Lars Maegdefessel

About me
Publications
Public outreach and news

Research

My research focus is on non-coding RNAs in vascular biology and medicine.
Please read more on my group's page [1].
[1] http://ki.se/en/meds/lars-maegdefessel-group

Articles

Article: CIRCULATION. 2024;149(24):1885-1898

Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease

Pan H; Ho SE; Xue C; Cui J; Johanson QS; Sachs N; Ross LS; Li F; Solomon RA; Connolly ES; Patel VI; Maegdefessel L; Zhang H; Reilly MP
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(4):930-945

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis

Bashore AC; Yan H; Xue C; Zhu LY; Kim E; Mawson T; Coronel J; Chung A; Sachs N; Ho S; Ross LS; Kissner M; Passegue E; Bauer RC; Maegdefessel L; Li M; Reilly MP
Article: MOLECULAR METABOLISM. 2024;82:101912

Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition

Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Article: ADVANCED HEALTHCARE MATERIALS. 2024;13(6):e2302907

Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases

Paloschi V; Pauli J; Winski G; Wu Z; Li Z; Botti L; Meucci S; Conti P; Rogowitz F; Glukha N; Hummel N; Busch A; Chernogubova E; Jin H; Sachs N; Eckstein H-H; Dueck A; Boon RA; Bausch AR; Maegdefessel L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024;44(1):3-6

Noncoding RNAs in the Vasculature: Basic Mechanisms and Therapeutic Perspectives

Maegdefessel L; Boon RA; Dimmeler S
Article: NAT CARDIOVASC RES. 2024;3(1):60-75

Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis

Fidler TP; Dunbar A; Kim E; Hardaway B; Pauli J; Xue C; Abramowicz S; Xiao T; O'Connor K; Sachs N; Wang N; Maegdefessel L; Levine R; Reilly M; Tall AR
Article: CIRCULATION RESEARCH. 2023;133(8):674-686

ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1

Sharifi MA; Wierer M; Dang TA; Milic J; Moggio A; Sachs N; von Scheidt M; Hinterdobler J; Mueller P; Werner J; Stiller B; Aherrahrou Z; Erdmann J; Zaliani A; Graettinger M; Reinshagen J; Gul S; Gribbon P; Maegdefessel L; Bernhagen J; Sager HB; Mann M; Schunkert H; Kessler T
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2023;33:848-865

The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms

Fasolo F; Winski G; Li Z; Wu Z; Winter H; Ritzer J; Glukha N; Roy J; Hultgren R; Pauli J; Busch A; Sachs N; Knappich C; Eckstein H-H; Boon RA; Paloschi V; Maegdefessel L
Article: JCI INSIGHT. 2023;8(17):e170845

Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta

Martinez MA; Ritsvall O; Bastrup JA; Celik S; Jakobsson G; Daoud F; Winqvist C; Aspberg A; Rippe C; Maegdefessel L; Schiopu A; Jepps TA; Holmberg J; Sward K; Albinsson S
Journal article: MEDRXIV. 2023;:2023.07.13.23292633

High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.

Bashore AC; Yan H; Xue C; Zhu LY; Kim E; Mawson T; Coronel J; Chung A; Ho S; Ross LS; Kissner M; Passegué E; Bauer RC; Maegdefessel L; Li M; Reilly MP
Article: BIOMOLECULES. 2023;13(7):1074

Apolipoprotein E (ApoE) Rescues the Contractile Smooth Muscle Cell Phenotype in Popliteal Artery Aneurysm Disease

Pauli J; Reisenauer T; Winski G; Sachs N; Chernogubova E; Freytag H; Otto C; Reeps C; Eckstein H-H; Scholz C-J; Maegdefessel L; Busch A
Article: CIRCULATION. 2023;148(1):47-67

INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10

Zhang W; Zhao J; Deng L; Ishimwe N; Pauli J; Wu W; Shan S; Kempf W; Ballantyne MD; Kim D; Lyu Q; Bennett M; Rodor J; Turner AW; Lu YW; Gao P; Choi M; Warthi G; Kim HW; Barroso MM; Bryant WB; Miller CL; Weintraub NL; Maegdefessel L; Miano JM; Baker AH; Long X
Article: MOLECULAR THERAPY. 2023;31(6):1775-1790

Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression

Winter H; Winski G; Busch A; Chernogubova E; Fasolo F; Wu Z; Baecklund A; Khomtchouk BB; Booven DJV; Sachs N; Eckstein H-H; Wittig I; Boon RA; Jin H; Maegdefessel L
Article: VASCULAR PHARMACOLOGY. 2023;150:107167

Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification

Skenteris NT; Hemme E; Delfos L; Karadimou G; Karlof E; Lengquist M; Kronqvist M; Zhang X; Maegdefessel L; Schurgers LJ; Arnardottir H; Biessen EAL; Bot I; Matic L
Article: CARDIOVASCULAR RESEARCH. 2023;119(3):867-878

E-cigarette exposure augments murine abdominal aortic aneurysm development: role of Chil1

Mulorz J; Spin JM; Mulorz P; Wagenhaeuser M; Deng A; Mattern K; Rhee YH; Toyama K; Adam M; Schelzig H; Maegdefessel L; Tsao PS
Article: THROMBOSIS AND HAEMOSTASIS. 2023;123(05):545-554

Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging

Ferraro B; Giustetto P; Schengel O; Weckbach LT; Maegdefessel L; Soehnlein O
Article: ATHEROSCLEROSIS. 2023;371:1-13

A comparative gene expression matrix in Apoe-deficient mice identifies unique and atherosclerotic disease stage-specific gene regulation patterns in monocytes and macrophages

Haerdtner C; Kumar A; Ehlert CA; Vico TA; Starz C; von Ehr A; Krebs K; Dufner B; Hoppe N; Stachon P; Heidt T; Wolf D; von zur Muehlen C; Gruening B; Robbins CS; Maegdefessel L; Westermann D; Dederichs T-S; Hilgendorf I
Article: VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE. 2023;52(2):124-132

CXCR4 - a possible serum marker for risk stratification of abdominal aortic aneurysms.

Reutersberg B; Metschl S; Salvermoser M; Eckstein H-H; Knappich C; Maegdefessel L; Jaroslav P; Busch A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(2):286-299

Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1)

Cynn E; Li DY; O'Reilly ME; Wang Y; Bashore AC; Jha A; Foulkes AS; Zhang H; Winter H; Maegdefessel L; Yan H; Li M; Ross L; Xue C; Reilly MP
Article: JVS - VASCULAR SCIENCE. 2023;4:100093

Rupture risk parameters upon biomechanical analysis independently change from vessel geometry during abdominal aortic aneurysm growth.

Zschäpitz D; Bohmann B; Lutz B; Eckstein H-H; Reeps C; Maegdefessel L; Gasser CT; Busch A
Article: SCIENTIFIC REPORTS. 2022;12(1):20990

Linking single nucleotide polymorphisms to signaling blueprints in abdominal aortic aneurysms

Lim C; Pratama MY; Rivera C; Silvestro M; Tsao PSS; Maegdefessel L; Gallagher KAA; Maldonado T; Ramkhelawon B
Article: CELL REPORTS. 2022;41(7):111670

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2.

Oo JA; Pálfi K; Warwick T; Wittig I; Prieto-Garcia C; Matkovic V; Tomašković I; Boos F; Izquierdo Ponce J; Teichmann T; Petriukov K; Haydar S; Maegdefessel L; Wu Z; Pham MD; Krishnan J; Baker AH; Günther S; Ulrich HD; Dikic I; Leisegang MS; Brandes RP
Article: NAT CARDIOVASC RES. 2022;1(11):1056-1071

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

Guillamat-Prats R; Hering D; Derle A; Rami M; Haerdtner C; Santovito D; Rinne P; Bindila L; Hristov M; Pagano S; Vuilleumier N; Schmid S; Janjic A; Enard W; Weber C; Maegdefessel L; Faussner A; Hilgendorf I; Steffens S
Article: CARDIOVASCULAR RESEARCH. 2022;118(13):2792-2804

Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells

Wang Y; Gao H; Wang F; Ye Z; Mokry M; Turner AW; Ye J; Koplev S; Luo L; Alsaigh T; Adkar SS; Elishaev M; Gao X; Maegdefessel L; Bjorkegren JLM; Pasterkamp G; Miller CL; Ross EG; Leeper NJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2022;79(10):512

Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation.

