PublicationsAll publications from group members Preprint: MEDRXIV. 2025 Lysophosphatidylcholines are elevated after selective serotonin reuptake inhibitor exposure during neural differentiation and correlate with early neurodevelopmental symptoms Arora A; Vacy K; Marques C; Degeratu M-O; Mastropasqua F; Humphrey J; Ye X; Oksanen M; Vuillermin P; Ponsonby A-L; Lanekoff I; Tammimies K Article: CELL. 2025;188(10):2586-2602.e24 Cell membranes sustain phospholipid imbalance via cholesterol asymmetry. Doktorova M; Symons JL; Zhang X; Wang H-Y; Schlegel J; Lorent JH; Heberle FA; Sezgin E; Lyman E; Levental KR; Levental I Journal article: CHEM. 2025;11(3):102399 A roadmap toward the synthesis of life Kriebisch CME; Bantysh O; Pellejero LB; Belluati A; Bertosin E; Dai K; de Roy M; Fu H; Galvanetto N; Gibbs JM; Gomez SS; Granatelli G; Griffo A; Guix M; Gurdap CO; Harth-Kitzerow J; Haugerud IS; Haefner G; Jaiswal P; Javed S; Karimi A; Kato S; Kriebisch BAK; Laha S; Lee P-W; Lipinski WP; Matreux T; Michaels TCT; Poppleton E; Ruf A; Slootbeek AD; Smokers IBA; Soria-Carrera H; Sorrenti A; Stasi M; Stevenson A; Thatte A; Tran M; van Haren MHI; Vuijk HD; Wickham SFJ; Zambrano P; Adamala KP; Alim K; Andersen ES; Bonfio C; Braun D; Frey E; Gerland U; Huck WTS; Juelicher F; Laohakunakorn N; Mahadavan L; Otto S; Saenz J; Schwille P; Goepfrich K; Weber CA; Boekhoven J Review: NATURE PROTOCOLS. 2025;:1-29 Measuring plasma membrane fluidity using confocal microscopy Carravilla P; Andronico L; Schlegel J; Urem YB; Sjule E; Ragaller F; Weber F; Gurdap CO; Ascioglu Y; Sych T; Lorent J; Sezgin E Preprint: BIORXIV. 2025 Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation Oksanen M; Mastropasqua F; Mazan-Mamczarz K; Martindale JL; Ye X; Arora A; Banskota N; Gorospe M; Tammimies K Article: NANO LETTERS. 2025;25(6):2173-2180 Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy Sych T; Gorgens A; Steiner L; Gucluler G; Huge Y; Alamdari F; Johansson M; Aljabery F; Sherif A; Gabrielsson S; El Andaloussi S; Sezgin E Journal article: NATURE COMMUNICATIONS. 2025;16(1):1857 WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses O'May JB; Vanes L; de Boer LL; Lewis DA; Hartweger H; Kunzelmann S; Hayward D; Llorian M; Kochl R; Tybulewicz VLJ Journal article: PLOS ONE. 2025;20(5):e0323368 Effects of sonication on particle dispersions from a size, biodissolution, cytotoxicity and transferred dose perspective - a case study on nickel and nickel oxide particles Blomberg E; Wang X; Herting G; Khort A; Arora A; Buxton S; Lyons-Darden T; Karlsson HL; Odnevall I Preprint: BIORXIV. 2024;BIORXIV Cell membranes sustain phospholipid imbalance via cholesterol asymmetry. Doktorova M; Symons JL; Zhang X; Wang H-Y; Schlegel J; Lorent JH; Heberle FA; Sezgin E; Lyman E; Levental KR; Levental I Article: MEMBRANES. 2024;14(12):261 "Head-to-Toe" Lipid Properties Govern the Binding and Cargo Transfer of High-Density Lipoprotein Weber F; Axmann M; Sezgin E; Amaro M; Sych T; Hochreiner A; Hof M; Schuetz GJ; Stangl H; Plochberger B Journal article: JOURNAL OF BIOMOLECULAR NMR. 2024;78(4):249-264 Optimising in-cell NMR acquisition for nucleic acids Annecke HTP; Eidelpes R; Feyrer H; Ilgen J; Guerdap CO; Dasgupta R; Petzold K Article: TRANSLATIONAL PSYCHIATRY. 2024;14(1):477 Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane Oasa S; Sezgin E; Ma Y; Horne DA; Radmilovic MD; Jovanovic-Talisman T; Martin-Fardon R; Vukojevic V; Terenius L Preprint: BIORXIV. 2024 Revised diffusion law permits quantitative nanoscale characterization of membrane organization Svobodová B; Šťastný D; Blom H; Mikhalyov I; Gretskaya N; Balleková A; Sezgin E; Hof M; Šachl R Article: NATURE BIOMEDICAL ENGINEERING. 2024;8(11):1453-1468 Antibody-displaying extracellular vesicles for targeted cancer therapy Wiklander OPB; Mamand DR; Mohammad DK; Zheng W; Jawad Wiklander R; Sych T; Zickler AM; Liang X; Sharma H; Lavado A; Bost J; Roudi S; Corso G; Lennaard AJ; Abedi-Valugerdi M; Maeger I; Alici E; Sezgin E; Nordin JZ; Gupta D; Goergens A; EL Andaloussi S Article: JOURNAL OF CELL SCIENCE. 2024;137(20):jcs262166 VISION - an open-source software for automated multi-dimensional image analysis of cellular biophysics Weber F; Iskrak S; Ragaller F; Schlegel J; Plochberger B; Sezgin E; Andronico LA Article: MOLECULAR THERAPY. 2024;32(9):3012-3024 Discovery of a novel inhibitor of macropinocytosis with antiviral activity Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Haggblad M; Ilmain J; Wright SC; Murga M; Schlegel J; Jarvius M; Lapins M; Sezgin E; Bhabha G; Lauschke VM; Carreras-Puigvert J; Lafarga M; Klingstrom J; Huhn D; Fernandez-Capetillo O Journal article: TOXICOLOGY LETTERS. 2024;399:s86-s87 Low cytotoxicity of environmentally relevant microplastics in lung cells and a co-culture Montes AM; Tagaras N; Arora A; Vallabani NVS; Karlsson HL Journal article: TOXICOLOGY LETTERS. 2024;399:s329-s330 Towards an understanding of the relative toxicity of nanoparticles from different transport sources Karlsson HL; Vallabani NVS; Arora A; Montes AM; Kuhn J; Olofsson U; Elihn K Article: BIOPHYSICAL JOURNAL. 2024;123(16):2484-2495 Quantification of membrane fluidity in bacteria using TIR-FCS Barbotin A; Billaudeau C; Sezgin E; Carballido-Lopez R Article: NATURE METHODS. 2024;21(7):1171-1174 Effects and avoidance of photoconversion-induced artifacts in confocal and STED microscopy Dasgupta A; Koerfer A; Kokot B; Urbancic I; Eggeling C; Carravilla P Preprint: BIORXIV. 2024 Imaging single particle profiler to study nanoscale bioparticles using conventional confocal microscopy Sych T; Görgens A; Steiner L; Gucluer G; Huge Y; Alamdari F; Johansson M; Aljabery F; Sherif A; Gabrielsson S; EL Andaloussi S; Sezgin E Preprint: BIORXIV. 2024 Structural diversity of Arc oligomers within the excitatory synapse Damenti M; Coceano G; Silva MM; Alvelid J; Sgattoni C; Volpato A; Rems L; Masullo LA; Unterauer EM; Kowalewski R; Delemotte L; Sezgin E; Jungmann R; Testa I Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590 High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fuerth D; Stevens MM; Sezgin E Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402 Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis Sommerauer C; Gallardo-Dodd CJ; Savva C; Hases L; Birgersson M; Indukuri R; Shen JX; Carravilla P; Geng K; Sondergaard JN; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-Andre M; Petersson C; Hagstrom H; Lauschke VM; Archer A; Williams C; Kutter C Preprint: BIORXIV. 2024 VISION — an open-source software for automated multi-dimensional image analysis of cellular biophysics Weber F; Iskrak S; Ragaller F; Schlegel J; Plochberger B; Sezgin E; Andronico LA Article: BIOPHYSICAL JOURNAL. 2024;123(6):745-755 Neural network informed photon filtering reduces fluorescence correlation spectroscopy artifacts. Seltmann A; Carravilla P; Reglinski K; Eggeling C; Waithe D Article: JOURNAL OF PHYSICAL CHEMISTRY B. 2024;128(9):2154-2167 Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements Ragaller F; Sjule E; Urem YB; Schlegel J; El R; Urbancic D; Urbancic I; Blom H; Sezgin E Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2024;300(2):105649 A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors Menon I; Sych T; Son Y; Morizumi T; Lee J; Ernst OP; Khelashvili G; Sezgin E; Levitz J; Menon AK Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):21a-22a The biophysical landscape of reconstituted immune synapses Ragaller F; Sych T; Andronico L; Achour A; Sezgin E Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):512a Lipid abundance asymmetry: An unexplored dimension of plasma membrane organization Doktorova M; Symons JL; Schegel J; Sezgin E; Wang H; Lyman ER; Levental KR; Levental I Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):449a-450a High-throughput and multi-parametric biophysical cell phenotyping with smart probes Gurdap C; Andronico L; Cowgill J; Sezgin E Preprint: BIORXIV. 