Mammalian Locomotor Laboratory
Research in the laboratory is directed to understand mechanisms by which neurons and neural networks operate to generate complex brain function. We use the rodent as a model system to study the molecular, cellular and network organization of spinal locomotor circuitries, their development and central control in mammals. We apply a broad technical approach that combines electrophysiology and anatomy with molecular mouse genetics, optogenetics and behavioral analyses.
We have deciphered the functional organization of spinal circuitries necessary for producing changes in timing and coordination of locomotion, and delineated brainstem circuits involved in gating or context-dependent selection of motor behaviors.
The lab is also engaged in characterizing plasticity in spinal networks and motor neurons following lesions of the cord and to devise targeted manipulation of these changes to alleviate dysfunctional motor symptoms following spinal cord injury.