Our research
Our research uses clinical pharmacology and pharmacometric modelling to improve treatment for infectious diseases, particularly malaria and other neglected tropical diseases.
We study how medicines behave in different patient populations and use pharmacokinetic and pharmacodynamic models to identify safe and effective doses, including individualized treatment approaches. Our work has informed global treatment recommendations for malaria, particularly in groups often under-represented in drug development, including young children and pregnant women.
We also develop and apply sensitive LC-MS/MS methods to measure drugs in clinical and biological samples. High-resolution mass spectrometry and omics approaches, including metabolomics, proteomics and lipidomics, help us study interactions between the host, medicines and pathogens. This work helps us understand dynamic disease processes, drug mechanisms of action and the development of drug resistance. We apply modelling and simulation to translational research and work on new pediatric formulations, including child-friendly triple-combination therapies for malaria.