Pediatric Systems Immunology – Petter Brodin's research group

Human immune variation "The influences of heritable and non-heritable factors shaping human immune systems have been quantified in an analysis of healthy twins" Newborn Immune Systems "Immune systems are shaped by environmental influences early in life" Precision Immunology "We work to implement systems immunology analyses for better diagnosis and patient stratification and to guide therapeutic decision making"

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Human Systems Immunology

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Petter Brodin

Professor/Specialist Physician
+46852481396

Systems immunology analyses for understanding human immune system variation

Introduction - Major research focus

Our group is working to understand human immune system variation between individuals and within individuals over time. We are interested in the factors that determine this variation and in particularly their influence early in life as they imprint on the developing immune system and shape its composition and function for with long-term consequences. We are also interested in understanding how these phenomena relate to the risk of severe infections, malignancies and immune mediated diseases.

To understand systems-level behaviors in the human immune system, we develop and apply novel experimental and data analysis tools that allow for comprehensive analyses of blood samples using mass cytometry, cell sorting and sequencing-based approaches. By simultaneously analyzing all blood cell populations from different individuals over time, their frequencies and functional states, and combining such analyzes with plasma protein measurements, we are aiming for systems-level characterization of this system in order to understand its regulation.

By combining the immune system analyses with microbiome analyses, biometrics and individual exposure data, we are hoping to understand how various influences shape immunity in humans.

More information on our external website: http://www.brodinlab.com/

Team members

Petter Brodin, Physician and researcher
Anna-Karin Bernhardsson, Specialist nurse
Dieudonné Nkulikiyimfura, Doctoral student
Axel Olin, Doctoral student
Christian Pou, Postdoc
Sayyed Auwn Muhammad, Postdoc
Jaromir Mikes, PhD, Senior scientist
Jun Wang, PhD Chemical physics, Lab engineer
Lakshmikanth Tadepally, PhD Immunology, Research coordinator
Yang Chen, PhD Information science, Senior data scientist

Links

Dramatic development of immune system after birth
Protective antibodies also found in premature babies
Keywords:
Adaptive Immunity Allergy and Immunology Anti-Inflammatory Agents Autoimmunity and Inflammation Immune System Show all
Content reviewer:
Petter Brodin
19-02-2025