Ping Chen research
We work on data-driven research in human cardiometabolic diseases.
We aim to integrate longitudinal patient data, cutting-edge multi-omics technologies, and novel computational approaches to monitor individual disease progression and dissect the underlying disease-driving mechanisms. In particular, we are interested in the roles of immune cells (macrophages, monocytes, dendritic cells, etc.) and RNA splicing-centric transcriptional regulation in disease progression.
Currently, we focus on obesity and its associated metabolic diseases, especially non-alcoholic fatty liver disease and diabetes.
Researcher Ping Chen
Research techniques
Single-cell omics, Spatial omics, Mass spectrometry, Bioinformatics, Artificial intelligence.
External funding
Region Stockholm CIMED, Jeanssons Stiftelser and Karolinska Institutet.
Selected publications
Macrophage functional diversity in NAFLD - more than inflammation.
Barreby E, Chen P, Aouadi M
Nat Rev Endocrinol 2022 Aug;18(8):461-472
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Azzimato V, Chen P, Barreby E, Morgantini C, Levi L, Vankova A, Jager J, Sulen A, Diotallevi M, Shen JX, Miller A, Ellis E, Rydén M, Näslund E, Thorell A, Lauschke VM, Channon KM, Crabtree MJ, Haschemi A, Craige SM, Mori M, Spallotta F, Aouadi M
Gastroenterology 2021 Dec;161(6):1982-1997.e11
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes.
He B*, Chen P*, Zambrano S, Dabaghie D, Hu Y, Möller-Hackbarth K, Unnersjö-Jess D, Korkut GG, Charrin E, Jeansson M, Bintanel-Morcillo M, Witasp A, Wennberg L, Wernerson A, Schermer B, Benzing T, Ernfors P, Betsholtz C, Lal M, Sandberg R, Patrakka J
Nat Commun 2021 Apr;12(1):2141
Single-cell RNA counting at allele and isoform resolution using Smart-seq3.
Hagemann-Jensen M, Ziegenhain C, Chen P, Ramsköld D, Hendriks GJ, Larsson AJM, Faridani OR, Sandberg R
Nat Biotechnol 2020 Jun;38(6):708-714
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Azzimato V*, Jager J*, Chen P*, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M
Sci Transl Med 2020 Feb;12(532):