Chronic inflammation with focus on rheumatology and cancer – Research group Per-Johan Jakobsson

Article: NATURE NEUROSCIENCE. 2024;27(8):1534-1544

NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling

Liu Y; Guo J; Matoga M; Korotkova M; Jakobsson P-J; Aguzzi A

Article: ARTHRITIS RESEARCH & THERAPY. 2024;26(1):61

Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis

Liu J; Idborg H; Korotkova M; Lend K; van Vollenhoven R; Lampa J; Rudin A; Nordstrom D; Gudbjornsson B; Grondal G; Uhlig T; Horslev-Petersen K; Merete HL; Ostergaard M; Nurmohamed M; Jakobsson P-J

Article: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(3):277-287

In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammation

Pertsinidou E; Saevarsdottir S; Manivel VA; Klareskog L; Alfredsson L; Mathsson-Alm L; Hansson M; Cornillet M; Serre G; Holmdahl R; Skriner K; Jakobsson P-J; Westerlind H; Askling J; Roennelid J

Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335

High-content screening of drug combinations of an mPGES-1 inhibitor in multicellular tumor spheroids leads to mechanistic insights into neuroblastoma chemoresistance

Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Spah J; Wermeling F; Kogner P; Korotkova M; Ostling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K

Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1372927

High-mannose glycans from Schistosoma mansoni eggs are important for priming of Th2 responses via Dectin-2 and prostaglandin E2

Almeida L; van Roey R; Patente TA; Otto F; Veldhuizen T; Ghorasaini M; van Diepen A; Schramm G; Liu J; Idborg H; Korotkova M; Jakobsson P-J; Giera M; Hokke CH; Everts B

Letter: NATURE COMMUNICATIONS. 2023;14(1):7172

Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples

O'Donnell VB; Schebb NH; Milne GL; Murphy MP; Thomas CP; Steinhilber D; Gelhaus SL; Kuehn H; Gelb MH; Jakobsson P-J; Blair IA; Murphy RC; Freeman BA; Brash AR; Fitzgerald GA

Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2023;27(11):1115-1123

The anti-inflammatory and vasoprotective properties of mPGES-1 inhibition offer promising therapeutic potential

Steinmetz-Spah J; Jakobsson P-J

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(15):1981-1998

Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice

Zhang Y; Steinmetz-Spah J; Idborg H; Zhu L; Li H; Rao H; Chen Z; Guo Z; Hu L; Xu C; Chen H; Korotkova M; Jakobsson P-J; Wang M

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2023;167:106738

Microsomal prostaglandin E synthase-1 inhibition promotes shunting in arachidonic acid metabolism during inflammatory responses in vitro

Liu J; Peng B; Steinmetz-Spah J; Idborg H; Korotkova M; Jakobsson P-J

Editorial comment: FRONTIERS IN PHARMACOLOGY. 2023;14:1135803

Editorial: Disease-modifying antirheumatic drugs: Approaches and lessons learned from traditional medicine

Mei L; Gao K; He X; Jakobsson P-J; Huang R

Editorial comment: FRONTIERS IN PHARMACOLOGY. 2023;14:1223761

Editorial: Insights in inflammation pharmacology: 2022

Patrignani P; Ballerini P; Jakobsson P-J; Steinhilber D

Article: JOURNAL OF AUTOIMMUNITY. 2023;134:102951

Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies

Preger C; Notarnicola A; Hellstrom C; Wigren E; Fernandes-Cerqueira C; Kvarnstrom M; Wahren-Herlenius M; Idborg H; Lundberg IE; Persson H; Graslund S; Jakobsson P-J

Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310

Biosynthesis of prostaglandin 15dPGJ₂ -glutathione and 15dPGJ₂-cysteine conjugates in macrophages and mast cells via MGST3

Steinmetz-Spah J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Ronnberg E; Merk D; Wermeling F; Haeggstrom JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J

Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903

Autoantibodies targeting malondialdehyde-modifications in rheumatoid arthritis regulate osteoclasts via inducing glycolysis and lipid biosynthesis

Sakuraba K; Krishnamurthy A; Sun J; Zheng X; Xu C; Peng B; Engstrom M; Jakobsson P-J; Wermeling F; Catrina S; Gronwall C; Catrina AI; Rethi B

Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(5):745-763

Where traditional Chinese medicine meets Western medicine in the prevention of rheumatoid arthritis

Jakobsson P-J; Robertson L; Welzel J; Zhang M; Yang Z; Gao K; Huang R; Wen Z; Korotkova M; Goransson U

Article: EMBO REPORTS. 2022;23(5):e54096

Helminthic dehydrogenase drives PGE₂ and IL-10 production in monocytes to potentiate Treg induction

Prodjinotho UF; Gres V; Henkel F; Lacorcia M; Dandl R; Haslbeck M; Schmidt V; Winkler AS; Sikasunge C; Jakobsson P-J; Henneke P; Bieren JE-V; da Costa CP

Article: LIFE SCIENCES. 2022;295:120394

Omega-3 fatty acids decrease CRYAB, production of oncogenic prostaglandin E₂ and suppress tumor growth in medulloblastoma

Ljungblad L; Bergqvist F; Tummler C; Madawala S; Olsen TK; Andonova T; Jakobsson P-J; Johnsen JI; Pickova J; Strandvik B; Kogner P; Gleissman H; Wickstrom M

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(7):1433-1449

Effects of microsomal prostaglandin E synthase-1 inhibition on resistance artery tone in patients with end stage kidney disease

Steinmetz-Spah J; Arefin S; Larsson K; Jahan J; Mudrovcic N; Wennberg L; Stenvinkel P; Korotkova M; Kublickiene K; Jakobsson P-J

Article: ARTHRITIS RESEARCH & THERAPY. 2022;24(1):62

Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome

Notarnicola A; Preger C; Lundstrom SL; Renard N; Wigren E; Van Gompel E; Galindo-Feria AS; Persson H; Fathi M; Grunewald J; Jakobsson P-J; Graslund S; Lundberg IE; Fernandes-Cerqueira C

Review: FRONTIERS IN PHARMACOLOGY. 2022;13:838782

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?

