Pediatric Systems Immunology – Petter Brodin's research group

Publications

All publications from group members

Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2024;45(1):31
Normalized Interferon Signatures and Clinical Improvements by IFNAR1 Blocking Antibody (Anifrolumab) in Patients with Type I Interferonopathies.
Kretzschmar G; Páez LP; Tan Z; Wang J; Gonzalez L; Mugabo CH; Johnsson A; Chen Y; Mikeš J; Lakshmikanth T; James A; Goldbach-Mansky R; Fischer M; Palmblad K; Alehashemi S; Horne A; Brodin P
Article: SCIENTIFIC REPORTS. 2024;14(1):24512
Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination.
Yalcinkaya A; Cavalli M; Aranda-Guillén M; Cederholm A; Güner A; Rietrae I; Mildner H; Behere A; Eriksson O; Gonzalez L; Mugabo CH; Johnsson A; Lakshmikanth T; Brodin P; Wadelius M; Hallberg P; Landegren N
Journal article: JOURNAL OF IMMUNOLOGY. 2024;:ji2400395
NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Children.
Dick JK; Sangala JA; Krishna VD; Khaimraj A; Hamel L; Erickson SM; Hicks D; Soigner Y; Covill LE; Johnson AK; Ehrhardt MJ; Ernste K; Brodin P; Koup RA; Khaitan A; Baehr C; Thielen BK; Henzler CM; Skipper C; Miller JS; Bryceson YT; Wu J; John CC; Panoskaltsis-Mortari A; Orioles A; Steiner ME; Cheeran MCJ; Pravetoni M; Hart GT
Journal article: JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY. 2024;13(Supplement_4):8-9
Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C)
Dick JK; Sangala JA; Krishna VD; Khaimraj A; Hamel L; Erickson SM; Hicks D; Soigner Y; Covill LE; Johnson AK; Ehrhardt MJ; Ernste K; Brodin P; Koup RA; Khaitan A; Baehr C; Thielen BK; Henzler CM; Skipper C; Miller JS; Bryceson YT; Wu J; John CC; Panoskaltsis-Mortari A; Orioles A; Steiner ME; Cheeran MC-J; Pravetoni M; Hart GT
Corrigendum: NATURE. 2024;634(8033):e5
Immune system adaptation during gender-affirming testosterone treatment (vol 633, pg 155, 2024)
Lakshmikanth T; Consiglio C; Sardh F; Forlin R; Wang J; Tan Z; Barcenilla H; Rodriguez L; Sugrue J; Noori P; Ivanchenko M; Paez LP; Gonzalez L; Mugabo CH; Johnsson A; Ryberg H; Hallgren A; Pou C; Chen Y; Mikes J; James A; Dahlqvist P; Wahlberg J; Hagelin A; Holmberg M; Degerblad M; Isaksson M; Duffy D; Kampe O; Landegren N; Brodin P
Journal article: NATURE REVIEWS IMMUNOLOGY. 2024;24(10):697-698
Immunological studies in trans-individuals undergoing gender affirming hormone therapy
James A; Brodin P
Journal article: NATURE REVIEWS IMMUNOLOGY. 2024;24(10):771
Publisher Correction: Immunological studies in trans-individuals undergoing gender affirming hormone therapy.
James A; Brodin P
Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2024
Cytokine Profile in Children Following SARS-CoV-2 Infection: Preliminary Findings.
Buonsenso D; Camporesi A; Di Sante G; Sali M; Boza MDCP; Morello R; Valentini P; Raffaelli F; Rodriguez L; Gonzalez L; Johnsson A; Mugabo CH; Lakshmikanth T; Brodin P
Article: NATURE. 2024;633(8028):155-164
Immune system adaptation during gender-affirming testosterone treatment
Lakshmikanth T; Consiglio C; Sardh F; Forlin R; Wang J; Tan Z; Barcenilla H; Rodriguez L; Sugrue J; Noori P; Ivanchenko M; Paez LP; Gonzalez L; Mugabo CH; Johnsson A; Ryberg H; Hallgren A; Pou C; Chen Y; Mikes J; James A; Dahlqvist P; Wahlberg J; Hagelin A; Holmberg M; Degerblad M; Isaksson M; Duffy D; Kampe O; Landegren N; Brodin P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(9):e20231725
SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency
Chan Y-H; Lundberg V; Le Pen J; Yuan J; Lee D; Pinci F; Volpi S; Nakajima K; Bondet V; Akesson S; Khobrekar NV; Bodansky A; Du L; Melander T; Mariaggi A-A; Seeleuthner Y; Saleh TS; Chakravarty D; Marits P; Dobbs K; Vonlanthen S; Hennings V; Thorn K; Rinchai D; Bizien L; Chaldebas M; Sobh A; Ozcelik T; Keles S; AlKhater SA; Prando C; Meyts I; Wilson MR; Rosain J; Jouanguy E; Aubart M; Abel L; Mogensen TH; Pan-Hammarstrom Q; Gao D; Duffy D; Cobat A; Berg S; Notarangelo LD; Harschnitz O; Rice CM; Studer L; Casanova J-L; Ekwall O; Zhang S-Y
Journal article: BMC MEDICINE. 2024;22(1):295
Foetal gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome
Moreno MDL; Gonzalez-Rovira M; Martinez-Pancorbo C; Martin-Camean M; Najar-Moyano AM; Romero M; de la Hoz E; Lopez-Beltran C; Mellado E; Bartha JL; Brodin P; Rodriguez-Herrera A; Sainz-Bueno JA; Sousa C
Article: NATURE METHODS. 2024;21(6):1044-1052
Molecular pixelation: spatial proteomics of single cells by sequencing
Karlsson F; Kallas T; Thiagarajan D; Karlsson M; Schweitzer M; Navarro JF; Leijonancker L; Geny S; Pettersson E; Rhomberg-Kauert J; Larsson L; van Ooijen H; Petkov S; Gonzalez-Granillo M; Bunz J; Dahlberg J; Simonetti M; Sathe P; Brodin P; Barrio AM; Fredriksson S
Journal article: BIORXIV. 2024;:2024.04.16.589585
Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C).
Dick JK; Sangala JA; Krishna VD; Khaimraj A; Hamel L; Erickson SM; Hicks D; Soigner Y; Covill LE; Johnson A; Ehrhardt MJ; Ernste K; Brodin P; Koup RA; Khaitan A; Baehr C; Thielen BK; Henzler CM; Skipper C; Miller JS; Bryceson YT; Wu J; John CC; Panoskaltsis-Mortari A; Orioles A; Steiner ME; Cheeran MC-J; Pravetoni M; Hart GT
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(4):e13346
Gut bacteria at 6 months of age are associated with immune cell status in 1-year-old children
Nilsen M; Nygaard UC; Brodin P; Carlsen KCL; Fredheim C; Haugen G; Hedlin G; Jonassen CM; Jonsmoen ULA; Lakshmikanth T; Nordlund B; Olin A; Rehbinder EM; Skjerven HO; Snipen L; Staff AC; Soederhaell C; Vettukattil R; Rudi K
Journal article: CANCER RESEARCH. 2024;84(6):6378
Systems-level immunomonitoring in children with solid tumors
Chen Q; Zhao B; Tan Z; Hedberg G; Wang J; Gonzalez L; Mugabo C; Johnsson A; Paez L; Rodriguez L; James A; Chen Y; Mikes J; Barcenilla H; Wang C; Davis MM; Carlson L-M; Pal N; Herold N; Blomgren K; Repsilber D; Lakshmikanth T; Kogner P; Ljungblad L; Brodin P
Preprint: BIORXIV. 2024
Cluster-free annotation of single cells using Earth mover’s distance-based classification
Forlin R; Tajvar P; Wang N; Dimarogonas D; Brodin P
Preprint: RESEARCH SQUARE. 2024
Fetal-maternal interactions with gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome
Moreno MDL; González-Rovira M; Martínez-Pancorbo C; Martín-Cameán M; Nájar-Moyano AM; Romero M; Hoz E; López-Beltrán C; Mellado E; Bartha JL; Brodin P; Rodríguez-Herrera A; Sainz-Bueno JL; Sousa C
Editorial comment: TRENDS IN MOLECULAR MEDICINE. 2024;30(3):200-201
Immune system perturbations in patients with long COVID
Rodriguez L; Brodin P
Article: NPJ VACCINES. 2024;9(1):42
No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
Yalcinkaya A; Cavalli M; Cederholm A; Aranda-Guillen M; Behere A; Mildner H; Lakshmikanth T; Gonzalez L; Mugabo CH; Johnsson A; Ekwall O; Kampe O; Bensing S; Brodin P; Hallberg P; Wadelius M; Landegren N
Article: NATURE. 2024;626(8000):827-835
Smoking changes adaptive immunity with persistent effects
Saint-Andre V; Charbit B; Biton A; Rouilly V; Posseme C; Bertrand A; Rotival M; Bergstedt J; Patin E; Albert ML; Quintana-Murci L; Duffy D
Preprint: MEDRXIV. 2024
Restrained memory CD8⁺T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID
Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Swank Z; Zuo F; Abolhassani H; Pavlovitch-Bedzyk AJ; Wang C; Gonzalez L; Mugabo CH; Johnsson A; Chen Y; James A; Mikes J; Kleberg L; Sundling C; Björnson M; Bonnier MN; Ståhlberg M; Runold M; Björkander S; Melén E; Meyts I; Weyenbergh JV; Hammarström Q-P; Davis M; Walt D; Landegren N; COVID Human Genetic Effort; Aiuti A; Casari G; Casanova J-L; Jamoulle M; Bruchfeld J; Brodin P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20231353
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Bastard P; Gervais A; Taniguchi M; Saare L; Sarekannu K; Le Voyer T; Philippot Q; Rosain J; Bizien L; Asano T; Garcia-Prat M; Parra-Martinez A; Migaud M; Tsumura M; Conti F; Belot A; Riviere JG; Morio T; Tanaka J; Javouhey E; Haerynck F; Duvlis S; Ozcelik T; Keles S; Tandjaoui-Lambiotte Y; Escoda S; Husain M; Pan-Hammarstrom Q; Hammarstrom L; Ahlijah G; Haidar AA; Soudee C; Arseguel V; Abolhassani H; Sahanic S; Tancevski I; Nukui Y; Hayakawa S; Chrousos GP; Michos A; Tatsi E-B; Filippatos F; Rodriguez-Palmero A; Troya J; Tipu I; Meyts I; Roussel L; Ostrowski SR; Schidlowski L; Prando C; Condino-Neto A; Cheikh N; Bousfiha AA; El Bakkouri J; Peterson P; Pujol A; Levy R; Quartier P; Vinh DC; Boisson B; Beziat V; Zhang S-Y; Borghesi A; Pession A; Andreakos E; Marr N; Mentis A-FA; Mogensen TH; Rodriguez-Gallego C; Soler-Palacin P; Colobran R; Tillmann V; Neven B; Trouillet-Assant S; Brodin P; Abel L; Jouanguy E; Zhang Q; Martinon-Torres F; Salas A; Gomez-Carballa A; Gonzalez-Granado LI; Kisand K; Okada S; Puel A; Cobat A; Casanova J-L
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2024;105(2):124-138
Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.
