Neuroradiology: neurodegeneration and neuroinflammation – Tobias Granberg's research group

Neurological disorders often cause changes in the brain and spinal cord that can be visualized and quantified using different imaging modalities.

Imaging of Neurodegenerative and Neuroinflammatory disorders

Our translational research group focuses on developing and applying new neuroimaging techniques clinically to benefit the diagnosis and follow-up of neurodegenerative and neuroinflammatory disorders. Our main research areas include dementia disorders, movement disorders, multiple sclerosis (MS) and rare neurological diseases.

The research team consists of a wide range of radiological and psychological expertise in close collaboration with neurologists, physicists and engineers at Karolinska as well as internationally. We create, validate and perform visual radiological ratings for morphometric analysis, complemented by volumetric segmentations. We work mainly with FreeSurfer, FSL, SPM and SyMRI but also create in-house analytic tools. A majority of our research projects is based on MRI (structural, functional, diffusion and synthetic) but we also work with CT and nuclear medicine modalities.

Cortical MS pathology is visualized
Cortical MS pathology visualized with MRI: Neurite density (upper left), Free diffusion (upper right), Microstructure (bottom left), unit-less color sale 0-0.6. Myelin-sensitive MRI (bottom right), normalized unit-less color sale 0-1.55.

Research Projects

  • Karolinska Imaging Dementia Study (KIDS): A large retrospective cohort study evaluating imaging biomarkers in patients with cognitive impairment.
  • Karolinska Imaging in Movement Disorders Study (KIMOVE): A combined retro- and prospective longitudinal cohort study of Parkinson’s disease and atypical Parkinsonism with both conventional and advanced MRI techniques.
  • Stockholm prospective assessment of MS (STOPMS): A large prospective study of new-onset MS-patients started in 2001 using volumetric MRI to study the value of imaging biomarkers in MS.
  • Synthetic MRI: Validation studies and practical neuroapplications of SyMRI including myelin quantification using REMyDI (Rapid Estimation of Myelin for Diagnostic Imaging).
  • Other projects include the study of: Gadolinium retention in brain structures, Radiolologically Isolated Syndrome (RIS), spinal atrophy, Quantitative Susceptibility Mapping (QSM).

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Selected publications

Staff and contact

Group leader

All members of the group

Team leader

A team leader operates as an additional leadership support to our research group leader and conducts its own research.
Research focus: Multiple sclerosis imaging (and ex vivo correlation studies)

Team members (Russell Ouellette's team)