Schebb NH; Kuehn H; Kahnt AS; Rund KM; O'Donnell VB; Flamand N; Peters-Golden M; Jakobsson P-J; Weylandt KH; Rohwer N; Murphy RC; Geisslinger G; FitzGerald GA; Hanson J; Dahlgren C; Alnouri MW; Offermanns S; Steinhilber D

Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2021;50(6):479-484

Temperature response to cold challenge and mobile phone thermography as outcome measures for systemic sclerosis-related Raynaud's phenomenon

Herrick AL; Heal C; Wilkinson J; Dinsdale G; Manning J; Gunnarsson K; Jakobsson P-J; Murray A

Other: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(6):1309

Anca Catrina 1971-2021 Obituary

Klareskog L; Rethi B; Hensvold A; Wahamaa H; Jakobsson P-J

Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2021;18(6):1463-1475

Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses

Adams RA; Fernandes-Cerqueira C; Notarnicola A; Mertsching E; Xu Z; Lo W-S; Ogilvie K; Chiang KP; Ampudia J; Rosengren S; Cubitt A; King DJ; Mendlein JD; Yang X-L; Nangle LA; Lundberg IE; Jakobsson P-J; Schimmel P

Article: EMBO REPORTS. 2021;22(3):e51329

Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells

Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A

Article: TRANSLATIONAL RESEARCH. 2021;229:69-82

Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay

Sundstrom Y; Shang M-M; Panda SK; Gronwall C; Wermeling F; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L

Article: CELL DEATH & DISEASE. 2021;12(2):135

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression

Rappl P; Roesser S; Maul P; Bauer R; Huard A; Schreiber Y; Thomas D; Geisslinger G; Jakobsson P-J; Weigert A; Bruene B; Schmid T

Editorial comment: FRONTIERS IN PHARMACOLOGY. 2021;12:707811

Editorial: Traditional Medicine and Rheumatology

Yang Z; Tang X; Liang H; Gao K; Wang M; He X; Jakobsson P-J; Huang R

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(41):13981-13993

Generation and validation of recombinant antibodies to study human aminoacyl-tRNA synthetases

Preger C; Wigren E; Ossipova E; Marks C; Lengqvist J; Hofstrom C; Andersson O; Jakobsson P-J; Graslund S; Persson H

Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(10):1658-1667

Anti-Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid Arthritis

Westerlind H; Ronnelid J; Hansson M; Alfredsson L; Mathsson-Alm L; Serre G; Cornillet M; Holmdahl R; Jakobsson P-J; Skriner K; Klareskog L; Saevarsdottir S; Askling J

Article: CARDIOVASCULAR RESEARCH. 2020;116(12):1972-1980

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

Kirkby NS; Raouf J; Ahmetaj-Shala B; Liu B; Mazi SI; Edin ML; Chambers MG; Korotkova M; Wang X; Wahli W; Zeldin DC; Nusing R; Zhou Y; Jakobsson P-J; Mitchell JA

Article: FASEB JOURNAL. 2020;34(8):11101-11114

Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting

Kock A; Bergqvist F; Steinmetz J; Elfman LHM; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P; Larsson K

Article: PHYTOCHEMISTRY LETTERS. 2020;38:6-11

Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells

Ryen AH; Goels T; Steinmetz J; Tahir A; Jakobsson P-J; Backlund A; Urban E; Glasl S

Article: ACS OMEGA. 2020;5(28):17242-17254

Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids

Steinmetz J; Senkowski W; Lengqvist J; Rubin J; Ossipova E; Herman S; Larsson R; Jakobsson P-J; Fryknas M; Kultima K

Article: ARTHRITIS RESEARCH & THERAPY. 2020;22(1):170

Presence of autoantibodies in "seronegative" rheumatoid arthritis associates with classical risk factors and high disease activity

Reed E; Hedstrom AK; Hansson M; Mathsson-Alm L; Brynedal B; Saevarsdottir S; Cornillet M; Jakobsson P-J; Holmdahl R; Skriner K; Serre G; Alfredsson L; Ronnelid J; Lundberg K

Article: SCIENCE TRANSLATIONAL MEDICINE. 2020;12(540):eaay0605

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products

Jimenez MDLR; Lechner A; Alessandrini F; Bohnacker S; Schindela S; Trompette A; Haimerl P; Thomas D; Henkel F; Mourao A; Geerlof A; da Costa CP; Chaker AM; Bruene B; Nuesing R; Jakobsson P-J; Nockher WA; Feige MJ; Haslbeck M; Ohnmacht C; Marsland BJ; Voehringer D; Harris NL; Schmidt-Weber CB; Esser-von Bieren J

Review: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2020;147:106383

A review on mPGES-1 inhibitors: From preclinical studies to clinical applications

Bergqvist F; Morgenstern R; Jakobsson P-J

Article: FRONTIERS IN PHARMACOLOGY. 2020;11:613

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E₂ Production

Bergqvist F; Sundstrom Y; Shang M-M; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L

Article: FRONTIERS IN IMMUNOLOGY. 2020;11:585282

Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis

Hegewald AB; Breitwieser K; Ottinger SM; Mobarrez F; Korotkova M; Rethi B; Jakobsson P-J; Catrina AI; Wahamaa H; Saul MJ

Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;121:109581

Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b⁺Gr1⁺MDSCs from bone marrow

Takahashi R; Amano H; Ito Y; Eshima K; Satoh T; Iwamura M; Nakamura M; Kitasato H; Uematsu S; Raouf J; Jakobsson P-J; Akira S; Majima M

Article: FRONTIERS IN MEDICINE. 2020;7:484

Chinese Herbal Formula Huayu-Qiangshen-Tongbi Decoction Compared With Leflunomide in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis: An Open-Label, Randomized, Controlled, Pilot Study

Wu J; Chen X; Lv Y; Gao K; Liu Z; Zhao Y; Chen X; He X; Chu Y; Wu X; Ou A; Wen Z; Zhang J; Peng J; Huang Z; Jakobsson P-J; Huang Q; Huang R

Article: FRONTIERS IN PHARMACOLOGY. 2020;11:196

Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells

Emmerich AC; Wellstein J; Ossipova E; Baumann I; Lengqvists J; Kultima K; Jakobsson P-J; Steinhilber D; Saul MJ

Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(1):179-191

Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies

Galindo-Feria AS; Albrecht I; Fernandes-Cerqueira C; Notarnicola A; James EA; Herrath J; Dastmalchi M; Sandalova T; Ronnblom L; Jakobsson P-J; Fathi M; Achour A; Grunewald J; Malmstrom V; Lundberg IE

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2019;145:106361

Urinary prostaglandin D₂ and E₂ metabolites associate with abdominal obesity, glucose metabolism, and triglycerides in obese subjects

Pawelzik S-C; Avignon A; Idborg H; Boegner C; Stanke-Labesque F; Jakobsson P-J; Sultan A; Back M

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(24):4625-4638

Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone

Larsson K; Steinmetz J; Bergqvist F; Arefin S; Spahiu L; Wannberg J; Pawelzik S-C; Morgenstern R; Stenberg P; Kublickiene K; Korotkova M; Jakobsson P-J

Corrigendum: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;105(4):880

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype (vol 105, pg 616, 2019)

Terao C; Brynedal B; Chen Z; Jiang X; Westerlind H; Hansson M; Jakobsson P-J; Lundberg K; Skriner K; Serre G; Ronnelid J; Mathsson-Alm L; Brink M; Dahlqvist SR; Padyukov L; Gregersen PK; Barton A; Alfredsson L; Klareskog L; Raychaudhuri S

Article: ACTA PAEDIATRICA. 2019;108(10):1879-1886

Urinary PGE₂ metabolite levels in hospitalised infants with infections compared to age-matched controls

Hamrin J; Perez-Manzo M; Idborg H; Jakobsson P-J; Bjork L; Eriksson M; Nilsson A; Herlenius E

Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;105(3):616-624

Distinct HLA Associations with Rheumatoid Arthritis Subsets Defined by Serological Subphenotype

Terao C; Brynedal B; Chen Z; Jiang X; Westerlind H; Hansson M; Jakobsson P-J; Lundberg K; Skriner K; Serre G; Ronnelid J; Mathsson-Alm L; Brink M; Dahlqvist SR; Padyukov L; Gregersen PK; Barton A; Alfredsson L; Klareskog L; Raychaudhuri S

Article: INTERNATIONAL JOURNAL OF OBESITY. 2019;43(9):1724-1734

Inflammation increases MMP levels via PGE₂ in human vascular wall and plasma of obese women

Ozen G; Boumiza S; Deschildre C; Topal G; Longrois D; Jakobsson PJ; Michel JB; Jacob MP; Chahed K; Norel X

Article: NATURE GENETICS. 2019;51(7):1082-1091

A genetics-led approach defines the drug target landscape of 30 immune-related traits

Fang H; Beckmann G; Bountra C; Bowness P; Burgess-Brown N; Carpenter L; Chen L; Damerell D; Egner U; Fujii R; Howe T; Jakobsson P-J; Katopodis A; Knight JC; Marsden BD; De Martino J; Matthias G; McVean G; Mueller-Fahrnow A; Malarstig A; O'Callaghan CA; Ostermann N; Paez-cortez JR; Peeters PJ; Prinz F; Soulard P; Sundstrom M; Yabuki C; Vlach J; De Wolf H; Knezevic B; Burnham KL; Osgood J; Sanniti A; Lara AL; Kasela S; De Cesco S; Wegner JK; Handunnetthi L; McCann FE; Sekine T; Brennan PE; Sundstrom Y; Milani L; Berg L; Gohlmann HW; Fairfax BP

Article: FASEB JOURNAL. 2019;33(6):6933-6947

miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction

Saul MJ; Baumann I; Bruno A; Emmerich AC; Wellstein J; Ottinger SM; Contursi A; Dovizio M; Donnini S; Tacconelli S; Raouf J; Idborg H; Stein S; Korotkova M; Savai R; Terzuoli E; Sala G; Seeger W; Jakobsson P-J; Patrignani P; Suess B; Steinhilber D

Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):74

Divergent roles of prostacyclin and PGE₂ in human tendinopathy

Bergqvist F; Carr AJ; Wheway K; Watkins B; Oppermann U; Jakobsson P-J; Dakin SG

Article: JOURNAL OF PROTEOME RESEARCH. 2019;18(3):1208-1217

Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus

Torell F; Eketjall S; Idborg H; Jakobsson P-J; Gunnarsson I; Svenungsson E; Trygg J

Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62

Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjogren's syndrome differ in molecular signatures and treatment perspectives

Idborg H; Zandian A; Sandberg A-S; Nilsson B; Elvin K; Truedsson L; Sohrabian A; Ronnelid J; Mo J; Grosso G; Kvarnstrom M; Gunnarsson I; Lehtio J; Nilsson P; Svenungsson E; Jakobsson P-J

Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):60

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment

Estelius J; Lengqvist J; Ossipova E; Idborg H; Le Maitre E; Andersson MLA; Brundin L; Khademi M; Svenungsson E; Jakobsson P-J; Lampa J

Article: JOURNAL OF PROTEOMICS. 2019;190:67-76

The human CSF pain proteome

Khoonsari PE; Ossipova E; Lengqvist J; Svensson CI; Kosek E; Kadetoff D; Jakobsson P-J; Kultima K; Lampa J

Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2019;1161:89-100

Targeting the COX/mPGES-1/PGE2 Pathway in Neuroblastoma

Larsson K; Kock A; Kogner P; Jakobsson P-J

Article: FRONTIERS IN PHARMACOLOGY. 2019;10:640

Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes

Saul MJ; Hegewald AB; Emmerich AC; Ossipova E; Vogel M; Baumann I; Kultima K; Lengqivst J; Steinhilber D; Jakobsson PJ

Article: FRONTIERS IN PHARMACOLOGY. 2019;10:636

Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells

Bergqvist F; Ossipova E; Idborg H; Raouf J; Checa A; Englund K; Englund P; Khoonsari PE; Kultima K; Wheelock CE; Larsson K; Korotkova M; Jakobsson P-J

Editorial comment: FRONTIERS IN PHARMACOLOGY. 2019;10:1604

Editorial: New Therapies in the Field of Rheumatology

Chighizola CB; Jakobsson P-J; Gerosa M

Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients

Idborg H; Zandian A; Ossipova E; Wigren E; Preger C; Mobarrez F; Checa A; Sohrabian A; Pucholt P; Sandling JK; Fernandes-Cerqueira C; Ronnelid J; Oke V; Grosso G; Kvarnstrom M; Larsson A; Wheelock CE; Syvanen A-C; Ronnblom L; Kultima K; Persson H; Graslund S; Gunnarsson I; Nilsson P; Svenungsson E; Jakobsson P-J

Article: FRONTIERS IN MICROBIOLOGY. 2019;10:3121

sRNA scr5239 Involved in Feedback Loop Regulation of Streptomyces coelicolor Central Metabolism

Engel F; Ossipova E; Jakobsson P-J; Vockenhuber M-P; Suess B

Article: JOURNAL OF HEPATOLOGY. 2018;69(1):110-120

Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice

Nishizawa N; Ito Y; Eshima K; Ohkubo H; Kojo K; Inoue T; Raouf J; Jakobsson P-J; Uematsu S; Akira S; Narumiya S; Watanabe M; Majima M

Article: ACS CHEMICAL BIOLOGY. 2018;13(6):1525-1535

Stabilized Cyclic Peptides as Scavengers of Autoantibodies: Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

Gunasekera S; Fernandes-Cerqueira C; Wennmalm S; Wahamaa H; Sommarin Y; Catrina AI; Jakobsson P-J; Goransson U

Article: EBIOMEDICINE. 2018;32:84-92

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth

Kock A; Larsson K; Bergqvist F; Eissler N; Elfman LHM; Raouf J; Korotkova M; Johnsen JI; Jakobsson P-J; Kogner P

Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):83

Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis

Raouf J; Idborg H; Englund P; Alexanderson H; Dastmalchi M; Jakobsson P-J; Lundberg IE; Korotkova M

Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(2):203-211

Anticitrullinated protein/peptide antibody multiplexing defines an extended group of ACPA-positive rheumatoid arthritis patients with distinct genetic and environmental determinants

Ronnelid J; Hansson M; Mathsson-Alm L; Cornillet M; Reed E; Jakobsson P-J; Alfredsson L; Holmdahl R; Skriner K; Serre G; Lundberg K; Klareskog L

Article: LUPUS SCIENCE & MEDICINE. 2018;5(1):e000260

TNF-α and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus

Idborg H; Eketjall S; Pettersson S; Gustafsson JT; Zickert A; Kvarnstrom M; Oke V; Jakobsson P-J; Gunnarsson I; Svenungsson E