Dott T; Culina S; Chemali R; Mansour CA; Dubois F; Jagla B; Doisne JM; Rogge L; Huetz F; Jönsson F; Commere P-H; Di Santo J; Terrier B; Quintana-Murci L; Duffy D; Hasan M; Milieu Intérieur Consortium
Article: PEDIATRIC RESEARCH. 2024;95(3):762-769
Antisecretory factor in breastmilk is associated with reduced incidence of sepsis in preterm infants
Gustafsson A; Johansson E; Henckel E; Olin A; Rodriguez L; Brodin P; Lange S; Bohlin K
Article: SCIENCE. 2024;383(6680):eadg7942
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Cervia-Hasler C; Brueningk SC; Hoch T; Fan B; Muzio G; Thompson RC; Ceglarek L; Meledin R; Westermann P; Emmenegger M; Taeschler P; Zurbuchen Y; Pons M; Menges D; Ballouz T; Cervia-Hasler S; Adamo S; Merad M; Charney AW; Puhan M; Brodin P; Nilsson J; Aguzzi A; Raeber ME; Messner CB; Beckmann ND; Borgwardt K; Boyman O
Preprint: BIORXIV. 2024
High-throughput analysis of membrane fluidity unveils a hidden dimension in immune cell states
Andronico LA; Jiang Y; Carannante V; Iskrak S; Sandoz PA; Mikes J; Klymchenko A; Buggert M; Österborg A; Önfelt B; Brodin P; Sezgin E
Corrigendum: GENOME MEDICINE. 2024;16(1):6
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 (vol 15, 22, 2023)
Matuozzo D; Talouarn E; Marchal A; Zhang P; Manry J; Seeleuthner Y; Zhang Y; Bolze A; Chaldebas M; Milisavljevic B; Gervais A; Bastard P; Asano T; Bizien L; Barzaghi F; Abolhassani H; Tayoun AA; Aiuti A; Darazam IA; Allende LM; Alonso-Arias R; Arias AA; Aytekin G; Bergman P; Bondesan S; Bryceson YT; Bustos IG; Cabrera-Marante O; Carcel S; Carrera P; Casari G; Chaibi K; Colobran R; Condino-Neto A; Covill LE; Delmonte OM; Zein LE; Flores C; Gregersen PK; Gut M; Haerynck F; Halwani R; Hancerli S; Hammarstroem L; Hatipoglu N; Karbuz A; Keles S; Kyheng C; Leon-Lopez R; Franco JL; Mansouri D; Martinez-Picado J; Akcan OM; Migeotte I; Morange P-E; Morelle G; Martin-Nalda A; Novelli G; Novelli A; Ozcelik T; Palabiyik F; Pan-Hammarstroem Q; de Diego RP; Planas-Serra L; Pleguezuelo DE; Prando C; Pujol A; Reyes LF; Riviere JG; Rodriguez-Gallego C; Rojas J; Rovere-Querini P; Schlueter A; Shahrooei M; Sobh A; Soler-Palacin P; Tandjaoui-Lambiotte Y; Tipu I; Tresoldi C; Troya J; van de Beek D; Zatz M; Zawadzki P; Al-Muhsen SZ; Alosaimi MF; Alsohime FM; Baris-Feldman H; Butte MJ; Constantinescu SN; Cooper MA; Dalgard CL; Fellay J; Heath JR; Lau Y-L; Lifton RP; Maniatis T; Mogensen TH; von Bernuth H; Lermine A; Vidaud M; Boland A; Deleuze J-F; Nussbaum R; Kahn-Kirby A; Mentre F; Tubiana S; Gorochov G; Tubach F; Hausfater P; Meyts I; Zhang S-Y; Puel A; Notarangelo LD; Boisson-Dupuis S; Su HC; Boisson B; Jouanguy E; Casanova J-L; Zhang Q; Abel L; Cobat A
Review: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY. 2024;21(1):35-45
The maternal gut microbiome in pregnancy: implications for the developing immune system
Koren O; Konnikova L; Brodin P; Mysorekar IU; Collado MC
Article: SCIENCE IMMUNOLOGY. 2023;8(90):eabp8966
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs
Bastard P; Vazquez S; Liu J; Laurie MT; Wang CY; Gervais A; Le Voyer T; Bizien L; Zamecnik C; Philippot Q; Rosain J; Catherinot E; Willmore A; Mitchell AM; Bair R; Garcon P; Kenney H; Fekkar A; Salagianni M; Poulakou G; Siouti E; Sahanic S; Tancevski I; Weiss G; Nagl L; Manry J; Duvlis S; Arroyo-Sanchez D; Paz Artal E; Rubio L; Perani C; Bezzi M; Sottini A; Quaresima V; Roussel L; Vinh DC; Felipe Reyes L; Garzaro M; Hatipoglu N; Boutboul D; Tandjaoui-Lambiotte Y; Borghesi A; Aliberti A; Cassaniti I; Venet F; Monneret G; Halwani R; Sharif-Askari NS; Danielson J; Burrel S; Morbieu C; Stepanovskyy Y; Bondarenko A; Volokha A; Boyarchuk O; Gagro A; Neuville M; Neven B; Keles S; Hernu R; Bal A; Novelli A; Novelli G; Saker K; Ailioaie O; Antoli A; Jeziorski E; Rocamora-Blanch G; Teixeira C; Delaunay C; Lhuillier M; Le Turnier P; Zhang Y; Mahevas M; Pan-Hammarstrom Q; Abolhassani H; Bompoil T; Dorgham K; Group FCS; Gorochov G; Laouenan C; Rodriguez-Gallego C; Ng LFP; Renia L; Pujol A; Belot A; Raffi F; Allende LM; Martinez-Picado J; Ozcelik T; Keles S; Imberti L; Notarangelo LD; Troya J; Solanich X; Zhang S-Y; Puel A; Wilson MR; Trouillet-Assants S; Abe L; Jouanguy E; Ye CJ; Cobat A; Thompson LM; Andreakos E; Zhang Q; Anderson MS; Casanova J-L; DeRisi JL
Article: GUT MICROBES. 2023;15(2):2287618
Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.