2024 High-throughput analysis of membrane fluidity unveils a hidden dimension in immune cell states Andronico L; Jiang Y; Carannante V; Iskrak S; Sandoz P; Mikes J; Klymchenko A; Buggert M; Österborg A; Önfelt B; Brodin P; Sezgin E Article: NATURE COMMUNICATIONS. 2024;15(1):541 Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis Drexhage LZ; Zhang S; Dupont M; Ragaller F; Sjule E; Cabezas-Caballero J; Deimel LP; Robertson H; Russell RA; Dushek O; Sezgin E; Karaji N; Sattentau QJ Preprint: BIORXIV. 2024;BIORXIV A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. Menon I; Sych T; Son Y; Morizumi T; Lee J; Ernst OP; Khelashvili G; Sezgin E; Levitz J; Menon AK Corrigendum: PLOS ONE. 2024;19(12):e0315559 Urine metabolomic profiles of autism and autistic traits-A twin study (vol 19, e0308224, 2024) Arora A; Mastropasqua F; Bolte S; Tammimies K Article: PLOS ONE. 2024;19(9):e0308224 Urine metabolomic profiles of autism and autistic traits-A twin study Arora A; Mastropasqua F; Bolte S; Tammimies K Article: ACS APPLIED BIO MATERIALS. 2023;6(12):5746-5758 Protein-Decorated Microbubbles for Ultrasound-Mediated Cell Surface Manipulation Brans VA; Gray MD; Sezgin E; Stride EPJ Journal article: NATURE COMMUNICATIONS. 2023;14(1):7844 T cell migration requires ion and water influx to regulate actin polymerization de Boer LL; Vanes L; Melgrati S; O'May JB; Hayward D; Driscoll PC; Day J; Griffiths A; Magueta R; Morrell A; MacRae JI; Kochl R; Tybulewicz VLJ Preprint: BIORXIV. 2023 Discovery of a novel inhibitor of macropinocytosis with antiviral activity Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Häggblad M; Ilmain J; Wright S; Murga M; Shlegel J; Sezgin E; Bhabha G; Lauschke V; Lafarga M; Klingström J; Huhn D; Fernandez-Capetillo O Preprint: BIORXIV. 2023 Quantifying fluorescence lifetime responsiveness of environment sensitive probes for membrane fluidity measurements Ragaller F; Sjule E; Urem YB; Schlegel J; El R; Urbancic D; Urbancic I; Blom H; Sezgin E Journal article: BIOCONJUGATE CHEMISTRY. 2023;34(10):1923 Correction to Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells Sternstein C; Bohm T-M; Fink J; Meyr J; Ludemann M; Krug M; Kriukov K; Sezgin E; Ebert R; Seibel J Preprint: BIORXIV. 2023 Quantification of membrane fluidity in bacteria using TIR-FCS Barbotin A; Billaudeau C; Sezgin E; Carballido-López R Article: BIOLOGY OPEN. 2023;12(10):bio060113 Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis Mastropasqua F; Oksanen M; Soldini C; Alatar S; Arora A; Ballarino R; Molinari M; Agostini F; Poulet A; Watts M; Rabkina I; Becker M; Li D; Anderlid B-M; Isaksson J; Remnelius KL; Moslem M; Jacob Y; Falk A; Crosetto N; Bienko M; Santini E; Borgkvist A; Bo''lte S; Tammimies K Preprint: BIORXIV. 2023 Estrogen receptor activation remodelsTEAD1gene expression to alleviate nonalcoholic fatty liver disease Sommerauer C; Gallardo-Dodd C; Savva C; Hases L; Birgersson M; Indukuri R; Shen J; Carravilla P; Geng K; Nørskov Søndergaard J; Ferrer-Aumatell C; Mercier G; Sezgin E; Korach-André M; Petersson C; Hagström H; Lauschke V; Archer A; Williams C; Kutter C Preprint: BIORXIV. 2023 Neural Network Informed Photon Filtering Reduces Artifacts in Fluorescence Correlation Spectroscopy Data Seltmann A; Carravilla P; Reglinski K; Eggeling C; Waithe D Doctoral thesis: 2023 Genetic vulnerability, environmental exposures and neurodevelopmental disorders : clinical insights and in-vitro consequences Arora A Preprint: BIORXIV. 2023 Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis Drexhage LZ; Zhang S; DuPont M; Ragaller F; Sjule E; Caballero JC; Deimel L; Robertson H; Russell RA; Dushek O; Sezgin E; Karaji N; Sattentau QJ Article: NEUROPHARMACOLOGY. 2023;234:109562 Characterizing the metabolomic signature of attention-deficit hyperactivity disorder in twins Swann JR; Heijtz RD; Mayneris-Perxachs J; Arora A; Isaksson J; Bolte S; Tammimies K Corrigendum: COMMUNICATIONS BIOLOGY. 2023;6(1):831 Author Correction: Deep learning enables fast, gentle STED microscopy. Ebrahimi V; Stephan T; Kim J; Carravilla P; Eggeling C; Jakobs S; Han KY Preprint: RES SQ. 2023;RES SQ Naltrexone blocks alcohol-induced effects on kappa-opioid receptors in the plasma membrane. Terenius L; Oasa S; Sezgin E; Ma Y; Horne D; Radmiković M; Jovanović-Talisman T; Martin-Fardon R; Vukojevic V Article: BIOCONJUGATE CHEMISTRY. 2023;34(7):1221-1233 Development of an Effective Functional Lipid Anchor for Membranes (FLAME) for the Bioorthogonal Modification of the Lipid Bilayer of Mesenchymal Stromal Cells Sternstein C; Boehm T-M; Fink J; Meyr J; Luedemann M; Krug M; Kriukov K; Gurdap CO; Sezgin E; Ebert R; Seibel J Article: SCIENTIFIC REPORTS. 2023;13(1):10519 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics Arora A; Becker M; Marques C; Oksanen M; Li D; Mastropasqua F; Watts ME; Arora M; Falk A; Daub CO; Lanekoff I; Tammimies K Article: COMMUNICATIONS BIOLOGY. 2023;6(1):674 Deep learning enables fast, gentle STED microscopy. Ebrahimi V; Stephan T; Kim J; Carravilla P; Eggeling C; Jakobs S; Han KY Editorial comment: BIOPHYSICAL JOURNAL. 2023;122(11):E1-E4 Membranes in focus Sezgin E; Levental I Preprint: BIORXIV. 2023 Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response Deimel LP; Xue X; Khan A; Moynie L; Buchanan CJ; Sun G; McBride R; Schuster H; Gauthier C; Saliba R; Leonavicus K; Minall L; Bort G; Russell RA; Sezgin E; Paulson JC; Anthony DC; Baldwin AJ; Naismith J; Schiffner T; Davis BG; Sattentau QJ Other: NATURE CHEMICAL BIOLOGY. 2023;19(6):669-670 Do lipids tune B cell signaling? Urbancic I; Eggeling C; Sezgin E Article: NANO LETTERS. 2023;23(9):3701-3707 A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens Schlegel J; Porebski B; Andronico L; Hanke L; Edwards S; Brismar H; Murrell B; McInerney GM; Fernandez-Capetillo O; Sezgin E Preprint: MEDRXIV. 2023 Urine metabolomic profiles of autism and autistic traits – a twin study Arora A; Mastropasqua F; Bölte S; Tammimies K Corrigendum: NATURE METABOLISM. 2023;5(4):711 PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing (vol 5, pg 495, 2023) Cikes D; Elsayad K; Sezgin E; Koitai E; Torma F; Orthofer M; Yarwood R; Heinz LX; Sedlyarov V; Miranda ND; Taylor A; Grapentine S; Al-Murshedi F; Abot A; Weidinger A; Kutchukian C; Sanchez C; Cronin SJF; Novatchkova M; Kavirayani A; Schuetz T; Haubner B; Haas L; Hagelkruys A; Jackowski S; Kozlov AV; Jacquemond V; Knauf C; Superti-Furga G; Rullman E; Gustafsson T; McDermot J; Lowe M; Radak Z; Chamberlain JS; Bakovic M; Banka S; Penninger JM Editorial comment: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2023;24(4):237 Voices of the new generation: normalizing career choices outside academia Sezgin E Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(3):e20211827 B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice Hayward DA; Vanes L; Wissmann S; Sivapatham S; Hartweger H; O'May JB; de Boer LL; Mitter R; Kochl R; Stein JV; Tybulewicz VLJ Article: NATURE METABOLISM. 2023;5(3):495-515 PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing Cikes D; Elsayad K; Sezgin E; Koitai E; Torma F; Orthofer M; Yarwood R; Heinz LX; Sedlyarov V; Miranda ND; Taylor A; Grapentine S; al-Murshedi F; Abot A; Weidinger A; Kutchukian C; Sanchez C; Cronin SJF; Novatchkova M; Kavirayani A; Schuetz T; Haubner B; Haas L; Hagelkruys A; Jackowski S; Kozlov AV; Jacquemond V; Knauf C; Superti-Furga G; Rullman E; Gustafsson T; Mcdermot J; Lowe M; Radak Z; Chamberlain JS; Bakovic M; Banka S; Penninger JM Conference publication: BIOPHYSICAL JOURNAL. 2023;122(3):222A HDL-membrane-interactions are highly influenced by the target membrane-lipid composition Weber F; Stangl H; Synch T; Plochberger B; Sezgin E Conference publication: BIOPHYSICAL JOURNAL. 