Article: LUPUS SCIENCE & MEDICINE. 2018;5(1):e000254

Kynurenine pathway is altered in patients with SLE and associated with severe fatigue

Akesson K; Pettersson S; Stahl S; Surowiec IM; Hedenstrom M; Eketjall S; Trygg J; Jakobsson P-J; Gunnarsson I; Svenungsson E; Idborg H

Review: FRONTIERS IN PHARMACOLOGY. 2018;9:356

The Effectiveness and Safety of Tripterygium wilfordii Hook. F Extracts in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis

Zhou Y-Y; Xia X; Peng W-K; Wang Q-H; Peng J-H; Li Y-L; Wu J-X; Zhang J-Y; Zhao Y; Chen X-M; Huang R-Y; Jakobsson P-J; Wen Z-H; Huang Q-C

Article: PLOS ONE. 2018;13(2):e0193210

Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen

Revathikumar P; Estelius J; Karmakar U; Le Maitre E; Korotkova M; Jakobsson P-J; Lampa J

Review: FRONTIERS IN PHARMACOLOGY. 2018;9:914

The Bone-Protecting Efficiency of Chinese Medicines Compared With Western Medicines in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Comparative Studies

Cai X; Chen X-M; Xia X; Bao K; Wang R-R; Peng J-H; Liu H-J; Yang Q-W; Yan J-Y; Wang M-J; Yu H; Lu J-J; Hu Y-J; Jakobsson P-J; Wen Z-H; Huang R-Y; Huang Q-C

Article: THERANOSTICS. 2018;8(16):4477-4490

Integration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Herman S; Khoonsari PE; Tolf A; Steinmetz J; Zetterberg H; Akerfeldt T; Jakobsson P-J; Larsson A; Spjuth O; Burman J; Kultima K

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2017;174(22):4087-4098

Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI₂: a safer alternative to COX-2 inhibition

Ozen G; Gomez I; Daci A; Deschildre C; Boubaya L; Teskin O; Uydes-Dogan BS; Jakobsson P-J; Longrois D; Topal G; Norel X

Article: LUPUS. 2017;26(10):1023-1033

Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study

Checa A; Idborg H; Zandian A; Sar DG; Surowiec I; Trygg J; Svenungsson E; Jakobsson P-J; Nilsson P; Gunnarsson I; Wheelock CE

Article: METABOLOMICS. 2017;13(10):114

Multivariate strategy for the sample selection and integration of multi-batch data in metabolomics

Surowiec I; Johansson E; Torell F; Idborg H; Gunnarsson I; Svenungsson E; Jakobsson P-J; Trygg J

Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(1):58-69

Differences in the Spectrum of Anti-Citrullinated Protein Antibody Fine Specificities Between Malaysian and Swedish Patients With Rheumatoid Arthritis: Implications for Disease Pathogenesis

Too CL; Murad S; Hansson M; Alm LM; Dhaliwal JS; Holmdahl R; Jakobsson P-J; Alfredsson L; Klareskog L; Ronnelid J; Padyukov L

Article: CLINICAL SCIENCE. 2016;130(24):2295-2303

Deletion of mPGES-1 affects platelet functions in mice

Raouf J; Mobarrez F; Larsson K; Jakobsson P-J; Korotkova M

Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):256

Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism

Revathikumar P; Bergqvist F; Gopalakrishnan S; Korotkova M; Jakobsson P-J; Lampa J; Le Maitre E

Article: SCIENTIFIC REPORTS. 2016;6:31995

UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance

Saul MJ; Stein S; Grez M; Jakobsson P-J; Steinhilber D; Suess B

Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(7):1738-1750

Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis

Munters LA; Loell I; Ossipova E; Raouf J; Dastmalchi M; Lindroos E; Chen Y-W; Esbjornsson M; Korotkova M; Alexanderson H; Nagaraju K; Crofford LJ; Jakobsson P-J; Lundberg IE

Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):730-738

Autoantibodies to citrullinated proteins induce joint pain independent of inflammation via a chemokine-dependent mechanism

Wigerblad G; Bas DB; Fernades-Cerqueira C; Krishnamurthy A; Nandakumar KS; Rogoz K; Kato J; Sandor K; Su J; Miguel Jimenez-Andrade J; Finn A; Farinotti AB; Amara K; Lundberg K; Holmdahl R; Jakobsson P-J; Malmstrom V; Catrina AI; Klareskog L; Svensson CI

Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(4):721-729

Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss

Krishnamurthy A; Joshua V; Hensvold AH; Jin T; Sun M; Vivar N; Ytterberg AJ; Engstrom M; Fernandes-Cerqueira C; Amara K; Magnusson M; Wigerblad G; Kato J; Jimenez-Andrade JM; Tyson K; Rapecki S; Lundberg K; Catrina S-B; Jakobsson P-J; Svensson C; Malmstrom V; Klareskog L; Wahamaa H; Catrina AI

Article: SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES. 2016;33(1):17-28

ALTERATIONS IN THE MEMBRANE-ASSOCIATED PROTEOME FRACTION OF ALVEOLAR MACROPHAGES IN SARCOIDOSIS

Kjellin H; Silva E; Branca RM; Eklund A; Jakobsson P-J; Grunewald J; Lehtio J; Wheelock AM

Article: PLOS ONE. 2016;11(9):e0163600

Arg126 and Asp49 Are Essential for the Catalytic Function of Microsomal Prostaglandin E₂ Synthase 1 and Ser127 Is Not

Raouf J; Rafique N; Goodman MC; Idborg H; Bergqvist F; Armstrong RN; Jakobsson P-J; Morgenstern R; Spahiu L

Article: PLOS ONE. 2016;11(4):e0153751

Prostaglandin E₂ Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis

Garcia-Alonso V; Titos E; Alcaraz-Quiles J; Rius B; Lopategi A; Lopez-Vicario C; Jakobsson P-J; Delgado S; Lozano J; Claria J

Article: PLOS ONE. 2016;11(3):e0152116

Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs

Kumar RB; Zhu L; Idborg H; Radmark O; Jakobsson P-J; Rinaldo-Matthis A; Hebert H; Jegerschold C

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt B):155-162

Impaired vagus-mediated immunosuppression in microsomal prostaglandin E synthase-1 deficient mice

Le Maitre E; Revathikumar P; Idborg H; Raouf J; Korotkova M; Jakobsson P-J; Lampa J

Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(9):1772-1777

Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation

Ytterberg AJ; Joshua V; Reynisdottir G; Tarasova NK; Rutishauser D; Ossipova E; Hensvold AH; Eklund A; Skold CM; Grunewald J; Malmstrom V; Jakobsson PJ; Ronnelid J; Padyukov L; Zubarev RA; Klareskog L; Catrina AI

