Computational and Affective Psychiatry Lab (CAP Lab) – Marc Guitart Masip's Research Group

The research group uses computational models of behaviour to investigate the cognitive and computational mechanisms underlying psychiatric disorders and their relation to brain processes. By parametrising individual differences, the group identifies cognitive phenotypes in patients and examines their relation to clinical outcomes. The research aims to generate knowledge that can help improve clinical practice in psychiatry.

cross road

The research group focuses on computational psychiatry and affective decision-making processes. Using behavioural experiments, computational models, and neuroimaging, the group investigates how psychiatric symptoms emerge from disrupted brain computations. The research examines how the brain forms expectations, learns from reward, and regulates motivation, and how individual differences in these processes relate to affective disorders, particularly recurrent depression and bipolar disorder.

By combining longitudinal digital assessments with mechanistic modelling, the group develops quantitative cognitive phenotypes and investigates how these can improve diagnosis, predict illness trajectories, and guide personalised treatment.

Projects

The researchgroup has two ongoing projects:

Psychobiological markers to improve diagnosis and to predict affective episodes in bipolar disorder
The group has developed and validated a battery of behavioral tests that can be administered via a smartphone app and that measure two different aspects of behavior regulated by dopamine: reward learning and motivation. The app will be used to test patients with bipolar disorder longitudinally over a long period of time. Sleep and activity will also be measured using a smartwatch. The study will test whether affective episodes can be predicted in advance. The group has been collaborating with a patient advocacy organization for individuals with bipolar disorder to design, implement, and evaluate the protocol as testing unfolds. A feasibility and acceptability study is currently being conducted.

Cognitive Phenotyping for Stratifying Depression and Predicting Risk
Research in both humans and animal models has identified key neurocognitive dimensions relevant to depression. The group has developed a novel set of cognitive tests to assess these dimensions. In this project, these tests will be administered online to a large sample of patients receiving specialized psychiatric care, as well as to a comparison group of adults without psychiatric history. Using normative modeling, the group will quantify how much each patient deviates from the non-psychiatric norm. These cognitive deviations will be used to predict clinical outcomes via linkage to the National Registers and to identify clinically meaningful subtypes.

Publications

All publications from group members