2023;122(3):224A Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties Ragaller F; Andronico L; Sykora J; Kulig W; Rog T; Urem YB; Abhinav A; Danylchuk DI; Hof M; Klymchenko AS; Amaro M; Vattulainen I; Sezgin E Conference publication: BIOPHYSICAL JOURNAL. 2023;122(3):362A Measuring the fluidity of the membrane of Bacillus subtilis using TIR-FCS Barbotin AGL; Lablaine A; Billaudeau C; Sezgin E; Carballido-Lopez R Preprint: BIORXIV. 2023;BIORXIV Deep learning enables fast, gentle STED microscopy. Ebrahimi V; Stephan T; Kim J; Carravilla P; Eggeling C; Jakobs S; Han KY Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S83 High-throughput biophysical mapping for diagnostic Gurdap C; Andronico L; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S158 A guideline for quantitative characterization and application of environment-sensitive probes Urem YB; Sjule E; Ragaller F; Schlegel J; Andronico L; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S165 HDL-MEMBRANE-INTERACTIONS ARE HIGHLY INFLUENCED BY THE TARGET MEMBRANE-LIPID COMPOSITION Weber F; Stangl H; Synch T; Plochberger B; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S64 Single particle profiler for measuring content and properties of nano-sized bioparticles Sych T; Schlegel J; Barriga H; Ojansivu M; Hanke L; Weber F; Bostancioglu B; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Furth D; Stevens M; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S123 Interpretation of STED-FCS diffusion law plots for nanoscopically heterogeneous membranes Chmelova B; Koukalova A; Hof M; Sezgin E; Sachl R; Blom H Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S156 High-throughput and correlative membrane biophysical mapping of health and disease Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S169 Cell biophysical properties unlock a new dimension in defining functional state of cells in health and diseases. Andronico L; Jang Y; Iskrak S; Ragaller F; Sandoz P; Buggert M; Brodin P; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S164 Correlative spectral STED nanoscopy and STED-FCS elucidate the origin of anomalous diffusion in cellular membranes Urbancic I; Schneider F; Galiani S; Sezgin E; Eggeling C Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S151 Investigating contact formation and biophysical properties at the reconstituted immune synapse Ragaller F; Andronico L; Achour A; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S122 Revealing the mechanism of the lipid storage disorder Niemann-Pick C by combining multi-omics and biophysical imaging Carravilla P; Ceplaite U; Sommerauer C; Veiga RG; Sezgin E; Kutter C Article: NATURE COMMUNICATIONS. 2022;13(1):7868 Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease Leng H; Zhang H; Li L; Zhang S; Wang Y; Chavda SJ; Galas-Filipowicz D; Lou H; Ersek A; Morris EV; Sezgin E; Lee Y-H; Li Y; Lechuga-Vieco AV; Tian M; Mi J-Q; Yong K; Zhong Q; Edwards CM; Simon AK; Horwood NJ Journal article: JOURNAL OF PSYCHOPHARMACOLOGY. 2022;36(11):1280-1293 Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice Akinola LS; Bagdas D; Alkhlaif Y; Jackson A; Gurdap CO; Rahimpour E; Carroll FI; Papke RL; Damaj MI Article: BIOPHYSICAL JOURNAL. 2022;121(20):3826-3836 Influence of the extracellular domain size on the dynamic behavior of membrane proteins Gurdap CO; Wedemann L; Sych T; Sezgin E Preprint: BIORXIV. 2022 A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens Schlegel J; Porebski B; Andronico L; Hanke L; Edwards S; Brismar H; Murrell B; McInerney G; Fernandez-Capetillo O; Sezgin E Preprint: BIORXIV. 2022 Deficiency of the Heterogeneous Nuclear Ribonucleoprotein U locus leads to delayed hindbrain neurogenesis Mastropasqua F; Oksanen M; Soldini C; Alatar S; Arora A; Ballarino R; Molinari M; Agostini F; Poulet A; Watts M; Rabkina I; Becker M; Li D; Anderlid B-M; Isaksson J; Remnelius KL; Moslem M; Jacob Y; Falk A; Crosetto N; Bienko M; Santini E; Borgkvist A; Bölte S; Tammimies K Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(18):10767 Functional Delineation of a Protein-Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8 Insausti S; Garcia-Porras M; Torralba J; Morillo I; Ramos-Caballero A; de la Arada I; Apellaniz B; Caaveiro JMM; Carravilla P; Eggeling C; Rujas E; Nieva JL Article: OPEN BIOLOGY. 2022;12(9):220175 Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties Ragaller F; Andronico L; Sykora J; Kulig W; Rog T; Urem YB; Abhinav; Danylchuk DII; Hof M; Klymchenko A; Amaro M; Vattulainen I; Sezgin E Preprint: BIORXIV. 2022 Single particle profiler for measuring content and properties of nano-sized bioparticles Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; Andaloussi SE; Fürth D; Stevens MM; Sezgin E Preprint: BIORXIV. 2022 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics Arora A; Becker M; Marques C; Oksanen M; Li D; Mastropasqua F; Watts ME; Arora M; Falk A; Daub CO; Lanekoff I; Tammimies K Article: NATURE COMMUNICATIONS. 2022;13(1):3460 T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles Cespedes PF; Jainarayanan A; Fernandez-Messina L; Valvo S; Saliba DG; Kurz E; Kvalvaag A; Chen L; Ganskow C; Colin-York H; Fritzsche M; Peng Y; Dong T; Johnson E; Siller-Farfan JA; Dushek O; Sezgin E; Peacock B; Law A; Aubert D; Engledow S; Attar M; Hester S; Fischer R; Sanchez-Madrid F; Dustin ML Article: BIOPHYSICAL REPORTS. 2022;2(2):None-100055 Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 Galiani S; Reglinski K; Carravilla P; Barbotin A; Urbancic I; Ott J; Sehr J; Sezgin E; Schneider F; Waithe D; Hublitz P; Schliebs W; Erdmann R; Eggeling C Corrigendum: BIOPHYSICAL REPORTS. 2022;2(2):100057 Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes (vol 1, 100023, 2021) Carravilla P; Dasgupta A; Zhurgenbayeva G; Danylchuk DI; Klymchenko AS; Sezgin E; Eggeling C Preprint: BIORXIV. 2022 Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties Ragaller F; Andronico L; Sykora J; Kulig W; Rog T; Urem YB; Amaro M; Abhinav; Danylchuk DI; Klymchenko A; Hof M; Vattulainen I; Sezgin E Review: ANNUAL REVIEW OF BIOPHYSICS. 2022;51:135-156 Lipid-Protein Interactions in Plasma Membrane Organization and Function Sych T; Levental KR; Sezgin E Review: BIOCHEMICAL SOCIETY TRANSACTIONS. 2022;50(2):853-866 Understanding immune signaling using advanced imaging techniques Brameshuber M; Klotzsch E; Ponjavic A; Sezgin E Editorial comment: JOURNAL OF CELL SCIENCE. 2022;135(7):jcs259977 Uniting diversity to create a more inclusive academic environment Delemotte L; Garcia SL; Rodriguez-Gijon A; Sezgin E; Vihervaara A Article: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2022;1864(4):183857 Giant plasma membrane vesicles to study plasma membrane structure and dynamics Sezgin E Journal article: JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA. 2022;151(4):a154 Exploration of ultrasound-mediated microbubble-cell membrane interactions using novel protein-loaded microbubbles and their role in immunomodulation Brans VA; Gray M; Sezgin E; Stride EP Preprint: BIORXIV. 2022 T cell migration requires ion and water influx to regulate actin polymerization de Boer L; Vanes L; Melgrati S; O’May JB; Hayward D; Driscoll P; Day J; Griffiths A; Magueta R; Morrell A; MacRae J; Köchl R; Tybulewicz V Preprint: BIORXIV. 2022 WNK1-dependent water influx is required for CD4+T cell activation and T cell-dependent antibody responses O’May JB; Vanes L; de Boer L; Hartweger H; Kunzelmann S; Hayward D; Llorian M; Lewis D; Köchl R; Tybulewicz V Preprint: BIORXIV. 