Editorial comment: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt A):1-3

Special Issue 5th European Workshop on Lipid Mediators

Topal G; Claria J; Norel X; Steinhilber D; Jakobsson P-J; Dogan SU; Bannenberg G

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;120:161-165

Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment

Larsson K; Jakobsson P-J

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(26):8070-8075

COX/mPGES-1/PGE₂ pathway depicts an inflammatory-dependent high-risk neuroblastoma subset

Larsson K; Kock A; Idborg H; Henriksson MA; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson P-J

Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):155

Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens

Fernandes-Cerqueira C; Ossipova E; Gunasekera S; Hansson M; Mathsson L; Catrina AI; Sommarin Y; Klareskog L; Lundberg K; Ronnelid J; Goransson U; Jakobsson P-J

Article: ONCOTARGET. 2015;6(12):10284-10296

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

Olesch C; Sha W; Angioni C; Sha LK; Acaf E; Patrignani P; Jakobsson P-J; Radeke HH; Groesch S; Geisslinger G; von Knethen A; Weigert A; Bruene B

Editorial comment: NATURE REVIEWS DRUG DISCOVERY. 2015;14(3):149-150

Preclinical target validation using patient-derived cells

Edwards AM; Arrowsmith CH; Bountra C; Bunnage ME; Feldmann M; Knight JC; Patel DD; Prinos P; Taylor MD; Sundstrom M

Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(2):375-380

Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins

Hensvold AH; Magnusson PKE; Joshua V; Hansson M; Israelsson L; Ferreira R; Jakobsson P-J; Holmdahl R; Hammarstrom L; Malmstrom V; Askling J; Klareskog L; Catrina AI

Article: PLOS ONE. 2015;10(7):e0133669

Expression of Prostaglandin E₂ Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients

de Hair MJH; Leclerc P; Newsum EC; Maijer KI; van de Sande MGH; Ramwadhdoebe TH; van Schaardenburg D; van Baarsen LGM; Korotkova M; Gerlag DM; Tak P-P; Jakobsson P-J

Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275

Evaluation of urinary prostaglandin E₂ metabolite as a biomarker in infants with fever due to viral infection

Idborg H; Pawelzik S-C; Perez-Manso M; Bjork L; Hamrin J; Herlenius E; Jakobsson P-J

Article: ARTHRITIS RESEARCH & THERAPY. 2014;16(4):R167

Affinity purified anti-citrullinated protein/peptide antibodies target antigens expressed in the rheumatoid joint

Ossipova E; Cerqueira CF; Reed E; Kharlamova N; Israelsson L; Holmdahl R; Nandakumar KS; Engstrom M; Harre U; Schett G; Catrina AI; Malmstrom V; Sommarin Y; Klareskog L; Jakobsson P-J; Lundberg K

Review: NATURE REVIEWS RHEUMATOLOGY. 2014;10(4):229-241

Persisting eicosanoid pathways in rheumatic diseases

Korotkova M; Jakobsson P-J

Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014;114(1):64-69

Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors

Korotkova M; Jakobsson P-J

Article: PLOS ONE. 2014;9(2):e87951

Differentially Expressed Proteins in Malignant and Benign Adrenocortical Tumors

Kjellin H; Johansson H; Hoog A; Lehtio J; Jakobsson P-J; Kjellman M

Article: PLOS ONE. 2014;9(11):e113924

IgG Antibodies to Cyclic Citrullinated Peptides Exhibit Profiles Specific in Terms of IgG Subclasses, Fc-Glycans and a Fab-Peptide Sequence

Lundstrom SL; Fernandes-Cerqueira C; Ytterberg AJ; Ossipova E; Hensvold AH; Jakobsson P-J; Malmstrom V; Catrina AI; Klareskog L; Lundberg K; Zubarev RA

Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2014;114(1):13-17

Neutralization of AntiCitrullinated Protein Antibodies in Rheumatoid Arthritis - A Way to Go?

Cerqueira CF; Klareskog L; Jakobsson P-J

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;107:26-34

Characterization of a human and murine mPGES-1 inhibitor and comparison to mPGES-1 genetic deletion in mouse models of inflammation

Leclerc P; Idborg H; Spahiu L; Larsson C; Nekhotiaeva N; Wannberg J; Stenberg P; Korotkova M; Jakobsson P-J

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;107:18-25

Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice

Idborg H; Olsson P; Leclerc P; Raouf J; Jakobsson P-J; Korotkova M

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;106:99-105

Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis

Howe LR; Subbaramaiah K; Kent CV; Zhou XK; Chang S-H; Hla T; Jakobsson P-J; Hudis CA; Dannenberg AJ

Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(9):2193-2201

NOD2-Mediated Innate Immune Signaling Regulates the Eicosanoids in Atherosclerosis

Liu H-Q; Zhang X-Y; Edfeldt K; Nijhuis MO; Idborg H; Back M; Roy J; Hedin U; Jakobsson P-J; Laman JD; de Kleijn DP; Pasterkamp G; Hansson GK; Yan Z-Q

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(25):10258-10263

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

Zirath H; Frenzel A; Oliynyk G; Segerstrom L; Westermark UK; Larsson K; Persson MM; Hultenby K; Lehtio J; Einvik C; Pahlman S; Kogner P; Jakobsson P-J; Henriksson MA

Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(6):2622-2629

Mass Spectrometry-Based Proteomics Identifies UPF1 as a Critical Gene Expression Regulator in MonoMac 6 Cells

Ochs MJ; Ossipova E; Oliynyk G; Steinhilber D; Suess B; Jakobsson P-J

Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(5):350-360

IL-1 β/HMGB1 Complexes Promote The PGE₂ Biosynthesis Pathway in Synovial Fibroblasts

Leclerc P; Wahamaa H; Idborg H; Jakobsson PJ; Harris HE; Korotkova M

Article: CARCINOGENESIS. 2013;34(5):1081-1088

Low-dose aspirin delays an inflammatory tumor progression in vivo in a transgenic mouse model of neuroblastoma

Carlson L-M; Rasmuson A; Idborg H; Segerstrom L; Jakobsson P-J; Sveinbjornsson B; Kogner P

Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;102:1-12

Characterization of a new mPGES-1 inhibitor in rat models of inflammation

Leclerc P; Pawelzik S-C; Idborg H; Spahiu L; Larsson C; Stenberg P; Korotkova M; Jakobsson P-J

Article: ARTHRITIS & RHEUMATOLOGY. 2013;65(4):899-910

Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis

Brink M; Hansson M; Mathsson L; Jakobsson P-J; Holmdahl R; Hallmans G; Stenlund H; Ronnelid J; Klareskog L; Rantapaa-Dahlqvist S

Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(2):293-299

Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis

Loell I; Munters LA; Pandya J; Zong M; Alexanderson H; Fasth AE; Hallengren CS; Radmark O; Lundberg IE; Jakobsson P-J; Korotkova M

Article: PEDIATRIC RESEARCH. 2012;72(5):460-467

mPGES-1 and prostaglandin E₂: vital role in inflammation, hypoxic response, and survival

