Takahiro Seki

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: ISCIENCE. 2024;27(2):108797
A tumor endothelial cell-specific microRNA replacement therapy for hepatocellular carcinoma
Iwamoto H; Suzuki H; Masuda A; Sakaue T; Nakamura T; Tanaka T; Sakai M; Imamura Y; Yano H; Torimura T; Koga H; Yasuda K; Tsurusaki M; Seki T; Kawaguchi T
Article: NATURE COMMUNICATIONS. 2023;14(1):7610
Mirabegron displays anticancer effects by globally browning adipose tissues
Sun X; Sui W; Mu Z; Xie S; Deng J; Li S; Seki T; Wu J; Jing X; He X; Wang Y; Li X; Yang Y; Huang P; Ge M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(29):e2303740120
KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas
Hosaka K; Andersson P; Wu J; He X; Du Q; Jing X; Seki T; Gao J; Zhang Y; Sun X; Huang P; Yang Y; Ge M; Cao Y
Article: CANCER COMMUNICATIONS. 2023;43(6):637-660
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors
Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
Journal article: CHINESE JOURNAL OF CANCER. 2023;43(4):i
Cover Image, Volume 43, Issue 4
Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: CANCER COMMUNICATIONS. 2023;43(4):415-434
Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors
Suzuki H; Iwamoto H; Seki T; Nakamura T; Masuda A; Sakaue T; Tanaka T; Imamura Y; Niizeki T; Nakano M; Shimose S; Shirono T; Noda Y; Kamachi N; Sakai M; Morita K; Nakayama M; Yoshizumi T; Kuromatsu R; Yano H; Cao Y; Koga H; Torimura T
Article: NATURE METABOLISM. 2022;4(12):1674-1683
COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119
Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo
Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
Article: NATURE. 2022;608(7922):421-428
Brown-fat-mediated tumour suppression by cold-altered global metabolism
Seki T; Yang Y; Sun X; Lim S; Xie S; Guo Z; Xiong W; Kuroda M; Sakaue H; Hosaka K; Jing X; Yoshihara M; Qu L; Li X; Chen Y; Cao Y
Article: CELL CHEMICAL BIOLOGY. 2022;29(4):572-585.e8
CETSA interaction proteomics define specific RNA-modification pathways as key components of fluorouracil-based cancer drug cytotoxicity
Liang YY; Bacanu S; Sreekumar L; Ramos AD; Dai L; Michaelis M; Cinatl J; Seki T; Cao Y; Coffill CR; Lane DP; Prabhu N; Nordlund P
Article: NATURE COMMUNICATIONS. 2020;11(1):3704
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors
Hosaka K; Yang Y; Seki T; Du Q; Jing X; He X; Wu J; Zhang Y; Morikawa H; Nakamura M; Scherzer M; Sun X; Xu Y; Cheng T; Li X; Liu X; Li Q; Liu Y; Hong A; Chen Y; Cao Y
Article: SCIENTIFIC REPORTS. 2019;9(1):19384
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance
Langeback A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Loof S
Article: CELL METABOLISM. 2018;28(1):104-117.e5
Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
Iwamoto H; Abe M; Yang Y; Cui D; Seki T; Nakamura M; Hosaka K; Lim S; Wu J; He X; Sun X; Lu Y; Zhou Q; Shi W; Torimura T; Nie G; Li Q; Cao Y
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2018;215(2):611-626
Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning
Seki T; Hosaka K; Fischer C; Lim S; Andersson P; Abe M; Iwamoto H; Gao Y; Wang X; Fong G-H; Cao Y
Article: CELL DISCOVERY. 2018;4:3
Dual roles of endothelial FGF-2-FGFR1-PDGF-BB and perivascular FGF-2-FGFR2-PDGFRβ signaling pathways in tumor vascular remodeling
Hosaka K; Yang Y; Nakamura M; Andersson P; Yang X; Zhang Y; Seki T; Scherzer M; Dubey O; Wang X; Cao Y
Article: NATURE COMMUNICATIONS. 2017;8(1):2079
A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning
Fischer C; Seki T; Lim S; Nakamura M; Andersson P; Yang Y; Honek J; Wang Y; Gao Y; Chen F; Samani NJ; Zhang J; Miyake M; Oyadomari S; Yasue A; Li X; Zhang Y; Liu Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(45):E9635-E9644
Off-tumor targets compromise antiangiogenic drug sensitivity by inducing kidney erythropoietin production
Nakamura M; Zhang Y; Yang Y; Sonmez C; Zheng W; Huang G; Seki T; Iwamoto H; Ding B; Yin L; Foukakis T; Hatschek T; Li X; Hosaka K; Li J; Yu G; Wang X; Liu Y; Cao Y
Article: JCI INSIGHT. 2017;2(4):e89044
Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions
Yang X; Sui W; Zhang M; Dong M; Lim S; Seki T; Guo Z; Fischer C; Lu H; Zhang C; Yang J; Zhang M; Wang Y; Cao C; Gao Y; Zhao X; Sun M; Sun Y; Zhuang R; Samani NJ; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627
Pericyte-fibroblast transition promotes tumor growth and metastasis
Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12680
Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism
Yang Y; Zhang Y; Iwamoto H; Hosaka K; Seki T; Andersson P; Lim S; Fischer C; Nakamura M; Abe M; Cao R; Skov PV; Chen F; Chen X; Lu Y; Nie G; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12152
