Falk laboratory - Selected publications

A list of selected publications from the Falk laboratory at the Department of Neuroscience.

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.
Čančer M, Hutter S, Holmberg KO, Rosén G, Sundström A, Tailor J, et al
Cell Stem Cell 2019 Dec;25(6):855-870.e11

Ataxia in Patients With Bi-Allelic NFASC Mutations and Absence of Full-Length NF186.
Kvarnung M, Shahsavani M, Taylan F, Moslem M, Breeuwsma N, Laan L, et al
Front Genet 2019 ;10():896

Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality.
Lam M, Moslem M, Bryois J, Pronk RJ, Uhlin E, Ellström ID, et al
Exp. Cell Res. 2019 Oct;383(1):111469

Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models.
Lundin A, Delsing L, Clausen M, Ricchiuto P, Sanchez J, Sabirsh A, et al
Stem Cell Reports 2018 03;10(3):1030-1045

An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis.
Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, et al
Mol. Psychiatry 2018 07;23(7):1674-1684

Derivation of human iPS cell lines from monozygotic twins in defined and xeno free conditions.
Uhlin E, Rönnholm H, Day K, Kele M, Tammimies K, Bölte S, et al
Stem Cell Res 2017 01;18():22-25

Spider silk for xeno-free long-term self-renewal and differentiation of human pluripotent stem cells.
Wu S, Johansson J, Damdimopoulou P, Shahsavani M, Falk A, Hovatta O, et al
Biomaterials 2014 Oct;35(30):8496-502

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons.
Zhang D, Pekkanen-Mattila M, Shahsavani M, Falk A, Teixeira AI, Herland A
Biomaterials 2014 Feb;35(5):1420-8

Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency.
Tailor J, Kittappa R, Leto K, Gates M, Borel M, Paulsen O, et al
J. Neurosci. 2013 Jul;33(30):12407-22

Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells.
Fujimoto Y, Abematsu M, Falk A, Tsujimura K, Sanosaka T, Juliandi B, et al
Stem Cells 2012 Jun;30(6):1163-73

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.
Falk A, Koch P, Kesavan J, Takashima Y, Ladewig J, Alexander M, et al
PLoS ONE 2012 ;7(1):e29597