Siljehav V; Hofstetter AO; Jakobsson P-J; Herlenius E

Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(5):R201

Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides

Hansson M; Mathsson L; Schlederer T; Israelsson L; Matsson P; Nogueira L; Jakobsson P-J; Lundberg K; Malmstrom V; Serre G; Holmdahl R; Nystrand M; Klareskog L; Ronnelid J

Article: CIRCULATION. 2012;125(23):2904-2913

Lack of Microsomal Prostaglandin E₂ Synthase-1 in Bone Marrow-Derived Myeloid Cells Impairs Left Ventricular Function and Increases Mortality After Acute Myocardial Infarction

Degousee N; Simpson J; Fazel S; Scholich K; Angoulvant D; Angioni C; Schmidt H; Korotkova M; Stefanski E; Wang X-H; Lindsay TF; Ofek E; Pierre S; Butany J; Jakobsson P-J; Keating A; Li R-K; Nahrendorf M; Geisslinger G; Backx PH; Rubin BB

Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(3):R121

Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue

Gheorghe KR; Sadique S; Leclerc P; Idborg H; Wobst I; Catrina AI; Jakobsson P-J; Korotkova M

Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(5):1791-1802

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

Harre U; Georgess D; Bang H; Bozec A; Axmann R; Ossipova E; Jakobsson P-J; Baum W; Nimmerjahn F; Szarka E; Sarmay G; Krumbholz G; Neumann E; Toes R; Scherer H-U; Catrina AI; Klareskog L; Jurdic P; Schett G

Article: BIOCHEMISTRY. 2012;51(11):2348-2356

Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone 15-Deoxy-Δ^12,14-prostaglandin J₂

Prage EB; Morgenstern R; Jakobsson P-J; Stec DF; Voehler MW; Armstrong RN

Review: CHEMICAL REVIEWS. 2011;111(10):5821-5865

Enzymes of the Cyclooxygenase Pathways of Prostanoid Biosynthesis

Smith WL; Urade Y; Jakobsson P-J

Article: BIOCHEMISTRY. 2011;50(35):7684-7693

Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1

Prage EB; Pawelzik S-C; Busenlehner LS; Kim K; Morgenstern R; Jakobsson P-J; Armstrong RN

Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(8):908-914

Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis

Korotkova M; Daha NA; Seddighzadeh M; Ding B; Catrina AI; Lindblad S; Huizinga TWJ; Toes REM; Alfredsson L; Klareskog L; Jakobsson P-J; Padyukov L

Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;178(4):1676-1688

Expression of Prostaglandin E Synthases in Periodontitis Immunolocalization and Cellular Regulation

Bage T; Kats A; Lopez BS; Morgan G; Nilsson G; Burt I; Korotkova M; Corbett L; Knox AJ; Pino L; Jakobsson P-J; Modeer T; Yucel-Lindberg T

Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:A3

HUMORAL IMMUNE RESPONSE AGAINST FIBRINOGEN EPITOPES CITRULLINATED IN VIVO IN RHEUMATOID ARTHRITIS SYNOVIAL TISSUE DETECTED BY AUTOANTIBODY MULTIPLEXING

Ronnelid J; Ossipova E; Mathsson L; Catrina A; Matsson P; Israelsson L; Malmstrom V; Klareskog L; Jakobsson P-J

Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a23-A24

PROTEOME ANALYSIS REVEALS AN UPREGULATION OF HEAT-SHOCK PROTEINS IN LPS-INDUCED PERITONEAL MACROPHAGES FROM MPGES-1 KNOCK-OUT MICE

Korotkova M; Ossipova E; Idborg H; Ghorghe K; Leclerc P; Jakobsson P-J

Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:A75

LIMITED EFFECTS OF METHOTREXATE ON ENZYMES OF THE PGE₂ PATHWAY IN RHEUMATOID ARTHRITIS SYNOVIAL TISSUE

Gheorghe KR; Sadique S; Idborg H; Wobst Y; Catrina AI; Jakobsson P-J; Korotkova M

Article: AMINO ACIDS. 2011;40(2):697-711

Observed peptide pI and retention time shifts as a result of post-translational modifications in multidimensional separations using narrow-range IPG-IEF

Lengqvist J; Eriksson H; Gry M; Uhlen K; Bjorklund C; Bjellqvist B; Jakobsson P-J; Lehtio J

Article: PLOS ONE. 2011;6(1):e16378

Prostaglandin E₂ Synthesizing Enzymes in Rheumatoid Arthritis B Cells and the Effects of B Cell Depleting Therapy on Enzyme Expression

Gheorghe KR; Thurlings RM; Westman M; Boumans MJ; Malmstrom V; Trollmo C; Korotkova M; Jakobsson P-J; Tak P-P

Editorial comment: NATURE REVIEWS RHEUMATOLOGY. 2010;6(12):679-681

PAIN How macrophages mediate inflammatory pain via ATP signaling

Jakobsson P-J

Article: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY. 2010;152(2):205-209

C. albicans activates cyclooxygenase but not its product prostaglandin E₂ in HPV 16-stabilized cells

Deva R; Sczepanski M; Saha S; Zafiriou M-P; Kerstin N; Jakobsson P-J; Inoue Y; Nigam S

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(38):29254-29261

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

Pawelzik S-C; Uda NR; Spahiu L; Jegerschold C; Stenberg P; Hebert H; Morgenstern R; Jakobsson P-J

Article: PROTEOMICS CLINICAL APPLICATIONS. 2010;4(5):511-518

MS analysis of rheumatoid arthritic synovial tissue identifies specific citrullination sites on fibrinogen

Hermansson M; Artemenko K; Ossipova E; Eriksson H; Lengqvist J; Makrygiannakis D; Catrina AI; Nicholas AP; Klareskog L; Savitski M; Zubarev RA; Jakobsson P-J

Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(4):462-472

Hyperforin induces Ca²⁺-Andependent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A₂ activation through select phospholipid interactions

Hoffmann M; Lopez JJ; Pergola C; Feisst C; Pawelczik S; Jakobsson P-J; Sorg BL; Glaubitz C; Steinhilber D; Werz O

Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:a4-A5

IDENTIFICATION OF SPECIFIC CITRULLINATION SITES ON FIBRINOGEN IN RA

Ossipova E; Malmstrom V; Catrina AI; Klareskog L; Zubarev R; Jakobsson P-J

Article: NEUROSCIENCE LETTERS. 2010;470(1):10-12

Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide

Elander L; Ruud J; Korotkova M; Jakobsson P-J; Blomqvist A

Article: FRONTIERS IN PHARMACOLOGY. 2010;1:146

Microsomal prostaglandin E synthase-1 in rheumatic diseases

Korotkova M; Jakobsson P-J

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762

Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells

Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjornsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Radmark O

Article: LEUKEMIA & LYMPHOMA. 2009;50(7):1198-1203

Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide

Johansson A-S; Pawelzik S-C; Larefalk A; Jakobsson P-J; Holmberg D; Lindskog M

Article: JOURNAL OF NEUROSCIENCE. 2009;29(5):1404-1413

Inducible Prostaglandin E₂ Synthesis Interacts in a Temporally Supplementary Sequence with Constitutive Prostaglandin-Synthesizing Enzymes in Creating the Hypothalamic-Pituitary-Adrenal Axis Response to Immune Challenge