Delavy M; Sertour N; Patin E; Le Chatelier E; Cole N; Dubois F; Xie Z; Saint-André V; Manichanh C; Walker AW; Quintana-Murci L; Duffy D; d'Enfert C; Bougnoux M-E; Consortium MI
Conference publication: 2023;00:715-720
Modelling Pathogen Response of the Human Immune System in a Reduced State Space
Tajvar P; Forlin R; Brodin P; Dimarogonas DV
Article: NATURE. 2023;623(7988):803-813
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Le Voyer T; Parent AV; Liu X; Cederholm A; Gervais A; Rosain J; Nguyen T; Lorenzo MP; Rackaityte E; Rinchai D; Zhang P; Bizien L; Hancioglu G; Ghillani-Dalbin P; Charuel J-L; Philippot Q; Gueye MS; Renkilaraj MRLM; Ogishi M; Soudee C; Migaud M; Rozenberg F; Momenilandi M; Riller Q; Imberti L; Delmonte OM; Mueller G; Keller B; Orrego J; Gallego WAF; Rubin T; Emiroglu M; Parvaneh N; Eriksson D; Aranda-Guillen M; Berrios DI; Vong L; Katelaris CH; Mustillo P; Raedler J; Bohlen J; Celik JB; Astudillo C; Winter S; McLean C; Guffroy A; DeRisi JL; Yu D; Miller C; Feng Y; Guichard A; Beziat V; Bustamante J; Pan-Hammarstrom Q; Zhang Y; Rosen LB; Holland SM; Bosticardo M; Kenney H; Castagnoli R; Slade CA; Boztug K; Mahlaoui N; Latour S; Abraham RS; Lougaris V; Hauck F; Sediva A; Atschekzei F; Sogkas G; Poli MC; Slatter MA; Palterer B; Keller MD; Pinzon-Charry A; Sullivan A; Droney L; Suan D; Wong M; Kane A; Hu H; Ma C; Grombirikova H; Ciznar P; Dalal I; Aladjidi N; Hie M; Lazaro E; Franco J; Keles S; Malphettes M; Pasquet M; Maccari ME; Meinhardt A; Ikinciogullari A; Shahrooei M; Celmeli F; Frosk P; Goodnow CC; Gray PE; Belot A; Kuehn HS; Rosenzweig SD; Miyara M; Licciardi F; Servettaz A; Barlogis V; Le Guenno G; Herrmann V-M; Kuijpers T; Ducoux G; Sarrot-Reynauld F; Schuetz C; Cunningham-Rundles C; Rieux-Laucat F; Tangye SG; Sobacchi C; Doffinger R; Warnatz K; Grimbacher B; Fieschi C; Berteloot L; Bryant VL; Assant ST; Su H; Neven B; Abel L; Zhang Q; Boisson B; Cobat A; Jouanguy E; Kampe O; Bastard P; Roifman CM; Landegren N; Notarangelo LD; Anderson MS; Casanova J-L; Puel A
Preprint: MEDRXIV. 2023
A systematic investigation into the non-genetic and genetic factors affecting the human anti-viral antibody repertoire
Olin A; Jaquaniello A; Tan Z; Pou C; Dubois F; Charbit B; Bloch E; White M; Rotival M; Brodin P; Duffy D; Patin E; Quintana-Murci L; Consortium MI
Journal article: CIRCULATION. 2023;148:a16646
Evidence of Protein Dysregulation in Patients With Post-Acute COVID-19 Syndrome With- and Without Postural Orthostatic Tachycardia Syndrome
Zhao A; Mahdi A; Fredengren E; Fedorowski A; Braunschweig F; Brodin P; Nygren-Bonnier M; Runold M; Bruchfeld J
Review: SEMINARS IN IMMUNOLOGY. 2023;69:101794
Immune responses to SARS-CoV-2 infection and vaccination in children
Brodin P
Journal article: JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2023;159:104065
Immune system adaptation during gender-affirming testosterone treatment
Consiglio C; Tadepally L; Sardh F; Forlin R; Wang J; Tan Z; Barcenilla H; Rodriguez L; Sugrue J; Noori P; Paez LP; Gonzalez L; Mugabo CH; Johnsson A; Hallgren A; Pou C; Chen Y; Mikes J; James A; Dahlqvist P; Wahlberg J; Hagelin A; Holmberg M; Degerblad M; Isaksson M; Duffy D; Kampe O; Landegren N; Brodin P
Article: ISCIENCE. 2023;26(8):107422
Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks.
Villain E; Chanson A; Mainka M; Kampschulte N; Le Faouder P; Bertrand-Michel J; Brandolini-Bulon M; Charbit B; Musvosvi M; Bilek N; Scriba TJ; Quintana-Murci L; Schebb NH; Duffy D; Gladine C; Milieu Interieur Consortium
Review: TRENDS IN IMMUNOLOGY. 2023;44(8):577-584
Making human immune systems more interpretable through systems immunology
Forlin R; James A; Brodin P
Article: IMMUNITY. 2023;56(6):1255-1268.e5
Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens
Bee GCW; Lokken-Toyli KL; Yeung ST; Rodriguez L; Zangari T; Anderson EE; Ghosh S; Rothlin CV; Brodin P; Khanna KM; Weiser JN
Preprint: BIORXIV. 2023
Scalablein-vitroimmunostimulation of human blood for in-depth profiling of acute immune response effects
Reitzner SM; Brodin P; Mikeš J
Preprint: BIORXIV. 2023
Molecular Pixelation: Single cell spatial proteomics by sequencing
Karlsson F; Kallas T; Thiagarajan D; Karlsson M; Schweitzer M; Navarro JF; Leijonancker L; Geny S; Pettersson E; Rhomberg-Kauert J; Granillo MG; Bunz J; Dahlberg J; Simonetti M; Sathe P; Brodin P; Barrio AM; Fredriksson S
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(16_suppl):3110
First-in-human (FIH) phase I dose escalation study (part A) of the first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) roginolisib in patients with advanced cancer and dose confirmation in uveal melanoma (part B).
Di Giacomo AM; Santangelo F; Amato G; Simonetti E; Graham J; Lahn MMF; Di Conza G; Hammett T; Zorrilla R; Durini M; Tan Z; Tadepally L; Brodin P; Occhipinti M; Simonelli M; Carlo-Stella C; Santoro A; Spiliopoulou P; Evans TRJ; Maio M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):233.07
Immune system perturbations in patients with severe long COVID
Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Gonzalez L; Mugabo C; Johnsson A; Chen Y; Mikes J; Landegren N; Runold M; Bruchfeld J; Brodin P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(5):e20220170
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Garcia-Garcia A; de Diego RP; Flores C; Rinchai D; Sole-Violan J; Deya-Martinez A; Garcia-Solis B; Lorenzo-Salazar JM; Hernandez-Brito E; Lanz A-L; Moens L; Bucciol G; Almuqamam M; Domachowske J; Colino E; Santos-Perez JL; Marco F; Pignata C; Bousfiha A; Turvey S; Bauer S; Haerynck F; Ocejo-Vinyals JG; Lendinez F; Prader S; Naumann-Bartsch N; Pachlopnik Schmid J; Biggs C; Hildebrand K; Dreesman A; Cardenes MA; Ailal F; Benhsaien I; Giardino G; Molina-Fuentes A; Fortuny C; Madhavarapu S; Conway D; Prando C; Schidlowski L; Alvarez MTMDS; Alfaro R; de Castro FR; Meyts I; Hauck F; Puel A; Bastard P; Boisson B; Jouanguy E; Abel L; Cobat A; Zhang Q; Casanova J-L; Alsina L; Rodriguez-Gallego C
Article: LANCET REGIONAL HEALTH-EUROPE. 2023;28:100608
Ambient air pollution exposure linked to long COVID among young adults: a nested survey in a population-based cohort in Sweden
Yu Z; Ekstrom S; Bellander T; Ljungman P; Pershagen G; Eneroth K; Kull I; Bergstrom A; Georgelis A; Stafoggia M; Gruzieva O; Melen E
Article: GENOME MEDICINE. 2023;15(1):22
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
Matuozzo D; Talouarn E; Marchal A; Zhang P; Manry J; Seeleuthner Y; Zhang Y; Bolze A; Chaldebas M; Milisavljevic B; Gervais A; Bastard P; Asano T; Bizien L; Barzaghi F; Abolhassani H; Abou Tayoun A; Aiuti A; Alavi Darazam I; Allende LM; Alonso-Arias R; Arias AA; Aytekin G; Bergman P; Bondesan S; Bryceson YT; Bustos IG; Cabrera-Marante O; Carcel S; Carrera P; Casari G; Chaibi K; Colobran R; Condino-Neto A; Covill LE; Delmonte OM; El Zein L; Flores C; Gregersen PK; Gut M; Haerynck F; Halwani R; Hancerli S; Hammarstroem L; Hatipoglu N; Karbuz A; Keles S; Kyheng C; Leon-Lopez R; Franco JL; Mansouri D; Martinez-Picado J; Metin Akcan O; Migeotte I; Morange P-E; Morelle G; Martin-Nalda A; Novelli G; Novelli A; Ozcelik T; Palabiyik F; Pan-Hammarstroem Q; de Diego RP; Planas-Serra L; Pleguezuelo DE; Prando C; Pujol A; Reyes LF; Riviere JG; Rodriguez-Gallego C; Rojas J; Rovere-Querini P; Schlueter A; Shahrooei M; Sobh A; Soler-Palacin P; Tandjaoui-Lambiotte Y; Tipu I; Tresoldi C; Troya J; van de Beek D; Zatz M; Zawadzki P; Al-Muhsen SZ; Alosaimi MF; Alsohime FM; Baris-Feldman H; Butte MJ; Constantinescu SN; Cooper MA; Dalgard CL; Fellay J; Heath JR; Lau Y-L; Lifton RP; Maniatis T; Mogensen TH; von Bernuth H; Lermine A; Vidaud M; Boland A; Deleuze J-F; Nussbaum R; Kahn-Kirby A; Mentre F; Tubiana S; Gorochov G; Tubach F; Hausfater P; Effort COVIDHG; Meyts I; Zhang S-Y; Puel A; Notarangelo LD; Boisson-Dupuis S; Su HC; Boisson B; Jouanguy E; Casanova J-L; Zhang Q; Abel L; Cobat A
Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;151(4):832-840
Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children.