2022 Critical role of PCYT2 in muscle health and aging Cikes D; Elsayad K; Sezgin E; Koitai E; Ferenc T; Orthofer M; Yarwood R; Heinz L; Sedlyarov V; Miranda ND; Taylor A; Grapentine S; al-Murshedi F; Abott A; Weidinger A; Kutchukian C; Sanchez C; Cronin SJF; Novatchkova M; Kavirayani A; Schuetz T; Haubner B; Haas L; Hagelkruys A; Jackowski S; Kozlov A; Jacquemond V; Knauf C; Superti-Furga G; Rullman E; Gustafsson T; McDermot J; Lowe M; Radak Z; Chamberlain J; Bakovic M; Banka S; Penninger J Conference publication: 2022;:5 From fluctuations to function: FFS to explore bio-molecular organisation Schneider F; Cespedes PF; Sezgin E; Fritzsche M; Fraser SE Article: AUTISM RESEARCH. 2022;15(3):434-446 Rare variants in the outcome of social skills group training for autism Li D; Choque Olsson N; Becker M; Arora A; Jiao H; Norgren N; Jonsson U; Bolte S; Tammimies K Preprint: BIORXIV. 2022 Purely enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR Feyrer H; Gurdap CO; Marušič M; Schlagnitweit J; Petzold K Conference publication: BIOPHYSICAL JOURNAL. 2022;121(3):302A Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 Reglinski K; Galiani S; Carravilla P; Barbotin A; Urbancic I; Sezgin E; Schneider F; Waithe D; Schliebs W; Erdmann R; Eggeling C Conference publication: BIOPHYSICAL JOURNAL. 2022;121(3):466A-467A SFCS provides a window to bio-molecular organization Schneider F; Cespedes PF; Fraser SE; Sezgin E; Fritzsche M Conference publication: BIOPHYSICAL JOURNAL. 2022;121(3):34 Long-term superresolution imaging and quantification of live-cell plasma membrane biophysical properties with smart exchangeable dyes Carravilla P; Dasgupta A; Zhurgenbayeva G; Danylchuk DI; Klymchenko AS; Sezgin E; Eggeling C Article: NATURE COMMUNICATIONS. 2022;13(1):155 A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM Article: PLOS ONE. 2022;17(7):e0264662 Enzymatic incorporation of an isotope-labeled adenine into RNA for the study of conformational dynamics by NMR Feyrer H; Gurdap CO; Marusic M; Schlagnitweit J; Petzold K Conference publication: FEBS OPEN BIO. 2022;12:205 Investigation of the functional role of neurotrophin receptor-associated death domain in neuronal development and microglia-glioblastoma interaction using the zebrafish model Ozalp O; Cark O; Azbazdar Y; Haykir B; Cucun G; Sezgin E; Morisse G; Mazzolini J; Sieger D; Ozhan G Book chapter: FLUORESCENCE SPECTROSCOPY AND MICROSCOPY IN BIOLOGY: SPRINGER SERIES ON FLUORESCENCE. 2022;p. 323-336 Diffusion Measurements at the Nanoscale with STED-FCS Schneider F; Sezgin E Article: BIOPHYSICAL REPORTS. 2021;1(2):None-100023 Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes Carravilla P; Dasgupta A; Zhurgenbayeva G; Danylchuk DI; Klymchenko AS; Sezgin E; Eggeling C Article: SCIENCE ADVANCES. 2021;7(49):eabj9247 FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency Rota IA; Handel AE; Maio S; Klein F; Dhalla F; Deadman ME; Cheuk S; Newman JA; Michaels YS; Zuklys S; Prevot N; Hublitz P; Charles PD; Gkazi AS; Adamopoulou E; Qasim W; Davies EG; Hanson I; Pagnamenta AT; Camps C; Dreau HM; White A; James K; Fischer R; Gileadi O; Taylor JC; Fulga T; Lagerholm BC; Anderson G; Sezgin E; Hollaender GA Preprint: BIORXIV. 2021 Influence of the extracellular domain size on the dynamic behavior of membrane proteins Gurdap CO; Wedemann L; Sych T; Sezgin E Article: CELL REPORTS. 2021;37(5):109911 Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis Matias MI; Yong CS; Foroushani A; Goldsmith C; Mongellaz C; Sezgin E; Levental KR; Talebi A; Perrault J; Riviere A; Dehairs J; Delos O; Bertand-Michel J; Portais J-C; Wong M; Marie JC; Kelekar A; Kinet S; Zimmermann VS; Levental I; Yvan-Charvet L; Swinnen JV; Muljo SA; Hernandez-Vargas H; Tardito S; Taylor N; Dardalhon V Article: ISCIENCE. 2021;24(9):102987 Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile Rujas E; Leaman DP; Insausti S; Carravilla P; Garcia-Porras M; Largo E; Morillo I; Sanchez-Eugenia R; Zhang L; Cui H; Iloro I; Elortza F; Julien J-P; Eggeling C; Zwick MB; Caaveiro JMM; Nieva JL Preprint: BIORXIV. 2021 B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses Hayward D; Vanes L; Wissmann S; Sivapatham S; Hartweger H; O’May JB; Boer LD; Mitter R; Köchl R; Stein J; Tybulewicz V Preprint: RESEARCH SQUARE. 2021 Improving bone health via modulation of glycosphingolipid metabolism and autophagy Leng H; Zhang H; Li L; Zhang S; Wang Y; Chavda S; Galas-Filipowicz D; Ersek A; Morris E; Sezgin E; Lee Y-H; Li Y; Mi J-Q; Yong K; Zhong Q; Edwards C; Simon AK; Horwood N Article: FEBS LETTERS. 2021;595(16):2127-2146 Aggregation and mobility of membrane proteins interplay with local lipid order in the plasma membrane of T cells Urbancic I; Schiffelers L; Jenkins E; Gong W; Santos AM; Schneider F; O'Brien-Ball C; Vuong MT; Ashman N; Sezgin E; Eggeling C Preprint: BIORXIV. 2021 STED super-resolution imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes Carravilla P; Dasgupta A; Zhurgenbayeva G; Danylchuk D; Klymchenko A; Sezgin E; Eggeling C Article: COMMUNICATIONS BIOLOGY. 2021;4(1):681 The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function Oftedal BE; Maio S; Handel AE; White MPJ; Howie D; Davis S; Prevot N; Rota IA; Deadman ME; Kessler BM; Fischer R; Trede NS; Sezgin E; Maizels RM; Hollander GA Preprint: BIORXIV. 2021 Synthetic antigen-presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses Céspedes PF; Jainarayanan A; Fernández-Messina L; Saliba DG; Valvo S; Kvalvaag A; Chen L; Kurz E; Ganskow C; Colin-York H; Fritzsche M; Peng Y; Dong T; Johnson E; Siller-Farfán JA; Dushek O; Sezgin E; Peacock B; Law A; Aubert D; Engledow S; Attar M; Hester S; Fischer R; Sánchez-Madrid F; Dustin ML Preprint: BIORXIV. 2021 Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 Galiani S; Reglinski K; Carravilla P; Barbotin A; Urbančič I; Ott J; Sehr J; Sezgin E; Schneider F; Waithe D; Hublitz P; Schliebs W; Erdmann R; Eggeling C Preprint: MEDRXIV. 2021 Rare variants in the outcome of social skills group training for autism Li D; Olsson NC; Becker M; Arora A; Jiao H; Norgren N; Jonsson U; Bölte S; Tammimies K Review: MEMBRANES. 2021;11(5):323 How Does Liquid-Liquid Phase Separation in Model Membranes Reflect Cell Membrane Heterogeneity? Sych T; Gurdap CO; Wedemann L; Sezgin E Preprint: BIORXIV. 2021 A FOXN1 mutation competitively displaces wild-type FOXN1 from higher-order nuclear condensates to cause immunodeficiency Rota IA; Handel AE; Klein F; Maio S; Dhalla F; Deadman ME; Cheuk S; Newman JA; Michaels YS; Zuklys S; Prevot N; Hublitz P; Charles PD; Gkazi AS; Adamopoulou E; Qasim W; Davies EG; Hanson C; Pagnamenta AT; Camps C; Dreau HM; White A; James K; Fischer R; Gileadi O; Taylor JC; Fulga T; Lagerholm BC; Anderson G; Sezgin E; Holländer GA Preprint: BIORXIV. 2021 A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo Hanke L; Das H; Sheward D; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith N; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen G; Coquet J; Hällberg M; Murrell B; McInerney G Preprint: BIORXIV. 2021 The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease Leng H; Zhang H; Li L; Zhang S; Wang Y; Ersek A; Morris E; Sezgin E; Lee Y-H; Li Y; Mi J; Zhong Q; Edwards C; Simon AK; Horwood NJ Review: FEBS JOURNAL. 2021;288(4):1070-1090 Model membrane systems to reconstitute immune cell signaling Cespedes PF; Beckers D; Dustin ML; Sezgin E Article: BIOELECTROCHEMISTRY. 2021;137:107641 Single-molecule conformational dynamics of viroporin ion channels regulated by lipid-protein interactions. Largo E; Queralt-Martín M; Carravilla P; Nieva JL; Alcaraz A Article: ISCIENCE. 2021;24(1):101891 Influence of nanobody binding on fluorescence emission, mobility, and organization of GFP-tagged proteins Schneider F; Sych T; Eggeling C; Sezgin E Article: BIOMOLECULES. 2021;11(1):100 Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis Ozalp O; Cark O; Azbazdar Y; Haykir B; Cucun G; Kucukaylak I; Alkan-Yesilyurt G; Sezgin E; Ozhan G Article: JOURNAL OF CONTROLLED RELEASE. 