Brandhofer M; Hoffmann A; Blanchet X; Siminkovitch E; Rohlfing A-K; El Bounkari O; Nestele JA; Bild A; Kontos C; Hille K; Rohde V; Fröhlich A; Golemi J; Gokce O; Krammer C; Scheiermann P; Tsilimparis N; Sachs N; Kempf WE; Maegdefessel L; Otabil MK; Megens RTA; Ippel H; Koenen RR; Luo J; Engelmann B; Mayo KH; Gawaz M; Kapurniotu A; Weber C; von Hundelshausen P; Bernhagen J
Article: METABOLITES. 2022;12(9):840

Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR

Bauer S; Eigenmann J; Zhao Y; Fleig J; Hawe JS; Pan C; Bongiovanni D; Wengert S; Ma A; Lusis AJ; Kovacic JC; Bjoerkegren JLM; Maegdefessel L; Schunkert H; von Scheidt M
Article: THROMBOSIS AND HAEMOSTASIS. 2022;122(9):1513-1523

Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture.

Metschl S; Bruder L; Paloschi V; Jakob K; Reutersberg B; Reeps C; Maegdefessel L; Gee M; Eckstein H-H; Pelisek J
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2022;64(2-3):255-264

Radiation and Chemotherapy are Associated with Altered Aortic Aneurysm Growth in Patients with Cancer: Impact of Synchronous Cancer and Aortic Aneurysm

von Rose AB; Kobus K; Bohmann B; Lindquist-Lilljequist M; Eilenberg W; Bassermann F; Reeps C; Eckstein H-H; Trenner M; Maegdefessel L; Neumayer C; Brostjan C; Roy J; Hultgren R; Schwaiger BJ; Busch A
Article: CIRCULATION RESEARCH. 2022;131(1):42-58

miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages

My-Anh N; Huy-Dung H; Rasheed A; Duchez A-C; Wyatt H; Cottee ML; Graber TE; Susser L; Robichaud S; Berber I; Geoffrion M; Ouimet M; Kazan H; Maegdefessel L; Mulvihill EE; Alain T; Rayner KJ
Article: JOURNAL OF CELL SCIENCE. 2022;135(12):jcs259671

The long non-coding RNA MEG8 induces an endothelial barrier through regulation of microRNA-370 and-494 processing

Kremer V; Stanicek L; van Ingen E; Bink DI; Hilderink S; Tijsen AJ; Wittig I; Maegdefessel L; Nossent AY; Boon RA
Article: NATURE COMMUNICATIONS. 2022;13(1):2867

ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries.

Kaufmann JO; Brangsch J; Kader A; Saatz J; Mangarova DB; Zacharias M; Kempf WE; Schwaar T; Ponader M; Adams LC; Möckel J; Botnar RM; Taupitz M; Mägdefessel L; Traub H; Hamm B; Weller MG; Makowski MR
Article: EUROPEAN HEART JOURNAL. 2022;43(19):1864-1877

Interferon regulatory factor-5-dependent CD11c⁺ macrophages contribute to the formation of rupture-prone atherosclerotic plaques

Edsfeldt A; Swart M; Singh P; Dib L; Sun J; Cole JE; Park I; Al-Sharify D; Persson A; Nitulescu M; Borges PDN; Kassiteridi C; Goddard ME; Lee R; Volkov P; Orho-Melander M; Maegdefessel L; Nilsson J; Udalova I; Goncalves I; Monaco C
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):197

PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle

Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Roell W; Pfeifer A
Article: NAT CARDIOVASC RES. 2022;1(3):253-262

The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis

Jarr K-U; Ye J; Kojima Y; Ye Z; Gao H; Schmid S; Luo L; Baylis RA; Lotfi M; Lopez N; Eberhard AV; Smith BR; Weissman IL; Maegdefessel L; Leeper NJ
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(2):e682

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification

Skenteris NT; Seime T; Witasp A; Karlof E; Wasilewski GB; Heuschkel MA; Jaminon AMG; Oduor L; Dzhanaev R; Kronqvist M; Lengquist M; Peeters FECM; Soderberg M; Hultgren R; Roy J; Maegdefessel L; Arnardottir H; Bengtsson E; Goncalves I; Quertermous T; Goettsch C; Stenvinkel P; Schurgers LJ; Matic L
Article: DIABETES. 2022;71(2):285-297

Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes

Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: PLOS ONE. 2022;17(9):e0265160

Aging-regulated TUG1 is dispensable for endothelial cell function

Gimbel AT; Koziarek S; Theodorou K; Schulz JF; Stanicek L; Kremer V; Ali T; Guenther S; Kumar S; Jo H; Huebner N; Maegdefessel L; Dimmeler S; van Heesch S; Boon RA
Article: CARDIOVASCULAR RESEARCH. 2021;117(14):2767-2780

Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability

Tsantilas P; Lao S; Wu Z; Eberhard A; Winski G; Vaerst M; Nanda V; Wang Y; Kojima Y; Ye J; Flores A; Jarr K-U; Pelisek J; Eckstein H-H; Matic L; Hedin U; Tsao PS; Paloschi V; Maegdefessel L; Leeper NJ
Article: BIOMOLECULES. 2021;11(11):1683

Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease.

Neiburga KD; Vilne B; Bauer S; Bongiovanni D; Ziegler T; Lachmann M; Wengert S; Hawe JS; Güldener U; Westerlund AM; Li L; Pang S; Yang C; Saar K; Huebner N; Maegdefessel L; DigiMed Bayern Consortium; Lange R; Krane M; Schunkert H; von Scheidt M
Article: CIRCULATION. 2021;144(19):1567-1583

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Baecklund A; Bergmark C; Paloschi V; Maegdefessel L
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2021;62(5):716-726

Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling

Karlof E; Buckler A; Liljeqvist ML; Lengquist M; Kronqvist M; Toonsi MA; Maegdefessel L; Matic LP; Hedin U
Article: EUROPEAN HEART JOURNAL. 2021;42(39):4077-4088

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis

Hinterdobler J; Schott S; Jin H; Meesmann A; Steinsiek A-L; Zimmermann A-S; Wobst J; Mueller P; Mauersberger C; Vilne B; Baecklund A; Chen C-S; Moggio A; Braster Q; Molitor M; Krane M; Kempf WE; Ladwig K-H; Hristov M; Hulsmans M; Hilgendorf I; Weber C; Wenzel P; Scheiermann C; Maegdefessel L; Soehnlein O; Libby P; Nahrendorf M; Schunkert H; Kessler T; Sager HB
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2021;10(17):e020231

Parallel Murine and Human Aortic Wall Genomics Reveals Metabolic Reprogramming as Key Driver of Abdominal Aortic Aneurysm Progression

Gabel G; Northoff BH; Balboa A; Becirovic-Agic M; Petri M; Busch A; Maegdefessel L; Mahlmann A; Ludwig S; Teupser D; de Waard V; Golledge J; Wanhainen A; Wagsater D; Holdt LM; Lindeman JHN
Article: JCI INSIGHT. 2021;6(15):140364

Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility

Busch A; Pauli J; Winski G; Bleichert S; Chernogubova E; Metschl S; Winter H; Trenner M; Wiegering A; Otto C; Fischer J; Reiser J; Werner J; Roy J; Brostjan C; Knappich C; Eckstein H-H; Paloschi V; Maegdefessel L
Article: TRANSLATIONAL RESEARCH. 2021;233:32-46

Histone citrullination as a novel biomarker and target to inhibit progression of abdominal aortic aneurysms

Eilenberg W; Zagrapan B; Bleichert S; Ibrahim N; Knobl V; Brandau A; Martelanz L; Grasl M-T; Hayden H; Nawrozi P; Rajic R; Hausler C; Potolidis A; Schirwani N; Scheuba A; Klopf J; Teubenbacher P; Weigl MP; Kirchweger P; Beitzke D; Stiglbauer-Tscholakoff A; Panzenbock A; Lang I; Mauracher L-M; Hell L; Pabinger I; Bailey MA; Scott DJA; Maegdefessel L; Busch A; Huk I; Neumayer C; Brostjan C
Article: MOLECULAR THERAPY NUCLEIC ACIDS. 2021;24:188-199

MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening

Schellinger IN; Wagenhaeuser M; Chodisetti G; Mattern K; Dannert A; Petzold A; Jakubizka-Smorag J; Emrich F; Haunschild J; Schuster A; Schwob E; Schulz K; Maegdefessel L; Spin JM; Stumvoll M; Hasenfuss G; Tsao PS; Raaz U
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(6):2038-2048

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability

Georgakis MK; van der Laan SW; Asare Y; Mekke JM; Haitjema S; Schoneveld AH; de Jager SCA; Nurmohamed NS; Kroon J; Stroes ESG; de KDPV; de Borst GJ; Maegdefessel L; Soehnlein O; Pasterkamp G; Dichgans M
Article: CELLS. 2021;10(6):1276

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification

Seime T; Akbulut AC; Liljeqvist ML; Siika A; Jin H; Winski G; van Gorp RH; Karlof E; Lengquist M; Buckler AJ; Kronqvist M; Waring OJ; Lindeman JHN; Biessen EAL; Maegdefessel L; Razuvaev A; Schurgers LJ; Hedin U; Matic L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(5):1738-1750