Bucciol G; COVID Human Genetic Effort; Meyts I
Article: LANCET RHEUMATOLOGY. 2023;5(4):e184-e199
Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study
Channon-Wells S; Vito O; McArdle AJ; Seaby EG; Patel H; Shah P; Pazukhina E; Wilson C; Broderick C; D'Souza G; Keren I; Nijman RG; Tremoulet A; Munblit D; Ulloa-Gutierrez R; Carter MJ; Ramnarayan P; De T; Hoggart C; Whittaker E; Herberg JA; Kaforou M; Cunnington AJ; Blyuss O; Levin M
Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;151(4):818-831
Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity
Tangye SG
Editorial comment: SCIENCE. 2023;379(6632):538-539
Exaggerated responses to a virus long gone Multisystem inflammatory syndrome in children is caused by abnormal cell activation
Brodin P
Article: SCIENCE. 2023;379(6632):eabo3627
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children
Lee D; Le Pen J; Yatim A; Dong B; Aquino Y; Ogishi M; Pescarmona R; Talouarn E; Rinchai D; Zhang P; Perret M; Liu Z; Jordan I; Bozdemir SE; Bayhan GI; Beaufils C; Bizien L; Bisiaux A; Lei W; Hasan M; Chen J; Gaughan C; Asthana A; Libri V; Luna JM; Jaffre F; Hoffmann HH; Michailidis E; Moreews M; Seeleuthner Y; Bilguvar K; Mane S; Flores C; Zhang Y; Arias AA; Bailey R; Schluter A; Milisavljevic B; Bigio B; Le Voyer T; Materna M; Gervais A; Moncada-Velez M; Pala F; Lazarov T; Levy R; Neehus A-L; Rosain J; Peel J; Chan Y-H; Morin M-P; Pino-Ramirez RM; Belkaya S; Lorenzo L; Anton J; Delafontaine S; Toubiana J; Bajolle F; Fumado V; DeDiego ML; Fidouh N; Rozenberg F; Perez-Tur J; Chen S; Evans T; Geissmann F; Lebon P; Weiss SR; Bonnet D; Duval X; Pan-Hammarstrom Q; Planas AM; Meyts I; Haerynck F; Pujol A; Sancho-Shimizu V; Dalgard CL; Bustamante J; Puel A; Boisson-Dupuis S; Boisson B; Maniatis T; Zhang Q; Bastard P; Notarangelo L; Beziat V; de Diego RP; Rodriguez-Gallego C; Su HC; Lifton RP; Jouanguy E; Cobat A; Alsina L; Keles S; Haddad E; Abel L; Belot A; Quintana-Murci L; Rice CM; Silverman RH; Zhang S-Y; Casanova J-L
Article: OXFORD OPEN IMMUNOLOGY. 2023;4(1):iqad003
Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance.
Rodriguez L; Pou C; Lakshmikanth T; Zhang J; Mugabo CH; Wang J; Mikes J; Olin A; Chen Y; Rorbach J; Juto J-E; Li TQ; Julin P; Brodin P
Review: CAMB PRISM PRECIS MED. 2023;1:e25
Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders.
Baglaenko Y; Wagner C; Bhoj VG; Brodin P; Gershwin ME; Graham D; Invernizzi P; Kidd KK; Korsunsky I; Levy M; Mammen AL; Nizet V; Ramirez-Valle F; Stites EC; Williams MS; Wilson M; Rose NR; Ladd V; Sirota M
Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)
Immune system perturbations in patients with severe long COVID
Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Gonzalez L; Mugabo C; Johnsson A; Chen Y; Mikes J; Landegren N; Runold M; Bruchfeld J; Brodin P
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2023;43(1):136-150
Three Adult Cases of STAT1 Gain-of-Function with Chronic Mucocutaneous Candidiasis Treated with JAK Inhibitors
Borgstrom EW; Edvinsson M; Perez LP; Norlin AC; Enoksson SL; Hansen S; Fasth A; Friman V; Kampe O; Mansson R; Estupinan HY; Qing W; Tan Z; Lakshmikanth T; Smith CIE; Brodin P; Bergman P
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2023;75:4913-4915
Anifrolumab Normalizes the Type I Interferon Signature in a Cohort of Patients with Type I Interferonopathies
Alehashemi S; Baumgardner A; Shakoory B; de Jesus AA; Park S; Uss K; Robles MP; Palmblad K; Horne A; Brodin P; Akoghlanian S; Abraham R; Mustillo P; Barillas-Arias L; Heras A; Muskardin TW; Lawrence MG; Mannem HC; Nolan BE; Canna S; Reinhardt A; Binstadt B; Goldbach-Mansky R
Editorial comment: BMJ-BRITISH MEDICAL JOURNAL. 2022;379:o2750
The challenges of doing paediatric research during the first year of the covid-19 pandemic
Buonsenso D; Roland D; Yock-Corrales A; Gonzalez-Dambrauskas S; Brodin P; Santiago-Garcia B; Soriano-Arandes A; Koenraads M; De Luca D; Whittaker E
Article: CELL REPORTS MEDICINE. 2022;3(11):100804
Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort
Sugrue JA; Posseme C; Tan Z; Pou C; Charbit B; Bondet V; Bourke NM; Brodin P; Duffy D; O'Farrelly C
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(11):e20220514
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Zhang Q; Pizzorno A; Miorin L; Bastard P; Gervais A; Le Voyer T; Bizien L; Manry J; Rosain J; Philippot Q; Goavec K; Padey B; Cupic A; Laurent E; Saker K; Vanker M; Saerekannu K; Garcia-Salum T; Ferres M; Le Corre N; Sanchez-Cespedes J; Balsera-Manzanero M; Carratala J; Retamar-Gentil P; Abelenda-Alonso G; Valiente A; Tiberghien P; Zins M; Debette S; Meyts I; Haerynck F; Castagnoli R; Notarangelo LD; Gonzalez-Granado LI; Dominguez-Pinilla N; Andreakos E; Triantafyllia V; Rodriguez-Gallego C; Sole-Violan J; Ruiz-Hernandez JJ; Rodriguez de Castro F; Ferreres J; Briones M; Wauters J; Vanderbeke L; Feys S; Kuo C-Y; Lei W-T; Ku C-L; Tal G; Etzioni A; Hanna S; Fournet T; Casalegno J-S; Queromes G; Argaud L; Javouhey E; Rosa-Calatrava M; Cordero E; Aydillo T; Medina RA; Kisand K; Puel A; Jouanguy E; Abel L; Cobat A; Trouillet-Assant S; Garcia-Sastre A; Casanova J-L
Article: NATURE COMMUNICATIONS. 2022;13(1):5895
The immune factors driving DNA methylation variation in human blood
Bergstedt J; Azzou SAK; Tsuo K; Jaquaniello A; Urrutia A; Rotival M; Lin DTS; MacIsaac JL; Kobor MS; Albert ML; Duffy D; Patin E; Quintana-Murci L
Article: MOLECULAR ONCOLOGY. 2022;16(19):3452-3464
Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity
Classon J; Zamboni M; Engblom C; Alkass K; Mantovani G; Pou C; Nkulikiyimfura D; Brodin P; Druid H; Mold J; Frisen J
Editorial comment: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(7):1354-1359
Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis
Bolze A; Mogensen TH; Zhang S-Y; Abel L; Andreakos E; Arkin LM; Borghesi A; Brodin P; Hagin D; Novelli G; Okada S; Peter J; Renia L; Severe K; Tiberghien P; Vinh DC; Cirulli ET; Casanova J-L; Hsieh EWY
Article: BMC PEDIATRICS. 2022;22(1):565
Transplantation of maternal intestinal flora to the newborn after elective cesarean section (SECFLOR): study protocol for a double blinded randomized controlled trial
Carpen N; Brodin P; de Vos WM; Salonen A; Kolho K-L; Andersson S; Helve O
Article: SCIENTIFIC REPORTS. 2022;12(1):14937
Selective transfer of maternal antibodies in preterm and fullterm children
Dolatshahi S; Butler AL; Pou C; Henckel E; Bernhardsson AK; Gustafsson A; Bohlin K; Shin SA; Lauffenburger DA; Brodin P; Alter G
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(8):e20220131
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Zhang Q; Matuozzo D; Le Pen J; Lee D; Moens L; Asano T; Bohlen J; Liu Z; Moncada-Velez M; Kendir-Demirkol Y; Jing H; Bizien L; Marchal A; Abolhassani H; Delafontaine S; Bucciol G; Bayhan GI; Keles S; Kiykim A; Hancerli S; Haerynck F; Florkin B; Hatipoglu N; Ozcelik T; Morelle G; Zatz M; Ng LFP; Lye DC; Young BE; Leo Y-S; Dalgard CL; Lifton RP; Renia L; Meyts I; Jouanguy E; Hammarstrom L; Pan-Hammarstrom Q; Boisson B; Bastard P; Su HC; Boisson-Dupuis S; Abel L; Rice CM; Zhang S-Y; Cobat A; Casanova J-L
Article: ALLERGY. 2022;77(8):2415-2430
Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures
Taeschler P; Cervia C; Zurbuchen Y; Hasler S; Pou C; Tan Z; Adamo S; Raeber ME; Bachli E; Rudiger A; Stussi-Helbling M; Huber LC; Brodin P; Nilsson J; Probst-Muller E; Boyman O
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(7):e20220202
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency
Campbell TM; Liu Z; Zhang Q; Moncada-Velez M; Covill LE; Zhang P; Darazam IA; Bastard P; Bizien L; Bucciol G; Enoksson SL; Jouanguy E; Karabela SN; Khan T; Kendir-Demirkol Y; Augusto Arias A; Mansouri D; Marits P; Marr N; Migeotte I; Moens L; Ozcelik T; Pellier I; Sendel A; Senoglu S; Shahrooei M; Smith CIE; Vandernoot I; Willekens K; Yasar KK; Bergman P; Abel L; Cobat A; Casanova J-L; Meyts I; Bryceson YT
Letter: LANCET GASTROENTEROLOGY & HEPATOLOGY. 2022;7(7):594-595
Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens
Brodin P; Arditi M
Article: CELL REPORTS. 2022;39(13):110989
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation
Posseme C; Llibre A; Charbit B; Bondet V; Rouilly V; Saint-Andre V; Boussier J; Bergstedt J; Smith N; Townsend L; Sugrue JA; Cheallaigh CN; Conlon N; Rotival M; Kobor MS; Mottez E; Pol S; Patin E; Albert ML; Quintana-Murci L; Duffy D
Journal article: FRONTIERS IN SYSTEMS BIOLOGY. 2022;2:918792
Data Availability of Open T-Cell Receptor Repertoire Data, a Systematic Assessment
Huang Y-N; Patel NA; Mehta JH; Ginjala S; Brodin P; Gray CM; Patel YM; Cowell LG; Burkhardt AM; Mangul S
Review: SCIENCE. 2022;376(6596):945-950
Immune-microbe interactions early in life: A determinant of health and disease long term
Brodin P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(21):e2200413119
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
Manry J; Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Michailidis E; Hoffmann H-H; Eto S; Garcia-Prat M; Bizien L; Parra-Martinez A; Yang R; Haljasmagi L; Migaud M; Sarekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt C-E; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garcon P; Riviere JG; Lagier J-C; Gentile S; Rosen LB; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux P-L; Sene D; Stepanian A; Megarbane B; Triantafyllia V; Fekkar A; Heath JR; Franco JL; Anaya J-M; Sole-Violan J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte OM; Zhang Y; Snow AL; Holland SM; Biggs CM; Moncada-Velez M; Arias AA; Lorenzo L; Boucherit S; Anglicheau D; Planas AM; Haerynck F; Duvlis S; Ozcelik T; Keles S; Bousfiha AA; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarstrom Q; Hammarstrom L; Dupont A; Kurolap A; Metz CN; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros LA; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye SG; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann NY; Shcherbina A; Lau Y-L; Leung D; Coulongeat M; Marlet J; Koning R; Reyes LF; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig MC; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer AH; Kennelly S; Bourkeh NM; Halwan R; Sharif-Askar FS; Dorgham K; Sallette J; Sedkaoui SM; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh DC; Erikstrup C; Condino-Neto A; Prando C; Bondarenko A; Spaan AN; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton RP; Mane S; Anderson MS; Boisson B; Beziat V; Zhang S-Y; Andreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; de Lamballerie X; Burdet C; Bouadma L; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen PK; Piemonti L; Rodriguez-Gallego C; D Notarangelo L; Su HC; Kisand K; Okada S; Puel A; Jouanguy E; Rice CM; Tiberghien P; Zhang Q; Casanova J-L; Abel L; Cobat A
Article: ALLERGY. 2022;77(5):1583-1595
Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle
Olin A; Acevedo N; Lakshmikanth T; Chen Y; Johansson C; Alm J; Scheynius A; Brodin P
Letter: NATURE MEDICINE. 2022;28(5):879-882
Studying severe long COVID to understand post-infectious disorders beyond COVID-19
Brodin P; Casari G; Townsend L; O'Farrelly C; Tancevski I; Loeffler-Ragg J; Mogensen TH; Casanova JL
Article: J ALLERGY CLIN IMMUNOL GLOB. 2022;1(2):37-42
Lung function before and after COVID-19 in young adults: A population-based study.
Mogensen I; Hallberg J; Björkander S; Du L; Zuo F; Hammarström L; Pan-Hammarström Q; Ekström S; Georgelis A; Palmberg L; Janson C; Bergström A; Melén E; Kull I; BAMSE COVID-19 Study Group
Preprint: BIORXIV. 2022
Data availability of open T-cell receptor repertoire data, a systematic assessment
Huang Y-N; Patel NA; Mehta JH; Ginjala S; Brodin P; Gray C; Patel Y; Cowell L; Burkhardt A; Mangul S
Article: GENES AND IMMUNITY. 2022;23(2):93-98
Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.
Sugrue JA; Smith M; Posseme C; Charbit B; Milieu Interieur Consortium; Bourke NM; Duffy D; O'Farrelly C
Article: JAMA NETWORK OPEN. 2022;5(4):e228109
Association of Short-term Air Pollution Exposure With SARS-CoV-2 Infection Among Young Adults in Sweden
Yu Z; Bellander T; Bergstrom A; Dillner J; Eneroth K; Engardt M; Georgelis A; Kull I; Ljungman P; Pershagen G; Stafoggia M; Melen E; Gruzieva O
Review: NATURE. 2022;603(7902):587-598
Human genetic and immunological determinants of critical COVID-19 pneumonia
Zhang Q; Bastard P; Cobat A; Casanova J-L
Preprint: BIORXIV. 2022
Graph deep learning reveals multiple signal pathways activated in anti-citrullinated protein antibodies stimulated synoviocytes
Sun M; Chen Y; Brodin P; Catrina A
Preprint: RESEARCH SQUARE. 2022
Three adult cases of STAT1-gain-of-function with chronic mucocutaneous candidiasis treated with JAK inhibitors
Borgström EW; Edvinsson M; Perez LP; Norlin A-C; Hansen S; Fasth A; Friman V; Kämpe O; Månsson R; Tan Z; Smith CIE; Brodin P; Bergman P
Article: GENOME MEDICINE. 2022;14(1):28
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.
Caron B; Patin E; Rotival M; Charbit B; Albert ML; Quintana-Murci L; Duffy D; Rausell A; Milieu Intérieur Consortium
Review: IMMUNITY. 2022;55(2):201-209
SARS-CoV-2 infections in children: Understanding diverse outcomes
Brodin P
Article: NATURE IMMUNOLOGY. 2022;23(2):159-164
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection
Andreakos E; Abel L; Vinh DC; Kaja E; Drolet BA; Zhang Q; O'Farrelly C; Novelli G; Rodriguez-Gallego C; Haerynck F; Prando C; Pujol A; Su HC; Casanova J-L; Spaan AN; Bastard P; Biggs CM; Bigio B; Boisson B; Bolze A; Bondarenko A; Brodin P; Chakravorty S; Christodoulou J; Cobat A; Condino-Neto A; Constantinescu SN; Feldman HB; Fellay J; Halwani R; Jouanguy E; Lau Y-L; Meyts I; Mogensen TH; Okada S; Okamoto K; Ozcelik T; Pan-Hammarstrom Q; Planas AM; Puel A; Quintana-Murci L; Renia L; Resnick I; Sediva A; Shcherbina A; Slaby O; Tancevski I; Turvey SE; Uddin KMF; van de Beek D; Zatz M; Zawadzki P; Zhang S-Y
Article: ACTA PAEDIATRICA. 2022;111(2):354-362
Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms
Kahn R; Berg S; Berntson L; Berthold E; Brodin P; Backstrom F; Compagno M; Fasth A; Framme JL; Horne A; Hattting J; Krol P; Kukka AJ; Mossberg M; Mansson B; Nordenhall C; Nordstrom SI; Nystrom FK; Palmblad K; Rasti R; Rudolph A; Rydenman K; Sundberg E; Save-Soderbergh E; Altman M
Corrigendum: NATURE IMMUNOLOGY. 2022;23(2):341
A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection (Oct, 10.1038/s41590-021-01030-z, 2021)
Andreakos E; Abel L; Vinh DC; Kaja E; Drolet BA; Zhang Q; O'Farrelly C; Novelli G; Rodriguez-Gallego C; Haerynck F; Prando C; Pujol A; Su HC; Casanova J-L; Spaan AN
Preprint: MEDRXIV. 2022
Autoantibodies in COVID-19 correlate with anti-viral humoral responses and distinct immune signatures
Taeschler P; Cervia C; Zurbuchen Y; Hasler S; Pou C; Tan Z; Adamo S; Raeber ME; Bächli E; Rudiger A; Stüssi-Helbling M; Huber LC; Brodin P; Nilsson J; Probst-Müller E; Boyman O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):65-75.e8
SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults
Bjorkander S; Du L; Zuo F; Ekstrom S; Wang Y; Wan H; Sherina N; Schoutens L; Andrell J; Andersson N; Georgelis A; Bergstrom A; Marcotte H; Kull I; Hammarstrom L; Melen E; Pan-Hammarstrom Q
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(12):2791-2796
From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic-Associated Pernio