2021;329:205-222 Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations. Hidalgo A; Garcia-Mouton C; Autilio C; Carravilla P; Orellana G; Islam MN; Bhattacharya J; Bhattacharya S; Cruz A; Pérez-Gil J Editorial comment: FRONTIERS IN IMMUNOLOGY. 2021;12:740373 Editorial: The Role of Biomembranes and Biophysics in Immune Cell Signaling Shi Y; Sezgin E; Chen W Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;94(6) WASP regulates early B cell receptor signaling and cytoskeletal rearrangements Saeed M; Taal J; Sezgin E; Blom H; Westerberg L Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:235 Maturation of monocyte-derived DCs leads to increased cellular stiffness, higher membrane fluidity, and changed lipid composition Luhr JJ; Alex N; Amon L; Kraeter M; Kubankova M; Sezgin E; Lehmann CHK; Heger L; Heidkamp GF; Smith AS; Zaburdaev V; Boeckmann RA; Levental I; Dustin ML; Eggeling C; Guck J; Dudziak D Preprint: SSRN ELECTRONIC JOURNAL. 2021 Mitochondrial Metabolism Drives Triacylglycerol Synthesis to Control Regulatory T Cell Differentiation Matias MI; Yong C; Foroushani A; Sezgin E; Levental K; Talebi A; Mongellaz C; Perrault J; Rivière A; Dehair J; Wong M; Kinet S; Zimmermann V; Levental I; Yvan-Charvet L; Swinnen J; Muljo S; Tardito S; Dardalhon V; Taylor N Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2021;50(SUPPL 1):100 Nanosized lipid particle profiling with fluorescence fluctuometry Sych T; Plochberger B; Stangl H; Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2021;50(SUPPL 1):189 Membrane order change due to lipoprotein particles Weber F; Axmann M; Sych T; Stangl H; Sezgin E; Plochberger B Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2021;50(SUPPL 1):81 Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells Urbancic I; Schiffelers L; Jenkins E; Gong W; Santos AM; Schneider F; Sezgin E; Eggeling C Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2021;50(SUPPL 1):80 Nanoscale biophysical properties of plasma membrane Sezgin E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2021;50(SUPPL 1):150 Exchangeable polarity-sensitive dyes for real-time quantification of membrane biophysical properties using STED super-resolution microscopy Carravilla P; Dasgupta A; Zhurgenbayeva G; Danylchuk DI; Klymchenko AS; Sezgin E; Eggeling C Preprint: BIORXIV. 2020 Aggregation and immobilisation of membrane proteins interplay with local lipid order in the plasma membrane of T cells Urbančič I; Schiffelers L; Jenkins E; Gong W; Santos AM; Schneider F; O’Brien-Ball C; Vuong MT; Ashman N; Sezgin E; Eggeling C Article: BIOCHEMISTRY. 2020;59(45):4421-4428 Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors Plochberger B; Sych T; Weber F; Novacek J; Axmann M; Stangl H; Sezgin E Article: ANALYTICAL CHEMISTRY. 2020;92(21):14798-14805 Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes Danylchuk DI; Sezgin E; Chabert P; Klymchenko AS Preprint: BIORXIV. 2020 Lipoprotein particles interact with membranes and transfer their cargo without receptors Plochberger B; Sych T; Weber F; Novacek J; Axmann M; Stangl H; Sezgin E Preprint: BIORXIV. 2020 αKG inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism Matias M; Yong C; Foroushani A; Sezgin E; Levental K; Talebi A; Mongellaz C; Dehair J; Wong M; Kinet S; Zimmermann V; Levental I; Yvan-Charvet L; Swinnen J; Muljo S; Tardito S; Dardalhon V; Taylor N Article: CELL REPORTS. 2020;32(7):108037 Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments Rujas E; Insausti S; Leaman DP; Carravilla P; Gonzalez-Resines S; Monceaux V; Sanchez-Eugenia R; Garcia-Porras M; Iloro I; Zhang L; Elortza F; Julien J-P; Saez-Cirion A; Zwick MB; Eggeling C; Ojida A; Domene C; Caaveiro JMM; Nieva JL Article: ACS INFECTIOUS DISEASES. 2020;6(8):2155-2168 Cholesterol Constrains the Antigenic Configuration of the Membrane-Proximal Neutralizing HIV-1 Epitope Torralba J; de la Arada I; Carravilla P; Insausti S; Rujas E; Largo E; Eggeling C; Arrondo JLR; Apellaniz B; Nieva JL Preprint: BIORXIV. 2020 The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function Oftedal BE; Maio S; Handel A; White MP; Howie D; Davis S; Prevot N; Rota IA; Deadman ME; Kessler BM; Fischer R; Trede NS; Sezgin E; Maizels RM; Holländer GA Journal article: CHEMICAL SCIENCE. 2020;11(33):8955-8960 Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad Frawley AT; Wycisk V; Xiong Y; Galiani S; Sezgin E; Urbancic I; Jentzsch AV; Leslie KG; Eggeling C; Anderson HL Article: PLOS PATHOGENS. 2020;16(7):e1008656 Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation Sieben C; Sezgin E; Eggeling C; Manley S Preprint: BIORXIV. 2020 Influence of nanobody binding on fluorescence emission, mobility and organization of GFP-tagged proteins Schneider F; Eggeling C; Sezgin E Corrigendum: NATURE CHEMICAL BIOLOGY. 2020;16(6):710 Author Correction: Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape Lorent JH; Levental KR; Ganesan L; Rivera-Longsworth G; Sezgin E; Doktorova M; Lyman E; Levental I Journal article: NATURE CHEMICAL BIOLOGY. 2020;16(6):710 Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape (vol 45, pg 513, 2020) Lorent JH; Levental KR; Ganesan L; Rivera-Longsworth G; Sezgin E; Doktorova M; Lyman E; Levental I Article: NATURE CHEMICAL BIOLOGY. 2020;16(6):644-652 Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape Lorent JH; Levental KR; Ganesan L; Rivera-Longsworth G; Sezgin E; Doktorova MD; Lyman E; Levental I Article: BIOPHYSICAL JOURNAL. 2020;118(10):2448-2457 z-STED Imaging and Spectroscopy to Investigate Nanoscale Membrane Structure and Dynamics Barbotin A; Urbancic I; Galiani S; Eggeling C; Booth M; Sezgin E Article: JOURNAL OF PHYSICS D-APPLIED PHYSICS. 2020;53(16):164003 High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy Schneider F; Hernandez-Varas P; Lagerholm BC; Shrestha D; Sezgin E; Roberti MJ; Ossato G; Hecht F; Eggeling C; Urbancic I Review: VIRUSES-BASEL. 2020;12(3):E348-348 Fluorescence Microscopy of the HIV-1 Envelope Carravilla P; Nieva JL; Eggeling C Article: JOURNAL OF PHYSICAL CHEMISTRY B. 2020;124(8):1487-1494 Impact of Nanoscale Hindrances on the Relationship between Lipid Packing and Diffusion in Model Membranes Beckers D; Urbancic D; Sezgin E Article: MEMBRANES. 2020;10(2):E30-30 Creating Supported Plasma Membrane Bilayers Using Acoustic Pressure Sezgin E; Carugo D; Levental I; Stride E; Eggeling C Article: NATURE COMMUNICATIONS. 2020;11(1):756 Regulation of lipid saturation without sensing membrane fluidity Ballweg S; Sezgin E; Doktorova M; Covino R; Reinhard J; Wunnicke D; Haenelt I; Levental I; Hummer G; Ernst R Journal article: BIOPHYSICAL JOURNAL. 2020;118(3):389a Simulations of an Asymmetric Mammalian Lipidome Doktorova M; Levental KR; Sezgin E; Levental I; Lyman ER Preprint: BIORXIV. 2020 Creating supported plasma membrane bilayers using acoustic pressure Sezgin E; Carugo D; Levental I; Stride E; Eggeling C Preprint: BIORXIV. 2020 Impact of nanoscale hindrances on the relationship between lipid packing and diffusion in model membranes Beckers D; Urbancic D; Sezgin E Article: BIOPHYSICAL JOURNAL. 2020;118(1):44-56 The Bilayer Collective Properties Govern the Interaction of an HIV-1 Antibody with the Viral Membrane Carravilla P; Darre L; Oar-Arteta IR; Vesga AG; Rujas E; de las Heras-Martinez G; Domene C; Nieva JL; Requejo-Isidro J Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:608484 Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse Felce JH; Parolini L; Sezgin E; Cespedes PF; Korobchevskaya K; Jones M; Peng Y; Dong T; Fritzsche M; Aarts D; Frater J; Dustin ML Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:574363 Fluidity and Lipid Composition of Membranes of Peroxisomes, Mitochondria and the ER From Oleic Acid-Induced Saccharomyces cerevisiae Reglinski K; Steinfort-Effelsberg L; Sezgin E; Klose C; Platta HW; Girzalsky W; Eggeling C; Erdmann R Journal article: PATIENT SAFETY IN SURGERY. 