Virtual Transcriptomics Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging

Buckler AJ; Karlof E; Lengquist M; Gasser TC; Maegdefessel L; Perisic Matic L; Hedin U
Article: REDOX BIOLOGY. 2021;41:101903

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm

Gao P; Gao P; Zhao J; Shan S; Luo W; Slivano OJ; Zhang W; Tabuchi A; LeMaire SA; Maegdefessel L; Shen YH; Miano JM; Singer HA; Long X
Article: CIRCULATION. 2021;143(3):254-266

Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion

Schumski A; Ortega-Gomez A; Wichapong K; Winter C; Lemnitzer P; Viola JR; Pinilla-Vera M; Folco E; Solis-Mezarino V; Volker-Albert M; Maas SL; Pan C; Olivares LP; Winter J; Hackeng T; Karlsson MCI; Zeller T; Imhof A; Baron RM; Nicolaes GAF; Libby P; Maegdefessel L; Kamp F; Benoit M; Doring Y; Soehnlein O
Journal article: CIRCULATION. 2021;144(19):1567-1583

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

Fasolo F; Jin H; Winski G; Chernogubova E; Pauli J; Winter H; Li DYY; Glukha N; Bauer S; Metschl S; Wu Z; Koschinsky ML; Reilly M; Pelisek J; Kempf W; Eckstein H-H; Soehnlein O; Matic L; Hedin U; Backlund A; Bergmark C; Paloschi V; Maegdefessel L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(12):2821-2828

18F-Fluorodeoxyglucose-Positron Emission Tomography Imaging Detects Response to Therapeutic Intervention and Plaque Vulnerability in a Murine Model of Advanced Atherosclerotic Disease-Brief Report.

Jarr K-U; Ye J; Kojima Y; Nanda V; Flores AM; Tsantilas P; Wang Y; Hosseini-Nassab N; Eberhard AV; Lotfi M; Käller M; Smith BR; Maegdefessel L; Leeper NJ
Article: ATHEROSCLEROSIS. 2020;314:1-9

A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?

Rakipovski G; Rolin B; Barascuk N; Lund HE; Bonde MFB; Djordjevic D; Wulff-Larsen PG; Petersen M; Kirk RK; Hultman K; Manfe V; Blume N; Zahn S; Lengquist M; Maegdefessel L; Hovingh GK; Conde-Knape K; Hedin U; Matic L; Nyberg M
Article: NATURE COMMUNICATIONS. 2020;11(1):5981

Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting.

Kontos C; El Bounkari O; Krammer C; Sinitski D; Hille K; Zan C; Yan G; Wang S; Gao Y; Brandhofer M; Megens RTA; Hoffmann A; Pauli J; Asare Y; Gerra S; Bourilhon P; Leng L; Eckstein H-H; Kempf WE; Pelisek J; Gokce O; Maegdefessel L; Bucala R; Dichgans M; Weber C; Kapurniotu A; Bernhagen J
Article: BASIC RESEARCH IN CARDIOLOGY. 2020;115(6):67

Functional investigation of the coronary artery disease gene SVEP1

Winkler MJ; Mueller P; Sharifi AM; Wobst J; Winter H; Mokry M; Ma L; van der Laan SW; Pang S; Miritsch B; Hinterdobler J; Werner J; Stiller B; Gueldener U; Webb TR; Asselbergs FW; Bjorkegren JLM; Maegdefessel L; Schunkert H; Sager HB; Kessler T
Article: ANTIOXIDANTS & REDOX SIGNALING. 2020;33(9):602-620

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease

Knappich C; Spin JM; Eckstein H-H; Tsao PS; Maegdefessel L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15818-15826

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Wang Y; Nanda V; Direnzo D; Ye J; Xiao S; Kojima Y; Howe KL; Jarr K-U; Flores AM; Tsantilas P; Tsao N; Rao A; Newman AAC; Eberhard AV; Priest JR; Ruusalepp A; Pasterkamp G; Maegdefessel L; Miller CL; Lind L; Koplev S; Bjorkegren JLM; Owens GK; Ingelsson E; Weissman IL; Leeper NJ
Article: NEUROLOGY. 2020;94(22):e2346-e2360

Thrombus NET content is associated with clinical outcome in stroke and myocardial infarction.

Novotny J; Oberdieck P; Titova A; Pelisek J; Chandraratne S; Nicol P; Hapfelmeier A; Joner M; Maegdefessel L; Poppert H; Pircher J; Massberg S; Friedrich B; Zimmer C; Schulz C; Boeckh-Behrens T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(6):1464-1478

Macrophage-Enriched lncRNA RAPIA: A Novel Therapeutic Target for Atherosclerosis.

Sun C; Fu Y; Gu X; Xi X; Peng X; Wang C; Sun Q; Wang X; Qian F; Qin Z; Qu W; Piao M; Zhong S; Liu S; Zhang M; Fang S; Tian J; Li C; Maegdefessel L; Tian J; Yu B
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2020;75(15):1788-1800

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury.

Hinkel R; Ramanujam D; Kaczmarek V; Howe A; Klett K; Beck C; Dueck A; Thum T; Laugwitz K-L; Maegdefessel L; Weber C; Kupatt C; Engelhardt S
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2020;40(2):412-425

MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice

Cheng J; Cheng A; Clifford BL; Wu X; Hedin U; Maegdefessel L; Pamir N; Sallam T; Tarling EJ; Vallim TQDA
Article: MOLECULAR THERAPY. 2019;27(9):1681-1693

The Role of MicroRNA-21 in Venous Neointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment

Kilari S; Cai C; Zhao C; Sharma A; Chernogubova E; Simeon M; Wu C-C; Song H-L; Maegdefessel L; Misra S
Article: ATHEROSCLEROSIS. 2019;288:175-185

Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization

Karlof E; Seime T; Dias N; Lengquist M; Witasp A; Almqvist H; Kronqvist M; Gadin JR; Odeberg J; Maegdefessel L; Stenvinkel P; Matic LP; Hedin U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(33):16410-16419

Regulation of CCL2 expression in human vascular endothelial cells by a neighboring divergently transcribed long noncoding RNA

Khyzha N; Khor M; DiStefano PV; Wang L; Matic L; Hedin U; Wilson MD; Maegdefessel L; Fish JE
Article: THROMBOSIS AND HAEMOSTASIS. 2019;119(8):1205-1211

Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis

Paloschi V; Winter H; Viola J; Soehnlein O; Maegdefessel L
Article: CIRCULATION. 2019;139(21):2466-2482

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability

Centa M; Jin H; Hofste L; Hellberg S; Busch A; Baumgartner R; Verzaal NJ; Enoksson SL; Matic LP; Boddul SV; Atzler D; Li DY; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Lutgens E; Binder CJ; Maegdesfessel L; Malin SG
Article: NATURE. 2019;569(7755):236-240

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

Silvestre-Roig C; Braster Q; Wichapong K; Lee EY; Marie Teulon J; Berrebeh N; Winter J; Adrover JM; Santos GS; Froese A; Lemnitzer P; Ortega-Gomez A; Chevre R; Marschner J; Schumski A; Winter C; Perez-Olivares L; Pan C; Paulin N; Schoufour T; Hartwig H; Gonzalez-Ramos S; Kamp F; Megens RTA; Mowen KA; Gunzer M; Maegdefessel L; Hackeng T; Lutgens E; Daemen M; von Blume J; Anders H-J; Nikolaev VO; Pellequer J-L; Weber C; Hidalgo A; Nicolaes GAF; Wong GCL; Soehnlein O
Article: THROMBOSIS AND HAEMOSTASIS. 2019;119(4):542-552

Therapeutic Targeting of Neutrophil Extracellular Traps in Atherogenic Inflammation

Van Avondt K; Maegdefessel L; Soehnlein O
Article: ATHEROSCLEROSIS. 2019;283:127-136

Dual roles of heparanase in human carotid plaque calcification

Aldi S; Eriksson L; Kronqvist M; Lengquist M; Lofling M; Folkersen L; Matic LP; Maegdefessel L; Grinnemo K-H; Li J-P; Osterholm C; Hedin U
Article: NON-CODING RNA. 2019;5(2):E31-31

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

Gomes CPDC; Agg B; Andova A; Arslan S; Baker A; Bartekova M; Beis D; Betsou F; Wettinger SB; Bugarski B; Condorelli G; da Silva GJJ; Danilin S; de Gonzalo-Calvo D; Buil A; Carmo-Fonseca M; Enguita FJ; Felekkis K; Ferdinandy P; Gyoengyoesi M; Hackl M; Karaduzovic-Hadziabdic K; Hellemans J; Heymans S; Hlavackova M; Hoydal MA; Jankovic A; Jusic A; Kardassis D; Kerkela R; Kuster GM; Lakkisto P; Leszek P; Lustrek M; Maegdefessel L; Martelli F; Novella S; O'Brien T; Papaneophytou C; Pedrazzini T; Pinet F; Popescu O; Potocnjak I; Robinson E; Sasson S; Scholz M; Simionescu M; Stoll M; Varga ZV; Vinciguerra M; Xuereb A; Yilmaz MB; Emanueli C; Devaux Y
Article: CIRCULATION. 2019;139(10):1320-1334

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

Cremer S; Michalik KM; Fischer A; Pfisterer L; Jae N; Winter C; Boon RA; Muhly-Reinholz M; John D; Uchida S; Weber C; Poller W; Guenther S; Braun T; Li DY; Maegdefessel L; Matic LP; Hedin U; Soehnlein O; Zeiher A; Dimmeler S
Article: JOURNAL OF CLINICAL MEDICINE. 2019;8(2):E251-251

Biobanking: Objectives, Requirements, and Future Challenges-Experiences from the Munich Vascular Biobank.