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T; Hosaka K; Lim S; Fischer C; Honek J; Yang Y; Andersson P; Nakamura M; Naslund E; Yla-Herttuala S; Sun M; Iwamoto H; Li X; Liu Y; Samani NJ; Cao Y
Article: SCIENCE ADVANCES. 2015;1(3):e1400244
PlGF-induced VEGFR1-dependent vascular remodeling determines opposing antitumor effects and drug resistance to Dll4-Notch inhibitors
Iwamoto H; Zhang Y; Seki T; Yang Y; Nakamura M; Wang J; Yang X; Torimura T; Cao Y
Article: CELL REPORTS. 2014;9(2):569-580
VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization
Lim S; Zhang Y; Zhang D; Chen F; Hosaka K; Feng N; Seki T; Andersson P; Li J; Zang J; Sun B; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(41):14906-14911
Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues
Honek J; Seki T; Iwamoto H; Fischer C; Li J; Lim S; Samani NJ; Zang J; Cao Y
Article: CARCINOGENESIS. 2013;34(12):2833-2841
Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involves suppression of oxidative stress and inflammatory cytokines
Fang J; Seki T; Tsukamoto T; Qin H; Yin H; Liao L; Nakamura H; Maeda H
Article: SCIENCE. 2013;341(6141):84-87
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Molina DM; Jafari R; Ignatushchenko M; Seki T; Larsson EA; Dan C; Sreekumar L; Cao Y; Nordlund P
Article: CELL METABOLISM. 2013;18(1):118-129
Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
Dong M; Yang X; Lim S; Cao Z; Honek J; Lu H; Zhang C; Seki T; Hosaka K; Wahlberg E; Yang J; Zhang L; Lanne T; Sun B; Li X; Liu Y; Zhang Y; Cao Y
Article: NATURE COMMUNICATIONS. 2013;4:2129
Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis
Hosaka K; Yang Y; Seki T; Nakamura M; Andersson P; Rouhi P; Yang X; Jensen L; Lim S; Feng N; Xue Y; Li X; Larsson O; Ohhashi T; Cao Y
Article: NATURE PROTOCOLS. 2012;7(3):606-615
Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice
Lim S; Honek J; Xue Y; Seki T; Cao Z; Andersson P; Yang X; Hosaka K; Cao Y
Article: JOURNAL OF CONTROLLED RELEASE. 2011;156(3):381-389
Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway
Seki T; Carroll F; Illingworth S; Green N; Cawood R; Bachtarzi H; Subr V; Fisher KD; Seymour LW
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2011;339(3):779-789
Therapeutic Potential of Pegylated Hemin for Reactive Oxygen Species-Related Diseases via Induction of Heme Oxygenase-1: Results from a Rat Hepatic Ischemia/Reperfusion Injury Model
Fang J; Qin H; Seki T; Nakamura H; Tsukigawa K; Shin T; Maeda H
Article: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2010;7(4):447-457
Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under Vigorous Condition
Seki T; Kida K; Maeda H
Article: EXPERIMENTAL BIOLOGY AND MEDICINE. 2010;235(4):487-496
Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene-maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia-reperfusion injury
Fang J; Seki T; Qin H; Bharate GY; Iyer AK; Maeda H
Article: ANTICANCER RESEARCH. 2010;30(1):111-118
Cancer Preventive Effect of Kumaizasa Bamboo Leaf Extracts Administered Prior to Carcinogenesis or Cancer Inoculation
Seki T; Maeda H
Article: CANCER SCIENCE. 2009;100(12):2426-2430
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
Seki T; Fang J; Maeda H
Article: JOURNAL OF CONTROLLED RELEASE. 2009;135(3):211-217
SMA-copolymer conjugate of AHPP: A polymeric inhibitor of xanthine oxidase with potential antihypertensive effect
Fang J; Iyer AK; Seki T; Nakamura H; Greish K; Maeda H
Article: NUTRITION AND CANCER. 2008;60(6):776-783
Immunostimulation-Mediated Antitumor Activity by Preconditioning with Rice-Shochu Distillation Residue Against Implanted Tumor in Mice
Seki T; Morimura S; Ohba H; Tang Y; Shigematsu T; Maeda H; Kida K
Article: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2008;56(10):3785-3790
Antioxidant activity of vinegar produced from distilled residues of the Japanese liquor shochu
Seki T; Morimura S; Tabata S; Tang Y; Shigematsu T; Kida K
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;122(7):1445-1454
4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils
Cao X; Tsukamoto T; Seki T; Tanaka H; Morimura S; Cao L; Mizoshita T; Ban H; Toyoda T; Maeda H; Tatematsu M
Article: JOURNAL OF DRUG TARGETING. 2007;15(7-8):496-506
Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation
Iyer AK; Greish K; Seki T; Okazaki S; Fang F; Takeshita K; Maeda H
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Review: ADVANCED DRUG DELIVERY REVIEWS. 2009;61(4):290-302
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
Fang J; Seki T; Maeda H
Published conference paper: BIOFACTORS. 2004;22(1-4):103-105
Antitumor activity of rice-shochu post-distillation slurry and vinegar produced from the post-distillation slurry via oral administration in a mouse model
Seki T; Morimura S; Shigematsu T; Maeda H; Kida K

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