE R; CAO YH; OELLIG C; TAMMINGA C; GOLDSTEIN M; PETTERSSON RF; HOKFELT T
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1991;88(21):9843-9847
BRAIN-DERIVED NEUROTROPHIC FACTOR - SUBCELLULAR COMPARTMENTALIZATION AND INTERNEURONAL TRANSFER AS VISUALIZED WITH ANTIPEPTIDE ANTIBODIES
WETMORE C; CAO YH; PETTERSSON RF; OLSON L
Journal article: NEUROREPORT. 1991;2(10):597-600
BASIC FGF IS PRESENT IN DOPAMINERGIC-NEURONS OF THE VENTRAL MIDBRAIN OF THE RAT
CINTRA A; CAO YH; OELLIG C; TINNER B; BORTOLOTTI F; GOLDSTEIN M; PETTERSSON RF; FUXE K
Journal article: NEURON. 1991;7(3):349-364
PROMINENT EXPRESSION OF ACIDIC FIBROBLAST GROWTH-FACTOR IN MOTOR AND SENSORY NEURONS
ELDE R; CAO Y; CINTRA A; BRELJE TC; PELTOHUIKKO M; JUNTTILA T; FUXE K; PETTERSSON RF; HOKFELT T
Journal article: GROWTH FACTORS. 1990;3(1):1-13
Human acidic fibroblast growth factor overexpressed in insect cells is not secreted into the medium.
Cao YH; Pettersson RF
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Alla övriga publikationer

Review: NATIONAL MEDICAL JOURNAL OF CHINA. 2024;137(17):2043-2051
Tumor angiogenesis and anti-angiogenic therapy
Guo Z; Jing X; Sun X; Sun S; Yang Y; Cao Y
Editorial comment: NATIONAL MEDICAL JOURNAL OF CHINA. 2024;137(6):636-637
Angiogenesis in diseases: A half-century excursion from the initial therapeutic concept to current clinical benefits
Cao Y
Review: NATURE REVIEWS DRUG DISCOVERY. 2023;22(6):476-495
Targeting angiogenesis in oncology, ophthalmology and beyond
Cao Y; Langer R; Ferrara N
Editorial comment: NATIONAL MEDICAL JOURNAL OF CHINA. 2022;135(22):2647-2652
Blood vessels in fat tissues and vasculature-derived signals in controlling lipid metabolism and metabolic disease
Cao Y
Preprint: RESEARCH SQUARE. 2022
New splice variants of VEGF as relevant targets for the treatment of renal cell carcinoma
Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Kamenskaya A; Négrier S; Bernhard JC; Borchiellini D; Cao Y; Pagès G
Review: NATURE MEDICINE. 2022;28(11):2273-2287
The landscape of mRNA nanomedicine
Huang X; Kong N; Zhang X; Cao Y; Langer R; Tao W
Corrigendum: NATURE METABOLISM. 2022;4(10):1421
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Preprint: RESEARCH SQUARE. 2022
New splice variants of VEGF as relevant targets for the treatment of Renal Cell Carcinoma
Montemagno C; Durivault J; Gastaldi C; Dufies M; Vial V; He X; Ambrosetti D; Négrier S; Bernhard J-C; Borchiellini D; Cao Y; Pagès G
Review: NATURE REVIEWS CARDIOLOGY. 2022;19(4):228-249
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Chen W; Schilperoort M; Cao Y; Shi J; Tabas I; Tao W
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(20):e153448
Lymphatics in the broken heart
Brakenhielm E; Chen Y; Cao Y
Preprint: BIORXIV. 2020
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death
Szekely L; Bozoky B; Bendek M; Ostad M; Lavignasse P; Haag L; Wu J; Jing X; Gupta S; Saccon E; Sönnerborg A; Cao Y; Björnstedt M; Szakos A
Preprint: MEDRXIV. 2020
A novel mechanism of HIF2-dependent PLK1-mediated metastasis and drug resistance of clear cell Renal Cell Carcinoma
Dufies M; Verbiest A; Cooley LS; Ndiaye PD; Viotti J; He X; Nottet N; Souleyreau W; Hagege A; Torrino S; Parola J; Giuliano S; Borchiellini D; Schiappa R; Mograbi B; Zucman-Rossi J; Bensalah K; Ravaud A; Auberger P; Bikfalvi A; Chamorey E; Rioux-Leclercq N; Mazure NM; Beuselinck B; Cao Y; Bernhard JC; Ambrosetti D; Pagès G
