Vascular Functions in Metabolic and CNS Diseases – Ulf Eriksson group

Publications

Selected publications

• Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;:e171077

  PDGFRα inhibition reduces myofibroblast expansion in the fibrotic rim and enhances recovery after ischemic stroke.

  Protzmann J; Zeitelhofer M; Stefanitsch C; Torrente D; Adzemovic MZ; Matjunins K; Randel SJ; Lewandowski SA; Muhl L; Eriksson U; Nilsson I; Su EJ; Lawrence DA; Fredriksson L
• Article: KIDNEY INTERNATIONAL. 2024;:S0085-2538(24)00872-X

  Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease.

  Folestad E; Mehlem A; Ning FC; Oosterveld T; Palombo I; Singh J; Olauson H; Witasp A; Thorell A; Stenvinkel P; Ebefors K; Nyström J; Eriksson U; Falkevall A
• Journal article: CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH. 2024;37:100559

  “Regulation of adipose-derived fatty acid flux to the liver”-Impact on metabolic dysfunction-associated steatotic liver disease

  Folestad E; Falkevall A
• Doctoral thesis: 2024

  Regulation of endothelial fatty acid uptake by VEGF-B : mechanisms and therapeutic implications

  Sahlgren BH
• Article: BIORXIV. 2024;:2024.10.11.617532

  Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent effect on adipose lipolysis.

  Nilsson I; Su EJ; Fredriksson L; Sahlgren BH; Bagoly Z; Moessinger C; Stefanitsch C; Ning FC; Zeitelhofer M; Muhl L; Lawrence A-LE; Scotney PD; Lu L; Samén E; Ho H; Keep RF; Medcalf RL; Lawrence DA; Eriksson U
• Doctoral thesis: 2024

  Shedding light on the blood-brain barrier in ischemic stroke

  Protzmann J
• Article: FLUIDS AND BARRIERS OF THE CNS. 2024;21(1):35

  Analysis of ischemic stroke-mediated effects on blood-brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging

  Protzmann J; Jung F; Jakobsson L; Fredriksson L
• Article: JOURNAL OF HEPATOLOGY. 2023;78(5):901-913

  Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue

  Falkevall A; Mehlem A; Folestad E; Ning FC; Osorio-Conles O; Radmann R; de Hollanda A; Wright SD; Scotney P; Nash A; Eriksson U
• Article: BLOOD. 2022;140(4):388-400

  Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin

  Goncalves A; Su EJ; Muthusamy A; Zeitelhofer M; Torrente D; Nilsson I; Protzmann J; Fredriksson L; Eriksson U; Antonetti DA; Lawrence DA
• Article: SCIENTIFIC REPORTS. 2020;10(1):22383

  Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier

  Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
• Article: EMBO REPORTS. 2020;21(7):e49343

  VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content

  Moessinger C; Nilsson I; Muhl L; Zeitelhofer M; Heller Sahlgren B; Skogsberg J; Eriksson U
• Doctoral thesis: 2020

  VEGF-B in islet of langerhans : role in vascular signaling and lipid handling

  Ning, Frank Chenfei
• Article: SCIENTIFIC REPORTS. 2020;10(1):923

  VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

  Ning FC; Jensen N; Mi J; Lindstrom W; Balan M; Muhl L; Eriksson U; Nilsson I; Nyqvist D
• Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2020;15(1_SUPPL):624-625

  PDGFRA ANTAGONISM DAMPENS REACTIVE GLIOSIS AND SCAR FORMATION AFTER ISCHEMIC STROKE

  Zeitelhofer M; Stefanitsch C; Adzemovic M; Sue J; Lewandowski S; Muhl L; Nilsson I; Lawrence D; Fredriksson L
• Article: SCIENTIFIC REPORTS. 2019;9(1):14636

  Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours

  Balan M; Trusohamn M; Ning FC; Jacob S; Pietras K; Eriksson U; Berggren P-O; Nyqvist D
• Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:930

  Blocking PDGFR-a decreases multiple sclerosis-like neuroinflammation by inhibiting disruption of blood brain barrier integrity

  Zeitelhofer M; Adzemovic MZ; Huang J; Stefanitsch C; Mossinger C; Hochmeister S; Strell C; Muhl L; Lassmann H; Kockum I; Fredriksson L; Olsson T; Nilsson I; Eriksson U
• Editorial comment: CELL METABOLISM. 2018;27(6):1161-1162

  Visualizing Fatty Acid Flux

  Eriksson U; Falkevall A
• Article: PLOS ONE. 2018;13(7):e0200649

  Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC^hum mice

  Zeitelhofer M; Li H; Adzemovic MZ; Nilsson I; Muhl L; Scott AM; Eriksson U
• Article: PLOS ONE. 2018;13(7):e0201089

  Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo

  Li H; Zeitelhofer M; Nilsson I; Liu X; Allan L; Gloria B; Perani A; Murone C; Catimel B; Neville AM; Scott FE; Scott AM; Eriksson U
• Article: ACTA NEUROPATHOLOGICA. 2017;134(4):585-604

  Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke

  Su EJ; Cao C; Fredriksson L; Nilsson I; Stefanitsch C; Stevenson TK; Zhao J; Ragsdale M; Sun Y-Y; Yepes M; Kuan C-Y; Eriksson U; Strickland DK; Lawrence DA; Zhang L
• Article: JOURNAL OF CELL SCIENCE. 2017;130(8):1365-1378

  Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling

  Muhl L; Folestad EB; Gladh H; Wang Y; Moessinger C; Jakobsson L; Eriksson U
• Article: CELL METABOLISM. 2017;25(3):713-726

  Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease

  Falkevall A; Mehlem A; Palombo I; Sahlgren BH; Ebarasi L; He L; Ytterberg AJ; Olauson H; Axelsson J; Sundelin B; Patrakka J; Scotney P; Nash A; Eriksson U
• Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2017;43(2):154-168

  tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS

  Fredriksson L; Lawrence DA; Medcalf RL
• Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(3):273-283

  Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis

  Wahlgren N; Thoren M; Hojeberg B; Kall T-B; Laska A-C; Sjostrand C; Hoijer J; Almqvist H; Holmin S; Lilja A; Fredriksson L; Lawrence D; Eriksson U; Ahmed N
• Review: PHARMACOLOGY & THERAPEUTICS. 2016;167:108-119

  Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders

  Lewandowski SA; Fredriksson L; Lawrence DA; Eriksson U
• Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63

  Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney

  Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Yla-Herttuala S; Eriksson U
• Article: KIDNEY INTERNATIONAL. 2016;89(4):848-861

  The role of PDGF-D in healthy and fibrotic kidneys

  Buhl EM; Djudjaj S; Babickova J; Klinkhammer BM; Folestad E; Borkham-Kamphorst E; Weiskirchen R; Hudkins K; Alpers CE; Eriksson U; Floege J; Boor P
• Article: DIABETES. 2016;65(4):861-873

  PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B

  Mehlem A; Palombo I; Wang X; Hagberg CE; Eriksson U; Falkevall A
• Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464

  Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration

  Lewandowski SA; Nilsson I; Fredriksson L; Lonnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
• Article: PLOS ONE. 2016;11(3):e0152276

  Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype

  Gladh H; Folestad EB; Muhl L; Ehnman M; Tannenberg P; Lawrence A-L; Betsholtz C; Eriksson U
• Doctoral thesis: 2015

  Vascular endothelial growth factor B-role in metabolism, lipotoxicity and disease

  Mehlem, Annika
• Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2015;9:456

  tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations

  Stefanitsch C; Lawrence A-LE; Olverling A; Nilsson I; Fredriksson L
• Article: NATURE PROTOCOLS. 2013;8(6):1149-1154

  Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

  Mehlem A; Hagberg CE; Muhl L; Eriksson U; Falkevall A
• Article: CANCER RESEARCH. 2013;73(7):2139-2149

  Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments

  Ehnman M; Missiaglia E; Folestad E; Selfe J; Strell C; Thway K; Brodin B; Pietras K; Shipley J; Ostman A; Eriksson U
• Review: PHYSIOLOGY. 2013;28(2):125-134

  Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

  Hagberg C; Mehlem A; Falkevall A; Muhl L; Eriksson U
• Article: NATURE. 2012;490(7420):426-430

  Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

  Hagberg CE; Mehlem A; Falkevall A; Muhl L; Fam BC; Ortsater H; Scotney P; Nyqvist D; Samen E; Lu L; Stone-Elander S; Proietto J; Andrikopoulos S; Sjoholm A; Nash A; Eriksson U
• Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(3):1136-1144

  Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities

  Fredriksson L; Nilsson I; Su EJ; Andrae J; Ding H; Betsholtz C; Eriksson U; Lawrence DA
• Article: PLOS ONE. 2012;7(6):e38760

  Imatinib Enhances Functional Outcome after Spinal Cord Injury

  Abrams MB; Nilsson I; Lewandowski SA; Kjell J; Codeluppi S; Olson L; Eriksson U
• Article: NATURE. 2010;464(7290):917-921

  Vascular endothelial growth factor B controls endothelial fatty acid uptake

  Hagberg CE; Falkevall A; Wang X; Larsson E; Huusko J; Nilsson I; van Meeteren LA; Samen E; Lu L; Vanwildemeersch M; Klar J; Genove G; Pietras K; Stone-Elander S; Claesson-Welsh L; Yla-Herttuala S; Lindahl P; Eriksson U
• Article: NATURE MEDICINE. 2008;14(7):731-737

  Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

  Su EJ; Fredriksson L; Geyer M; Folestad E; Cale J; Andrae J; Gao Y; Pietras K; Mann K; Yepes M; Strickland DK; Betsholtz C; Eriksson U; Lawrence DA
• Article: EMBO JOURNAL. 2004;23(19):3793-3802

  Tissue plasminogen activator is a potent activator of PDGF-CC

  Fredriksson L; Li H; Fieber C; Li X; Eriksson U
• Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2004;15(4):197-204

  The PDGF family: four gene products form five dimeric isoforms

  Fredriksson L; Li H; Eriksson U
• Article: NATURE CELL BIOLOGY. 2001;3(5):512-516

  PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.

