Annelie Falkevall

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Articles

Article: KIDNEY INTERNATIONAL. 2025;107(3):492-507
Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease
Folestad E; Mehlem A; Ning FC; Oosterveld T; Palombo I; Singh J; Olauson H; Witasp A; Thorell A; Stenvinkel P; Ebefors K; Nystrom J; Eriksson U; Falkevall A
Journal article: CURRENT OPINION IN ENDOCRINE AND METABOLIC RESEARCH. 2024;37:100559
"Regulation of adipose-derived fatty acid flux to the liver"-Impact on metabolic dysfunction-associated steatotic liver disease
Folestad E; Falkevall A
Article: JOURNAL OF HEPATOLOGY. 2023;78(5):901-913
Inhibition of VEGF-B signaling prevents non-alcoholic fatty liver disease development by targeting lipolysis in the white adipose tissue
Falkevall A; Mehlem A; Folestad E; Ning FC; Osorio-Conles O; Radmann R; de Hollanda A; Wright SD; Scotney P; Nash A; Eriksson U
Article: CELL METABOLISM. 2017;25(3):713-726
Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease
Falkevall A; Mehlem A; Palombo I; Sahlgren BH; Ebarasi L; He L; Ytterberg AJ; Olauson H; Axelsson J; Sundelin B; Patrakka J; Scotney P; Nash A; Eriksson U
Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63
Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney
Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Yla-Herttuala S; Eriksson U
Article: DIABETES. 2016;65(4):861-873
PGC-1α Coordinates Mitochondrial Respiratory Capacity and Muscular Fatty Acid Uptake via Regulation of VEGF-B
Mehlem A; Palombo I; Wang X; Hagberg CE; Eriksson U; Falkevall A
Article: NATURE PROTOCOLS. 2013;8(6):1149-1154
Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease
Mehlem A; Hagberg CE; Muhl L; Eriksson U; Falkevall A
Article: NATURE. 2012;490(7420):426-430
Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
Hagberg CE; Mehlem A; Falkevall A; Muhl L; Fam BC; Ortsater H; Scotney P; Nyqvist D; Samen E; Lu L; Stone-Elander S; Proietto J; Andrikopoulos S; Sjoholm A; Nash A; Eriksson U
Article: PLOS ONE. 2010;5(11):e14109
Suppressive Effects of Vascular Endothelial Growth Factor-B on Tumor Growth in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis
Albrecht I; Kopfstein L; Strittmatter K; Schomber T; Falkevall A; Hagberg CE; Lorentz P; Jeltsch M; Alitalo K; Eriksson U; Christofori G; Pietras K
Article: NATURE. 2010;464(7290):917-921
Vascular endothelial growth factor B controls endothelial fatty acid uptake
Hagberg CE; Falkevall A; Wang X; Larsson E; Huusko J; Nilsson I; van Meeteren LA; Samen E; Lu L; Vanwildemeersch M; Klar J; Genove G; Pietras K; Stone-Elander S; Claesson-Welsh L; Yla-Herttuala S; Lindahl P; Eriksson U
Article: CIRCULATION. 2009;119(6):845-856
Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1-and Neuropilin Receptor-1-Dependent Mechanisms
Laehteenvuo JE; Laehteenvuo MT; Kivelae A; Rosenlew C; Falkevall A; Klar J; Heikura T; Rissanen TT; Vaehaekangas E; Korpisalo P; Enholm B; Carmeliet P; Alitalo K; Eriksson U; Ylae-Herttuala S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(39):29096-29104
Degradation of the amyloid β-protein by the novel mitochondrial peptidasome, PreP
Falkevall A; Alikhani N; Bhushan S; Pavlov PF; Busch K; Johnson KA; Eneqvist T; Tjernberg L; Ankarcrona M; Glaser E
Article: EMBO JOURNAL. 2006;25(9):1977-1986
The closed structure of presequence protease PreP forms a unique 10 000 A³ chamber for proteolysis
Johnson KA; Bhushan S; Stahl A; Hallberg BM; Frohn A; Glaser E; Eneqvist T
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;349(4):847-860
Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different
Ståhl A; Nilsson S; Lundberg P; Bhushan S; Biverståhl H; Moberg P; Morisset M; Vener A; Mäler L; Langel U; Glaser E
Article: PLANT AND CELL PHYSIOLOGY. 2005;46(6):985-996
Catalysis, subcellular localization, expression and evolution of the targeting peptides degrading protease, AtPreP2.
Bhushan S; Ståhl A; Nilsson S; Lefebvre B; Seki M; Roth C; McWilliam D; Wright SJ; Liberles DA; Shinozaki K; Bruce BD; Boutry M; Glaser E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2004;336(5):1129-1140
NMR solution structure of the mitochondrial F1beta presequence from Nicotiana plumbaginifolia.
Moberg P; Nilsson S; Ståhl A; Eriksson A-C; Glaser E; Mäler L
Article: PLANT JOURNAL. 2003;36(5):616-628
Characterization of a novel zinc metalloprotease involved in degrading targeting peptides in mitochondria and chloroplasts.
Moberg P; Ståhl A; Bhushan S; Wright SJ; Eriksson A; Bruce BD; Glaser E
Article: EMBO REPORTS. 2003;4(11):1073-1078
Dual targeting and function of a protease in mitochondria and chloroplasts.
Bhushan S; Lefebvre B; Ståhl A; Wright SJ; Bruce BD; Boutry M; Glaser E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(44):41931-41939
Isolation and identification of a novel mitochondrial metalloprotease (PreP) that degrades targeting presequences in plants
Ståhl A; Moberg P; Ytterberg J; Panfilov O; von Löwenhielm HB; Nilsson F; Glaser E
Article: BIOCHEMICAL JOURNAL. 2000;349 Pt 3(Pt 3):703-707
Rapid degradation of the presequence of the f1beta precursor of the ATP synthase inside mitochondria.
Ståhl A; Pavlov PF; Szigyarto C; Glaser E

All other publications

Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S78
Inhibition of VEGF-B signalling prevents non-alcoholic fatty liver disease development and progression
Falkevall A; Mehlem A; Folestad E; Zeitelhofer M; Scotney P; Eriksson U
Editorial comment: CELL METABOLISM. 2018;27(6):1161-1162
Visualizing Fatty Acid Flux
Eriksson U; Falkevall A
Review: PHYSIOLOGY. 2013;28(2):125-134
Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B
Hagberg C; Mehlem A; Falkevall A; Muhl L; Eriksson U

Grants

Growth-factor mediated regulation of blood vessel physiology - implications in several major diseases
Swedish Research Council
1 January 2017 - 31 December 2020

Employments

Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2012-

Degrees and Education

Docent, Karolinska Institutet, 2025

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