Linda Fredriksson

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Articles

Article: FLUIDS AND BARRIERS OF THE CNS. 2024;21(1):35
Analysis of ischemic stroke-mediated effects on blood-brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging
Protzmann J; Jung F; Jakobsson L; Fredriksson L
Article: EMBO MOLECULAR MEDICINE. 2022;14(12):e15809
Sex differences and risk factors for bleeding in Alagille syndrome
Hankeova S; Van Hul N; Laznovsky J; Verboven E; Mangold K; Hensens N; Adori C; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Sjoqvist M; Johansson BR; Hassan MG; Fredriksson L; Baumgartel K; Bryja V; Lendahl U; Jheon A; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Article: TRANSLATIONAL STROKE RESEARCH. 2022;13(5):801-815
Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke
Torrente D; Su EJ; Fredriksson L; Warnock M; Bushart D; Mann KM; Emal CD; Lawrence DA
Article: BLOOD. 2022;140(4):388-400
Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin
Goncalves A; Su EJ; Muthusamy A; Zeitelhofer M; Torrente D; Nilsson I; Protzmann J; Fredriksson L; Eriksson U; Antonetti DA; Lawrence DA
Article: SCIENTIFIC REPORTS. 2020;10(1):22383
Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier
Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
Article: ACTA NEUROPATHOLOGICA. 2017;134(4):585-604
Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke
Su EJ; Cao C; Fredriksson L; Nilsson I; Stefanitsch C; Stevenson TK; Zhao J; Ragsdale M; Sun Y-Y; Yepes M; Kuan C-Y; Eriksson U; Strickland DK; Lawrence DA; Zhang L
Article: SEMINARS IN THROMBOSIS AND HEMOSTASIS. 2017;43(2):154-168
tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS
Fredriksson L; Lawrence DA; Medcalf RL
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(3):273-283
Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis
Wahlgren N; Thoren M; Hojeberg B; Kall T-B; Laska A-C; Sjostrand C; Hoijer J; Almqvist H; Holmin S; Lilja A; Fredriksson L; Lawrence D; Eriksson U; Ahmed N
Article: BIOLOGY OPEN. 2016;5(4):461-474
A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
Andrae J; Gouveia L; Gallini R; He L; Fredriksson L; Nilsson I; Johansson BR; Eriksson U; Betsholtz C
Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration
Lewandowski SA; Nilsson I; Fredriksson L; Lonnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
Article: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. 2015;2(7):722-738
Identification of a neurovascular signaling pathway regulating seizures in mice
Fredriksson L; Stevenson TK; Su EJ; Ragsdale M; Moore S; Craciun S; Schielke GP; Murphy GG; Lawrence DA
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2015;9:456
tPA Deficiency in Mice Leads to Rearrangement in the Cerebrovascular Tree and Cerebroventricular Malformations
Stefanitsch C; Lawrence A-LE; Olverling A; Nilsson I; Fredriksson L
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2015;9:385
Imatinib treatment reduces brain injury in a murine model of traumatic brain injury
Su EJ; Fredriksson L; Kanzawa M; Moore S; Folestad E; Stevenson TK; Nilsson I; Sashindranath M; Schielke GP; Warnock M; Ragsdale M; Mann K; Lawrence A-LE; Medcalf RL; Eriksson U; Murphy GG; Lawrence DA
Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(3):1136-1144
Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities
Fredriksson L; Nilsson I; Su EJ; Andrae J; Ding H; Betsholtz C; Eriksson U; Lawrence DA
Article: ONCOGENE. 2009;28(4):534-544
The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth
Ehnman M; Li H; Fredriksson L; Pietras K; Eriksson U
Article: CANCER RESEARCH. 2009;69(1):369-378
Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts
Anderberg C; Li H; Fredriksson L; Andrae J; Betsholtz C; Li X; Eriksson U; Pietras K
Article: NATURE MEDICINE. 2008;14(7):731-737
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
Su EJ; Fredriksson L; Geyer M; Folestad E; Cale J; Andrae J; Gao Y; Pietras K; Mann K; Yepes M; Strickland DK; Betsholtz C; Eriksson U; Lawrence DA
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):281-289
PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis
Eitner F; Buecher E; van Roeyen C; Kunter U; Rong S; Seikrit C; Villa L; Boor P; Fredriksson L; Bakstrom G; Eriksson U; Ostman A; Floege J; Ostendorf T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):26856-26862
Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator
Fredriksson L; Ehnman M; Fieber C; Eriksson U
Article: EMBO JOURNAL. 2004;23(19):3793-3802
Tissue plasminogen activator is a potent activator of PDGF-CC.
Fredriksson L; Li H; Fieber C; Li X; Eriksson U
Article: ONCOGENE. 2003;22(10):1501-1510
PDGF-D is a potent transforming and angiogenic growth factor.
Li H; Fredriksson L; Li X; Eriksson U
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All other publications