Pelisek J; Hegenloh R; Bauer S; Metschl S; Pauli J; Glukha N; Busch A; Reutersberg B; Kallmayer M; Trenner M; Wendorff H; Tsantilas P; Schmid S; Knappich C; Schaeffer C; Stadlbauer T; Biro G; Wertern U; Meisner F; Stoklasa K; Menges A-L; Radu O; Dallmann-Sieber S; Karlas A; Knipfer E; Reeps C; Zimmermann A; Maegdefessel L; Eckstein H-H
Article: CIRCULATION RESEARCH. 2019;124(4):619-630

Role of Noncoding RNAs in the Pathogenesis of Abdominal Aortic Aneurysm Possible Therapeutic Targets?

Kumar S; Boon RA; Maegdefessel L; Dimmeler S; Jo H
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(1):72-82

miR-29b Mediates the Chronic Inflammatory Response in Radiotherapy-Induced Vascular Disease

Eken SM; Christersdottir T; Winski G; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Backlund A; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
Article: JOURNAL OF VASCULAR RESEARCH. 2019;56(5):217-229

Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.

Sangha GS; Busch A; Acuna A; Berman AG; Phillips EH; Trenner M; Eckstein H-H; Maegdefessel L; Goergen CJ
Article: NATURE METABOLISM. 2019;1(1):98-110

The long noncoding RNA CHROME regulates cholesterol homeostasis in primates

Hennessy EJ; van Solingen C; Scacalossi KR; Ouimet M; Afonso MS; Prins J; Koelwyn GJ; Sharma M; Ramkhelawon B; Carpenter S; Busch A; Chernogubova E; Matic LP; Hedin U; Maegdefessel L; Caffrey BE; Hussein MA; Ricci EP; Temel RE; Garabedian MJ; Berger JS; Vickers KC; Kanke M; Sethupathy P; Teupser D; Holdt LM; Moore KJ
Article: CARDIOVASCULAR RESEARCH. 2019;115(1):230-242

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling

Hofmann P; Sommer J; Theodorou K; Kirchhof L; Fischer A; Li Y; Perisic L; Hedin U; Maegdefessel L; Dimmeler S; Boon RA
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(6):719-727

Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms

Petri MH; Thul S; Andonova T; Lindquist-Liljeqvist M; Jin H; Skenteris N-T; Arnardottir H; Maegdefessel L; Caidahl K; Perretti M; Roy J; Back M
Article: CIRCULATION. 2018;138(15):1551-1568

H19 Induces Abdominal Aortic Aneurysm Development and Progression

Li DY; Busch A; Jin H; Chernogubova E; Pelisek J; Karlsson J; Sennblad B; Liu S; Lao S; Hofmann P; Baecklund A; Eken SM; Roy J; Eriksson P; Dacken B; Ramanujam D; Dueck A; Engelhardt S; Boon RA; Eckstein H-H; Spin JM; Tsao PS; Maegdefessel L
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):1796-1805

Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm

Adam M; Kooreman NG; Jagger A; Wagenhaeuser MU; Mehrkens D; Wang Y; Kayama Y; Toyama K; Raaz U; Schellinger IN; Maegdefessel L; Spin JM; Hamming JF; Quax PHA; Baldus S; Wu JC; Tsao PS
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2018;56(1):102-109

Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion

Busch A; Chernogubova E; Jin H; Meurer F; Eckstein H-H; Kim M; Maegdefessel L
Article: MOLECULAR THERAPY. 2018;26(4):1040-1055

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions

Jin H; Li DY; Chernogubova E; Sun C; Busch A; Eken SM; Saliba-Gustafsson P; Winter H; Winski G; Raaz U; Schellinger IN; Simon N; Hegenloh R; Matic LP; Jagodic M; Ehrenborg E; Pelisek J; Eckstein H-H; Hedin U; Backlund A; Maegdefessel L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(8):1907-1912

Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm

Di Gennaro A; Araujo AC; Busch A; Jin H; Wagsater D; Vorkapic E; Caidahl K; Eriksson P; Samuelsson B; Maegdefessel L; Haeggstrom JZ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(1):49-63

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration

Nguyen M-A; Karunakaran D; Geoffrion M; Cheng HS; Tandoc K; Perisic Matic L; Hedin U; Maegdefessel L; Fish JE; Rayner KJ
Article: CIRCULATION JOURNAL. 2017;81(12):1945-1952

Increased Carotid Artery Lesion Inflammation Upon Treatment With the CD137 Agonistic Antibody 2A

Soderstrom LA; Jin H; Caravaca AS; Klement ML; Li Y; Gistera A; Hedin U; Maegdefessel L; Hansson GK; Olofsson PS
Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2017;148(4):425-433

Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms

Busch A; Grimm C; Hartmann E; Paloschi V; Kickuth R; Lengquist M; Otto C; Eriksson P; Kellersmann R; Lorenz U; Maegdefessel L
Article: CIRCULATION. 2017;136(1):65-79

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

Leisegang MS; Fork C; Josipovic I; Richter FM; Preussner J; Hu J; Miller MJ; Epah J; Hofmann P; Guenther S; Moll F; Valasarajan C; Heidler J; Ponomareva Y; Freiman TM; Maegdefessel L; Plate KH; Mittelbronn M; Uchida S; Kuenne C; Stellos K; Schermuly RT; Weissmann N; Devraj K; Wittig I; Boon RA; Dimmeler S; Pullamsetti SS; Looso M; Miller FJJ; Brandes RP
Article: PLOS GENETICS. 2017;13(5):e1006750

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

Kim JB; Pjanic M; Trieu N; Miller CL; Iyer D; Liu B; Wang T; Sazonova O; Carcamo-Orive I; Matic LP; Maegdefessel L; Hedin U; Quertermous T
Article: CIRCULATION RESEARCH. 2017;120(4):633-644

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions

Eken SM; Jin H; Chernogubova E; Li Y; Simon N; Sun C; Korzunowicz G; Busch A; Backlund A; Osterholm C; Razuvaev A; Renne T; Eckstein HH; Pelisek J; Eriksson P; Diez MG; Matic LP; Schellinger IN; Raaz U; Leeper NJ; Hansson GK; Paulsson-Berne G; Hedin U; Maegdefessel L
Article: HUMAN MOLECULAR GENETICS. 2017;26(3):637-649

Genome- wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels

Sennblad B; Basu S; Mazur J; Suchon P; Martinez-Perez A; Vlieg AVH; Vinh T; Li Y; Gadin JR; Tang W; Grossman V; de Haan HG; Handin N; Silveira A; Carlos Souto J; Franco-Cereceda A; Morange P-E; Gagnon F; Manuel Soria J; Eriksson P; Hamsten A; Maegdefessel L; Rosendaal FR; Wild P; Folsom AR; Tregouet D-A; Sabater-Lleal M
Article: CIRCULATION. 2016;134(24):1973-1990

MicroRNA-Based Therapy of GATA 2-Deficient Vascular Disease

Hartmann D; Fiedler J; Sonnenschein K; Just A; Pfanne A; Zimmer K; Remke J; Foinquinos A; Butzlaff M; Schimmel K; Maegdefessel L; Hilfiker-Kleiner D; Lachmann N; Schober A; Froese N; Heineke J; Bauersachs J; Batkai S; Thum T
Article: DIABETES. 2016;65(10):2888-2899

Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness

Strawbridge RJ; Hilding A; Silveira A; Osterholm C; Sennblad B; McLeod O; Tsikrika P; Foroogh F; Tremoli E; Baldassarre D; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Mannarino E; Grossi E; Syvanen A-C; Humphries SE; de Faire U; Ostenson C-G; Maegdefessel L; Hamsten A; Backlund A
Article: NATURE MEDICINE. 2016;22(10):1140-1150

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

Stellos K; Gatsiou A; Stamatelopoulos K; Matic LP; John D; Lunella FF; Jae N; Rossbach O; Amrhein C; Sigala F; Boon RA; Fuertig B; Manavski Y; You X; Uchida S; Keller T; Boeckel J-N; Franco-Cereceda A; Maegdefessel L; Chen W; Schwalbe H; Bindereif A; Eriksson P; Hedin U; Zeiher AM; Dimmeler S
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(9):1947-1961