Arkin LM; Moon JJ; Tran JM; Asgan S; O'Farrelly C; Casanova J-L; Cowen EW; Mays JW; Singh AM; Drolet BA
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2021;32(8):1833-1842
Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology
Cotugno N; Ruggiero A; Pascucci GR; Bonfante F; Petrara MR; Pighi C; Cifaldi L; Zangari P; Bernardi S; Cursi L; Santilli V; Manno EC; Amodio D; Linardos G; Piccioni L; Barbieri MA; Perrotta D; Campana A; Dona D; Giaquinto C; Concato C; Brodin P; Rossi P; De Rossi A; Palma P
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4348
X-linked recessive TLR7 deficiency in ∼1% of men under 60 years old with life-threatening COVID-19
Asano T; Boisson B; Onodi F; Matuozzo D; Moncada-Velez M; Renkilaraj MRLM; Zhang P; Meertens L; Bolze A; Materna M; Korniotis S; Gervais A; Talouarn E; Bigio B; Seeleuthner Y; Bilguvar K; Zhang Y; Neehus A-L; Ogishi M; Pelham SJ; Le Voyer T; Rosain J; Philippot Q; Soler-Palacin P; Colobran R; Martin-Nalda A; Riviere JG; Tandjaoui-Lambiotte Y; Chaibi K; Shahrooei M; Darazam IA; Olyaei NA; Mansouri D; Palabiyik F; Ozcelik T; Novelli G; Novelli A; Casari G; Aiuti A; Carrera P; Bondesan S; Barzaghi F; Rovere-Querini P; Tresoldi C; Franco JL; Rojas J; Reyes LF; Bustos IG; Arias AA; Morelle G; Kyheng C; Troya J; Planas-Serra L; Schluter A; Gut M; Pujol A; Allende LM; Rodriguez-Gallego C; Flores C; Cabrera-Marante O; Pleguezuelo DE; de Diego RP; Keles S; Aytekin G; Akcan OM; Bryceson YT; Bergman P; Brodin P; Smole D; Smith CIE; Norlin A-C; Campbell TM; Covill LE; Hammarstrom L; Pan-Hammarstrom Q; Abolhassani H; Mane S; Marr N; Ata M; Al Ali F; Khan T; Spaan AN; Dalgard CL; Bonfanti P; Biondi A; Tubiana S; Burdet C; Nussbaum R; Kahn-Kirby A; Snow AL; Bustamante J; Puel A; Boisson-Dupuis S; Zhang S-Y; Beziat V; Lifton RP; Bastard P; Notarangelo LD; Abel L; Su HC; Jouanguy E; Amara A; Soumelis V; Cobat A; Zhang Q; Casanova J-L
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4340
Autoantibodies neutralizing type I IFNs are present in ∼4% of uninfected individuals over 70 years old and account for ∼20% of COVID-19 deaths
Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Manry J; Michailidis E; Hoffmann H-H; Eto S; Garcia-Prat M; Bizien L; Parra-Martinez A; Yang R; Haljasmagi L; Migaud M; Sarekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt C-E; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garcon P; Riviere JG; Lagier J-C; Gentile S; Rosen LB; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux P-L; Sene D; Stepanian A; Megarbane B; Triantafyllia V; Fekkar A; Heath JR; Franco JL; Anaya J-M; Sole-Violan J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte OM; Zhang Y; Snow AL; Holland SM; Biggs CM; Moncada-Velez M; Arias AA; Lorenzo L; Boucherit S; Coulibaly B; Anglicheau D; Planas AM; Haerynck F; Duvlis S; Nussbaum RL; Ozcelik T; Keles S; Bousfiha AA; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarstrom Q; Hammarstrom L; Dupont A; Kurolap A; Metz CN; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros LA; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye SG; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann NY; Shcherbina A; Lau Y-L; Leung D; Coulongeat M; Marlet J; Koning R; Reyes LF; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig MC; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer AH; Kennelly SP; Bourke NM; Halwani R; Sharif-Askari NS; Dorgham K; Sallette J; Sedkaoui SM; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh DC; Ostrowski SR; Condino-Neto A; Prando C; Bondarenko A; Spaan AN; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton RP; Mane S; Anderson MS; Boisson B; Beziat V; Zhang S-Y; Andreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; de Lamballerie X; Duval X; Mentre F; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen PK; Piemonti L; Rodriguez-Gallego C; Notarangelo LD; Su HC; Kisand K; Okada S; Puel A; Jouanguy E; Rice CM; Tiberghien P; Zhang Q; Cobat A; Abel L; Casanova J-L
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2021;40(1):240
A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation
Maio M; Lahn M; Di Giacomo AM; Covre A; Calabro L; Ibrahim R; Fox B
Article: CELL. 2021;184(15):3884-3898.e11
Bifidobacteria-mediated immune system imprinting early in life
Henrick BM; Rodriguez L; Lakshmikanth T; Pou C; Henckel E; Arzoomand A; Olin A; Wang J; Mikes J; Tan Z; Chen Y; Ehrlich AM; Bernhardsson AK; Mugabo CH; Ambrosiani Y; Gustafsson A; Chew S; Brown HK; Prambs J; Bohlin K; Mitchell RD; Underwood MA; Smilowitz JT; German JB; Frese SA; Brodin P
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(1):96-98
Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis
Lemarquis A; Campbell T; Aranda-Guillen M; Hennings V; Brodin P; Kampe O; Blennow K; Zetterberg H; Wenneras C; Eriksson K; Landegren N; Bryceson Y; Berg S; Ekwall O
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2021;385(1):11-22
Treatment of Multisystem Inflammatory Syndrome in Children
McArdle AJ; Vito O; Patel H; Seaby EG; Shah P; Wilson C; Broderick C; Nijman R; Tremoulet AH; Munblit D; Ulloa-Gutierrez R; Carter MJ; De T; Hoggart C; Whittaker E; Herberg JA; Kaforou M; Cunnington AJ; Levin M
Review: JOURNAL OF EXPERIMENTAL MEDICINE. 2021;218(6):e20210446
SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
Sancho-Shimizu V; Brodin P; Cobat A; Biggs CM; Toubiana J; Lucas CL; Henrickson SE; Belot A; Tangye SG; Milner JD; Levin M; Abel L; Bogunovic D; Casanova J-L; Zhang S-Y
Editorial comment: NATURE METHODS. 2021;18(6):588-591
Diversity in immunogenomics: the value and the challenge
Peng K; Safonova Y; Shugay M; Popejoy AB; Rodriguez OL; Breden F; Brodin P; Burkhardt AM; Bustamante C; Cao-Lormeau V-M; Corcoran MM; Duffy D; Fuentes-Guajardo M; Fujita R; Greiff V; Jonsson VD; Liu X; Quintana-Murci L; Rossetti M; Xie J; Yaari G; Zhang W; Abedalthagafi MS; Adekoya KO; Ahmed RA; Chang W-C; Gray C; Nakamura Y; Lees WD; Khatri P; Alachkar H; Scheepers C; Watson CT; Karlsson Hedestam GB; Mangul S
Article: LAKARTIDNINGEN. 2021;118:21136
Viktigt att uppmärksamma MIS-A inom vuxensjukvården.
Brodin P
Article: PSYCHONEUROENDOCRINOLOGY. 2021;126:105162
Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease
Just D; Rasmusson AJ; Nilsson P; Noreland M; Malmstrom E; Brodin P; Manberg A; Cunningham JL
Article: CELL REPORTS. 2021;34(11):108852
Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies
Cotugno N; Ruggiero A; Bonfante F; Petrara MR; Zicari S; Pascucci GR; Zangari P; De Ioris MA; Santilli V; Manno EC; Amodio D; Bortolami A; Pagliari M; Concato C; Linardos G; Campana A; Dona D; Giaquinto C; Brodin P; Rossi P; De Rossi A; Palma P
Article: PEDIATRIC RESEARCH. 2021;89(3):604-612
Dramatic changes in blood protein levels during the first week of life in extremely preterm infants
Zhong W; Danielsson H; Tebani A; Karlsson MJ; Elfvin A; Hellgren G; Brusselaers N; Brodin P; Hellstrom A; Fagerberg L; Uhlen M
Article: IMMUNITY & AGEING. 2021;18(1):5
Aging and CMV discordance are associated with increased immune diversity between monozygotic twins
Yan Z; Maecker HT; Brodin P; Nygaard UC; Lyu SC; Davis MM; Nadeau KC; Andorf S
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:727300
High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids
Silva CS; Sundling C; Folkesson E; Froberg G; Nobrega C; Canto-Gomes J; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Kallenius G
Article: NATURE MEDICINE. 2021;27(1):28-33
Immune determinants of COVID-19 disease presentation and severity
Brodin P
Article: MED. 2020;1(1):14-20
Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.