Review: NATURE REVIEWS MATERIALS. 2020;5(11):847-860
A materials-science perspective on tackling COVID-19
Tang Z; Kong N; Zhang X; Liu Y; Hu P; Mou S; Liljestrom P; Shi J; Tan W; Kim JS; Cao Y; Langer R; Leong KW; Farokhzad OC; Tao W
Editorial comment: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(8):1730-1732
Endothelial life discontinues without Erk
Cao Y
Review: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(8):3006-3017
Adipocyte and lipid metabolism in cancer drug resistance
Cao Y
Conference publication: ANGIOGENESIS. 2019;22(4):600
Decreased expression of VEGFR1 contributes to the pathogenesis of hereditary hemorrhagic telangiectasia type 2
Thalgott J; Dos-Santos-Luis D; Hosman A; Martin S; Lamande N; Bracquart D; Srun S; Galaris G; de Boer H; Tual-Chalot S; Kroon S; Arthur H; Cao Y; Snijder R; Disch F; Mager J; Rabelink T; Mummery C; Raymond K; Lebrin F
Editorial comment: CELL METABOLISM. 2018;27(6):1163-1165
Obesity Protects Cancer from Drugs Targeting Blood Vessels
Cao Y
Conference publication: INTERNATIONAL JOURNAL OF UROLOGY. 2018;25:308
Off tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Cao Y; Homma Y
Book chapter: ANGIOGENESIS-BASED DERMATOLOGY. 2017;p. 1-26
Angiogenesis: General Concepts
Jensen L; Cao Y
Conference publication: CANCER RESEARCH. 2016;76:3933
CETSA as a diagnostic tool to guide personalized breast cancer therapy
Oeberg A; Laursen H; Packham S; Molina DM; Seki T; Cao Y; Hartman J; Bergh J; Nordlund P; Loeoef S
Review: CHINESE JOURNAL OF CANCER. 2016;35:21-9
Future options of anti-angiogenic cancer therapy
Cao Y
Review: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2015;30(5):689-721
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
Pettersen EO; Ebbesen P; Gieling RG; Williams KJ; Dubois L; Lambin P; Ward C; Meehan J; Kunkler IH; Langdon SP; Ree AH; Flatmark K; Lyng H; Calzada MJ; del Peso L; Landazuri MO; Goerlach A; Flamm H; Kieninger J; Urban G; Weltin A; Singleton DC; Haider S; Buffa FM; Harris AL; Scozzafava A; Supuran CT; Moser I; Jobst G; Busk M; Toustrup K; Overgaard J; Alsner J; Pouyssegur J; Chiche J; Mazure N; Marchiq I; Parks S; Ahmed A; Ashcroft M; Pastorekova S; Cao Y; Rouschop KM; Wouters BG; Koritzinsky M; Mujcic H; Cojocari D
Editorial comment: ONCOIMMUNOLOGY. 2015;4(3):e989777
Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis
Cao R; Ji H; Yang Y; Cao Y
Book chapter: HANDBOOK OF VASCULAR BIOLOGY TECHNIQUES. 2015;p. 221-229
Adipose Angiogenesis
Fischer C; Lim S; Honek J; Cao Y
Book chapter: HANDBOOK OF VASCULAR BIOLOGY TECHNIQUES. 2015;p. 195-207
Methods for Studying Developmental Angiogenesis in Zebrafish
Ali Z; Wang J; Cao Y; Jensen LD
Review: NATURE REVIEWS ENDOCRINOLOGY. 2014;10(9):530-539
VEGF-targeted cancer therapeutics - paradoxical effects in endocrine organs
Cao Y
Review: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2014;19(1):5-11
Brown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects.
Honek J; Lim S; Fischer C; Iwamoto H; Seki T; Cao Y
Review: CHEMICAL IMMUNOLOGY AND ALLERGY. 2014;99:170-179
Angiogenesis as a therapeutic target for obesity and metabolic diseases.