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM

Matic LP; Rykaczewska U; Razuvaev A; Sabater-Lleal M; Lengquist M; Miller CL; Ericsson I; Rohl S; Kronqvist M; Aldi S; Magne J; Paloschi V; Vesterlund M; Li Y; Jin H; Diez MG; Roy J; Baldassarre D; Veglia F; Humphries SE; de Faire U; Tremoli E; Odeberg J; Vukojevic V; Lehtio J; Maegdefessel L; Ehrenborg E; Paulsson-Berne G; Hansson GK; Lindeman JHN; Eriksson P; Quertermous T; Hamsten A; Hedin U
Article: NATURE. 2016;536(7614):86-90

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Kojima Y; Volkmer J-P; McKenna K; Civelek M; Lusis AJ; Miller CL; Direnzo D; Nanda V; Ye J; Connolly AJ; Schadt EE; Quertermous T; Betancur P; Maegdefessel L; Matic LP; Hedin U; Weissman IL; Leeper NJ
Article: SCIENCE ADVANCES. 2016;2(7):e1600224

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

Karunakaran D; Geoffrion M; Wei L; Gan W; Richards L; Shangari P; DeKemp EM; Beanlands RA; Perisic L; Maegdefessel L; Hedin U; Sad S; Guo L; Kolodgie FD; Virmani R; Ruddy T; Rayner KJ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(5):942-951

miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux

Ouimet M; Hennessy EJ; van Solingen C; Koelwyn GJ; Hussein MA; Ramkhelawon B; Rayner KJ; Temel RE; Perisic L; Hedin U; Maegdefessel L; Garabedian MJ; Holdt LM; Teupser D; Moore KJ
Article: RNA. 2016;22(5):667-676

Guidelines for the functional annotation of microRNAs using the Gene Ontology

Huntley RP; Sitnikov D; Orlic-Milacic M; Balakrishnan R; D'Eustachio P; Gillespie ME; Howe D; Kalea AZ; Maegdefessel L; Osumi-Sutherland D; Petri V; Smith JR; Van Auken K; Wood V; Zampetaki A; Mayr M; Lovering RC
Article: JOURNAL OF INTERNAL MEDICINE. 2016;279(3):293-308

Gene expression signatures, pathways and networks in carotid atherosclerosis

Perisic L; Aldi S; Sun Y; Folkersen L; Razuvaev A; Roy J; Lengquist M; Akesson S; Wheelock CE; Maegdefessel L; Gabrielsen A; Odeberg J; Hansson GK; Paulsson-Berne G; Hedin U
Article: CIRCULATION RESEARCH. 2016;118(2):230-240

CDKN2B Regulates TGFβ Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels

Nanda V; Downing KP; Ye J; Xiao S; Kojima Y; Spin JM; DiRenzo D; Nead KT; Connolly AJ; Dandona S; Perisic L; Hedin U; Maegdefessel L; Dalman J; Guo L; Zhao X; Kolodgie FD; Virmani R; Davis HRJ; Leeper NJ
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(1):E81-81

Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology

Busch A; Busch M; Scholz C-J; Kellersmann R; Otto C; Chernogubova E; Maegdefessel L; Zernecke A; Lorenz U
Article: PLOS ONE. 2016;11(2):e0149288

Heme Oxygenase-1 Expression Affects Murine Abdominal Aortic Aneurysm Progression

Azuma J; Wong RJ; Morisawa T; Hsu M; Maegdefessel L; Zhao H; Kalish F; Kayama Y; Wallenstein MB; Deng AC; Spin JM; Stevenson DK; Dalman RL; Tsao PS
Article: GENOMICS DATA. 2015;5:36-37

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap.

Nurnberg ST; Cheng K; Raiesdana A; Kundu R; Miller CL; Kim JB; Arora K; Carcamo-Oribe I; Xiong Y; Tellakula N; Nanda V; Murthy N; Boisvert WA; Hedin U; Perisic L; Aldi S; Maegdefessel L; Pjanic M; Owens GK; Tallquist MD; Quertermous T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(9):1945-1953

Local MicroRNA Modulation Using a Novel Anti-miR21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis

Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Li Y; Busch A; Heeger C-H; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Schrepfer S; Maegdefessel L
Article: CIRCULATION RESEARCH. 2015;117(6):513-524

Transcription Factor Runx2 Promotes Aortic Fibrosis and Stiffness in Type 2 Diabetes Mellitus

Raaz U; Schellinger IN; Chernogubova E; Warnecke C; Kayama Y; Penov K; Hennigs JK; Salomons F; Eken S; Emrich FC; Zheng WH; Adam M; Jagger A; Nakagami F; Toh R; Toyama K; Deng A; Buerke M; Maegdefessel L; Hasenfuss G; Spin JM; Tsao PS
Article: CIRCULATION RESEARCH. 2015;117(3):266-278

Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis

Karunakaran D; Thrush AB; My-Anh N; Richards L; Geoffrion M; Singaravelu R; Ramphos E; Shangari P; Ouimet M; Pezacki JP; Moore KJ; Perisic L; Maegdefessel L; Hedin U; Harper M-E; Rayner KJ
Article: CIRCULATION. 2015;131(20):1783-1795

Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development

Raaz U; Zoellner AM; Schellinger IN; Toh R; Nakagami F; Brandt M; Emrich FC; Kayama Y; Eken S; Adam M; Maegdefessel L; Hertel T; Deng A; Jagger A; Buerke M; Dalman RL; Spin JM; Kuhl E; Tsao PS
Article: PLOS GENETICS. 2015;11(5):e1005155

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap

Nurnberg ST; Cheng K; Raiesdana A; Kundu R; Miller CL; Kim JB; Arora K; Carcamo-Oribe I; Xiong Y; Tellakula N; Nanda V; Murthy N; Boisvert WA; Hedin U; Perisic L; Aldi S; Maegdefessel L; Pjanic M; Owens GK; Tallquist MD; Quertermous T
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(5):1226-1235

ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability

Magne J; Gustafsson P; Jin H; Maegdefessel L; Hultenby K; Wernerson A; Eriksson P; Franco-Cereceda A; Kovanen PT; Goncalves I; Ehrenborg E
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(1):2-6

MicroRNA Regulation of Vascular Smooth Muscle Function and Phenotype Early Career Committee Contribution

Maegdefessel L; Rayner KJ; Leeper NJ
Article: NATURE COMMUNICATIONS. 2014;5:5214

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

Maegdefessel L; Spin JM; Raaz U; Eken SM; Toh R; Azuma J; Adam M; Nagakami F; Heymann HM; Chernugobova E; Jin H; Roy J; Hultgren R; Caidahl K; Schrepfer S; Hamsten A; Eriksson P; McConnell MV; Dalman RL; Tsao PS
Article: NATURE. 2014;509(7502):641-644

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

Deuse T; Hua X; Wang D; Maegdefessel L; Heeren J; Scheja L; Bolanos JP; Rakovic A; Spin JM; Stubbendorff M; Ikeno F; Laenger F; Zeller T; Schulte-Uentrop L; Stoehr A; Itagaki R; Haddad F; Eschenhagen T; Blankenberg S; Kiefmann R; Reichenspurner H; Velden J; Klein C; Yeung A; Robbins RC; Tsao PS; Schrepfer S
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2014;(87)

Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models

Stubbendorff M; Hua X; Deuse T; Ali Z; Reichenspurner H; Maegdefessel L; Robbins RC; Schrepfer S
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(3):1083-1097

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Article: PLOS GENETICS. 2014;10(3):e1004263

Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation

Miller CL; Haas U; Diaz R; Leeper NJ; Kundu RK; Patlolla B; Assimes TL; Kaiser FJ; Perisic L; Hedin U; Maegdefessel L; Schunkert H; Erdmann J; Quertermous T; Sczakiel G
Article: VASCULAR MEDICINE. 2014;19(1):3-8

The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model

Downing KP; Nead KT; Kojima Y; Assimes T; Maegdefessel L; Quertermous T; Cooke JP; Leeper NJ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(1):e1-e10

Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation

Leeper NJ; Raiesdana A; Kojima Y; Kundu RK; Cheng H; Maegdefessel L; Toh R; Ahn G-O; Ali ZA; Anderson DR; Miller CL; Roberts SC; Spin JM; de Almeida PE; Wu JC; Xu B; Cheng K; Quertermous M; Kundu S; Kortekaas KE; Berzin E; Downing KP; Dalman RL; Tsao PS; Schadt EE; Owens GK; Quertermous T
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2012;(63):e3663

Human Internal Mammary Artery (IMA) Transplantation and Stenting: A Human Model to Study the Development of In-Stent Restenosis