Zhang Q; Bastard P; Bolze A; Jouanguy E; Zhang S-Y; COVID Human Genetic Effort; Cobat A; Notarangelo LD; Su HC; Abel L; Casanova J-L
Article: SCIENTIFIC REPORTS. 2020;10(1):20425
High CD45 expression of CD8+and CD4+T cells correlates with the size of HIV-1 reservoir in blood
Petkov S; Bekele Y; Lakshmikanth T; Hejdeman B; Zazzi M; Brodin P; Chiodi F
Article: CELL. 2020;183(4):968-981.e7
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Consiglio CR; Cotugno N; Sardh F; Pou C; Amodio D; Rodriguez L; Tan Z; Zicari S; Ruggiero A; Pascucci GR; Santilli V; Campbell T; Bryceson Y; Eriksson D; Wang J; Marchesi A; Lakshmikanth T; Campana A; Villani A; Rossi P; Landegren N; Palma P; Brodin P
Article: SCIENCE. 2020;370(6515):eabd4585
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Bastard P; Rosen LB; Zhang Q; Michailidis E; Hoffmann H-H; Zhang Y; Dorgham K; Philippot Q; Rosain J; Beziat V; Manry J; Shaw E; Haljasmagi L; Peterson P; Lorenzo L; Bizien L; Trouillet-Assant S; Dobbs K; de Jesus AA; Belot A; Kallaste A; Catherinot E; Tandjaoui-Lambiotte Y; Le Pen J; Kerner G; Bigio B; Seeleuthner Y; Yang R; Bolze A; Spaan AN; Delmonte OM; Abers MS; Aiuti A; Casari G; Lampasona V; Piemonti L; Ciceri F; Bilguvar K; Lifton RP; Vasse M; Smadja DM; Migaud M; Hadjadj J; Terrier B; Duffy D; Quintana-Murci L; van de Beek D; Roussel L; Vinh DC; Tangye SG; Haerynck F; Dalmau D; Martinez-Picado J; Brodin P; Nussenzweig MC; Boisson-Dupuis S; Rodriguez-Gallego C; Vogt G; Mogensen TH; Oler AJ; Gu J; Burbelo PD; Cohen JI; Biondi A; Bettini LR; D'Angio M; Bonfanti P; Rossignol P; Mayaux J; Rieux-Laucat F; Husebye ES; Fusco F; Ursini MV; Imberti L; Sottini A; Paghera S; Quiros-Roldan E; Rossi C; Castagnoli R; Montagna D; Licari A; Marseglia GL; Duval X; Ghosn J; Tsang JS; Goldbach-Mansky R; Kisand K; Lionakis MS; Puel A; Zhang S-Y; Holland SM; Gorochov G; Jouanguy E; Rice CM; Cobat A; Notarangelo LD; Abel L; Su HC; Casanova J-L
Article: SCIENCE. 2020;370(6515):eabd4570
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Zhang Q; Bastard P; Liu Z; Le Pen J; Moncada-Velez M; Chen J; Ogishi M; Sabli IKD; Hodeib S; Korol C; Rosain J; Bilguvar K; Ye J; Bolze A; Bigio B; Yang R; Arias AA; Zhou Q; Zhang Y; Onodi F; Korniotis S; Karpf L; Philippot Q; Chbihi M; Bonnet-Madin L; Dorgham K; Smith N; Schneider WM; Razooky BS; Hoffmann H-H; Michailidis E; Moens L; Han JE; Lorenzo L; Bizien L; Meade P; Neehus A-L; Ugurbil AC; Corneau A; Kerner G; Zhang P; Rapaport F; Seeleuthner Y; Manry J; Masson C; Schmitt Y; Schlueter A; Le Voyer T; Khan T; Li J; Fellay J; Roussel L; Shahrooei M; Alosaimi MF; Mansouri D; Al-Saud H; Al-Mulla F; Almourfi F; Al-Muhsen SZ; Alsohime F; Al Turki S; Hasanato R; van de Beek D; Biondi A; Bettini LR; D'Angio M; Bonfanti P; Imberti L; Sottini A; Paghera S; Quiros-Roldan E; Rossi C; Oler AJ; Tompkins MF; Alba C; Vandernoot I; Goffard J-C; Smits G; Migeotte I; Haerynck F; Soler-Palacin P; Martin-Nalda A; Colobran R; Morange P-E; Keles S; Colkesen F; Ozcelik T; Yasar KK; Senoglu S; Karabela SN; Rodriguez-Gallego C; Novelli G; Hraiech S; Tandjaoui-Lambiotte Y; Duval X; Laouenan C; Snow AL; Dalgard CL; Milner JD; Vinh DC; Mogensen TH; Marr N; Spaan AN; Boisson B; Boisson-Dupuis S; Bustamante J; Puel A; Ciancanelli MJ; Meyts I; Maniatis T; Soumelis V; Amara A; Nussenzweig M; Garcia-Sastre A; Krammer F; Pujol A; Duffy D; Lifton RP; Zhang S-Y; Gorochov G; Beziat V; Jouanguy E; Sancho-Shimizu V; Rice CM; Abel L; Notarangelo LD; Cobat A; Su HC; Casanova J-L
Editorial comment: JOURNAL OF CLINICAL IMMUNOLOGY. 2020;40(7):958-959
Unraveling the Immune Response in Severe COVID-19
Rodriguez L; Brodin P
Article: NATURE COMMUNICATIONS. 2020;11(1):4487
Integration of molecular profiles in a longitudinal wellness profiling cohort
Tebani A; Gummesson A; Zhong W; Koistinen IS; Lakshmikanth T; Olsson LM; Boulund F; Neiman M; Stenlund H; Hellstrom C; Karlsson MJ; Arif M; Dodig-Crnkovic T; Mardinoglu A; Lee S; Zhang C; Chen Y; Olin A; Mikes J; Danielsson H; von Feilitzen K; Jansson P-A; Angeras O; Huss M; Kjellqvist S; Odeberg J; Edfors F; Tremaroli V; Forsstrom B; Schwenk JM; Nilsson P; Moritz T; Backhed F; Engstrand L; Brodin P; Bergstrom G; Uhlen M; Fagerberg L
Article: CELL REPORTS MEDICINE. 2020;1(5):100078
Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19
Rodriguez L; Pekkarinen PT; Lakshmikanth T; Tan Z; Consiglio CR; Pou C; Chen Y; Mugabo CH; Nguyen NA; Nowlan K; Strandin T; Levanov L; Mikes J; Wang J; Kantele A; Hepojoki J; Vapalahti O; Heinonen S; Kekalainen E; Brodin P
Editorial comment: CURRENT OPINION IN IMMUNOLOGY. 2020;65:iv
Editorial overview: Evolutionary and systems immunology - methods to understand human immune system variation.
Brodin P; Quintana-Murci L
Review: CURRENT OPINION IN IMMUNOLOGY. 2020;65:28-31
Technologies for assessing vaccine responses in the very young
Brodin P
Preprint: BIORXIV. 2020
Single-cell classification using learned cell phenotypes
Chen Y; Lakshmikanth T; Mikes J; Brodin P
Article: CELL REPORTS. 2020;32(3):107923
Human Immune System Variation during 1 Year
Lakshmikanth T; Muhammad SA; Olin A; Chen Y; Mikes J; Fagerberg L; Gummesson A; Bergstrom G; Uhlen M; Brodin P
Editorial comment: CELL. 2020;181(6):1194-1199
A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection.
Casanova J-L; Su HC; COVID Human Genetic Effort
Editorial comment: ACTA PAEDIATRICA. 2020;109(6):1082-1083
Why is COVID-19 so mild in children?
Brodin P
Review: HUMAN GENETICS. 2020;139(6-7):795-799
New approaches to the study of immune responses in humans
Brodin P
Editorial comment: CELL. 2020;180(5):820-821
Stressful Beginnings with Long-Term Consequences
Consiglio CR; Brodin P
Article: GENOME MEDICINE. 2020;12(1):25
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
Merid SK; Novoloaca A; Sharp GC; Küpers LK; Kho AT; Roy R; Gao L; Annesi-Maesano I; Jain P; Plusquin M; Kogevinas M; Allard C; Vehmeijer FO; Kazmi N; Salas LA; Rezwan FI; Zhang H; Sebert S; Czamara D; Rifas-Shiman SL; Melton PE; Lawlor DA; Pershagen G; Breton CV; Huen K; Baiz N; Gagliardi L; Nawrot TS; Corpeleijn E; Perron P; Duijts L; Nohr EA; Bustamante M; Ewart SL; Karmaus W; Zhao S; Page CM; Herceg Z; Jarvelin M-R; Lahti J; Baccarelli AA; Anderson D; Kachroo P; Relton CL; Bergström A; Eskenazi B; Soomro MH; Vineis P; Snieder H; Bouchard L; Jaddoe VW; Sørensen TIA; Vrijheid M; Arshad SH; Holloway JW; Håberg SE; Magnus P; Dwyer T; Binder EB; DeMeo DL; Vonk JM; Newnham J; Tantisira KG; Kull I; Wiemels JL; Heude B; Sunyer J; Nystad W; Munthe-Kaas MC; Räikkönen K; Oken E; Huang R-C; Weiss ST; Antó JM; Bousquet J; Kumar A; Söderhäll C; Almqvist C; Cardenas A; Gruzieva O; Xu C-J; Reese SE; Kere J; Brodin P; Solomon O; Wielscher M; Holland N; Ghantous A; Hivert M-F; Felix JF; Koppelman GH; London SJ; Melén E
Article: SCIENCE. 2019;366(6472):eaax9198
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells
Uhlen M; Karlsson MJ; Zhong W; Tebani A; Pou C; Mikes J; Lakshmikanth T; Forsstrom B; Edfors F; Odeberg J; Mardinoglu A; Zhang C; von Feilitzen K; Mulder J; Sjostedt E; Hober A; Oksvold P; Zwahlen M; Ponten F; Lindskog C; Sivertsson A; Fagerberg L; Brodin P
Review: JAMA PEDIATRICS. 2019;173(11):1032-1040
Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety A Systematic Review and Meta-analysis
Achten NB; Klingenberg C; Benitz WE; Stocker M; Schlapbach LJ; Giannoni E; Bokelaar R; Driessen GJA; Brodin P; Uthaya S; van Rossum AMC; Plotz FB
Article: PLOS BIOLOGY. 2019;17(10):e3000383
Cell generation dynamics underlying naive T-cell homeostasis in adult humans
Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J
Editorial comment: ACTA PAEDIATRICA. 2019;108(7):1357-1358
Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants
Lundgren P; Klevebro S; Brodin P; Smith LEH; Hallberg B; Hellstrom A
Editorial comment: NATURE MEDICINE. 2019;25(7):1026
Seeking the ultimate challenge
Brodin P
Article: ELIFE. 2019;8:e43578
Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
Landegren N; Rosen LB; Freyhult E; Eriksson D; Fall T; Smith G; Ferre EMN; Brodin P; Sharon D; Snyder M; Lionakis M; Anderson M; Kampe O
Letter: IMMUNITY. 2019;50(6):1335-1336
A Call for Blood-In Human Immunology
Brodin P; Duffy D; Quintana-Murci L
Article: JCI INSIGHT. 2019;4(9):126492
B cell profiling in malaria reveals expansion and remodeling of CD11c⁺ B cell subsets
Sundling C; Ronnberg C; Yman V; Asghar M; Jahnmatz P; Lakshmikanth T; Chen Y; Mikes J; Forsell MN; Sonden K; Achour A; Brodin P; Persson KEM; Farnert A
Article: NATURE MEDICINE. 2019;25(4):591-596
The repertoire of maternal anti-viral antibodies in human newborns
Pou C; Nkulikiyimfura D; Henckel E; Olin A; Lakshmikanth T; Mikes J; Wang J; Chen Y; Bernhardsson AK; Gustafsson A; Bohlin K; Brodin P
Review: FEBS JOURNAL. 2019;286(8):1514-1522
The biology of the cell - insights from mass cytometry
Brodin P
Article: JCI INSIGHT. 2019;4(3):e125442
Mass cytometry identifies distinct CD4⁺ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation
Bekele Y; Lakshmikanth T; Chen Y; Mikes J; Nasi A; Petkov S; Hejdeman B; Brodin P; Chiodi F
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2019;19(2):87-88
Systems-level patterns emerge
Brodin P
Article: EBIOMEDICINE. 2019;40:517-527
B cell alterations during BAFF inhibition with belimumab in SLE
Ramskold D; Parodis I; Lakshmikanth T; Sippl N; Khademi M; Chen Y; Zickert A; Mikes J; Achour A; Amara K; Piehl F; Brodin P; Gunnarsson I; Malmstrom V
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1989:111-123
Automated Cell Processing for Mass Cytometry Experiments.