Elander L; Engstrom L; Ruud J; Mackerlova L; Jakobsson P-J; Engblom D; Nilsberth C; Blomqvist A

Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R83

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

Gheorghe KR; Korotkova M; Catrina AI; Backman L; Af Klint E; Claesson H-E; Radmark O; Jakobsson P-J

Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(11):1596-1602

Effects of immunosuppressive treatment on microsomal prostaglandin E synthase 1 and cyclooxygenases expression in muscle tissue of patients with polymyositis or dermatomyositis

Korotkova M; Helmers SB; Loell I; Alexanderson H; Grundtman C; Dorph C; Lundberg IE; Jakobsson P-J

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(32):11110-11115

Structural basis for induced formation of the inflammatory mediator prostaglandin E₂

Jegerschold C; Paweizik S-C; Purhonen P; Bhakat P; Gheorghe KR; Gyobu N; Mitsuoka K; Morgenstern R; Jakobsson P-J; Hebert H

Article: PROTEOMICS. 2008;8(15):3008-3018

Quantitative membrane proteomics applying narrow range peptide isoelectric focusing for studies of small cell lung cancer resistance mechanisms

Eriksson H; Lengqvist J; Hedlund J; Uhlen K; Orre LM; Bjellqvist B; Persson B; Lehtio J; Jakobsson P-J

Article: CIRCULATION. 2008;117(13):1701-1710

Microsomal prostaglandin E₂ synthase-1 deletion leads to adverse left ventricular remodeling after myocardial infarction

Degousee N; Fazel S; Angoulvant D; Stefanski E; Pawelzik S-C; Korotkova M; Arab S; Liu P; Lindsay TF; Zhuo S; Butany J; Li R-K; Audoly L; Schmidt R; Angioni C; Geisslinger G; Jakobsson P-J; Rubin BB

Review: PHARMACOLOGICAL REVIEWS. 2007;59(3):207-224

Membrane prostaglandin E synthase-1: A novel therapeutic target

Samuelsson B; Morgenstern R; Jakobsson P-J

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(23):9894-9899

The induced prostaglandin E₂ pathway is a key regulator of the respiratory response to infection and hypoxia in neonates

Hofstetter AO; Saha S; Siljehav V; Jakobsson P-J; Herlenius E

Article: FASEB JOURNAL. 2006;20(9):1352-1360

Inhibition of prostaglandin E₂ synthesis by SC-560 is independent of cyclooxygenase 1 inhibition

Brenneis C; Maier TJ; Schmidt R; Hofacker A; Zulauf L; Jakobsson P-J; Scholich K; Geisslinger G

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(24):16443-16452

c-Jun N-terminal kinase-mediated stabilization of microsomal prostaglandin E₂ synthase-1 mRNA regulates delayed microsomal prostaglandin E₂ synthase-1 expression and prostaglandin E₂ biosynthesis by cardiomyocytes

Degousee N; Angoulvant D; Fazel S; Stefanski E; Saha S; Iliescu K; Lindsay TF; Fish JE; Marsden PA; Li R-K; Audoly LP; Jakobsson P-J; Rubin BB

Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3439-3447

Effects of antirheumatic treatments on the prostaglandin E₂ Biosynthetic pathway

Korotkova M; Westman M; Gheorghe KR; af Klint E; Trollmo C; Ulfgren AK; Klareskog L; Jakobsson PJ

Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2005;288(5):R1100-R1107

Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1

Saha S; Engstrom L; Mackerlova L; Jakobsson PJ; Blomqvist A

Article: FEBS JOURNAL. 2005;272(7):1688-1703

Bioinformatic and enzymatic characterization of the MAPEG superfamily

Bresell A; Weinander R; Lundqvist G; Raza H; Shimoji M; Sun TH; Balk L; Wiklund R; Eriksson J; Jansson C; Persson B; Jakobsson PJ; Morgenstern R

Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2005;401:147-161

Human microsomal prostaglandin E synthase 1:: A member of the MAPEG protein superfamily

Pettersson PL; Thorén S; Jakobsson PJ

Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(1):87-94

Microsomal glutathione S-transferases:: selective up-regulation of leukotriene C₄ synthase during lipopolysaccharide-induced pyresis

Schröder O; Sjöström M; Qiu H; Jakobsson PJ; Haeggström JZ

Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S34

Effects of anti-rheumatic treatments on the prostaglandin E₂ biosynthetic pathway in synovial tissue and synovial fluid cells from patients with rheumatoid arthritis

Korotkova M; Westman M; Gheorghe KR; af Klint E; Trollmo C; Ulfgren A-K; Klareskog L; Jakobsson P-J

Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2005;7:S35

Expression of microsomal prostaglandin E synthase-1 in muscle tissue of patients with idiopathic inflammatory myopathies

Korotkova I; Barbasso S; Jakobsson P-J; Lundberg I

Meeting abstract: PEDIATRIC RESEARCH. 2004;56(3):482

Reduced expression of microsomal prostaglandin synthase 1 attenuates ventilatory effects of interleukin-1A in neonatal DBA/1LacJ mice

Hofstetter AO; Saha S; Lagercrantz H; Jakobsson PJ; Herlenius E

Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(6):1774-1780

Expression of microsomal prostaglandin E synthase 1 in rheumatoid arthritis synovium

Westman M; Korotkova M; af Klint E; Stark A; Audoly LP; Klareskog L; Ulfgren AK; Jakobsson P

Meeting abstract: ARTHRITIS RESEARCH & THERAPY. 2004;6:S32-S33

Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium

Korotkova M; Westman M; af Klint E; Ulfgren AK; Klareskog L; Jakobsson PJ

Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;312(2):271-276

Molecular and catalytic properties of three rat leukotriene C₄ synthase homologs

Schröder O; Sjöström M; Qiu H; Stein J; Jakobsson PJ; Haeggström JZ

Article: INTERNATIONAL JOURNAL OF CANCER. 2003;107(4):551-556

Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines

van Rees BP; Sivula A; Thorén S; Yokozaki H; Jakobsson PJ; Offerhaus GJA; Ristimäki A

Article: NATURE NEUROSCIENCE. 2003;6(11):1137-1138

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

Engblom D; Saha S; Engström L; Westman M; Audoly LP; Jakobsson PJ; Blomqvist A

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(15):9044-9049

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

Trebino CE; Stock JL; Gibbons CP; Naiman BM; Wachtmann TS; Umland JP; Pandher K; Lapointe JM; Saha S; Roach ML; Carter D; Thomas NA; Durtschi BA; McNeish JD; Hambor JE; Jakobsson PJ; Carty TJ; Perez JR; Audoly LP

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(25):22199-22209

Human microsomal prostaglandin E synthase-1 -: Purification, functional characterization, and projection structure determination

