Early human embryo
We work to uncover the fundamental principles underlying how the first cell types established in the early human embryo from totipotent morula, to blastocyst, implantation, gastrulation and early organ formation. For this we are utilising embryo culture, stem cell based embryo models and multiomic profiling. Please visit our human embryogenesis reference atlas
Research supported by
Develop embryonic stem cell-based strategies for treatment of Diabetes and vision loss.
We have establish a first clinically compliant good manufacturing practice (GMP) grade human embryonic stem cell line, KARO1.
Supported by
Treatment of Diabetes
Within our diabetic efforts we are actively working to establish methodology to efficiently produce glucose responsive pancreatic islets with correct cellular composition as well as sclaing our manufacturing process to clinically relevant batches.
This work is currently supported by
Treatment of age-related macular degeneration (AMD)
In an effort to develop a cell therapy for Age-related Macular Degeneration (AMD), we have developed and manufactured CellThRPE1, an embryonic stem cell based cell product together with Karolinska Center for Cell Therapy to undertake a phase 1 clinical trial at S:t Eriks Eye hospital. Our next effort is focused on establishing efficient methods to establish photoreceptors to be transplanted alone or together with RPE cells.
This research is supported by