Preprint: BIORXIV. 2021
Reduced myofibroblast transdifferentiation and fibrotic scarring in ischemic stroke after imatinib treatment
Zeitelhofer M; Stefanitsch C; Protzmann J; Torrente D; Adzemovic MZ; Lewandowski SA; Muhl L; Eriksson U; Nilsson I; Su EJ; Lawrence DA; Fredriksson L
Preprint: BIORXIV. 2021
Bleeding in patients and mice with Alagille syndrome: sex differences and risk factors
Hankeova S; Van Hul N; Laznovsky J; Hensen N; Verhoef E; Zikmund T; Dawit F; Kavkova M; Salplachta J; Li L; Sjöqvist M; Johansson BR; Hassan M; Bryja V; Lendahl U; Jheon A; Wang JS; Alten F; Fahnehjelm KT; Fischler B; Kaiser J; Andersson ER
Conference publication: INTERNATIONAL JOURNAL OF STROKE. 2020;15(1_SUPPL):624-625
PDGFRA ANTAGONISM DAMPENS REACTIVE GLIOSIS AND SCAR FORMATION AFTER ISCHEMIC STROKE
Zeitelhofer M; Stefanitsch C; Adzemovic M; Sue J; Lewandowski S; Muhl L; Nilsson I; Lawrence D; Fredriksson L
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2019;25:930
Blocking PDGFR-a decreases multiple sclerosis-like neuroinflammation by inhibiting disruption of blood brain barrier integrity
Zeitelhofer M; Adzemovic MZ; Huang J; Stefanitsch C; Mossinger C; Hochmeister S; Strell C; Muhl L; Lassmann H; Kockum I; Fredriksson L; Olsson T; Nilsson I; Eriksson U
Review: PHARMACOLOGY AND THERAPEUTICS. 2016;167:108-119
Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders
Lewandowski SA; Fredriksson L; Lawrence DA; Eriksson U
Conference publication: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2016;36:150-151
REGULATING THE BLOOD BRAIN BARRIER AFTER STROKE WITH TPA INHIBITORS
Su EJ; Fredriksson L; Warnock M; Bushart D; Lawrence DA
Published conference paper: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7(Suppl 1):155-158
Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke
Su EJ; Fredriksson L; Schielke GP; Eriksson U; Lawrence DA
Thesis / dissertation: 2006
Proteolytic activation and biological functions of the novel PDGFs
Fredriksson, Linda
Review: CYTOKINE AND GROWTH FACTOR REVIEWS. 2004;15(4):197-204
The PDGF family: four gene products form five dimeric isoforms.
Fredriksson L; Li H; Eriksson U

Grants

Development of novel drug candidates for stroke, fibrosis and cancer
Swedish Research Council
1 January 2017 - 31 December 2017
Platelet-derived growth factor signaling in the central nervous system - novel treatment options for neuropathology
Swedish Research Council
1 January 2013 - 31 December 2015
Identification of new treatment options for neuropathology - implementation of a murine stroke model
VINNOVA
1 December 2011 - 31 December 2016
Notification of the use of return grants for granted postdoctoral grants
Swedish Research Council
1 January 2011 - 31 December 2011

Employments

Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2017-

Degrees and Education

Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2006

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