Chris Tibbitt team - Defining the metabolic signatures of tissue resident human ILCs

The current focus of the Chris Tibbitt team is understanding tissue ILC specific metabolism in the context of allergy and cancer.

The Chris Tibbitt team is part of the Jenny Mjösberg research group at the Center for Infectious Medicine (CIM).

About our research

Induction of any immune response requires metabolic changes. While a number of genes and pathways have been evaluated in T cells, the factors that link activation to alterations in metabolic state remains to be profiled in depth for human ILCs. Using the latest techniques in metabolic profiling and single cell mutli-omics, we aim to map the metabolic profiles of human ILCs across a range of tissues and inflammatory conditions. Our aim is to assess whether biological therapies can impact upon cell intrinsic metabolism. We are also seeking to determine how host metabolic state (e.g. obesity) can alter the ILC phenotypes during asthma. 

Team leader

Chris Tibbitt

Researcher
H7 Department of Medicine, Huddinge

Chris completed his PhD studies at Newcastle University in 2015 characterizing the influence of TCR signaling on the development of autoimmune Th17 cells. During his postdoctoral studies in the Coquet and Mjösberg labs, he worked to define T helper cells and ILC responses using single cell based approaches. 

Team members

Sabrina Ferreira

Postdoctoral researcher
H7 Department of Medicine, Huddinge

Sabrina Ferreira completed her PhD at University of São Paulo in 2019 where she worked on the modulating effect of insulin in asthma. In 2017-2018 she worked as a visiting PhD student at Karolinska Institutet studying the effect of insulin secretion in beta cells in diabetes mellitus. From 2019-2022, she is a postdoctoral fellow at Karolinska Institutet, focusing on dissecting the underlying mechanism that regulates the tumor-associated macrophage's (TAMs) immunosuppressive phenotype.

Selected publications

  1. Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous TH 2 and TH 17 cell responses.
    Julian M. Stark, Jielu Liu, Christopher A. Tibbitt, Murray Christian, Junjie Ma, Anna Wintersand, Ben Murrell, Mikael Adner, Hans Grönlund, Guro Gafvelin, Jonathan M Coquet. Allergy 2022 Jun;(): PMID: 35657107
     
  2. CD45RA+CD62L- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs.
    Efthymia Kokkinou, Ram Vinay Pandey, Luca Mazzurana, Irene Gutierrez-Perez, Christopher A Tibbitt, Whitney Weigel, Tea Soini, Anna Carrasco, Anna Rao, Maho Nagasawa, Susanne Bal, Mats Jangard, Danielle Friberg, Ulrick Lindfoss, Caroline Nordenvall, Malin Ljunggren, Staffan Haapaniemi, Åsa Keita, Johan Söderholm, Charlotte Hedin, Hergen Spits, Yenan Bryceson, Jenny Mjösberg. Sci Immunol 2022 04;7(70):eabj8301 PMID: 35427178
     
  3. Intestinal helminth infection transforms the CD4+ T cell composition of the skin.
    Cajsa H Classon, Muzhen Li, Ada Lerma Clavero, Junjie Ma, Xiaogang Feng, Christopher A Tibbitt, Julian M Stark, Rebeca Cardoso, Emma Ringqvist, Louis Boon, Eduardo J Villablanca, Antonio Gigliotti Rothfuchs, Liv Eidsmo, Jonathan M Coquet, Susanne Nylén. Mucosal Immunol 2022 02;15(2):257-267 PMID: 34931000
     
  4. Single-cell analysis pinpoints distinct populations of cytotoxic CD4+ T cells and an IL-10+CD109+ TH2 cell population in nasal polyps.
    Junjie Ma*, Christopher A Tibbitt*, Susanna K Georén, Murray Christian, Ben Murrell, Lars-Olaf Cardell, Claus Bachert, Jonathan M Coquet.
    Sci Immunol 2021 08;6(62): PMID:34389612 *denotes joint authorship.
     
  5. GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens.
    Rohrbeck, Leona, Monika Adori, Shan Wang, Chenfei He, Christopher A Tibbitt, Mark Chernyshev, Madle Sirel, Ulf Ribacke, Mohammad Bohooly-Y, Mikael Karlsson, Gunilla Karlsson Hedstam, Jonathan M Coquet. Immunol Cell Biol 2021 02;99(2):234-243 PMID: 32888232
     
  6. PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ.
    Batyrova, Banu, Fien Luwaert, Panagiota Maravelia, Yuria Miyabayashi, Neha Vashist, Julian M. Stark, Sara Y. Soori, Christopher A Tibbitt, Paulo Reise, Jonthan M Coquet, Benedict Chambers. Immun Inflamm Dis 2020 03;8(1):8-23 PMID:31742928
     
  7. Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.
    Christopher A Tibbitt*, Julian M Stark*, Liesbet Martens, Junjie Ma, Jeffrey E Mold, Kim Deswarte, Ganna Oliynk, Xiaogang Feng, Bart N Lambrecht, Pieter De Bleser, Susanne Nylén, Hamida Hammad, Marie Aresenian Henriksson, Yvan Saeys, Jonathan M Coquet. Immunity 2019 07;51(1):169-184.e5 PMID:31231035 *Denotes joint authorship.
     
  8. The Role of PPAR-γ in Allergic Disease.
    Julian M Stark, Jonathan M Coquet, Christopher A TibbittCurr Allergy Asthma Rep 2021 10;21(11):45 PMID: 34697644
     
  9. The Metabolic Requirements of Th2 Cell Differentiation.
    Julian M Stark^, Christopher A Tibbitt^, Jonathan M Coquet. Front Immunol 2019 ;10():2318 PMID: 31611881 ^Denotes joint authorship.
     
  10. PPAR-γ promotes type 2 immune responses in allergy and nematode infection.
    Ting Chen*, Christopher A Tibbitt*, Xiaogang Feng, Julian M Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K Sedimbi, Mikael CI Karlsson, Bart N Lambrecht, Gunilla B Karlsson Hedestam, Rudi W Hendriks, Benedict J Chambers, Susanne Nylén, Jonathan M Coquet. Sci Immunol 2017 Mar;2(9): PMID: 28783701