The Chris Tibbitt team is part of the Jenny Mjösberg research group at the Center for Infectious Medicine (CIM).
About our research
Induction of any immune response requires metabolic changes. While a number of genes and pathways have been evaluated in T cells, the factors that link activation to alterations in metabolic state remains to be profiled in depth for human ILCs. Using the latest techniques in metabolic profiling and single cell mutli-omics, we aim to map the metabolic profiles of human ILCs across a range of tissues and inflammatory conditions. Our aim is to assess whether biological therapies can impact upon cell intrinsic metabolism. We are also seeking to determine how host metabolic state (e.g. obesity) can alter the ILC phenotypes during asthma.