Research Group Johan Ärnlöv

My research group has two major lines of research. We investigate different aspects of the detrimental interplay between the kidney and the cardiovascular system. We currently focus on the importance of the gut and urinary microbiome for the development of kidney disease and cardiovascular disease. As a separate project we also investigate the importance of chronic pain for the development of cardiovascular disease.

Research Project

The microbiome in the gut-kidney-cardiovascular axis

Chronic kidney disease and cardiovascular disease cause enormous suffering for patients and high costs for society.  It has been suggested that the microbiome (bacteria and other microbes) in the gut and urine play an important role for the development of these diseases but community-based data are scarce. The overall aim of this proposal is to investigate the role of gut and urinary microbiome in the development of kidney and cardiovascular disease in a large community based cohort (SCAPIS) with detailed data on kidney and cardiovascular phenotypes.

SCAPIS is the largest study to date with gut microbiome data analysed with state-of-the-art whole genome shotgun metagenomics (n=10,000). In addition, with this proposal I will carry out the first-ever urinary microbiome-wide association study in the community. Moreover, I will create a unique multi-omics database with microbiomics, metabolomics and proteomics analyses in faeces, blood and urine and adress our research questions with novel state-of-the-art advanced machine learning methods. Moreover,  will apply Mendelian Randomization analyses in order to establish causal associations that may help guide future experimental and intervention studies. 

If successful, the present research proposal may open up new horizons for research that in the end may lead to improved diagnosis, prognostication and treatments for patients with kidney or cardiovascular disease in clinical practice.

Collaborations

We are involved in several international research consortia such as

We also collaborate with a large number of individual Swedish and international researchers.  

