Epidemiology of HPV-related cancer prevention – Jiayao Lei's research group

Our research group works at the intersection of cancer epidemiology, vaccine epidemiology, and data-driven prevention to advance the prevention and early detection of HPV-related cancers. We evaluate HPV vaccination, screening, and risk-stratified strategies, with a focus on real-world effectiveness, equity, and timely translation of evidence into medical policy and practice.

Part of the:

Our research 

A central goal of our research is to understand how HPV vaccination, infection, screening, and disease progression interact across the cancer prevention pathway. Our research mainly is largely based on an established linkage of multiple nationwide registers for HPV prevention through ACCES (Advancing Cervical Cancer Eradication Strategies) project. 

Our group has made major contributions to evidence on HPV vaccine effectiveness, including cervical cancer prevention, long-term protection, dose schedules, herd effects, and protection against non-cervical HPV-related outcomes. We also aim to optimize cancer screening through HPV-based triage, risk stratification, and machine learning–supported prediction models. Beyond cancer prevention, we investigate the impact of HPV infection and HPV vaccination on pregnancy outcomes, broadening our understanding of the wider health implications of HPV prevention.

Our work has been published in leading international medical and public health journals, including The New England Journal of Medicine, BMJ, The Lancet Public Health, JAMA Oncology, The Lancet Regional Health – Europe, and eClinicalMedicine.

Publications

All publications from group members

Staff and contact

Group leader

All members of the group

Visiting address

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Nobels väg 12A, Solna, 17177, Sverige

Postal address

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Nobels väg 12A, Solna, 17177, Sverige