Chris Tibbitt

Publications
Grants
Public outreach and news

Articles

Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362
MAIT cell heterogeneity across paired human tissues reveals specialization of distinct regulatory and enhanced effector profiles
Kammann T; Cai C; Sekine T; Mouchtaridi E; Boulouis C; Nilsen V; Ballesteros OR; Mueller TR; Gao Y; Raineri EJM; Mily A; Adamo S; Constantz C; Niessl J; Weigel W; Kokkinou E; Stamper C; Marchalot A; Bassett J; Ferreira S; Rodahl I; Wild N; Brownlie D; Tibbitt C; Mak JYW; Fairlie DP; Leeansyah E; Michaelsson J; Marquardt N; Mjosberg J; Jorns C; Buggert M; Sandberg JK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(4):e2350660
Single-cell RNA sequencing of cells from fresh or frozen tissue reveals a signature of freezing marked by heightened stress and activation
Stamper CT; Marchalot A; Tibbitt CA; Weigel W; Jangard M; Theorell J; Mjosberg J
Article: NATURE COMMUNICATIONS. 2024;15(1):683
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Dean I; Lee CYC; Tuong ZK; Li Z; Tibbitt CA; Willis C; Gaspal F; Kennedy BC; Matei-Rascu V; Fiancette R; Nordenvall C; Lindforss U; Baker SM; Stockmann C; Sexl V; Hammond SA; Dovedi SJ; Mjoesberg J; Hepworth MR; Carlesso G; Clatworthy MR; Withers DR
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;78(9):2533-2536
Innate lymphoid cells type 2 and CD8+ T cells are perturbed in overweight and obese individuals with asthma.
Björkander S; Maier P; Kere M; Merid SK; Wirth L; Wiegel W; Ekström S; Kull I; Bergström A; Melén E; Mjösberg J; Tibbitt CA
Article: CELL REPORTS MEDICINE. 2023;4(5):101038
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Idestrom M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjosberg J
Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2023;13(3):e12238
Obese asthma phenotypes display distinct plasma biomarker profiles.
Björkander S; Klevebro S; Hernandez-Pacheco N; Kere M; Ekström S; Sparreman Mikus M; van Hage M; James A; Kull I; Bergström A; Mjösberg J; Tibbitt CA; Melén E
Article: ISCIENCE. 2022;25(10):105137
PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype
Wagner AK; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresley E; Campbell N; Trittel S; Riese P; Ribacke U; Sandalova T; Achour A; Karre K; Chambers BJ
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(10):2987-3001
Recombinant multimeric dog allergen prevents airway hyperresponsiveness in a model of asthma marked by vigorous T_H2 and T_H17 cell responses
Stark JM; Liu J; Tibbitt CA; Christian M; Ma J; Wintersand A; Dunst J; Kreslavsky T; Murrell B; Adner M; Gronlund H; Gafvelin G; Coquet JM
Article: SCIENCE IMMUNOLOGY. 2022;7(70):eabj8301
CD45RA⁺CD62L^- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs
Kokkinou E; Pandey RV; Mazzurana L; Gutierrez-Perez I; Tibbitt CA; Weigel W; Soini T; Carrasco A; Rao A; Nagasawa M; Bal SM; Jangard M; Friberg D; Lindforss U; Nordenvall C; Ljunggren M; Haapaniemi S; Keita AV; Soderholm J; Hedin C; Spits H; Bryceson YT; Mjosberg J
Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267
Intestinal helminth infection transforms the CD4⁺ T cell composition of the skin
Classon CH; Li M; Clavero AL; Ma J; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs AG; Eidsmo L; Coquet JM; Nylen S
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabg6356
Single-cell analysis pinpoints distinct populations of cytotoxic CD4⁺ T cells and an IL-10⁺CD109⁺ T_H2 cell population in nasal polyps
Ma J; Tibbitt CA; Georen SK; Christian M; Murrell B; Cardell L-O; Bachert C; Coquet JM
Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243
GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens
Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
Article: IMMUNITY, INFLAMMATION AND DISEASE. 2020;8(1):8-23
PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ
Batyrova B; Luwaert F; Maravelia P; Miyabayashi Y; Vashist N; Stark JM; Soori SY; Tibbitt CA; Riese P; Coquet JM; Chambers BJ
Article: IMMUNITY. 2019;51(1):169-184.e5
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
Tibbitt CA; Stark JM; Martens L; Ma J; Mold JE; Deswarte K; Oliynyk G; Feng X; Lambrecht BN; De Bleser P; Nylen S; Hammad H; Henriksson MA; Saeys Y; Coquet JM
Article: JOURNAL OF AUTOIMMUNITY. 2019;98:86-94
Multi-faceted inhibition of dendritic cell function by CD4⁺ Foxp3⁺ regulatory T cells
Seitz C; Liu S; Klocke K; Joly A-L; Czarnewski PV; Tibbitt CA; Parigi SM; Westerberg LS; Coquet JM; Villablanca EJ; Wing K; Andersson J
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2018;38(8):e145-e158
Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis
Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196
PPAR-γ promotes type 2 immune responses in allergy and nematode infection
Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(7):1633-1643
Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
Tibbitt C; Falconer J; Stoop J; van Eden W; Robinson JH; Hilkens CMU
Journal article: BIO-PROTOCOL. 2016;6(14)
House Dust Mite Extract and Cytokine Instillation of Mouse Airways and Subsequent Cellular Analysis
Tibbitt C; Coquet J
Article: IMMUNOLOGY. 2013;138(1):68-75
The choice of adjuvant determines the cytokine profile of T cells in proteoglycan-induced arthritis but does not influence disease severity
Stoop JN; Tibbitt CA; van Eden W; Robinson JH; Hilkens CMU