Hua X; Deuse T; Michelakis ED; Haromy A; Tsao PS; Maegdefessel L; Erben RG; Bergow C; Behnisch BB; Reichenspurner H; Robbins RC; Schrepfer S
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(122):122ra22

MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion

Maegdefessel L; Azuma J; Toh R; Deng A; Merk DR; Raiesdana A; Leeper NJ; Raaz U; Schoelmerich AM; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(2):497-506

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

Maegdefessel L; Azuma J; Toh R; Merk DR; Deng A; Chin JT; Raaz U; Schoelmerich AM; Raiesdana A; Leeper NJ; McConnell MV; Dalman RL; Spin JM; Tsao PS
Article: CIRCULATION RESEARCH. 2012;110(2):312-324

miR-29b Participates in Early Aneurysm Development in Marfan Syndrome

Merk DR; Chin JT; Dake BA; Maegdefessel L; Miller MO; Kimura N; Tsao PS; Iosef C; Berry GJ; Mohr FW; Spin JM; Alvira CM; Robbins RC; Fischbein MP
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2011;32(4):417-425

Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study

Kaeberich A; Reindl I; Raaz U; Maegdefessel L; Vogt A; Linde T; Steinseifer U; Perzborn E; Hauroeder B; Buerke M; Werdan K; Schlitt A
Article: PHYSIOLOGICAL GENOMICS. 2011;43(17):993-1003

Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm

Spin JM; Hsu M; Azuma J; Tedesco MM; Deng A; Dyer JS; Maegdefessel L; Dalman RL; Tsao PS
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2011;226(4):1035-1043

MicroRNA-26a Is a Novel Regulator of Vascular Smooth Muscle Cell Function

Leeper NJ; Raiesdana A; Kojima Y; Chun HJ; Azuma J; Maegdefessel L; Kundu RK; Quertermous T; Tsao PS; Spin JM
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2011;31(2):270-279

Influences of Aortic Motion and Curvature on Vessel Expansion in Murine Experimental Aneurysms

Goergen CJ; Azuma J; Barr KN; Magdefessel L; Kallop DY; Gogineni A; Grewall A; Weimer RM; Connolly AJ; Dalman RL; Taylor CA; Tsao PS; Greve JM
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2011;7:693-699

Comparison of outcome in 1809 patients treated with drug-eluting stents or bare-metal stents in a real-world setting.

Vogt A; Schoelmerich A; Pollner F; Schlitt M; Raaz U; Maegdefessel L; Reindl I; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2011;2011:252141

Assessment of Elastase-Induced Murine Abdominal Aortic Aneurysms: Comparison of Ultrasound Imaging with In Situ Video Microscopy

Azuma J; Maegdefessel L; Kitagawa T; Dalman RL; McConnell MV; Tsao PS
Article: THROMBOSIS RESEARCH. 2010;126(3):e196-e200

In vitro comparison of dabigatran, unfractionated heparin, and low-molecular-weight heparin in preventing thrombus formation on mechanical heart valves

Maegdefessel L; Linde T; Krapiec F; Hamilton K; Steinseifer U; van Ryn J; Raaz U; Buerke M; Werdan K; Schlitt A
Article: THROMBOSIS AND HAEMOSTASIS. 2010;103(4):808-814

The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro

Raaz U; Kaeberich A; Maegdefessel L; Buerke M; Busshardt M; Schubert S; Russ M; Plehn A; Ebelt H; Werdan K; Schlitt A
Article: JOURNAL OF THROMBOSIS AND THROMBOLYSIS. 2010;29(3):265-270

Efficacy of enoxaparin, certoparin and dalteparin in preventing cardiac catheter thrombosis: an in vitro approach

Raaz U; Buerke M; Busshardt M; Maegdefessel L; Plehn A; Hauroeder B; Werdan K; Schlitt A
Article: LIPIDS. 2010;45(2):129-135

Serum Phospholipid Transfer Protein Activity After a High Fat Meal in Patients with Insulin-Treated Type 2 Diabetes

Schlitt A; Schwaab B; Fingscheidt K; Lackner KJ; Heine GH; Vogt A; Buerke M; Maegdefessel L; Raaz U; Werdan K; Jiang X-C
Article: THROMBOSIS AND HAEMOSTASIS. 2009;101(6):1163-1169

Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves Results of an in-vitro study

Maegdefessel L; Linde T; Michel T; Hamilton K; Steinseifer U; Friedrich I; Schubert S; Hauroeder B; Raaz U; Buerke M; Werdan K; Schlitt A
Article: JOURNAL OF LIPID RESEARCH. 2009;50(4):723-729

PLTP activity is a risk factor for subsequent cardiovascular events in CAD patients under statin therapy: the AtheroGene Study

Schlitt A; Blankenberg S; Bickel C; Lackner KJ; Heine GH; Buerke M; Werdan K; Maegdefessel L; Raaz U; Rupprecht HJ; Munzel T; Jiang X-C
Article: VASCULAR HEALTH AND RISK MANAGEMENT. 2009;5:849-857

Patients with insulin-dependent diabetes or coronary heart disease following rehabilitation express serum fractalkine levels similar to those in healthy control subjects.

Maegdefessel L; Schlitt A; Pippig S; Schwaab B; Fingscheidt K; Raaz U; Buerke M; Loppnow H
Article: THROMBOSIS AND HAEMOSTASIS. 2008;100(4):693-698

Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis Results of an in-vitro study

Maegdefessel L; Buerke M; Schubert S; Reindl I; Michel T; Hauroeder B; Carter JM; Peetz D; Werdan K; Schlitt A
Article: MEDIZINISCHE KLINIK. 2008;103(9):628-632

Anticoagulant and/or antiplatelet treatment in patients with atrial fibrillation after percutaneous coronary intervention

Maegdefessel L; Schlitt A; Faerber J; Bond SP; Messow C-M; Buerke M; Raaz U; Werdan K; Munzel T; Weiss C
Article: INTERNIST. 2008;49(7):868-872

27-year old pregnant woman with syncope and dyspnea after aortic alloplastic heart valve replacement 15 years ago

Maegdefessel L; Issa H; Scheler C; Thaele V; Schlitt A; Hartelt U; Grabitz R; Buerke M
Article: CORONARY ARTERY DISEASE. 2008;19(4):279-284

In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus

Schlitt A; Rupprecht HJ; Reindl I; Schubert S; Hauroeder B; Carter JM; Peetz D; Kropff SS; Maegdefessel L; Russ M; Schmidt H; Ebelt H; Werdan K; Buerke M
Article: JOURNAL OF HEART VALVE DISEASE. 2006;15(6):809-814

Comparison of fondaparinux, low molecular-weight heparin and unfractionated heparin in preventing thrombus formation on mechanical heart valves: Results of an in-vitro study

Schlitt A; Hamilton K; Maegdefessel L; Dahm M; Theis C; Eichler M; Brockmann O; Steinseifer U; Hauroeder B; Hitzler WE; Rupprecht HJ
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Review: CLINICAL RESEARCH IN CARDIOLOGY. 2024;113(5):672-679

The challenges of research data management in cardiovascular science: a DGK and DZHK position paper-executive summary

Steffens S; Schroeder K; Krueger M; Maack C; Streckfuss-Boemeke K; Backs J; Backofen R; Baessler B; Devaux Y; Gilsbach R; Heijman J; Knaus J; Kramann R; Linz D; Lister AL; Maatz H; Maegdefessel L; Mayr M; Meder B; Nussbeck SY; Rog-Zielinska EA; Schulz MH; Sickmann A; Yigit G; Kohl P
Preprint: MEDRXIV. 2023;MEDRXIV

Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.

von Scheidt M; Bauer S; Ma A; Hao K; Kessler T; Vilne B; Wang Y; Hodonsky CJ; Ghosh SKB; Mokry M; Gao H; Kawai K; Sakamoto A; Kaiser J; Bongiovanni D; Fleig J; Oldenbuettel L; Chen Z; Moggio A; Sager HB; Hecker JS; Bassermann F; Maegdefessel L; Miller CL; Koenig W; Zeiher AM; Dimmeler S; Graw M; Braun C; Ruusalepp A; Leeper NJ; Kovacic JC; Björkegren JLM; Schunkert H
Editorial comment: EUROPEAN HEART JOURNAL. 2023;44(25):2267-2269

Targeting non-coding RNAs for novel treatment strategies in vascular diseases

Winter H; Maegdefessel L
Review: ATHEROSCLEROSIS. 2023;374:99-106

Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing

Bink DI; Pauli J; Maegdefessel L; Boon RA
Review: ATHEROSCLEROSIS. 2023;374:34-43

Long non-coding RNAs at the crossroad of vascular smooth muscle cell phenotypic modulation in atherosclerosis and neointimal formation

Fasolo F; Paloschi V; Maegdefessel L
Preprint: BIORXIV. 2023;BIORXIV

INKILN is a novel long noncoding RNA promoting vascular smooth muscle inflammation via scaffolding MKL1 and USP10.

