Uncovering the molecular and physical principles governing early embryonic division and nuclear organization – Jan Ellenberg Group

Our research focuses on uncovering the molecular and physical principles governing early embryonic division and nuclear organization. By leveraging advanced fluorescence-based imaging technologies, we aim to study unique division processes in a non-invasive and quantitative manner.

Our Research

Our research focuses on uncovering the molecular and physical principles governing early embryonic division and nuclear organization. By leveraging advanced fluorescence-based imaging technologies, we aim to study unique division processes in in a non-invasive and quantitative manner. 

Previous work, performed by professor Ellenberg´s group at EMBL Heidelberg, has included large-scale RNAi screening to identify cell division genes, high-throughput live-cell imaging, and the development of a protein atlas of the human dividing cell. The group has also used super-resolution microscopy to resolve nuclear pore complex structures and study chromatin dynamics. 

Moving forward, the newly formed group at Karolinska Institutet and SciLifeLab seeks to deepen our understanding of mitotic division in mammalian embryos, nuclear organization, and early embryonic development through cutting-edge imaging and computational approaches.

Keywords:
Aneuploidy Chromatin Assembly and Disassembly Chromosome Segregation Developmental Biology Embryonic Development Molecular Biology Nuclear Pore Complex Proteins Show all
Content reviewer:
Sara Lidman
29-04-2025