2020;14(1):28 Lessons learned from the mechanisms of posttraumatic inflammation extrapolated to the inflammatory response in COVID-19: a review Teuben MPJ; Pfeifer R; Teuber H; De Boer LL; Halvachizadeh S; Shehu A; Pape H-C Article: FRONTIERS IN IMMUNOLOGY. 2020;11:590121 Maturation of Monocyte-Derived DCs Leads to Increased Cellular Stiffness, Higher Membrane Fluidity, and Changed Lipid Composition Luhr JJ; Alex N; Amon L; Krater M; Kubankova M; Sezgin E; Lehmann CHK; Heger L; Heidkamp GF; Smith A-S; Zaburdaev V; Bockmann RA; Levental I; Dustin ML; Eggeling C; Guck J; Dudziak D Preprint: BIORXIV. 2019 z-STED imaging and spectroscopy to investigate nanoscale membrane structure and dynamics Barbotin A; Urbančič I; Galiani S; Eggeling C; Booth M; Sezgin E Preprint: BIORXIV. 2019 High photon count rates improve the quality of super-resolution fluorescence fluctuation spectroscopy Schneider F; Hernandez-Varas P; Lagerholm C; Shrestha D; Sezgin E; Roberti J; Ossato G; Hecht F; Eggeling C; Urbančič I Journal article: BEHAVIOURAL PHARMACOLOGY. 2019;30(6):534-537 Neuropathic insult increases the responsiveness to acetic acid in mice Gurdap CO; Markwalter PSJ; Neddenriep B; Bagdas D; Damaj MI Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(34):12599-12609 Nanoscale dynamics of cholesterol in the cell membrane Pinkwart K; Schneider F; Lukoseviciute M; Sauka-Spengler T; Lyman E; Eggeling C; Sezgin E Preprint: BIORXIV. 2019 Regulation of lipid saturation without sensing membrane fluidity Ballweg S; Sezgin E; Wunnicke D; Hänelt I; Ernst R Preprint: BIORXIV. 2019 The mammalian plasma membrane is defined by transmembrane asymmetries in lipid unsaturation, leaflet packing, and protein shape Lorent J; Levental K; Ganesan L; Rivera-Longsworth G; Sezgin E; Doktorova; Lyman E; Levental I Preprint: BIORXIV. 2019 Mechanical properties of plasma membrane vesicles correlate with lipid order and viscosity and depend on cell density Steinkühler J; Sezgin E; Urbančič I; Eggeling C; Dimova R Preprint: BIORXIV. 2019 Nanoscale dynamics of cholesterol in the cell membrane Pinkwart K; Schneider F; Lukoseviciute M; Sauka-Spengler T; Lyman E; Eggeling C; Sezgin E Article: NANO LETTERS. 2019;19(4):2562-2567 Receptor-Independent Transfer of Low Density Lipoprotein Cargo to Biomembranes Axmann M; Sezgin E; Karner A; Novacek J; Brodesser MD; Roehrl C; Preiner J; Stangl H; Plochberger B Article: NATURE PROTOCOLS. 2019;14(4):1054-1083 Measuring nanoscale diffusion dynamics in cellular membranes with super-resolution STED-FCS Sezgin E; Schneider F; Galiani S; Urbancic I; Waithe D; Lagerholm BC; Eggeling C Journal article: BIOPHYSICAL JOURNAL. 2019;116(3):327a-328a Measuring Hindered Diffusion Dynamics in Live Cell Plasma Membranes with Confocal and Super-Resolution Imaging Schneider F; Sezgin E; Waithe D; Fritzsche M; Eggeling C Article: NATURE COMMUNICATIONS. 2019;10(1):78 Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions Carravilla P; Chojnacki J; Rujas E; Insausti S; Largo E; Waithe D; Apellaniz B; Sicard T; Julien J-P; Eggeling C; Nieva JL Article: COMMUNICATIONS BIOLOGY. 2019;2:337 Mechanical properties of plasma membrane vesicles correlate with lipid order, viscosity and cell density Steinkuehler J; Sezgin E; Urbancic I; Eggeling C; Dimova R Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019;7:281 More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Azbazdar Y; Ozalp O; Sezgin E; Veerapathiran S; Duncan AL; Sansom MSP; Eggeling C; Wohland T; Karaca E; Ozhan G Article: SCIENCE SIGNALING. 2018;11(561):eaat0756 CD45 exclusion- and cross-linking-based receptor signaling together broaden FcεRI reactivity Felce JH; Sezgin E; Wane M; Brouwer H; Dustin ML; Eggeling C; Davis SJ Article: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2018;1860(11):2436-2445 How to minimize dye-induced perturbations while studying biomembrane structure and dynamics: PEG linkers as a rational alternative Mobarak E; Javanainen M; Kulig W; Honigmann A; Sezgin E; Aho N; Eggeling C; Rog T; Vattulainen I Article: JOURNAL OF CELL SCIENCE. 2018;132(4):jcs219709 Reconstitution of immune cell interactions in free-standing membranes Jenkins E; Santos AM; O'Brien-Ball C; Felce JH; Wilcock MJ; Hatherley D; Dustin ML; Davis SJ; Eggeling C; Sezgin E Journal article: MYCOSES. 2018;61(9):665-673 Airway persistence by the emerging multi-azole-resistant Rasamsonia argillacea complex in cystic fibrosis Abdolrasouli A; Bercusson AC; Rhodes JL; Hagen F; Buil JB; Tang AYY; de Boer LL; Shah A; Milburn AJ; Elborn JS; Jones AL; Meis JF; Fisher MC; Schelenz S; Simmonds NJ; Armstrong-James D Article: ACS NANO. 2018;12(8):8540-8546 Statistical Analysis of Scanning Fluorescence Correlation Spectroscopy Data Differentiates Free from Hindered Diffusion Schneider F; Waithe D; Lagerholm BC; Shrestha D; Sezgin E; Eggeling C; Fritzsche M Journal article: ATHEROSCLEROSIS. 2018;275:e23 INTERACTION OF LIPOPROTEIN PARTICLES WITH LIPID BILAYER-MEMBRANES Plochberger B; Roehrl C; Preiner J; Karner A; Axmann M; Novacek J; Sezgin E; Eggeling C; Hinterndorfer P; Schuetz GJ; Stangl H Article: NANO LETTERS. 2018;18(7):4233-4240 Nanoscale Spatiotemporal Diffusion Modes Measured by Simultaneous Confocal and Stimulated Emission Depletion Nanoscopy Imaging Schneider F; Waithe D; Galiani S; de la Serna JB; Sezgin E; Eggeling C Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(7):1120-1136 Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signaling Hertzog J; Dias AGJ; Rigby RE; Donald CL; Mayer A; Sezgin E; Song C; Jin B; Hublitz P; Eggeling C; Kohl A; Rehwinkel J Article: JOURNAL OF PHYSICS D-APPLIED PHYSICS. 2018;51(23):235401 Complementary studies of lipid membrane dynamics using iSCAT and super-resolved fluorescence correlation spectroscopy Reina F; Galiani S; Shrestha D; Sezgin E; de Wit G; Cole D; Lagerholm BC; Kukura P; Eggeling C Preprint: BIORXIV. 2018 Reconstitution of immune cell interactions in free-standing membranes Jenkins E; Santos AM; Felce J; Hatherley D; Dustin M; Davis S; Eggeling C; Sezgin E Journal article: CHEMICAL SCIENCE. 2018;9(15):3892 Spironaphthoxazine switchable dyes for biological imaging (vol 9, pg 3029, 2018) Xiong Y; Jentzsch AV; Osterrieth JWM; Sezgin E; Sazanovich IV; Reglinski K; Galiani S; Parker AW; Eggeling C; Anderson HL Preprint: BIORXIV. 2018 Nanoscale spatio-temporal diffusion modes measured by simultaneous confocal and STED imaging Schneider F; Waithe D; Galiani S; de la Serna JB; Sezgin E; Eggeling C Article: CHEMICAL SCIENCE. 2018;9(11):3029-3040 Spironaphthoxazine switchable dyes for biological imaging Xiong Y; Jentzsch AV; Osterrieth JWM; Sezgin E; Sazanovich IV; Reglinski K; Galiani S; Parker AW; Eggeling C; Anderson HL Conference publication: 2018;10500:105000l-22 Interferometric scattering (iSCAT) microscopy: studies of biological membrane dynamics Reina F; Galiani S; Shrestha D; Sezgin E; Lagerholm BC; Cole D; Kukura P; Eggeling C Preprint: BIORXIV. 2018 Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation Sieben C; Sezgin E; Eggeling C; Manley S Conference publication: BIOPHYSICAL JOURNAL. 2018;114(3):273A Cell-Like Mechanical Response in Passive Plasma Membrane Vesicles Steinkuehler J; Bhatial T; Urbancic I; Sezgin E; Westermann M; Lipowsky R; Dimova R Conference publication: BIOPHYSICAL JOURNAL. 2018;114(3):347A-348A Direct Visualization of Lipoprotein Mediated Cholesterol Transport at the Phospholipid Bilayer Interface Plochberger B; Axmann M; Sezgin E; Preiner J; Karner A; Roehrl C; Brodesser MD; Eggeling C; Schuetz GJ; Stangl H Conference publication: BIOPHYSICAL JOURNAL. 2018;114(3):108A-109A Triggering of the High-Affinity IgE Receptor in an AggregationIn-dependent Manner Felce J; Sezgin E; Wane M; Dustin M; Eggeling C; Davis S Conference publication: BIOPHYSICAL JOURNAL. 