Imaging of Neurodegenerative and Neuroinflammatory disorders
Our translational research group focuses on developing and applying new neuroimaging techniques clinically to benefit the diagnosis and follow-up of neurodegenerative and neuroinflammatory disorders. Our main research areas include dementia disorders, movement disorders, multiple sclerosis (MS) and rare neurological diseases.
The research team consists of a wide range of radiological and psychological expertise in close collaboration with neurologists, physicists and engineers at Karolinska as well as internationally. We create, validate and perform visual radiological ratings for morphometric analysis, complemented by volumetric segmentations. We work mainly with FreeSurfer, FSL, SPM and SyMRI but also create in-house analytic tools. A majority of our research projects is based on MRI (structural, functional, diffusion and synthetic) but we also work with CT and nuclear medicine modalities.
Research Projects
- Karolinska Imaging Dementia Study (KIDS): A large retrospective cohort study evaluating imaging biomarkers in patients with cognitive impairment.
- Karolinska Imaging in Movement Disorders Study (KIMOVE): A combined retro- and prospective longitudinal cohort study of Parkinson’s disease and atypical Parkinsonism with both conventional and advanced MRI techniques.
- Stockholm prospective assessment of MS (STOPMS): A large prospective study of new-onset MS-patients started in 2001 using volumetric MRI to study the value of imaging biomarkers in MS.
- Synthetic MRI: Validation studies and practical neuroapplications of SyMRI including myelin quantification using REMyDI (Rapid Estimation of Myelin for Diagnostic Imaging).
- Other projects include the study of: Gadolinium retention in brain structures, Radiolologically Isolated Syndrome (RIS), spinal atrophy, Quantitative Susceptibility Mapping (QSM).
News
Photo: Kajsa MüllersdorfTobias Granberg one of two KI researchers who win MedTechLabs' call for proposals
MedTechLabs has granted SEK 35 million for two new medical technology research programmes. One will develop a new method for monitoring foetal oxygenation during labour. The other will develop a new method for early diagnosis of brain diseases using MR-Elastography.
Photo: Nilla KarlssonDissertation Mana Shams, April 28 2023
Mana Shams defended her thesis on April 28, 2023.
Title: Microvascular Disease in Cognitive Impairment