Our research
Our lab integrates a range of approaches across virology, computational methods, structural biology, and biochemistry to study pathogens and the immune responses they elicit. We systematically use small specific inhibitors, such as camelid nanobodies and computationally designed proteins, to target pathogens and extract new mechanistic insights that are otherwise challenging to obtain at scale.
Through rational protein engineering along with chemical and enzymatic modification strategies, we functionalize our proteins for a growing list of biomedical applications, which can enhance detection, permit tracing, or facilitate immune recruitment. Our efforts aim to deepen the fundamental understanding of infection, ultimately guiding the rational design of effective vaccine antigens and targeted therapies.