Our research
Engineering therapeutic cell types in vivo
We are using molecular engineering to elicit regenerative glio- and neurogenesis from resident cells using the mouse spinal cord as a model system.
Synthetic gene circuits for regeneration
We aim to understand how cells in the mammalian brain and spinal cord respond to an injury and use this knowledge to develop the next generation of synthetic gene circuits for tissue regeneration while opening the door to develop programmable regenerative therapies.
Spatial genomics
We are developing technologies for spatially resolved molecular profiling to support our research lines. This allows us to interrogate how cells ‘talk’ to each when tissue homeostasis is perturbed and identify the molecular programs underlying pathological cell states within their native neural tissue environment.
Enric Llorens, Department of Cell and Molecular Biology.
Photo: Johan Marklund
Approaches
- Single cell genomics
- Spatial genomics
- Computational biology
- Gene delivery
- Mouse models of CNS injury