2018;114(3):99A Advanced STED Microscopy of the Membrane Organization in Activating T-Cells Urbancic I; Sezgin E; Schneider F; Reina F; Eggeling C Conference publication: BIOPHYSICAL JOURNAL. 2018;114(3):99A STED-FCS Reveals Diffusional Heterogeneity of Lipids and GPI-Anchored Proteins in the Plasma Membrane and Actin Cytoskeleton Free Plasma Membrane Vesicles Schneider F; Waithe D; Clausen MP; Galiani S; Koller T; Ozhan G; Eggeling C; Sezgin E Conference publication: BIOPHYSICAL JOURNAL. 2018;114(3):16A Spectral STED Imaging of Cell Membranes Sezgin E; Schneider F; Zilles V; Urbancic I; Garcia E; Waithe D; Klymchenko A; Eggeling C Article: FUTURE VIROLOGY. 2018;13(2):129-140 HIV antivirals: targeting the functional organization of the lipid envelope Carravilla P; Nieva JL Meeting abstract: BIOPHYSICAL JOURNAL. 2018;114(3):537a Single Virion Super-Resolution Microscopy Unveils Mechanistic Details of Env Glycoprotein Recognition by the Broadly Neutralizing Carravilla P; Rujas E; Oar-Arteta IR; Insausti S; Largo E; Chojnacki J; Sicard T; Julien J-P; Eggeling C; Huarte N; Requejo-Isidro J; Nieva JL Journal article: PLOS PATHOGENS. 2018;14(1):e1006627 From phagocytosis to metaforosis: Calcineurin's deadly role in innate processing of fungi Armstrong-James D; de Boer L; Bercusson A; Shah A Preprint: BIORXIV. 2017 Complementary studies of lipid membrane dynamics using iSCAT and STED microscopy Reina F; Galiani S; Shrestha D; Sezgin E; de Wit G; Cole D; Lagerholm BC; Kukura P; Eggeling C Article: SCIENTIFIC REPORTS. 2017;7(1):15886 HDL particles incorporate into lipid bilayers - a combined AFM and single molecule fluorescence microscopy study Plochberger B; Roehrl C; Preiner J; Rankl C; Brameshuber M; Madl J; Bittman R; Ros R; Sezgin E; Eggeling C; Hinterdorfer P; Stangl H; Schuetz GJ Article: BIOPHYSICAL JOURNAL. 2017;113(6):1321-1330 Polarity-Sensitive Probes for Superresolution Stimulated Emission Depletion Microscopy Sezgin E; Schneider F; Zilles V; Urbancic I; Garcia E; Waithe D; Klymchenko AS; Eggeling C Article: BIOPHYSICAL JOURNAL. 2017;113(6):1301-1310 Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes Carravilla P; Cruz A; Martin-Ugarte I; Oar-Arteta IR; Torralba J; Apellaniz B; Perez-Gil J; Requejo-Isidro J; Huarte N; Nieva JL Article: NATURE COMMUNICATIONS. 2017;8(1):545 Envelope glycoprotein mobility on HIV-1 particles depends on the virus maturation state Chojnacki J; Waithe D; Carravilla P; Huarte N; Galiani S; Enderlein J; Eggeling C Article: FEBS JOURNAL. 2017;284(15):2513-2526 Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments Sezgin E; Azbazdar Y; Ng XW; Teh C; Simons K; Weidinger G; Wohland T; Eggeling C; Ozhan G Review: JOURNAL OF PHYSICS-CONDENSED MATTER. 2017;29(27):273001 Super-resolution optical microscopy for studying membrane structure and dynamics Sezgin E Article: NATURE COMMUNICATIONS. 2017;8:15940 A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome Diepold A; Sezgin E; Huseyin M; Mortimer T; Eggeling C; Armitage JP Article: MOLECULAR BIOLOGY OF THE CELL. 2017;28(11):1507-1518 Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS Schneider F; Waithe D; Clausen MP; Galiani S; Koller T; Ozhan G; Eggeling C; Sezgin E Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2017;18(6):361-374 The mystery of membrane organization: composition, regulation and roles of lipid rafts Sezgin E; Levental I; Mayor S; Eggeling C Article: BMC BIOINFORMATICS. 2017;18(1):254 Spectral imaging toolbox: segmentation, hyperstack reconstruction, and batch processing of spectral images for the determination of cell and model membrane lipid order Aron M; Browning R; Carugo D; Sezgin E; de la Serna JB; Eggeling C; Stride E Article: JOURNAL OF PHYSICS D-APPLIED PHYSICS. 2017;50(13):134004 Laurdan and Di-4-ANEPPDHQ probe different properties of the membrane Amaro M; Reina F; Hof M; Eggeling C; Sezgin E Article: ACS OMEGA. 2017;2(3):994-1002 Electroformation of Giant Unilamellar Vesicles on Stainless Steel Electrodes Pereno V; Carugo D; Bau L; Sezgin E; de la Serna JB; Eggeling C; Stride E Article: NATURE COMMUNICATIONS. 2017;8:14347 Self-organizing actin patterns shape membrane architecture but not cell mechanics Fritzsche M; Li D; Colin-York H; Chang VT; Moeendarbary E; Felce JH; Sezgin E; Charras G; Betzig E; Eggeling C Preprint: BIORXIV. 2017 Polarity sensitive probes for super resolution STED microscopy Sezgin E; Schneider F; Zilles V; Garcia E; Waithe D; Klymchenko AS; Eggeling C Journal article: MATTERS. 2017 Rituximab capping triggers intracellular reorganization of B cells Koller T; Blok S; Santos AM; Oszmiana A; Davis D; Sezgin E; Eggeling C Article: FRONTIERS IN PHYSIOLOGY. 2017;8:252 Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin Rissanen S; Grzybek M; Orlowski A; Rog T; Cramariuc O; Levental I; Eggeling C; Sezgin E; Vattulainen I Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2017;28 Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS. Sezgin E; Eggeling C Journal article: MEDICAL MYCOLOGY. 2017;55(1):10-15 Endosomal sensing of fungi: current understanding and emerging concepts Bercusson A; de Boer L; Armstrong-James D Article: BIOMATERIALS. 2017;113:105-117 Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles Carugo D; Aron M; Sezgin E; de la Serna JB; Kuirnova MK; Eggeling C; Stride E Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2017;46:S375 Triggering of the high-affinity IgE receptor in an aggregation-independent manner Felce JH; Sezgin E; Wane M; Dustin ML; Eggeling C; Davis SJ Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2017;46:S251 Ratiometric imaging with super-resolution STED microscopy to reveal nanoscale membrane heterogeneity Sezgin E; Eggeling C Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2017;46:S127 Diffusion of lipids and GPI-anchored proteins in the plasma membrane and actin free vesicles Schneider F; Sezgin E; Waithe D; Eggeling C Article: SCIENTIFIC REPORTS. 2016;6:34190 Functional organization of the HIV lipid envelope Huarte N; Carravilla P; Cruz A; Lorizate M; Nieto-Garai JA; Kraeusslich H-G; Perez-Gil J; Requejo-Isidro J; Nieva JL Preprint: BIORXIV. 2016 Laurdan and Di-4-ANEPPDHQ probe different properties of the membrane Amaro M; Reina F; Hof M; Eggeling C; Sezgin E Preprint: BIORXIV. 2016 Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS Schneider F; Clausen M; Waithe D; Koller T; Ozhan G; Eggeling C; Sezgin E Editorial comment: TRAFFIC. 2016;17(9):1054-1057 Use of BODIPY-Cholesterol (TF-Chol) for Visualizing Lysosomal Cholesterol Accumulation Holtta-Vuori M; Sezgin E; Eggeling C; Ikonen E Article: ORGANIC LETTERS. 2016;18(15):3666-3669 Photoswitchable Spiropyran Dyads for Biological Imaging Xiong Y; Rivera-Fuentes P; Sezgin E; Jentzsch AV; Eggeling C; Anderson HL Article: BIOPHYSICAL JOURNAL. 2016;110(11):2441-2450 Reorganization of Lipid Diffusion by Myelin Basic Protein as Revealed by STED Nanoscopy Steshenko O; Andrade DM; Honigmann A; Mueller V; Schneider F; Sezgin E; Hell SW; Simons M; Eggeling C Article: BIOINFORMATICS. 2016;32(6):958-960 FoCuS-point: software for STED fluorescence correlation and time-gated single photon counting Waithe D; Clausen MP; Sezgin E; Eggeling C Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):521A Receptor-Mediated HDL-Lipid Uptake is Regulated by Elastic Properties of the Plasma Membrane Plochberger B; Roehrl C; Preiner J; Weghuber J; Sezgin E; Hinterdorfer P; Stangl H; Schuetz GJ Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):190A Membrane Heterogeneity and its Role in Immune Signaling Elucidated by Spectral Imaging Sezgin E; Eggeling C Article: JOURNAL OF LIPID RESEARCH. 