Zhang W; Zhao J; Deng L; Ishimwe N; Pauli J; Wu W; Shan S; Kempf W; Ballantyne MD; Kim D; Lyu Q; Bennett M; Rodor J; Turner AW; Lu YW; Gao P; Choi M; Warthi G; Kim HW; Barroso MM; Bryant WB; Miller CL; Weintraub NL; Maegdefessel L; Miano JM; Baker AH; Long X
Review: CARDIOVASCULAR RESEARCH. 2022;118(15):3016-3051

Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

van der Velden J; Asselbergs FW; Bakkers J; Batkai S; Bertrand L; Bezzina CR; Bot I; Brundel BJJM; Carrier L; Chamuleau S; Dawson MCD; Davidson SM; Dendorfer A; Duncker DJ; Eschenhagen T; Fabritz L; Falcao-Pires I; Ferdinandy P; Giacca M; Girao H; Gollmann-Tepekoeylue C; Gyongyosi M; Guzik TJ; Hamdani N; Heymans S; Hilfiker A; Hilfiker-Kleiner D; Hoekstra AG; Hulot J-S; Kuster DWD; van Laake LW; Lecour S; Leiner T; Linke WA; Lumens J; Lutgens E; Madonna R; Maegdefessel L; Mayr M; van der Meer P; Passier R; Perbellini F; Perrino C; Pesce M; Priori S; Remme CA; Rosenhahn B; Schotten U; Schulz R; Sipido KR; Sluijter JPG; van Steenbeek F; Steffens S; Terracciano CM; Tocchetti CG; Vlasman P; Yeung KK; Zacchigna S; Zwaagman D; Thum T; Ciccarelli M
Corrigendum: COMMUNICATIONS BIOLOGY. 2022;5(1):298

Author Correction: PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.

Hildebrand S; Ibrahim M; Schlitzer A; Maegdefessel L; Röll W; Pfeifer A
Review: CARDIOVASCULAR RESEARCH. 2021;117(14):2742-2754

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases

Paloschi V; Sabater-Lleal M; Middelkamp H; Vivas A; Johansson S; van der Meer A; Tenje M; Maegdefessel L
Review: JVS - VASCULAR SCIENCE. 2021;2:219-234

Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.

Busch A; Bleichert S; Ibrahim N; Wortmann M; Eckstein H-H; Brostjan C; Wagenhäuser MU; Goergen CJ; Maegdefessel L
Editorial comment: EUROPEAN HEART JOURNAL. 2020;41(26):2469-2471

Linking obesity with abdominal aortic aneurysm development

Eckstein H-H; Maegdefessel L
Meeting abstract: FASEB JOURNAL. 2020;34:1

The Interplay of Wnt- and PPARγ-signaling in macrophages & vascular smooth muscle cells during vascular calcification

Reinhold S; Temmerman L; Jin H; Maegdefessel L; Hedin U; Matic L; Biessen E; Schurgers L; Blankesteijn M; Foulquier S
Review: ATHEROSCLEROSIS. 2020;292:112-118

Long noncoding RNAs in key cellular processes involved in aortic aneurysms

Wu Z-Y; Trenner M; Boon RA; Spin JM; Maegdefessel L
Editorial comment: FRONTIERS IN PHYSIOLOGY. 2020;11:60

Editorial: Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System

Zampetaki A; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2019;115(12):1732-1756

Non-coding RNAs in cardiovascular cell biology and atherosclerosis

Fasolo F; Di Gregoli K; Maegdefessel L; Johnson JL
Published conference paper: JOURNAL OF VASCULAR SURGERY. 2019;70(4):1318-1326.e5

The structural atrophy of the aneurysm wall in secondary expanding aortic aneurysms with endoleak type II

Menges A-L; Busch A; Reutersberg B; Trenner M; Kath P; Chernogubova E; Maegdefessel L; Eckstein H-H; Zimmermann A
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e287

THE LONG NON-CODING RNA CHROMR REGULATES CHOLESTEROL HOMEOSTASIS IN PRIMATES

Van Solingen C; Hennessy E; Scacalossi K; Ouimet M; Afonso M; Prins J; Koelwyn G; Ramkhelawon B; Maegdefessel L; Teupser D; Holdt L; Moore K
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e269

TIME-DEPENDENT BIOPATHOLOGICAL ALTERNATIONS IN CAROTID ATHEROSCLEROTIC PLAQUES FROM SYMPTOMATIC PATIENTS

Pauli J; Tsantilas P; Kallmayer M; Maegdefessel L; Eckstein HH; Pelisek J
Meeting abstract: ATHEROSCLEROSIS. 2019;287:e47

EPIGENETIC LINK BETWEEN HISTONE MODIFICATION, LONG NON-CODING RNAS AND EXPRESSION OF MATRIX METALLOPROTEINASES IN ATHEROSCLEROTIC LESIONS OF THE EXTRACRANIAL CAROTID ARTERY

Bauer S; Maegdefessel L; Pelisek J; Eckstein HH
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(5):2164

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis (vol 124, pg 1083, 2014)

Kojima Y; Downing K; Kundu R; Miller C; Dewey F; Lancero H; Raaz U; Perisic L; Hedin U; Schadt E; Maegdefessel L; Quertermous T; Leeper NJ
Review: VASCULAR PHARMACOLOGY. 2019;114:110-121

Non-coding RNAs in aneurysmal aortopathy

Spin JM; Li DY; Maegdefessel L; Tsao PS
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2018;68(2):656

Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion

Busch A; Chernogubova E; Jin H; Meurer F; Eckstein HH; Kim M; Maegdefessel L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:95

REGULATION OF CCL2 EXPRESSION IN VASCULAR ENDOTHELIAL CELLS BY A LONG NONCODING RNA

Khyzha N; Khor M; Hedin U; Maegdefessel L; Wilson MD; Fish JE
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2018;67(6):e236

Inhibition of Abdominal Aortic Aneurysm Expansion in a Preclinical Atherosclerotic LDLR^-/- Minipig Model by miR-29b-Coated Balloon Angioplasty

Busch A; Eckstein H-H; Maegdefessel L
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:11-12

THERAPEUTICALLY TARGETING THE KINASE ACTIVITY OR GENE EXPRESSION OF RIP1 REDUCES INFLAMMATION-DRIVEN ATHEROSCLEROSIS AND PROMOTES PLAQUE STABILITY

Karunakaran D; Geoffrion M; Wei L; Gan W; Perisic L; Maegdefessel L; Hedin U; Sad S; Guo L; Kolodgie F; Ruddy T; Virmani R; Rayner K
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2018;32:9

LONG NON-CODING RNA MIAT REGULATES SMOOTH MUSCLE CELL AND MACROPHAGE ACTIVITY IN ATHEROSCLEROTIC LESIONS. A ROLE FOR LIPOPROTEIN(A)/OXIDIZED PHOSPHOLIPIDS

Bergmark CC; Maegdefessel L; Li Y; Perisic L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Nudt6 Inhibition Limits Smooth Muscle Cell Apoptosis and Abdominal Aortic Aneurysm Progression

Jin H; Winter H; Chernogubova E; Li Y; Winski G; Backlund A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Genetic Depletion of the Long Non-coding RNA H19 in Mice Protects from Elastase-induced Abdominal Aortic Aneurysms

Chernogubova E; Busch A; Li Y; Jin H; Winski G; Hofmann P; Boon RA; Backlund A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

MicroRNA-29b Mediates the Chronic Inflammatory Response in Radiotherapy-induced Vascular Disease

Wiggle G; Eken SM; Christersdottir T; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Tornvall P; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Regulation of CCL2 Expression in Vascular Endothelial Cells by a Long Noncoding RNA

Khyzha N; Khor M; Hedin U; Maegdefessel L; Wilson MD; Fish JE
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

CHI3L1 and Its Role in Vascular Smooth Muscle Cell Proliferation and Migration in Advanced Atherosclerosis

Tsantilas P; Lao S; Vaerst M; Li Y; Nanda V; Maegdefessel L; Leeper N
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Local Mir-29b Inhibition Using Drug-eluting Balloons Blocks Abdominal Aortic Aneurysm Expansion in Atherosclerotic Ldlr-/- Mini-pigs

Busch A; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Aorta-on-a-chip: a Tool to Gain Molecular and Translational Insight Into Vascular Diseases

Paloschi V; Rolli C; Buchmann B; Meucci S; Rogowitz F; Bausch A; Maegdefessel L
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(5):982-983

TIMPing the Aorta: Smooth Muscle Cell-Specific Deletion of BMAL1 Limits Murine Abdominal Aortic Aneurysm Development

Winter C; Soehnlein O; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

H19 Induces Abdominal Aortic Aneurysm Development and Progression

Li DY; Busch A; Jin H; Chernogubova E; Pelisek J; Eriksson P; Roy J; Hofmann P; Boon R; Spin J; Tsao P; Maegdefessel L
Meeting abstract: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38

