Coronary heart disease – Research group Per Svensson

Our research projects aim to answer clinically relevant research questions in patients with coronary heart disease as well as to advance the understanding of its risk factors throughout the life-course. Our long-term goal is to improve treatment, prevention and health equity in coronary heart disease.

Our research

Research covers different aspects of coronary heart disease and include (1) the assessment of the risk-benefit relationship between bleeding and ischemia in patients with myocardial infarction, (2) studies on the effects of family history and social determinants of health from preclinical to recurrent cardiovascular disease, (3) the effects of incretin treatments on coronary healing and restenosis after PCI, (4) the value of beta-blockers after myocardial infarction with preserved ejection fraction,  (5) diagnostic algorithms in the emergency room for patients with chest-pain and/or hypertension, (6) diagnostic assessments and prognosis of patients with myocardial infarction with normal coronary arteries (MINOCA).  The studies are both observational and interventional.



The nationwide cluster-randomized trial HELP-SWEDEHEART is evaluating whether Helicobacter Pylori screening can prevent upper gastrointestinal bleeding in patients with acute myocardial infarction. Robin Hofmann is the coordinating investigator and is leading this project together with a SWEDEHEART steering group. Other aspects of Helicobacter Pylori are studied in the related projects HELP-FIA3, HELP-TAMI3, HELP-KKT and HELP-SCAPIS.

Phd Students: Jonatan Wärme and Martin Sundqvist

Family history, socioeconomics and cardiovascular disease

The effects of family history and social determinants of health from preclinical to recurrent cardiovascular disease are studied in the population-based SCAPIS and TwinGene-studies, national quality registers and health data together with linked national registers. The project aims to advance the understanding on how family history and socioeconomics interact and cause cardiovascular disease and identify targets for treatment to reduce health inequity. 

Phd Students: Agnes Wahrenberg and Sebastian Herlitz 

Diabetes and coronary heart disease

The effect of diabetes, glycemic control and treatment with incretins on restenosis after coronary stenting is studied in both interventional and observational studies. 

Phd Student: Irene Santos Pardo

Betablockers and myocardial infarction

Different aspects of beta-blocker therapy after myocardial infarction with preserved ejection fraction are studied in observational and interventional studies such asthe REDUCE -study. 

Phd Student: Katarina Mars

Diagnostic algorithms in the emergency department

Diagnostic algorithms and risk factors for patients with suspected acute coronary syndrome in the emergency department (ED) are studied in observational studies based on regional health data and national quality registers. We participate in FAST-CCTA, a randomized study that evaluates a diagnostic strategy with early coronary computed tomography angiography (CCTA) in patients with chest pain and intermediate risk. We also study prognosis and algorithms for patients with elevated blood pressure in the ED.

Phd Students Ruslan Alam and Pontus Oras

Myocardial infarction with non obstructive coronary arteries

The diagnostic performance of early invasive coronary angiogram (ICA) and coronary computed tomography (CCTA) is studied in patients with myocardial infarction with non obstructive coronary arteries (MINOCA).

Phd Student Oscar Winnberg


Collaborators include other departments at Karolinska Institutet, Uppsala University, Umeå University.

Research support

The Swedish Research Council

Swedish Heart and Lung Foundation

The Swedish Heart and Lung Association


Selected publications

Staff and contact

Group leader

All members of the group

Biomarkers Cardiac and Cardiovascular Systems Heart Disease Risk Factors Helicobacter pylori Incretins Myocardial Infarction Socioeconomic Disparities in Health Show all
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