2016;57(2):299-309 A comparative study on fluorescent cholesterol analogs as versatile cellular reporters Sezgin E; Can FB; Schneider F; Clausen MP; Galiani S; Stanly TA; Waithe D; Colaco A; Honigmann A; Wustner D; Platt F; Eggeling C Review: INTERNATIONAL JOURNAL OF BIOMEDICAL IMAGING. 2016;2016:7462014-17 Insight into the Molecular Imaging of Alzheimer's Disease Arora A; Bhagat N Conference publication: FEBS JOURNAL. 2016;283:42 Investigating cell membrane dynamics by STED-FCS and spectral imaging Sezgin E; Eggeling C Article: METHODS. 2015;88:67-75 A straightforward approach for gated STED-FCS to investigate lipid membrane dynamics Clausen MP; Sezgin E; de la Serna JB; Waithe D; Lagerholm BC; Eggeling C Article: NANO LETTERS. 2015;15(9):5912-5918 STED-FLCS: An Advanced Tool to Reveal Spatiotemporal Heterogeneity of Molecular Membrane Dynamics Vicidomini G; Ta H; Honigmann A; Mueller V; Clausen MP; Waithe D; Galiani S; Sezgin E; Diaspro A; Hell SW; Eggeling C Journal article: CELL. 2015;161(6):1472 Membrane Nanoclusters-Tails of the Unexpected (vol 161, pg 433, 2015) Sezgin E; Davis SJ; Eggeling C Journal article: CHEMPHYSCHEM. 2015;16(7):1560 Back Cover: Spectral Imaging to Measure Heterogeneity in Membrane Lipid Packing (ChemPhysChem 7/2015) Sezgin E; Waithe D; de la Serna JB; Eggeling C Article: CHEMPHYSCHEM. 2015;16(7):1387-1394 Spectral Imaging to Measure Heterogeneity in Membrane Lipid Packing Sezgin E; Waithe D; de la Serna JB; Eggeling C Editorial comment: CELL. 2015;161(3):433-434 Membrane Nanoclusters-Tails of the Unexpected Sezgin E; Davis SJ; Eggeling C Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1853(4):802-809 Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains Beck-Garcia K; Beck-Garcia E; Bohler S; Zorzin C; Sezgin E; Levental I; Alarcon B; Schamel WWA Article: LANGMUIR. 2015;31(9):2808-2817 Two-Photon Laurdan Studies of the Ternary Lipid Mixture DOPC:SM:Cholesterol Reveal a Single Liquid Phase at Sphingomyelin:Cholesterol Ratios Lower Than 1 Carravilla P; Nieva JL; Goni FM; Requejo-Isidro J; Huarte N Article: PLOS ONE. 2015;10(4):e0123930 Adaptive Lipid Packing and Bioactivity in Membrane Domains Sezgin E; Gutmann T; Buhl T; Dirkx R; Grzybek M; Coskun U; Solimena M; Simons K; Levental I; Schwille P Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2015;44:S119 Role of membrane heterogeneity in immune signaling studied by model membranes and spectral imaging Sezgin E; Eggeling C Article: NATURE COMMUNICATIONS. 2014;5:5412 Scanning STED-FCS reveals spatiotemporal heterogeneity of lipid interaction in the plasma membrane of living cells Honigmann A; Mueller V; Ta H; Schoenle A; Sezgin E; Hell SW; Eggeling C Article: JOURNAL OF VIROLOGY. 2014;88(22):13367-13377 Cholesterol-Dependent Membrane Fusion Induced by the gp41 Membrane-Proximal External Region-Transmembrane Domain Connection Suggests a Mechanism for Broad HIV-1 Neutralization Apellaniz B; Rujas E; Carravilla P; Requejo-Isidro J; Huarte N; Domene C; Nieva JL Article: LANGMUIR. 2014;30(27):8160-8166 Measuring Lipid Packing of Model and Cellular Membranes with Environment Sensitive Probes Sezgin E; Sadowski T; Simons K Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(10):6565-6580 Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope IMPLICATIONS FOR ANTIBODY RECOGNITION MECHANISM AND IMMUNOGEN DESIGN Serrano S; Araujo A; Apellaniz B; Bryson S; Carravilla P; de la Arada I; Huarte N; Rujas E; Pai EF; Arrondo JLR; Domene C; Angeles Jimenez M; Nieva JL Conference publication: BIOPHYSICAL JOURNAL. 2014;106(2):392A HDL-Lipid Uptake is Regulated by Elastic Properties of the Plasma Membrane Plochberger B; Schuetz GJ; Roehrl C; Preiner J; Sezgin E; Brameshuber M; Weghuber J; Wieser S; Rankl C; Ruprecht V; Madl J; Bittman R; Hinterdorfer P; Stangl H Meeting abstract: BIOPHYSICAL JOURNAL. 2014;106(2):706a Insights into the Lateral Organization and Molecular Order of Lipid Mixtures that Mimic the HIV-1 Membrane by Multiphoton Fluorescence Microscopy Huarte N; Carravilla P; Nieva JL; Requejo-Isidro J Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(50):35660-35670 Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains Zhou Y; Maxwell KN; Sezgin E; Lu M; Liang H; Hancock JF; Dial EJ; Lichtenberger LM; Levental I Article: DEVELOPMENTAL CELL. 2013;26(4):331-345 Lypd6 Enhances Wnt/β-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains Oezhan G; Sezgin E; Wehner D; Pfister AS; Kuehl SJ; Kagermeier-Schenk B; Kuehl M; Schwille P; Weidinger G Article: CHEMBIOCHEM. 2013;14(6):695-698 Photoconversion of Bodipy-Labeled Lipid Analogues Sezgin E; Chwastek G; Aydogan G; Levental I; Simons K; Schwille P Journal article: CHEMBIOCHEM. 2013;14(6):657 Cover Picture: Photoconversion of Bodipy‐Labeled Lipid Analogues (ChemBioChem 6/2013) Sezgin E; Chwastek G; Aydogan G; Levental I; Simons K; Schwille P Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(35):14236-14240 Functional convergence of hopanoids and sterols in membrane ordering Saenz JP; Sezgin E; Schwille P; Simons K Article: MOLECULAR MEMBRANE BIOLOGY. 2012;29(5):144-154 Model membrane platforms to study protein-membrane interactions Sezgin E; Schwille P Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1818(7):1777-1784 Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes Sezgin E; Levental I; Grzybek M; Schwarzmann G; Mueller V; Honigmann A; Belov VN; Eggeling C; Coskun U; Simons K; Schwille P Article: NATURE PROTOCOLS. 2012;7(6):1042-1051 Elucidating membrane structure and protein behavior using giant plasma membrane vesicles Sezgin E; Kaiser H-J; Baumgart T; Schwille P; Simons K; Levental I Article: ACS NANO. 2012;6(3):2150-2156 Penetration of Amphiphilic Quantum Dots through Model and Cellular Plasma Membranes Dubavik A; Sezgin E; Lesnyak V; Gaponik N; Schwille P; Eychmueller A Conference publication: BIOPHYSICAL JOURNAL. 2012;102(3):296A-297A Partitioning, Diffusion, and Ligand Binding of Raft Lipid Analogs in Model and Cellular Plasma Membranes Sezgin E; Levantal I; Schwarzmann G; Mueller V; Honigmann A; Belov V; Eggeling C; Coskun U; Simons K; Schwille P Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2011;3(11):a009803 Fluorescence Techniques to Study Lipid Dynamics Sezgin E; Schwille P Article: COLLOIDS AND SURFACES B-BIOINTERFACES. 2009;71(2):315-318 Interaction of gold nanoparticles with mitochondria Karatas OF; Sezgin E; Aydin O; Culha M Journal article: Mitochondrial Metabolism Drives Triacylglycerol Synthesis to Control Regulatory T Cell DifferentiationMatias MI; Yong C; Foroushani A; Sezgin E; Levental K; Talebi A; Mongellaz C; Perrault J; Rivière A; Dehair J; Wong M; Kinet S; Zimmermann V; Levental I; Yvan-Charvet L; Swinnen J; Muljo S; Tardito S; Dardalhon V; Taylor N Show more
Staff and contactGroup leader Erdinc Sezgin Senior Lecturer | Docent Telephone +46852486021 E-mail erdinc.sezgin@ki.seAll members of the group Luca Andronico Postdoctoral Researcher E-mail luca.andronico@ki.se Abishek Arora Postdoctoral Researcher E-mail abishek.arora@ki.se Iro Beligianni Research Assistant E-mail iro.beligianni@ki.se Pablo Carravilla Affiliated to Research E-mail pablo.carravilla@ki.se Tomasz Czerniak Postdoctoral Researcher E-mail tomasz.czerniak@ki.se Cenk Gurdap Phd Student E-mail cenk.gurdap@ki.se Shahinez Hanna-Elias Research Assistant E-mail shahinez.hannaelias@ki.se Franziska Ragaller Clinical Assistant E-mail franziska.ragaller@ki.se Jan Schlegel Affiliated to Research E-mail jan.schlegel@ki.se Erdinc Sezgin Senior Lecturer | Docent Telephone +46852486021 E-mail erdinc.sezgin@ki.se Ellen Sjule Research Assistant E-mail ellen.sjule@ki.se Taras Sych Research Specialist E-mail taras.sych@ki.se Selim Tanriverdi Postdoctoral Researcher E-mail selim.tanriverdi@ki.se Florian Weber Phd Student E-mail florian.weber@ki.se Leonard de Boer Postdoctoral Researcher E-mail leonard.de.boer@ki.se