Team Lars Maegdefessel
Our team is focused on understanding the therapeutic and biomarker potential of non-coding RNAs in vascular diseases.
Molecular Vascular Medicine
The lab aims to determine the microarchitecture of atherosclerotic plaques using multi-omics approaches, such as single cell, bulk and spatial RNA sequencing and proteomics. By using multi-omics data, we aim to identify novel therapies and biomarkers for vascular diseases, such as carotid artery disease and aortic aneurysms.
Team members
Lars Maegdefessel
Principal researcher/ Team leader.- Ekaterina Chernogubova, Laboratory engineer
- Hong Jin ,Senior forskningsspecialist
- Greg Winski, Affiliated to research
Alumni:
- Daniel Y. Li, PhD
- Susanne Eken, MD PhD
- Albert Busch, MD, PhD
- Changyan Sun, MSc
- Alexandra Bäcklund, PhD
Consortia and Networks
- European Vascular Biology Organization (EVBO; council committee member)
- Arteriosclerosis Thrombosis and Vascular Biology Section of the American Heart Association (AHA; leadership council)
Funding
- ERC
- Vetenkapsrådet
- Hjärt Lungfonden
- Ragnar Söderberg Foundation
Prizes and Awards
- ERC Starting (2016) and Consolidator Grants (2022)
- Ragnar Söderberg Fellow in Medicine (2014)
- Prince Daniel Research Award from HLF (2014)
PhD thesis
Contact
Ekaterina Chernogubova
Laboratory engineer/ Research coordinator.Selected Publications
Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression.
Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L
Mol Ther 2023 Jun;31(6):1775-1790
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases.
Paloschi V, Sabater-Lleal M, Middelkamp H, Vivas A, Johansson S, van der Meer A, Tenje M, Maegdefessel L
Cardiovasc Res 2021 Dec;117(14):2742-2754
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O
Nature 2019 May;569(7755):236-240
Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization.
Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Bäcklund A, Bergmark C, Paloschi V, Maegdefessel L
Circulation 2021 Nov;144(19):1567-1583
miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease.
Eken SM, Christersdottir T, Winski G, Sangsuwan T, Jin H, Chernogubova E, Pirault J, Sun C, Simon N, Winter H, Backlund A, Haghdoost S, Hansson GK, Halle M, Maegdefessel L
JACC Basic Transl Sci 2019 Feb;4(1):72-82
H19 Induces Abdominal Aortic Aneurysm Development and Progression.
Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam D, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L
Circulation 2018 Oct;138(15):1551-1568
Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions.
Jin H, Li DY, Chernogubova E, Sun C, Busch A, Eken SM, Saliba-Gustafsson P, Winter H, Winski G, Raaz U, Schellinger IN, Simon N, Hegenloh R, Matic LP, Jagodic M, Ehrenborg E, Pelisek J, Eckstein HH, Hedin U, Backlund A, Maegdefessel L
Mol Ther 2018 Apr;26(4):1040-1055
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions.
Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L
Circ Res 2017 Feb;120(4):633-644
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis.
Kojima Y, Volkmer JP, McKenna K, Civelek M, Lusis AJ, Miller CL, Direnzo D, Nanda V, Ye J, Connolly AJ, Schadt EE, Quertermous T, Betancur P, Maegdefessel L, Matic LP, Hedin U, Weissman IL, Leeper NJ
Nature 2016 Aug;536(7614):86-90
Dichloroacetate prevents restenosis in preclinical animal models of vessel injury.
Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S
Nature 2014 May;509(7502):641-4