Cao Y
Review: CELL METABOLISM. 2013;18(4):478-489
Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity
Cao Y
Review: TRENDS IN MOLECULAR MEDICINE. 2013;19(8):460-473
Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
Cao Y
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2013;24(4):190-199
Erythropoietin in cancer: a dilemma in risk therapy
Cao Y
Conference publication: CANCER RESEARCH. 2013;73:B90
Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model
Rouhl P; Lee SL; Jensen LD; Zhang D; Ji H; Hauptmann G; Ingham P; Cao Y
Book chapter: ANGIOGENESIS IN ADIPOSE TISSUE. 2013;p. 187-228
Leptin, Adiponectin, and Other Adipokines in Regulation of Adipose Tissue Angiogenesis
Brakenhielm E; Cao Y
Book chapter: THE TEXTBOOK OF ANGIOGENESIS AND LYMPHANGIOGENESIS: METHODS AND APPLICATIONS. 2012;p. 85-99
Quantitative Methods to Study Adipose Angiogenesis
Lim S; Honek J; Cao Z; Seki T; Xue Y; Cao Y
Book chapter: MOLECULAR AND TRANSLATIONAL VASCULAR MEDICINE: MOLECULAR AND TRANSLATIONAL MEDICINE. 2012;p. 207-226
Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges
Cao Y
Review: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(114):114rv3
Forty-Year Journey of Angiogenesis Translational Research
Cao Y; Arbiser J; D'Amato RJ; D'Amore PA; Ingber DE; Kerbel R; Klagsbrun M; Lim S; Moses MA; Zetter B; Dvorak H; Langer R
Review: BIRTH DEFECTS RESEARCH PART C - EMBRYO TODAY: REVIEWS. 2011;93(2):182-193
Zebrafish Models to Study Hypoxia-Induced Pathological Angiogenesis in Malignant and Nonmalignant Diseases
Jensen LD; Rouhi P; Cao Z; Lanne T; Wahlberg E; Cao Y
Conference publication: EJC SUPPLEMENTS. 2010;8(7):153
The selective alpha5beta1 integrin antagonist, CLT-28643, inhibits tumors angiogenesis and growth
Caldirola P; Backman U; Cao Y
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1304-1308
Angiogenesis: What can it offer for future medicine?
Cao Y
Meeting abstract: GUT. 2010;59:A112
COLORECTAL CANCER LYMPHATICS DISPLAY AN ALTERED PHENOTYPE ASSOCIATED WITH LYMPH NODE METASTASIS
Royston DJ; Clasper S; Baban D; Cao Y; Jackson DG
Editorial comment: BLOOD. 2010;115(12):2336-2337
Wake-up call for endothelial cells
Cao Y
Book chapter: THERAPEUTIC ANGIOGENESIS FOR VASCULAR DISEASES. 2010;p. 95-113
Cancer Therapy by Targeting Vascular Endothelial Cell Growth Factor- and Non-Vascular Endothelial Cell Growth Factor-Mediated Angiogenesis
Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):982-991
In Vivo Angiogenesis and Lymphangiogenesis Models
Jensen LD; Cao R; Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):967-972
Monotherapy Versus Combination Therapy of Angiogenic and Arteriogenic Factors for the Treatment of Ischemic Disorders
Cao Y
Editorial comment: CURRENT MOLECULAR MEDICINE. 2009;9(8):928
Hot topic: Angiogenesis and Lymphangiogenesis in Common Diseases
Cao Y
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2009;19(5):277-278
Angiogenesis in malignancy
Cao Y
Review: SEMINARS IN CANCER BIOLOGY. 2009;19(5):338-343
Improvement of antiangiogenic cancer therapy by understanding the mechanisms of angiogenic factor interplay and drug resistance
Cao Y; Zhong W; Sun Y
Review: SCIENCE SIGNALING. 2009;2(59):re1
Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
Cao Y
Other: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(36):13203-13205
A review of Judah Folkman's remarkable achievements in biomedicine
Cao Y; Langer R
Review: JOURNAL OF MOLECULAR MEDICINE. 2008;86(7):785-789
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways
Cao Y; Cao R; Hedlund E-M
Review: CLINICAL LIPIDOLOGY. 2008;3(2):153-162
Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity
Cao Y; Cao R; Xue Y
Review: LYMPHATIC RESEARCH AND BIOLOGY. 2008;6(3-4):145-148
Why and how do tumors stimulate lymphangiogenesis?