Mikes J; Olin A; Lakshmikanth T; Chen Y; Brodin P
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1913:33-48
Systems-Level Immune Monitoring by Mass Cytometry.
Lakshmikanth T; Brodin P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(1):e12732
Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis
Tang Q; Ramskold D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Lakshmikanth T; Chen Y; Mikes J; Alexanderson H; Achour A; Brodin P; Vencovsky J; Lundberg IE; Malmstrom V
Article: CELL. 2018;174(5):1277-1292.e14
Stereotypic Immune System Development in Newborn Children
Olin A; Henckel E; Chen Y; Lakshmikanth T; Pou C; Mikes J; Gustafsson A; Bernhardsson AK; Zhang C; Bohlin K; Brodin P
Article: CLINICAL IMMUNOLOGY. 2018;193:70-79
Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains
Ju C-H; Blum LK; Kongpachith S; Lingampalli N; Mao R; Brodin P; Dekker CL; Davis MM; Robinson WH
Review: ANNUAL REVIEW OF IMMUNOLOGY. 2018;36:843-864
Rebooting Human Immunology
Davis MM; Brodin P
Article: CELL METABOLISM. 2018;27(2):378-392.e5
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2018;5:81
Continuous Immune Cell Differentiation Inferred From Single-Cell Measurements Following Allogeneic Stem Cell Transplantation
Chen Y; Lakshmikanth T; Olin A; Mikes J; Remberger M; Brodin P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(3):135-142
The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education
Ganesan S; Luu TT; Chambers BJ; Meinke S; Brodin P; Vivier E; Wetzel DM; Koleske AJ; Kadri N; Hoglund P
Article: CELL REPORTS. 2017;20(9):2238-2250
Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation
Lakshmikanth T; Olin A; Chen Y; Mikes J; Fredlund E; Remberger M; Omazic B; Brodin P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6097-E6106
Continuous immunotypes describe human immune variation and predict diverse responses
Kaczorowski KJ; Shekhar K; Nkulikiyimfura D; Dekker CL; Maecker H; Davis MM; Chakraborty AK; Brodin P
Article: NATURE COMMUNICATIONS. 2017;8:15627
Expression of CD226 is associated to but not required for NK cell education
Wagner AK; Kadri N; Snall J; Brodin P; Gilfillan S; Colonna M; Bernhardt GN; Hoglund P; Karre K; Chambers BJ
Editorial comment: CELL HOST & MICROBE. 2017;21(3):309-310
Life-Saving Degeneracy in the Human Immune System
Brodin P
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1130
Mass Cytometry Identifies Distinct Lung CD4⁺ T Cell Patterns in Lofgren's Syndrome and Non-Lofgren's Syndrome Sarcoidosis
Kaiser Y; Lakshmikanth T; Chen Y; Mikes J; Eklund A; Brodin P; Achour A; Grunewald J
Review: NATURE REVIEWS IMMUNOLOGY. 2017;17(1):21-29
Human immune system variation
Brodin P; Davis MM
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:717
Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease
Stikvoort A; Chen Y; Radestad E; Torlen J; Lakshmikanth T; Bjorklund A; Mikes J; Achour A; Gertow J; Sundberg B; Remberger M; Sundin M; Mattsson J; Brodin P; Uhlin M
Review: TRENDS IN IMMUNOLOGY. 2016;37(3):233-243
Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV
Roelle A; Brodin P
Editorial comment: IMMUNITY. 2015;43(6):1035-1037
Powerful Populations Respond to Viruses and Vaccines
Brodin P
Article: HAEMATOLOGICA. 2015;100(11):1477-1485
Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy
Nakasone H; Remberger M; Tian L; Brodin P; Sahaf B; Wu F; Mattsson J; Lowsky R; Negrin R; Miklos DB; Meyer E
Article: CELL. 2015;160(1-2):37-47
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Brodin P; Jojic V; Gao T; Bhattacharya S; Angel CJL; Furman D; Shen-Orr S; Dekker CL; Swan GE; Butte AJ; Maecker HT; Davis MM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(1):202-207
Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE)
Shekhar K; Brodin P; Davis MM; Chakraborty AK
Article: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2013;9(4):307-317
Systems level immune response analysis and personalized medicine
Brodin P; Valentini D; Uhlin M; Mattsson J; Zumla A; Maeurer MJ
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65
Natural killer cell inhibitory receptor expression in humans and mice: a closer look
Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Karre K; Malmberg K-J; Hoglund P; Mehr R
Article: INTERNATIONAL JOURNAL OF HEMATOLOGY. 2012;96(6):798-800
Major surgery in a neutropenic patient undergoing allogeneic stem cell transplantation for high risk myelofibrosis
Brodin P; Gilg S; Lundell L; Mattsson J
Article: ONCOGENESIS. 2012;1(3):e3
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
Article: JOURNAL OF IMMUNOLOGY. 2012;188(5):2218-2226
Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets
Brodin P; Lakshmikanth T; Karre K; Hoglund P
Thesis / dissertation: 2011
MHC class I molecules in natural killer cell education and tolerance
Brodin, Petter
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529
MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2
Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Stahle M; Sonkoly E; Pivarcsi A
Article: PLOS ONE. 2010;5(10):e13174
Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice
Brodin P; Lakshmikanth T; Mehr R; Johansson MH; Duru AD; Achour A; Salmon-Divon M; Karre K; Hoglund P; Johansson S
Review: NATURE REVIEWS IMMUNOLOGY. 2010;10(10):724-734
Current perspectives of natural killer cell education by MHC class I molecules
Hoeglund P; Brodin P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(4):1553-1558
MYCN-regulated microRNAs repress estrogen receptor-α (ESR1) expression and neuronal differentiation in human neuroblastoma
Loven J; Zinin N; Wahlstrom T; Muller I; Brodin P; Fredlund E; Ribacke U; Pivarcsi A; Pahlman S; Henriksson M
Article: JOURNAL OF NEUROSCIENCE. 2009;29(43):13503-13515
Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction
Thams S; Brodin P; Plantman S; Saxelin R; Karre K; Cullheim S
Article: PLOS ONE. 2009;4(6):e6046
Probing Natural Killer Cell Education by Ly49 Receptor Expression Analysis and Computational Modelling in Single MHC Class I Mice
Johansson S; Salmon-Divon M; Johansson MH; Pickman Y; Brodin P; Karre K; Mehr R; Hoglund P
Review: TRENDS IN IMMUNOLOGY. 2009;30(4):143-149
NK cell education: not an on-off switch but a tunable rheostat
Brodin P; Karre K; Hoglund P
Article: IMMUNITY. 2009;30(3):337-347
A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHIC Class I for Natural Killer Cell Education
Chalifour A; Scarpellino L; Back J; Brodin P; Devevre E; Gros F; Levy F; Leclercq G; Hoglund P; Beermann F; Held W
Article: BLOOD. 2009;113(11):2434-2441
The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells
Brodin P; Lakshmikanth T; Johansson S; Karre K; Hoglund P
Article: JOURNAL OF IMMUNOLOGY. 2009;182(3):1460-1468
Distinct and Overlapping Patterns of Cytokine Regulation of Thymic and Bone Marrow-Derived NK Cell Development
Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Hoglund P; Jacobsen SEW; Sitnicka E
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2008;38(11):2934-2937
Beyond licensing and disarming: A quantitative view on NK-cell education
Brodin P; Hoglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):1-11
IFN-γ production and degranulation are differentially regulated in response to stimulation in murine natural killer cells
Vahlne G; Becker S; Brodin P; Johansson MH
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):30-36
Critical role of Qa1^b in the protection of mature dendritic cells from NK cell-mediated killing
Persson CM; Assarsson E; Vahlne G; Brodin P; Chambers BJ
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Pediatric Systems Immunology – Petter Brodin's research group

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