All other publications

Review: CURRENT OPINION IN IMMUNOLOGY. 2024;91:102500
Metabolic requirements of type 2 lymphocytes in allergic disease
Tibbitt CA; Coquet JM
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:oa2495
Late Breaking Abstract - Dynamics of the blood innate lymphoid cell compartment in patients with severe asthma undergoing type 2 biologics treatment: Initial findings in the BIOCROSS study
Wirth L; Yasinska V; Tibbitt CA; Weigel W; Hochdorfer T; Andersson LI; Sparreman-Mikus M; Dahlen B; Dahlen S-E; Mjosberg J
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:pa4407
Peripheral innate lymphoid cell and T cell phenotypes are associated with treatable traits in young adults with asthma
Kere M; Bjorkander S; Tibbitt CA; Mjosberg J; Melen E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2023;62:oa2502
Innate lymphoid cells type 2 and CD8+T cells are perturbed in overweight and obese individuals with asthma
Bjorkander S; Maier P; Kere M; Merid SK; Wirth L; Weigel W; Mjosberg J; Melen E; Tibbitt C
Preprint: BIORXIV. 2023
Rapid establishment of a tumor-retained state curtails the contribution of conventional NK cells to anti-tumor immunity in solid cancers
Dean I; Lee CYC; Tuong Z; Li Z; Tibbitt C; Willis C; Gaspal F; Kennedy B; Matei-Rascu V; Fiancette R; Nordenvall C; Lindforss U; Baker SM; Stockmann C; Sexl V; Carlesso G; Hammond S; Dovedi S; Mjösberg J; Hepworth M; Clatworthy M; Withers D
Editorial comment: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;78(7):2061-2063
pH sensing shapes immune cell function: The role of GPR65 and its implications for allergic disease
Ferreira SDS; Bek MK; Tibbitt CA
Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2021;21(11):45
The Role of PPAR-γ in Allergic Disease
Stark JM; Coquet JM; Tibbitt CA
Preprint: BIORXIV. 2021
Intestinal helminth infection transforms the CD4+ T cell composition of the skin
Classon CH; Li M; Ma J; Clavero L; Feng X; Tibbitt CA; Stark JM; Cardoso R; Ringqvist E; Boon L; Villablanca EJ; Rothfuchs G; Eidsmo L; Coquet JM; Nylén S
Preprint: BIORXIV. 2021
PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency
Wagner A; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresly E; Campbell N; Trittel S; Riese P; Sandalova T; Achour A; Kärre K; Chambers B
Preprint: BIORXIV. 2021
Sublingual allergen immunotherapy with recombinant dog allergens prevents airway hyperresponsiveness in a model of asthma marked by vigorous T_H2 and T_H17 cell responses
Stark J; Liu J; Tibbitt C; Christian M; Ma J; Wintersand A; Murrell B; Adner M; Grönlund H; Gafvelin G; Coquet J
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:260
Nasal polyps are characterized by a population of CD109+CRTH2-Th2 cells that secrete interleukin-4 and interleukin-10
Ma J; Tibbitt CA; Georen SK; Georen SK; Christian M; Murrell B; Cardell LO; Cardell LO; Bachert C; Bachert C; Bachert C; Coquet JM
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;94(6)
Single-cell analysis pinpoints distinct populations of cytotoxic CD4 T cells and an IL-10+CD109+Th2 cell population in nasal polyps
Ma J; Tibbitt C; Georen S; Christian M; Murrell B; Cardell L; Bachert C; Coquet J
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49:403-404
Understanding the role of T helper cells during asthmatic inflammation
Stark JM; Tibbitt CA; Martens L; Ma J; Oliynyk G; Henriksson AM; Sayes Y; Coquet JM
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2318
The Metabolic Requirements of Th2 Cell Differentiation
Stark JM; Tibbitt CA; Coquet JM
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):275
Th2 cell metabolism
Stark JM; Tibbitt C; Oliynyk G; Henriksson MA; Coquet JM
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):250-251
Understanding the role T helper cells during asthmatic inflammation at the single cell level
Tibbitt C; Martens L; Saeys Y; Coquet J

Grants

Defining the metabolic signatures of tissue resident Innate Lymphoid Cells
Swedish Research Council
1 January 2021 - 31 December 2024

Articles

All other publications

Grants

News from KI

Events from KI