Research Funding

  • Swedish Research Council
  • Swedish Heart Lung foundation

Publications

Selected publications

  • Article: THE LANCET. 2020;395(10225):709-733
    Bikbov B; Purcell C; Levey AS; Smith M; Abdoli A; Abebe M; Adebayo OM; Afarideh M; Agarwal SK; Agudelo-Botero M; Ahmadian E; Al-Aly Z; Alipour V; Almasi-Hashiani A; Al-Raddadi RM; Alvis-Guzman N; Amini S; Andrei T; Andrei CL; Andualem Z; Anjomshoa M; Arabloo J; Ashagre AF; Asmelash D; Ataro Z; Atout MMW; Ayanore MA; Badawi A; Bakhtiari A; Ballew SH; Balouchi A; Banach M; Barquera S; Basu S; Bayih MT; Bedi N; Bello AK; Bensenor IM; Bijani A; Boloor A; Borzi AM; Camera LA; Carrero JJ; Carvalho F; Castro F; Catala-Lopez F; Chang AR; Chin KL; Chung S-C; Cirillo M; Cousin E; Dandona L; Dandona R; Daryani A; Das Gupta R; Demeke FM; Demoz GT; Desta DM; Huyen PD; Duncan BB; Eftekhari A; Esteghamati A; Fatima SS; Fernandes JC; Fernandes E; Fischer F; Freita M; Gad MM; Gebremeskel GG; Gebresillassie BM; Geta B; Ghafourifard M; Ghajar A; Ghith N; Gill PS; Ginawi IA; Gupta R; Hafezi-Nejad N; Haj-Mirzaian A; Haj-Mirzaian A; Hariyani N; Hasan M; Hasankhani M; Hasanzadeh A; Hassen HY; Hay SI; Heidari B; Herteliu C; Chi LH; Hosseini M; Hostiuc M; Irvani SSN; Islam SMS; Balalami NJ; James SL; Jassal SK; Jha V; Jonas JB; Joukar F; Jozwiak JJ; Kabir A; Kahsay A; Kasaeian A; Kassa TD; Kassaye HG; Khader YS; Khalilov R; Khan EA; Khan MS; Khang Y-H; Kisa A; Kovesdy CP; Defo BK; Kumar GA; Larsson AO; Lim L-L; Lopez AD; Lotufo PA; Majeed A; Malekzadeh R; Marz W; Masaka A; Meheretu HAA; Miazgowski T; Mirica A; Mirrakhimov EM; Mithra P; Moazen B; Mohammad DK; Mohammadpourhodki R; Mohammed S; Mokdad AH; Morales L; Velasquez IM; Mousavi SM; Mukhopadhyay S; Nachega JB; Nadkarni GN; Nansseu JR; Natarajan G; Nazari J; Neal B; Negoi RI; Cuong TN; Nikbakhsh R; Noubiap JJ; Nowak C; Olagunju AT; Ortiz A; Owolabi MO; Palladino R; Pathak M; Perico N; Poustchi H; Prakash S; Prasad N; Rafiei A; Raju SB; Ramezanzadeh K; Rawaf S; Rawaf DL; Rawal L; Reiner RCJ; Rezapour A; Ribeiro DC; Roever L; Rothenbacher D; Rwegerera GM; Saadatagah S; Safari S; Sahle BW; Salem H; Sanabria J; Santos IS; Sarveazad A; Sawhney M; Schaeffner E; Schmidt MI; Schutte AE; Sepanlou SG; Shaikh MA; Sharafi Z; Sharif M; Sharifi A; Santos Silva DA; Singh JA; Singh NP; Sisay MMM; Soheili A; Sutradhar I; Teklehaimanot BF; Tesfay BE; Teshome GF; Thakur JS; Tonelli M; Khanh BT; Tran BX; Candide TN; Ullah I; Valdez PR; Varughese S; Linh GV; Waheed Y; Werdecker A; Wolde HF; Wondmieneh AB; Hanson SW; Yamada T; Yeshaw Y; Yonemoto N; Yusefzadeh H; Zaidi Z; Zaki L; Bin Zaman S; Zamora N; Zarghi A; Zewdie KA; Arnlov J; Coresh J; Remuzzi G; Murray CJL; Vos T
  • Article: NATURE COMMUNICATIONS. 2018;9(1):3957
    Nowake C; Arnlov J
  • Article: EUROPEAN JOURNAL OF HEART FAILURE. 2018;20(1):55-62
    Stenemo M; Nowak C; Byberg L; Sundstrom J; Giedraitis V; Lind L; Ingelsson E; Fall T; Arnlov J
  • Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2016;68(9):934-945
    van der Laan SW; Fall T; Soumare A; Teumer A; Sedaghat S; Baumert J; Zabaneh D; van Setten J; Isgum I; Galesloot TE; Arpegard J; Amouyel P; Trompet S; Waldenberger M; Doerr M; Magnusson PK; Giedraitis V; Larsson A; Morris AP; Felix JF; Morrison AC; Franceschini N; Bis JC; Kavousi M; O'Donnell C; Drenos F; Tragante V; Munroe PB; Malik R; Dichgans M; Worrall BB; Erdmann J; Nelson CP; Samani NJ; Schunkert H; Marchini J; Patel RS; Hingorani AD; Lind L; Pedersen NL; de Graaf J; Kiemeney LALM; Baumeister SE; Franco OH; Hofman A; Uitterlinden AG; Koenig W; Meisinger C; Peters A; Thorand B; Jukema JW; Eriksen BO; Toft I; Wilsgaard T; Onland-Moret NC; van der Schouw YT; Debette S; Kumari M; Svensson P; van der Harst P; Kivimaki M; Keating BJ; Sattar N; Dehghan A; Reiner AP; Ingelsson E; den Ruijter HM; de Bakker PIW; Pasterkamp G; Arnlov J; Holmes MV; Asselbergs FW
  • Article: THE LANCET DIABETES AND ENDOCRINOLOGY. 2015;3(7):514-525
    Matsushita K; Coresh J; Sang Y; Chalmers J; Fox C; Guallar E; Jafar T; Jassal SK; Landman GWD; Muntner P; Roderick P; Sairenchi T; Schoettker B; Shankar A; Shlipak M; Tonelli M; Townend J; van Zuilen A; Yamagishi K; Yamashita K; Gansevoort R; Sarnak M; Warnock DG; Woodward M; Arnlov J
  • Article: NEW ENGLAND JOURNAL OF MEDICINE. 2013;369(10):932-943
    Shlipak MG; Matsushita K; Arnlov J; Inker LA; Katz R; Polkinghorne KR; Rothenbacher D; Sarnak MJ; Astor BC; Coresh J; Levey AS; Gansevoort RT
  • Article: JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (JAMA). 2011;306(10):1113-1121
    Jobs E; Ingelsson E; Riserus U; Nerpin E; Jobs M; Sundstrom J; Basu S; Larsson A; Lind L; Arnlov J
  • Article: CIRCULATION. 2010;121(2):230-236
    Arnlov J; Ingelsson E; Sundstrom J; Lind L
  • Article: NEW ENGLAND JOURNAL OF MEDICINE. 2008;358(20):2107-2116
    Zethelius B; Berglund L; Sundstrom J; Ingelsson E; Basu S; Larsson A; Venge P; Arnlov J
  • Article: CIRCULATION. 2005;112(7):969-975
    Ärnlöv J; Evans JC; Meigs JB; Wang TJ; Fox CS; Levy D; Benjamin EJ; D'Agostino RB; Vasan RS