Cao Y
Book chapter: METHODS IN MOLECULAR BIOLOGY. 2008;p. 65-81
Angiogenesis in adipose tissue.
Brakenhielm E; Cao Y
Review: ADVANCES IN CANCER RESEARCH. 2008;100:113-131
Molecular mechanisms and therapeutic development of angiogenesis inhibitors
Cao Y
Review: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(9):2362-2368
Angiogenesis modulates adipogenesis and obesity
Cao Y
Conference publication: TISSUE ENGINEERING. 2007;13(7):1695
Factors influencing angiogenic processes in the VascuPlug unit: Analysis of neovascularisation
Hiebl B; Cao Y; Knedlitschek G
Review: ADVANCES IN CANCER RESEARCH. 2007;97:203-224
Therapeutic targets of multiple angiogenic factors for the treatment of cancer and metastasis
Cao Y; Liu Q
Review: BRITISH JOURNAL OF CANCER. 2006;95(12):1611-1625
First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours
Van der Auwera I; Cao Y; Tille JC; Pepper MS; Jackson DG; Fox SB; Harris AL; Dirix LY; Vermeulen PB
Editorial comment: BLOOD. 2006;108(8):2506-2507
VEGF calls its receptors from the recycling compartment
Cao Y
Corrigendum: CANCER CELL. 2006;9(3):239
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004)
Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Gaiter D; Meister B; Ikomi F; Tritsoris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Book chapter: CELL BIOLOGY. 2006;p. 373-378
Chapter 46 Angiogenesis Assays
Cao Y
Book chapter: RESVERATROL IN HEALTH AND DISEASE. 2005;p. 149-165
Resveratrol as an Angiogenesis Inhibitor
Bråkenhielm E; Cao R; Cao Y
Book chapter: RESVERATROL IN HEALTH AND DISEASE: OXIDATIVE STRESS AND DISEASE. 2005;p. 149-165
Resveratrol as an Angiogenesis Inhibitor
Cao R; Cao Y; Brakenhielm E
Published conference paper: BIOMEDICINE & PHARMACOTHERAPY. 2005;59:S340-S343
Tumor angiogenesis and therapy
Cao Y
Review: NATURE REVIEWS CANCER. 2005;5(9):735-743
Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.
Cao Y
Review: CARDIOVASCULAR RESEARCH (CVR). 2005;65(3):639-648
Update on therapeutic neovascularization.
Cao Y; Hong A; Schulten H; Post MJ
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(4):A4
IL-20 is an angiogenic factor in psoriasis
Hansen A; Cao R; Cao Y; Clausen JT; Dissing S; Hasselager E; Myren M; Norby PL; Olsen UB; Tritsaris K
Book chapter: THE NPY FAMILY OF PEPTIDES IN IMMUNE DISORDERS, INFLAMMATION, ANGIOGENESIS AND CANCER: PROGRESS IN INFLAMMATION RESEARCH. 2005;p. 167-174
NPY-induced angiogenesis in retinopathy and wound healing
Björndahl M; Cao R; Xue L; Cao Y
Corrigendum: CIRCULATION RESEARCH. 2004;95(10):e83-e84
Blockage of VEGF-induced angiogenesis by preventing VEG secretion (vol 94, pg 1443, 2004)
Björndahl
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 2003;532:109-120
Angiogenesis inhibitors and their therapeutic potentials.
Yihai C
Review: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2002;2(6):667-681
Kringle structures and antiangiogenesis.
Cao Y; Cao R; Veitonmäki N
Review: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2002;13(7):380-390
Antiangiogenic mechanisms of diet-derived polyphenols.
Cao Y; Cao R; Bråkenhielm E
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2001;33(4):357-369
Endogenous angiogenesis inhibitors and their therapeutic implications.
Cao Y
Published conference paper: HAEMATOLOGICA. 1999;84(7):643-650
Therapeutic potentials of angiostatin in the treatment of cancer.
Cao Y
Letter: NATURE. 1999;398(6726):381
Angiogenesis inhibited by drinking tea.
Cao Y; Cao R
Conference publication: BLOOD. 1999;94(10):420B
Antiangiogenic gene therapy of murine B16F10 melanoma and L1210 leukemia tumors with angiostatin and endostatin containing MMuLV retroviral vectors.