  Bergsten E; Uutela M; Li X; Pietras K; Ostman A; Heldin CH; Alitalo K; Eriksson U
• Article: NATURE CELL BIOLOGY. 2000;2(5):302-309

  PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

  Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin CH; Alitalo K; Ostman A; Eriksson U
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(6):2576-2581

  Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

  Olofsson B; Pajusola K; Kaipainen A; von Euler G; Joukov V; Saksela O; Orpana A; Pettersson RF; Alitalo K; Eriksson U
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Funding

Grants

• Preventing thrombolyis-induced lipolysis to prolong the therapeutic window after acute ischemic stroke

  Ulla Hamberg Angeby and Lennart Angeby´s foundation
• Lilly Young Investigator Award

  European Foundation for the Study of Diabetes
• Eriksson, Ulf Per-Erik – Metabolic aspects of cancer development and treatment with a focus on liver cancer and cachexia

  Swedish Cancer Society
• Metabolic aspects of cancer development and treatment with a focus on liver cancer and cachexia

  Swedish Cancer Society
• Metabolic aspects of cancer development and treatment with a focus on liver cancer and cachexia

  Swedish Cancer Society
• Role of VEGF-B i diabetic complications

  Novo Nordisk Foundation
• Metabolic aspects of the onset and treatment of cancer with a focus on liver cancer and cachexia

  Swedish Cancer Society
• Studies of vascular diseases and the underlying mechanisms

  Swedish Research Council
• Development of novel drug candidates for stroke, fibrosis and cancer

  Swedish Research Council
• Role of VEGF-B signaling in diabetic complications

  Novo Nordisk Foundation
• Metabolic aspects of the onset and treatment of cancer with a focus on liver cancer and cachexia

  Swedish Cancer Society
• Growth-factor mediated regulation of blood vessel physiology - implications in several major diseases

  Swedish Research Council
• Metabolic aspects of the onset and treatment of cancer with a focus on liver cancer and cachexia

  Swedish Cancer Society
• Importance of some growth factors in tumor biology, with particular focus on members of the VEGF / PDGF family

  Swedish Cancer Society
• Importance of some growth factors in tumor biology, with particular focus on members of the VEGF / PDGF family

  Swedish Cancer Society
• Platelet-derived growth factor signaling in the central nervous system - novel treatment options for neuropathology

  Swedish Research Council
• Growth-factor mediated regulation of blood vessel physiology - implications in several major diseases

  Swedish Research Council
• Identification of new treatment options for neuropathology - implementation of a murine stroke model

  VINNOVA
• Identification and development of novel drug targets in stroke and other CNS injuries

  VINNOVA
• Growth factor-mediated regulation of blood vessel growth and function

  Swedish Research Council
• Exploring the Role of PDGF-CC in Vascular Permeability in the CNS

  Swedish Research Council
• Transatlantic Network of Excellence for the Identification of Novel Genetic Targets in Hemorrhagic Stroke

  Fondation Leducq

Staff and contact

Group leader

• 

  Ulf Eriksson

  Professor, Senior

  Telephone +46852487109

  E-mail ulf.pe.eriksson@ki.se

All members of the group

• 

  Ulf Eriksson

  Professor, Senior

  Telephone +46852487109

  E-mail ulf.pe.eriksson@ki.se
• Annelie Falkevall

  Researcher

  Telephone +46852486168

  E-mail annelie.falkevall@ki.se
• Erika Folestad

  Researcher

  E-mail erika.folestad@ki.se
• 

  Linda Fredriksson

  Researcher

  E-mail linda.fredriksson@ki.se
• 

  Benjamin Heller Sahlgren

  Phd Student

  E-mail benjamin.heller.sahlgren@ki.se
• 

  Ingrid Nilsson

  Researcher

  E-mail ingrid.nilsson@ki.se
• 

  Frank Chenfei Ning

  Affiliated to Research

  E-mail frank.chenfei.ning@ki.se
• 

  Jil Protzmann

  Phd Student

  E-mail jil.protzmann@ki.se
• Manuel Zeitelhofer

  Researcher | Docent

  E-mail manuel.zeitelhofer@ki.se

Other people connected to the group

• Randel, Stella