Thorén S; Weinander R; Saha S; Jegerschöld C; Pettersson PL; Samuelsson B; Hebert H; Hamberg M; Morgenstern R; Jakobsson PJ

Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1627(2-3):79-84

Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3

Ekström L; Lyrenäs L; Jakobsson PJ; Morgenstern R; Kelner MJ

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(47):44877-44885

Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides

Kozak KR; Crews BC; Morrow JD; Wang LH; Ma YH; Weinander R; Jakobsson PJ; Marnett LJ

Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2002;452(3):205-214

Induction of microsomal prostaglandin E synthase in the rat brain endothelium and parenchyma in adjuvant-induced arthritis

Engblom D; Ek M; Andersson IM; Saha S; Dahlström M; Jakobsson PJ; Ericsson-Dahlstrand A; Blomqvist A

Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1583(1):53-62

Human mast cells express two leukotriene C₄ synthase isoenzymes and the CysLT₁ receptor

Sjöström M; Jakobsson PJ; Juremalm M; Ahmed A; Nilsson G; Macchia L; Haeggström JZ

Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;507:287-291

Characterization of microsomal, glutathione dependent prostaglandin E synthase

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B

Article: NEUROSCIENCE. 2002;115(3):891-897

Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system

Fetissov SO; Schröder O; Jakobsson PJ; Samuelsson B; Haeggström JZ; Hökfelt T

Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2002;80(1):5-15

Prostaglandins as inflammatory messengers across the blood-brain barrier

Engblom D; Ek M; Saha S; Ericsson-Dahlstrand A; Jakobsson PJ; Blomqvist A

Article: CLINICAL CANCER RESEARCH. 2001;7(12):3971-3976

Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer

Yoshimatsu K; Golijanin D; Paty PB; Soslow RA; Jakobsson PJ; DeLellis RA; Subbaramaiah K; Dannenberg AJ

Article: CLINICAL CANCER RESEARCH. 2001;7(9):2669-2674

Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer

Yoshimatsu K; Altorki NK; Golijanin D; Zhang F; Jakobsson PJ; Dannenberg AJ; Subbaramaiah K

Article: JOURNAL OF IMMUNOLOGY. 2001;167(1):469-474

Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells

Stichtenoth DO; Thorén S; Bian HM; Peters-Golden M; Jakobsson PJ; Crofford LJ

Article: FEBS JOURNAL. 2001;268(9):2578-2586

Human umbilical vein endothelial cells generate leukotriene C₄ via microsomal glutathione S-transferase type 2 and express the CysLT₁ receptor

Sjöström M; Jakobsson PJ; Heimburger M; Palmblad J; Haeggström JZ

Article: NATURE. 2001;410(6827):430-431

Inflammatory response - Pathway across the blood-brain barrier

Ek M; Engblom D; Saha S; Blomqvist A; Jakobsson PJ; Ericsson-Dahlstrand A

Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):301-303

Structure and transcriptional regulation of the human microsomal glutathione transferase 1 (MGST1) and prostaglandin E synthase (PGES) genes

Forsberg L; Persson L; Kelner MJ; Jakobsson PJ; Morgenstern R

Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):153-154

Prostaglandin E synthase:: a microsomal, glutathione dependent, inducible member of the MAPEG superfamily

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B

Article: FEBS JOURNAL. 2000;267(21):6428-6434

Coordinate up- and down-regulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells -: Inhibition by NS-398 and leukotriene C₄

Thorén S; Jakobsson PJ

Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;276(2):488-492

Functional coupling of cyclooxygenase 1 and 2 to discrete prostanoid synthases in liver macrophages

Dieter P; Scheibe R; Jakobsson PJ; Watanabe K; Kolada A; Kamionka S

Article: FEBS LETTERS. 2000;471(1):78-82

Human glutathione dependent prostaglandin E synthase:: gene structure and regulation

Forsberg L; Leeb L; Thorén S; Morgenstern R; Jakobsson PJ

Article: BLOOD. 2000;95(4):1456-1464

Aberrant expression of active leukotriene C₄ synthase in CD16⁺ neutrophils from patients with chronic myeloid leukemia

Sjölinder M; Stenke L; Näsman-Glaser B; Widell S; Doucet J; Jakobsson PJ; Lindgren J

Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2):S20-S24

Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG) - A widespread protein superfamily

Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(13):7220-7225

Identification of human prostaglandin E synthase:: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Jakobsson PJ; Thorén S; Morgenstern R; Samuelsson B

Article: PROTEIN SCIENCE. 1999;8(3):689-692

Common structural features of MAPEG -: A widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

Jakobsson PJ; Morgenstern R; Mancini J; Ford-Hutchinson A; Persson B

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(36):22934-22939

Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.

Jakobsson PJ; Mancini JA; Riendeau D; Ford-Hutchinson AW

Article: JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING. 1997;17(1):15-19

Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer.

Jakobsson PJ; Scoggan KA; Yergey J; Mancini JA; Ford-Hutchinson AW

Article: CELL DEATH AND DIFFERENTIATION. 1997;4(6):479-486

Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells

Vanags DM; Larsson P; Feltenmark S; Jakobsson PJ; Orrenius S; Claesson HE; AguilarSantelises M

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(15):10182-10187

Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes.

Scoggan KA; Jakobsson PJ; Ford-Hutchinson AW

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(36):22203-22210

Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase.

Jakobsson PJ; Mancini JA; Ford-Hutchinson AW

Article: FEBS JOURNAL. 1995;232(1):37-46

STUDIES ON THE REGULATION AND LOCALIZATION OF 5-LIPOXYGENASE IN HUMAN B-LYMPHOCYTES

JAKOBSSON PJ; SHASKIN P; LARSSON P; FELTENMARK S; ODLANDER B; AGUILARSANTELISES M; JONDAL M; BIBERFELD P; CLAESSON HE

Article: BRITISH JOURNAL OF HAEMATOLOGY. 1995;90(3):585-594

DIVERSE EXPRESSION OF CYTOSOLIC PHOSPHOLIPASE-A(2), 5-LIPOXYGENASE AND PROSTAGLANDIN-H SYNTHASE-2 IN ACUTE PRE-B-LYMPHOCYTIC LEUKEMIA-CELLS

FELTENMARK S; RUNARSSON G; LARSSON P; JAKOBSSON PJ; BJORKHOLM M; CLAESSON HE

Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:293-298

THE 5-LIPOXYGENASE PATHWAY IN NORMAL AND MALIGNANT HUMAN B-LYMPHOCYTES

JAKOBSSON PJ; LARSSON P; FELTENMARK S; ODLANDER B; RUNARSSON G; BJORKHOLM M; CLAESSON HE

Chronic inflammation with focus on rheumatology and cancer – Research group Per-Johan Jakobsson

Publications

All publications from group members

Staff and contact

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All members of the group

Chronic inflammation with focus on rheumatology and cancer – Research group Per-Johan Jakobsson

Team

Publications

All publications from group members

Staff and contact

Group leader

All members of the group