Scappaticci FA; Smith R; Schloss D; Cao Y; Engleman EG; Nolan GP; Leung L
Review: PROGRESS IN MOLECULAR AND SUBCELLULAR BIOLOGY. 1998;20:161-176
Endogenous angiogenesis inhibitors: angiostatin, endostatin, and other proteolytic fragments.
Cao Y
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 267-284
18 Acidic and Basic Fibroblast Growth Factors are Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons
BEAN AJ; ELDE R; OELLIG C; CAO Y; PETTERSSON RF; HÖKFELT T
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 151-165
9 Localization of Neurotrophins and Their Receptors at the mRNA and Protein Level
OLSON L; WETMORE C; BEAN AJ; CAO Y; PETTERSSON RF
Book chapter: TROPHIC REGULATION OF THE BASAL GANGLIA. 1994;p. 1-41
1 Fibroblast Growth Factor-2, Ganglioside GM1 and the Trophic Regulation of the Basal Ganglia. Focus on the Nigrostriatal Dopamine Neurons
FUXE K; CHADI G; AGNATI LF; TINNER B; ROSÉN L; JANSON AM; MØLLER A; CINTRA A; CAO Y; GOLDSTEIN M; LINDAHL U; DAVID G; ÖGREN SO; TOFFANO G; BAIRD A; PETTERSSON RF
Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1993;:280
LOCALIZATION OF OVEREXPRESSED AFGF IN SENSORY AND MOTOR NEURONS IN CULTURES OF RAT DORSAL-ROOT GANGLIA AND VENTRAL ROOTS
OELLIG C; TAYLOR L; LILJESTROM P; CAO YH; PETTERSSON R
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Forskningsbidrag

Implementation of a zebrafish cancer model in diagnosis of human cancer invasion and prediction of drug responses
Swedish Research Council
1 January 2022 - 31 December 2024
Induce vascular networks in large degradable porous scaffolds by influencing the local microenvironment; spatiotemporal control of growth factors and patterning of mechanical signals
Swedish Research Council
1 January 2021 - 31 December 2024
Interdisciplinary framework on the role of adaptive cellular immunity in SARS-CoV-2 protection
Swedish Research Council
1 January 2021 - 31 December 2023
Mechanistic study of the vasculature-modulated tumor microenvironment in tumor growth, metastasis and drug responses
Swedish Research Council
1 January 2020 - 31 December 2024
Mechanistic and translational research on tumor angiogenesis
Swedish Cancer Society
1 January 2018
Mechanistic and translational research on tumor angiogenesis
Swedish Cancer Society
1 January 2017
Angiogenesis in diseases: mechanisms and therapeutic challenges
Swedish Research Council
1 January 2016 - 31 December 2019
Mechanisms and therapeutic challenges in tumor angiogenesis
Swedish Cancer Society
1 January 2016
Modulation of Adipose Angiogenesis: A New Concept of Treatment of Obesity, Diabetes and other Metabolic Disease
Novo Nordisk Foundation
1 January 2015 - 31 December 2019
Mechanisms and therapeutic challenges in tumor angiogenesis
Swedish Cancer Society
1 January 2015
Hitting cancer on target – Novel strategies for optimizing drug target engagement for improved brest cancer therapies
Knut and Alice Wallenberg Foundation
1 January 2014 - 1 January 2019
Mechanisms and therapeutic challenges in tumor angiogenesis
Swedish Cancer Society
1 January 2014
Cold-induced lipolysis and angiogenesis significantly contribute to development of cardiovascular disease
Novo Nordisk Foundation
29 August 2013 - 29 August 2014
Translational research on angiogenesis in diseases
Swedish Research Council
1 January 2012 - 31 December 2016
New mechanisms of angiogenesis modulators in switching between white and brown adipose tissues
European Research Council
1 March 2010 - 28 February 2015
Angiogenesis as a therapeutic target for non-malignant diseases
Swedish Research Council
1 January 2009 - 31 December 2011

Anställningar

Professor, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2004-

Examina och utbildning

Docent, Angiogenesis och Cellbiologi, Karolinska Institutet, 1995

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Examina och utbildning

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