Repression of Map1lc3a During Atherosclerosis Progression Plays an Important Role in the Regulation of Vascular Smooth Muscle Cell Phenotype

Magne J; Paloschi V; Goncalves I; Saliba-Gustafsson P; Skogsberg J; Razuvaev A; Jin H; Li Y; Ketelhuth DFJ; Maegdefessel L; Hedin U; Eriksson P; Ehrenborg E
Meeting abstract: CARDIOVASCULAR RESEARCH. 2018;114:s69

Hanging drops: a novel in vitro method to analyze human monocytes of relevance for atherosclerosis

Trattner M; Kehe K; Steinritz D; Pelisek J; Kuehnl A; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2018;114(4):611-621

Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease

Leeper NJ; Maegdefessel L
Letter: CIRCULATION. 2018;137(7):750-753

Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation

Kojima Y; Werner N; Ye J; Nanda V; Tsao N; Wang Y; Flores AM; Miller CL; Weissman I; Deng H; Xu B; Dalman RL; Eken SM; Pelisek J; Li Y; Maegdefessel L; Leeper NJ
Editorial comment: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2017;10(4):e001859

Towards Point-of-Care Measurements Using Noncoding RNAs A Novel Tool to Monitor Aggravation of Advanced Atherosclerotic Lesions

Paloschi V; Maegdefessel L
Meeting abstract: JOURNAL OF VASCULAR SURGERY. 2017;65(6):23S-24S

Combination of Preoperative CT and Carotid Plaque Gene Expression Profiling Demonstrates an Association Between Calcification and Plaque-Stabilizing Processes

Karlof E; Dias N; Lengquist M; Witasp A; Stenvinkel P; Maegdefessel L; Matic LP; Hedin U
Meeting abstract: TRANSPLANTATION. 2017;101(5):S28

Local microRNA Modulation is a Suitable Way to Prevent In-Stent Restenosis and Coronary Allograft Arteriosclerosis

Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Heeger C; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Maegdefessel L; Schrepfer S
Meeting abstract: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2017;69(11):2023

NON-CODING RNAS COMPREHENSIVELY COUNTERACT ADVERSE ARTERIAL REMODELING AND STIFFENING IN TYPE 2 DIABETES

Raaz U; Schellinger I; Mattern K; Mattes L; Spin J; Schuster A; Maegdefessel L; Hasenfuss G; Tsao P
Review: FRONTIERS IN PHYSIOLOGY. 2017;8:429

Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression

Li Y; Maegdefessel L
Review: ANNALS OF TRANSLATIONAL MEDICINE. 2016;4(12):236

Prospective and therapeutic screening value of non-coding RNA as biomarkers in cardiovascular disease

Busch A; Eken SM; Maegdefessel L
Editorial comment: ANNALS OF TRANSLATIONAL MEDICINE. 2016;4(7):144

My heart will go on-beneficial effects of anti-MiR-30 after myocardial infarction

Li Y; Maegdefessel L
Letter: CIRCULATION. 2016;133(1):e11-e12

Response to Letters Regarding Article, "Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development"

Raaz U; Zoellner AM; Schellinger IN; Toh R; Nakagami F; Brandt M; Emrich FC; Kayama Y; Eken S; Adam M; Maegdefessel L; Hertel T; Deng A; Jagger A; Buerke M; Dalman RL; Spin JM; Kuhl E; Tsao PS
Meeting abstract: ATHEROSCLEROSIS. 2015;241(1):E1-E2

ATG16L1 EXPRESSION IN CAROTID ATHEROSCLEROTIC PLAQUES IS ASSOCIATED WITH PLAQUE VULNERABILITY

Magne J; Gustafsson P; Jin H; Maegdefessel L; Hultenby K; Wernerson A; Eriksson P; Franco-Cereceda A; Kovanen PT; Goncalves I; Ehrenborg E
Meeting abstract: VASCULAR MEDICINE. 2015;20(3):301-302

Cyclin-Dependent Kinase Inhibitor 2B Regulates Transforming Growth Factor Beta 1 Mediated Smooth Muscle Cell Recruitment to Ischemic Blood Vessels

Nanda V; Downing K; Kojima Y; DiRenzo D; Dalman J; Connolly AJ; Maegdefessel L; Perisic L; Dandona S; Guo L; Davis HR; Virmani R; Spin J; Leeper N
Meeting abstract: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2015;34(4):S39

Coronary Allograft Arteriosclerosis: Local MicroRNA Modulation Using a Novel Anti-Mir-21-Eluting Stent Prevents in-Stent Restenosis

Wang D; Deuse T; Stubbendorff M; Chernogubova E; Erben RG; Eken SM; Jin H; Heeger C; Behnisch B; Reichenspurner H; Robbins RC; Spin JM; Tsao PS; Maegdefessel L; Schrepfer S
Corrigendum: NATURE COMMUNICATIONS. 2015;6:6506

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development (vol 5, 5214, 2014)

Maegdefessel L; Spin JM; Raaz U; Eken SM; Toh R; Azuma J; Adam M; Nakagami F; Heymann HM; Chernogubova E; Jin H; Roy J; Hultgren R; Caidahl K; Schrepfer S; Hamsten A; Eriksson P; McConnell MV; Dalman RL; Tsao PS
Review: JOURNAL OF INTERNAL MEDICINE. 2014;276(6):633-644

The emerging role of microRNAs in cardiovascular disease

Maegdefessel L
Editorial comment: THROMBOSIS AND HAEMOSTASIS. 2014;112(1):15

Micro-effects of smoking in cardiovascular disease aetiology

Maegdefessel L
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2014;34(7):1339-1340

New Ways to Dismantle a Ticking Time Bomb MicroRNA 712/205 and Abdominal Aortic Aneurysm Development

Maegdefessel L; Spin JM; Tsao PS
Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(6):914-928

Hemodynamic Regulation of Reactive Oxygen Species: Implications for Vascular Diseases

Raaz U; Toh R; Maegdefessel L; Adam M; Nakagami F; Emrich FC; Spin JM; Tsao PS
Review: ANNUAL REVIEW OF MEDICINE. 2014;65:49-62

Pathogenesis of Abdominal Aortic Aneurysms: MicroRNAs, Proteases, Genetic Associations

Maegdefessel L; Dalman RL; Tsao PS
Review: TRENDS IN CARDIOVASCULAR MEDICINE. 2014;24(1):1-6

MicroRNA-29b regulation of abdominal aortic aneurysm development

Maegdefessel L; Azuma J; Tsao PS
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2013;14(7):14374-14394

Micromanaging Abdominal Aortic Aneurysms

Maegdefessel L; Spin JM; Adam M; Raaz U; Toh R; Nakagami F; Tsao PS
Editorial comment: CURRENT VASCULAR PHARMACOLOGY. 2013

Therapeutic Potential of MicroRNAs in Vascular Disease.

Maegdefessel L
Editorial comment: CURRENT VASCULAR PHARMACOLOGY. 2013;13(3):277-279

Therapeutic Potential of microRNAs in Vascular Disease

Maegdefessel L
Review: JOURNAL OF DIABETES RESEARCH. 2013;2013:834727-10

Making Sense in Antisense: Therapeutic Potential of Noncoding RNAs in Diabetes-Induced Vascular Dysfunction

Eken SM; Jin H; Chernogubova E; Maegdefessel L
Review: CARDIOVASCULAR RESEARCH. 2012;95(2):147-155

Vascular smooth muscle cell phenotypic plasticity: focus on chromatin remodelling

Spin JM; Maegdefessel L; Tsao PS
Meeting abstract: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2012;31(4):S126-S127

Pyruvate Dehydrogenase Kinase 2 Controls Vascular Remodeling

Deuse T; Hun X; Laenger F; Gossler T; Stubbendorff M; Rakovic A; Klein C; Sutendra G; Dromparis P; Maegdefessel L; Tsao PS; Velden J; Reichenspurner H; Robbins RC; Haddad F; Michelakis E; Schrepfer S
Review: VASCULAR HEALTH AND RISK MANAGEMENT. 2010;6:339-349

New options with dabigatran etexilate in anticoagulant therapy.

Maegdefessel L; Spin JM; Azuma J; Tsao PS
Review: VASCULAR HEALTH AND RISK MANAGEMENT. 2010;6:95-103

Modern role for clopidogrel in management of atrial fibrillation and stroke reduction.

Maegdefessel L; Azuma J; Tsao PS
Letter: THROMBOSIS RESEARCH. 2009;124(2):242-243

INR matters: A case on managing argatroban for bridging oral anticoagulation in a patient with heparin induced thrombocytopenia type II after mechanical heart valve replacement

Raaz U; Maegdefessel L; Buerke M; Janusch M; Werdan K; Schlitt A
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