Lung-brain Axis – Lara Kular's team

Publications

All publications from group members

• Preprint: BIORXIV. 2026

  Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

  Han Y; Zheleznyakova GY; Sorini C; Kakhki MP; Ruffin N; Liang H; Hallen N; Prakash CR; Beckers V; Ivanova E; Khademi M; Karlsson MCI; Piehl F; Olsson T; Kelsey G; Kular L; Needhamsen M; Jagodic M
• Article: GENOME BIOLOGY. 2026;27(1):52

  Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects

  Pahlevan Kakhki M; Rangani F; Ewing E; Starvaggi Cucuzza C; Zheleznyakova G; Kalomoiri M; Kenny L; Raghavan A; Rao Prakash C; van den Hoeven G; Venkata S. Badam T; Covacu R; Andreou I; Needhamsen M; Kular L; Jagodic M
• Editorial: BRAIN. 2025;148(9):3026-3028

  Tackling neuronal stress and neuroinflammation to prevent side effects of brain radiotherapy

  Kular L; Gubanski M; Bartek J; Jagodic M
• Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2025;31(3):1098

  Exploration of small non-coding RNAs in Multiple Sclerosis

  Rangani F; Kakhki MP; Prakash CR; Badam TVS; Ekman D; Sagir F; Piket E; Manouchehrinia A; Khademi M; Piehl F; Olsson T; Needhamsen M; Jagodic M
• Article: BMC BIOINFORMATICS. 2025;26(1):219

  GeneSetCluster 2.0: a comprehensive toolset for summarizing and integrating gene-sets analysis

  Ortega-Legarreta A; Maillo A; Mouzo D; Lopez-Perez AR; Kular L; Pahlevan Kakhki M; Jagodic M; Tegner J; Lagani V; Ewing E; Gomez-Cabrero D
• Article: EBIOMEDICINE. 2024;110:105470

  Epigenetic age acceleration as a biomarker of amyotrophic lateral sclerosis severity?

  Lewandowski SA; Kular L; Jagodic M
• Article: NATURE COMMUNICATIONS. 2024;15(1):6419

  A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis

  Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
• Article: BRAIN, BEHAVIOR, & IMMUNITY - HEALTH. 2024;38:100787

  The lung-brain axis in multiple sclerosis: Mechanistic insights and future directions

  Kular L
• Article: ACTA NEUROPATHOLOGICA. 2024;147(1):82

  Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS

  Windener F; Grewing L; Thomas C; Dorion M-F; Otteken M; Kular L; Jagodic M; Antel J; Albrecht S; Kuhlmann T
• Article: NATURE IMMUNOLOGY. 2024;25(3):432-447

  The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology

  Linnerbauer M; Loesslein L; Vandrey O; Peter A; Han Y; Tsaktanis T; Wogram E; Needhamsen M; Kular L; Nagel L; Zissler J; Andert M; Meszaros L; Hanspach J; Zuber F; Naumann UJ; Diebold M; Wheeler MA; Beyer T; Nirschl L; Cirac A; Laun FB; Guenther C; Winkler J; Baeuerle T; Jagodic M; Hemmer B; Prinz M; Quintana FJ; Rothhammer V
• Book chapter: NEUROPSYCHIATRIC DISORDERS AND EPIGENETICS. 2024;p. 183-223

  Chapter 9 Epigenetics and multiple sclerosis

  Kular L; Castelo-Branco G; Jagodic M
• Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2023;79:104991

  Smoking affects epigenetic ageing of lung bronchoalveolar lavage cells in Multiple Sclerosis

  Klose D; Needhamsen M; Ringh MV; Hagemann-Jensen M; Jagodic M; Kular L
• Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1251772

  Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing

  Kalomoiri M; Prakash CR; Lagstroem S; Hauschulz K; Ewing E; Shchetynsky K; Kular L; Needhamsen M; Jagodic M
• Article: NEUROLOGY. 2023;101(7):e679-e689

  Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis

  Maltby V; Xavier A; Ewing E; Campagna M-P; Sampangi S; Scott RJ; Butzkueven H; Jokubaitis V; Kular L; Bos S; Slee M; van der Mei IA; Taylor BV; Ponsonby A-L; Jagodic M; Lea R; Lechner-Scott J
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(16):12576

  DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes

  Xavier A; Maltby VE; Ewing E; Campagna MP; Burnard SM; Tegner JN; Slee M; Butzkueven H; Kockum I; Kular L; Jokubaitis VG; Kilpatrick T; Alfredsson L; Jagodic M; Ponsonby A-L; Taylor BV; Scott RJ; Lea RA; Lechner-Scott J
• Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2023;160:217-224

  Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt: A cross-sectional study of suicide attempters

  Bostrom AED; Jamshidi E; Manu D-M; Kular L; Schioth HB; Asberg M; Jokinen J
• Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:926468

  Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients

  Kular L; Klose D; Urdanoz-Casado A; Ewing E; Planell N; Gomez-Cabrero D; Needhamsen M; Jagodic M
• Article: EPIGENETICS. 2022;17(11):1311-1330

  DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients

  Kular L; Ewing E; Needhamsen M; Kakhki MP; Covacu R; Gomez-Cabrero D; Brundin L; Jagodic M
• Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026

  Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking

  Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Jagodic M; Ekstrom TJ; Ockinger J; Kular L
• Article: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS. 2020;37(9):2137-2150

  Culture of human ovarian tissue in xeno-free conditions using laminin components of the human ovarian extracellular matrix

  Hao J; Tuck AR; Prakash CR; Damdimopoulos A; Sjodin MOD; Lindberg J; Niklasson B; Pettersson K; Hovatta O; Damdimopoulou P
• Article: EPIGENETICS. 2020;15(6-7):646-663

  Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression

  Ciuculete DM; Voisin S; Kular L; Welihinda N; Jonsson J; Jagodic M; Mwinyi J; Schioth HB
• Article: CLINICAL EPIGENETICS. 2020;12(1):99

  meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes

  Ciuculete DM; Voisin S; Kular L; Jonsson J; Rask-Andersen M; Mwinyi J; Schioth HB
• Review: JOURNAL OF INTERNAL MEDICINE. 2020;288(1):82-102

  Epigenetic insights into multiple sclerosis disease progression

  Kular L; Jagodic M
• Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852

  C-type lectin receptors Mcl and Mincle contro development of multiple sclerosis like neuroinflammation

  N'diaye M; Brauner S; Flytzani S; Kular L; Warnecke A; Adzemovic MZ; Piket E; Min J-H; Edwards W; Mela F; Choi HY; Magg V; James T; Linden M; Reichardt HM; Daws MR; van Horssen J; Kockum I; Harris RA; Olsson T; Guerreiro-Cacais AO; Jagodic M
• Article: EBIOMEDICINE. 2019;46:290-304

  Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells

  Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjoholm LK; Slavec L; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Ockinger J; Ekstrom TJ
• Article: JOURNAL OF AUTOIMMUNITY. 2019;101:17-25

  Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview

  Piket E; Zheleznyakova GY; Kular L; Jagodic M
• Article: CLINICAL EPIGENETICS. 2019;11(1):86

  Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

  Kular L; Needhamsen M; Adzemovic MZ; Kramarova T; Gomez-Cabrero D; Ewing E; Piket E; Tegner J; Beck S; Piehl F; Brundin L; Jagodic M
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452

  Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration

  Li D; Kular L; Vij M; Herter EK; Li X; Wang A; Chu T; Toma M-A; Zhang L; Liapi E; Mota A; Blomqvist L; Serezal IG; Rollman O; Wikstrom JD; Bienko M; Berglund D; Stahle M; Sommar P; Jagodic M; Landen NX
• Article: EBIOMEDICINE. 2019;43:411-423

  Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression

  Ewing E; Kular L; Fernandes SJ; Karathanasis N; Lagani V; Ruhrmann S; Tsamardinos I; Tegner J; Piehl F; Gomez-Cabrero D; Jagodic M
• Review: EVOLUTION PSYCHIATRIQUE. 2019;84(1):207-221

  Epigenetics as a partner of psychiatry: Toward a personalized approach of the patient

  Kular S; Kular L
• Article: NATURE COMMUNICATIONS. 2018;9(1):4845

  Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

  Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
• Article: MULTIPLE SCLEROSIS JOURNAL. 2018;24(10):1288-1300

  Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

  Ruhrmann S; Ewing E; Piket E; Kular L; Lorenzi JCC; Fernandes SJ; Morikawa H; Aeinehband S; Sayols-Baixeras S; Aslibekyan S; Absher DM; Arnett DK; Tegner J; Gomez-Cabrero D; Piehl F; Jagodic M
• Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2018;102:44-51

  Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents

  Ciuculete DM; Bostrom AE; Tuunainen A-K; Sohrabi F; Kular L; Jagodic M; Voisin S; Mwinyi J; Schioth HB
• Article: NATURE COMMUNICATIONS. 2018;9(1):2397

  DNA methylation as a mediator of HLA-DRB1^☆15:01 and a protective variant in multiple sclerosis

  Kular L; Liu Y; Ruhrmann S; Zheleznyakova G; Marabita F; Gomez-Cabrero D; James T; Ewing E; Linden M; Gornikiewicz B; Aeinehband S; Stridh P; Link J; Andlauer TFM; Gasperi C; Wiendl H; Zipp F; Gold R; Tackenberg B; Weber F; Hemmer B; Strauch K; Heilmann-Heimbach S; Rawal R; Schminke U; Schmidt CO; Kacprowski T; Franke A; Laudes M; Dilthey AT; Celius EG; Sondergaard HB; Tegner J; Harbo HF; Oturai AB; Olafsson S; Eggertsson HP; Halldorsson BV; Hjaltason H; Olafsson E; Jonsdottir I; Stefansson K; Olsson T; Piehl F; Ekstroem TJ; Kockum I; Feinberg AP; Jagodic M
• Article: NATURE IMMUNOLOGY. 2018;19(5):1-7

  Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

  Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
• Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892

  Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis

  Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
• Review: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2018;72(4):195-211

  Epigenetics applied to psychiatry: Clinical opportunities and future challenges

  Kular L; Kular S
• Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):4340

  Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship (vol 7, 14589, 2017)

  Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(6):479-485

  Decreased Expression of IFNG-AS1, IFNG and IL-1B Inflammatory Genes in Medicated Schizophrenia and Bipolar Patients

  Ghafelehbashi H; Kakhki MP; Kular L; Moghbelinejad S; Ghafelehbashi SH
• Article: BMC BIOINFORMATICS. 2017;18(1):486

  Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies

  Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
• Article: SCIENTIFIC REPORTS. 2017;7(1):14589

  Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship

  Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
• Review: PHYSIOLOGICAL GENOMICS. 2017;49(9):447-461

  Epigenetic research in multiple sclerosis: progress, challenges, and opportunities

  Zheleznyakova GY; Piket E; Marabita F; Kakhki MP; Ewing E; Ruhrmann S; Needhamsen M; Jagodic M; Kular L
• Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2015;67:49-57

  Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?

  Ruhrmann S; Stridh P; Kular L; Jagodic M
• Article: JOURNAL OF IMMUNOLOGY. 2013;190(8):4066-4075

  Next-Generation Sequencing Identifies MicroRNAs that Associate with Pathogenic Autoimmune Neuroinflammation in Rats

  Bergman P; James T; Kular L; Ruhrmann S; Kramarova T; Kvist A; Supic G; Gillett A; Pivarcsi A; Jagodic M
• Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:36

  NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9.

  Kular L; Rivat C; Lelongt B; Calmel C; Laurent M; Pohl M; Kitabgi P; Melik-Parsadaniantz S; Martinerie C
• Review: BIOCHIMIE. 2011;93(3):377-388

  The CCN family: a new class of inflammation modulators?

  Kular L; Pakradouni J; Kitabgi P; Laurent M; Martinerie C
• Review: FRONTIERS IN NEUROENDOCRINOLOGY. 2011;32(1):10-24

  Chemokines and chemokine receptors: new actors in neuroendocrine regulations.

  Rostène W; Guyon A; Kular L; Godefroy D; Barbieri F; Bajetto A; Banisadr G; Callewaere C; Conductier G; Rovère C; Mélik-Parsadaniantz S; Florio T
• Article: GLIA. 2010;58(12):1510-1521

  NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins.

  Le Dréau G; Kular L; Nicot AB; Calmel C; Melik-Parsadaniantz S; Kitabgi P; Laurent M; Martinerie C
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Funding

Staff and contact

Group leader

• 

  Lara Kular

  Senior Research Specialist | Docent

  E-mail lara.kular@ki.se

All members of the group

• Mitra Barzine

  Affiliated to Research

  E-mail mitra.barzine@ki.se
• Paula Luisa Gigerl

  Research Assistant

  E-mail paula.gigerl@ki.se
• 

  Chandana Rao Prakash

  Phd Student

  E-mail chandana.rao.prakash@ki.se